D B Dunger

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Growth and body composition in type 1 diabetes mellitus
    David Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Horm Res 58:66-71. 2002
  2. ncbi request reprint Session 7: Early nutrition and later health early developmental pathways of obesity and diabetes risk
    D B Dunger
    University Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Proc Nutr Soc 66:451-7. 2007
  3. doi request reprint Genetics of size at birth
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, U K
    Diabetes Care 30:S150-5. 2007
  4. ncbi request reprint Can we identify adolescents at high risk for nephropathy before the development of microalbuminuria?
    D B Dunger
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Diabet Med 24:131-6. 2007
  5. ncbi request reprint Early and late weight gain and the timing of puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 254:140-5. 2006
  6. doi request reprint Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): Urinary Screening and Baseline Biochemical and Cardiovascular Assessments
    M Loredana Marcovecchio
    Corresponding author David B Dunger
    Diabetes Care 37:805-13. 2014
  7. pmc Higher levels of IGF-I and adrenal androgens at age 8 years are associated with earlier age at menarche in girls
    Ajay Thankamony
    Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 97:E786-90. 2012
  8. doi request reprint DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial
    Wendy N Cooper
    2 Department of Paediatrics, Box 116, Level 8, Addenbrooke s Hospital, University of Cambridge, Hills Rd, Cambridge CB2 0QQ, UK
    FASEB J 26:1782-90. 2012
  9. pmc The prevalence of stunting, overweight and obesity, and metabolic disease risk in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    BMC Public Health 10:158. 2010
  10. pmc Nutritional status and HIV in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, South Africa
    BMC Pediatr 11:23. 2011

Detail Information

Publications154 found, 100 shown here

  1. ncbi request reprint Growth and body composition in type 1 diabetes mellitus
    David Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Horm Res 58:66-71. 2002
    ..Furthermore, hyperinsulinaemia in these subjects may also lead to ovarian hyperandrogenism, increased early risk of microvascular complications and long-term risk of cardiovascular disease...
  2. ncbi request reprint Session 7: Early nutrition and later health early developmental pathways of obesity and diabetes risk
    D B Dunger
    University Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Proc Nutr Soc 66:451-7. 2007
    ....
  3. doi request reprint Genetics of size at birth
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, U K
    Diabetes Care 30:S150-5. 2007
  4. ncbi request reprint Can we identify adolescents at high risk for nephropathy before the development of microalbuminuria?
    D B Dunger
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Diabet Med 24:131-6. 2007
    ..To determine whether higher than average albumin excretion during early puberty identifies subjects who will subsequently develop microalbuminuria (MA) and clinical proteinuria...
  5. ncbi request reprint Early and late weight gain and the timing of puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 254:140-5. 2006
    ..Trans-generational recurrence of low birth weight, early catch-up weight gain, earlier menarche, and shorter adult stature have been observed in women, and could contribute to the strong heritability in age at menarche...
  6. doi request reprint Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): Urinary Screening and Baseline Biochemical and Cardiovascular Assessments
    M Loredana Marcovecchio
    Corresponding author David B Dunger
    Diabetes Care 37:805-13. 2014
    ..CONCLUSIONS Our data demonstrate that in adolescents with type 1 diabetes, the group with the highest tertile of albumin excretion showed more evidence of early renal and CV disease than those in the lower tertiles. ..
  7. pmc Higher levels of IGF-I and adrenal androgens at age 8 years are associated with earlier age at menarche in girls
    Ajay Thankamony
    Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 97:E786-90. 2012
    ..Earlier age at menarche is associated with rapid infancy weight gain and childhood obesity. The role of hormone levels in mediating these associations is unclear...
  8. doi request reprint DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial
    Wendy N Cooper
    2 Department of Paediatrics, Box 116, Level 8, Addenbrooke s Hospital, University of Cambridge, Hills Rd, Cambridge CB2 0QQ, UK
    FASEB J 26:1782-90. 2012
    ..This pilot study is the first to analyze DNA methylation in the context of a randomized controlled trial, and it provides suggestive evidence that periconceptional maternal nutrition alters offspring methylation at imprinted loci...
  9. pmc The prevalence of stunting, overweight and obesity, and metabolic disease risk in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa
    BMC Public Health 10:158. 2010
    ..This study aimed to investigate the prevalence and patterns of stunting and overweight/obesity, and hence risk for metabolic disease, in a group of children and adolescents in rural South Africa...
  10. pmc Nutritional status and HIV in rural South African children
    Elizabeth W Kimani-Murage
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, Faculty of Health Sciences, University of Witwatersrand, South Africa
    BMC Pediatr 11:23. 2011
    ..This study describes HIV prevalence in children, patterns of malnutrition by HIV status and determinants of nutritional status...
  11. pmc A randomised controlled trial of early insulin therapy in very low birth weight infants, "NIRTURE" (neonatal insulin replacement therapy in Europe)
    Kathryn Beardsall
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital NHS Trust, Hills Road, Cambridge, CB2 2QQ, UK
    BMC Pediatr 7:29. 2007
    ....
  12. pmc Closed-loop insulin delivery for treatment of type 1 diabetes
    Daniela Elleri
    Department of Paediatrics and Institute of Metabolic Science, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
    BMC Med 9:120. 2011
    ....
  13. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
    ....
  14. ncbi request reprint Genetic variations and normal fetal growth
    D B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, UK
    Horm Res 65:34-40. 2006
    ..This suggests that fetal genes, and in particular paternally expressed genes, may have significant effects on fetal growth during pregnancies where maternal restraint of fetal growth is less evident...
  15. ncbi request reprint Serum insulin-like growth factor-I levels and potential risk of type 2 diabetes
    D B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Horm Res 60:131-5. 2003
    ....
  16. pmc ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents
    D B Dunger
    University of Cambridge, Department of Paediatrics, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK
    Arch Dis Child 89:188-94. 2004
    ..There is agreement that prevention of DKA and reduction of its incidence should be a goal in managing children with diabetes...
  17. ncbi request reprint Babies born small for gestational age: insulin sensitivity and growth hormone treatment
    David B Dunger
    University of Cambridge, Department of Paediatrics, Addenbrooke s Hospital, Cambridge, UK
    Horm Res 64:58-65. 2005
    ....
  18. ncbi request reprint Effects of obesity on growth and puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Best Pract Res Clin Endocrinol Metab 19:375-90. 2005
    ..Rapid early weight gain, obesity and early development may have implications for later health through the development of PCOS and overall association with cancer risk...
  19. ncbi request reprint Endocrine and metabolic consequences of intrauterine growth retardation
    David B Dunger
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Endocrinol Metab Clin North Am 34:597-615, ix. 2005
    ....
  20. ncbi request reprint European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents
    David B Dunger
    European Society for Paediatric Endocrinology, West Smithfield, London, United Kingdom
    Pediatrics 113:e133-40. 2004
  21. ncbi request reprint Childhood and adolescent diabetes
    David B Dunger
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Endocr Dev 9:107-20. 2005
    ..The combined treatment is better tolerated and may result in reduced tissue exposure to high levels of 'free' IGF-I. Longer term clinical studies with this IGF-I/IGFBP-3 combination are needed...
  22. ncbi request reprint Abundance of adiponectin in the newborn
    David Dunger
    Department of Paediatrics, University of Cambridge, UK
    Clin Endocrinol (Oxf) 61:416-7. 2004
  23. ncbi request reprint Insulin-like growth factor I and impaired glucose tolerance
    David Dunger
    University Department of Paediatrics, University of Cambridge, Cambridge, UK
    Horm Res 62:101-7. 2004
    ....
  24. pmc Obesity and the insulin resistance syndrome
    D B Dunger
    Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Arch Dis Child 90:1. 2005
  25. doi request reprint Insulin therapy in preterm newborns
    Kathryn Beardsall
    Clinical Lecturer Neonatology, University Department of Paediatrics, Addenbrooke s Hospital Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, United Kingdom
    Early Hum Dev 84:839-42. 2008
    ..It may also have longer term health effects however the outcomes of clinical trials are currently awaited...
  26. doi request reprint Absorption patterns of meals containing complex carbohydrates in type 1 diabetes
    D Elleri
    University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Box 289, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 56:1108-17. 2013
    ..We studied eight young participants with type 1 diabetes to investigate a large low-glycaemic-load (LG) meal and another eight participants to investigate a high-glycaemic-load (HG) meal matched for carbohydrates (121 g)...
  27. ncbi request reprint Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels
    K K Ong
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK
    Diabetologia 47:1064-70. 2004
    ..The largest variations in growth rates occur during the first postnatal years. We hypothesised that early postnatal variations in height and weight gain and IGF-I levels may be associated with risk markers for adult disease...
  28. pmc Validity of triple- and dual-tracer techniques to estimate glucose appearance
    A Haidar
    Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, United Kingdom
    Am J Physiol Endocrinol Metab 302:E1493-501. 2012
    ..The TT technique tends to outperform slightly the DT technique, but the latter benefits from reduced experimental and computational complexity...
  29. ncbi request reprint The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children
    J A Edge
    Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
    Diabetologia 49:2002-9. 2006
    ..Our objective was to determine the impact of baseline biochemical factors and of treatment-related variables on risk of the development of cerebral oedema in children with DKA...
  30. doi request reprint Pathophysiology of postprandial hyperglycaemia in women with type 1 diabetes during pregnancy
    H R Murphy
    University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Box 289, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Diabetologia 55:282-93. 2012
    ..We aimed to describe glucose turnover in pregnant women with type 1 diabetes, according to stage of gestation (early vs late gestation)...
  31. doi request reprint Ambulatory blood pressure measurements are related to albumin excretion and are predictive for risk of microalbuminuria in young people with type 1 diabetes
    M L Marcovecchio
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 52:1173-81. 2009
    ..As microalbuminuria is preceded by a gradual rise in albumin excretion within the normal range, we hypothesised that ambulatory BP (ABP) may be closely related to albumin excretion and progression to microalbuminuria...
  32. doi request reprint Unchanged incidence of microalbuminuria in children with type 1 diabetes since 1986: a UK based inception cohort
    R Amin
    University Department of Paediatrics, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Arch Dis Child 94:258-62. 2009
    ..To prospectively determine the change in prevalence of microalbuminuria in relation to changes in glycaemic control in children diagnosed with type 1 diabetes between 1986 and 1996...
  33. ncbi request reprint Elevated leptin levels are associated with excess gains in fat mass in girls, but not boys, with type 1 diabetes: longitudinal study during adolescence
    M L Ahmed
    University Department of Pediatrics, Addenbrooke's Hospital, Cambridge, United Kingdom CB2 2QQ
    J Clin Endocrinol Metab 86:1188-93. 2001
    ..006 +/- 0.003; P = 0.04) and greater gains in fat mass. Hyperinsulinemia and raised leptin levels are associated with gains in fat mass throughout puberty in girls, but not boys, with type 1 diabetes...
  34. ncbi request reprint Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis
    Ken K L Ong
    Department of Paediatrics, University of Cambridge, Addenbrookes Hospital, Cambridge, UK
    Pediatr Res 52:863-7. 2002
    ..The sequence of fetal growth restraint and postnatal catch-up growth may predispose to obesity risk in this contemporary population...
  35. pmc Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth
    Cathy E Elks
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS Med 7:e1000284. 2010
    ..Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity...
  36. doi request reprint Suspended insulin infusion during overnight closed-loop glucose control in children and adolescents with Type 1 diabetes
    D Elleri
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabet Med 27:480-4. 2010
    ..We assessed an extended interruption of subcutaneous insulin delivery during overnight closed-loop glucose control in children and adolescents with Type 1 diabetes (T1D)...
  37. ncbi request reprint Prolonged cardiac repolarisation during spontaneous nocturnal hypoglycaemia in children and adolescents with type 1 diabetes
    N P Murphy
    Department of Paediatrics, University of Oxford, UK
    Diabetologia 47:1940-7. 2004
    ..It has been postulated that hypoglycaemia-related cardiac dysrhythmia and, in particular, prolonged cardiac repolarisation, may contribute to increased mortality rates in children and adolescents with type 1 diabetes...
  38. pmc Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
    A Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetologia 51:811-5. 2008
    ..We therefore examined the association between common genetic variation in IGF1 and predisposition to type 1 diabetes, childhood growth and metabolism...
  39. pmc Overnight closed-loop insulin delivery with model predictive control: assessment of hypoglycemia and hyperglycemia risk using simulation studies
    Malgorzata E Wilinska
    Cambridge University Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    J Diabetes Sci Technol 3:1109-20. 2009
    ..Additionally, a comparison was made against incidence observed experimentally during open-loop single-night in-clinic studies in young people with type 1 diabetes mellitus (T1DM) treated by continuous SC insulin infusion...
  40. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  41. ncbi request reprint Effects of recombinant human IGF-I/IGF-binding protein-3 complex on glucose and glycerol metabolism in type 1 diabetes
    Tero Saukkonen
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Diabetes 55:2365-70. 2006
    ..In conclusion, rhIGF-I/IGFBP-3 enhances glucose metabolism by controlling both endogenous glucose output and peripheral glucose uptake...
  42. ncbi request reprint Growth hormone binding protein levels in children are associated with birth weight, postnatal weight gain, and insulin secretion
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge CB2 0QQ, UK
    Metabolism 56:1412-7. 2007
    ..Increased GH sensitivity in such children could contribute to links between rapid infancy weight gain and subsequent faster rates of childhood growth and maturation...
  43. ncbi request reprint Dose-dependent effects of recombinant human insulin-like growth factor (IGF)-I/IGF binding protein-3 complex on overnight growth hormone secretion and insulin sensitivity in type 1 diabetes
    Tero Saukkonen
    Department of Paediatrics, University of Cambridge, Box 116, Level 8, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 89:4634-41. 2004
    ..8 mg/kg.d). Thus, restoration of circulating IGF-I and IGFBP-3 levels with rhIGF-I/IGFBP-3 suppresses GH secretion in adolescents with type 1 diabetes, leading to reduced insulin requirements and improvements in insulin sensitivity...
  44. ncbi request reprint Metabolic impact of puberty on the course of type 1 diabetes
    C L Acerini
    Department of Paediatrics, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Diabetes Metab 27:S19-25. 2001
    ....
  45. ncbi request reprint Monitoring of concordance in growth hormone therapy
    R R Kapoor
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Arch Dis Child 93:147-8. 2008
    ..Lower concordance was associated with longer duration on GH therapy (p<0.005), lack of choice of delivery device (p<0.005) and short prescription durations (p<0.005), and predicted lower height velocities (p<0.05)...
  46. ncbi request reprint A randomized cross-over trial to identify the optimal use of insulin glargine in prepubertal children using a three-times daily insulin regimen
    E E Fröhlich-Reiterer
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabet Med 24:1406-11. 2007
    ..However, young children may not tolerate such intensive insulin regimens. We investigated the effects of glargine in various three-injections-daily insulin combinations on 24-h glucose control in prepubertal children...
  47. pmc Longitudinal relation between limited joint mobility, height, insulin-like growth factor 1 levels, and risk of developing microalbuminuria: the Oxford Regional Prospective Study
    R Amin
    University Department of Paediatrics, Addenbrookes Hospital, Cambridge, UK
    Arch Dis Child 90:1039-44. 2005
    ..To determine risk factors for development of microalbuminuria (MA) in relation to detection of limited joint mobility (LJM+) of the interphalangeal joints in a longitudinal cohort of type 1 diabetic (T1DM) subjects...
  48. doi request reprint Asymmetric dimethylarginine in young people with Type 1 diabetes: a paradoxical association with HbA(1c)
    M L Marcovecchio
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 28:685-91. 2011
    ..The aim of the present study was therefore to perform a longitudinal evaluation of plasma ADMA and of its determinants in young people with childhood-onset Type 1 diabetes...
  49. ncbi request reprint Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 53:1128-33. 2004
    ..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
  50. ncbi request reprint Hypoglycemia and resistance to ketoacidosis in a subject without functional insulin receptors
    A L Ogilvy-Stuart
    Department of Pediatrics, Addenbrooke s Hospital, Cambridge, United Kingdom CB2 2QQ
    J Clin Endocrinol Metab 86:3319-26. 2001
    ..As GH plays a critical role in the regulation of ketogenesis during insulinopenia in humans, but not in rodents, this may contribute to the distinct phenotype of human vs. mouse insulin receptor knockouts...
  51. doi request reprint The development of microalbuminuria is associated with raised longitudinal adiponectin levels in female but not male adolescent patients with type 1 diabetes
    R Amin
    University Department of Paediatrics, Box 116, Level 8, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Diabetologia 51:1707-13. 2008
    ..We determined the longitudinal relationship between adiponectin levels and the development of microalbuminuria in an inception cohort of children with type 1 diabetes...
  52. ncbi request reprint Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood
    D B Dunger
    Department of Paediatrics, University of Oxford, John Radcliffe Hospital, Headington, UK
    Nat Genet 19:98-100. 1998
    ..Common genetic variation of this kind may contribute to reported associations between birth size and adult disease...
  53. doi request reprint The effect of prolonged fasting on levels of growth hormone-binding protein and free growth hormone
    B Salgin
    University Department of Paediatrics, Institute of Metabolic Science, University of Cambridge, UK
    Growth Horm IGF Res 22:76-81. 2012
    ..Our aim was to explore the relationships between GHBP, free GH, total GH and non-esterified fatty acid (NEFA) levels during overnight and 24-hour fasts in healthy young adults...
  54. ncbi request reprint Insulin lispro: a potential role in preventing nocturnal hypoglycaemia in young children with diabetes mellitus
    M E Ford-Adams
    Department of Paediatrics, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Diabet Med 20:656-60. 2003
    ..We examined whether replacing soluble insulin with insulin lispro reduced this risk in children on a three times daily insulin regimen...
  55. doi request reprint The descriptive epidemiology of congenital and acquired cryptorchidism in a UK infant cohort
    C L Acerini
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Arch Dis Child 94:868-72. 2009
    ..Recent studies in other European countries suggest that the prevalence of congenital cryptorchidism continues to increase. This study aimed to explore the prevalence and natural history of congenital cryptorchidism in a UK centre...
  56. ncbi request reprint IGF-I and diabetes in adolescence
    D B Dunger
    Department of Paediatrics, John Radcliffe Hospital, Oxford, UK
    Diabetes Metab 24:101-7. 1998
    ....
  57. ncbi request reprint The effects of a specific growth hormone antagonist on overnight insulin requirements and insulin sensitivity in young adults with Type 1 diabetes mellitus
    R M Williams
    University of Cambridge, Department of Paediatrics, Addenbrooke s Hospital, Hills Rd, Cambridge, UK
    Diabetologia 46:1203-10. 2003
    ..Our aim was to determine the effects of specific growth hormone blockade on insulin sensitivity and lipolysis in young adults with Type 1 diabetes...
  58. pmc Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects
    B Salgin
    University Department of Paediatrics, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Am J Physiol Endocrinol Metab 296:E454-61. 2009
    ..The use of acipimox during the prolonged fast increased the disposition index, suggesting a partial reversal of the effects of fasting on the acute insulin response and insulin sensitivity...
  59. ncbi request reprint Reduced gains in fat and fat-free mass, and elevated leptin levels in children and adolescents with cystic fibrosis
    M L Ahme
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Acta Paediatr 93:1185-91. 2004
    ..We have investigated the role of leptin (a potential satiety factor) and changes in body composition, height and weight with respect to age and clinical outcome...
  60. ncbi request reprint Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants
    Kathryn Beardsall
    Department of Paediatrics, University of Cambridge, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK
    J Pediatr 151:611-7, 617.e1. 2007
    ..IGF-I is the dominant hormone involved in fetal growth, and low levels have been implicated in neonatal morbidities, such as retinopathy of prematurity...
  61. ncbi request reprint Short-term suppression of elevated growth hormone concentrations following insulin-like growth factor 1 administration in young adults with type 1 diabetes does not alter glomerular filtration or albumin excretion rates
    Rachel M Williams
    University of Cambridge, Department of Paediatrics, Cambridge, UK
    Clin Endocrinol (Oxf) 65:439-45. 2006
    ..We tested the hypothesis that restoration of circulating IGF-I concentrations in young adults with T1DM might suppress GH secretion, GFR and urinary albumin excretion...
  62. ncbi request reprint Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency
    Kevin C J Yuen
    Department of Endocrinology and Paediatrics, Addenbrooke s Hospital, Cambridge, UK
    Clin Endocrinol (Oxf) 63:428-36. 2005
    ....
  63. ncbi request reprint Low IGF-I and elevated testosterone during puberty in subjects with type 1 diabetes developing microalbuminuria in comparison to normoalbuminuric control subjects: the Oxford Regional Prospective Study
    Rakesh Amin
    University Department of Pediatrics, Addenbrookes Hospital, Cambridge, UK
    Diabetes Care 26:1456-61. 2003
    ..To describe longitudinal variations in pubertal hormonal variables in subjects with and without microalbuminuria (MA)...
  64. ncbi request reprint Increasing urine albumin excretion is associated with growth hormone hypersecretion and reduced clearance of insulin in adolescents and young adults with type 1 diabetes: the Oxford Regional Prospective Study
    Rakesh Amin
    University Department of Paediatrics, Addenbrookes Hospital, Cambridge, UK
    Clin Endocrinol (Oxf) 62:137-44. 2005
    ..By inference lower IGF-I levels may be associated with higher GH levels and changes in insulin sensitivity...
  65. pmc Causes of death in children with insulin dependent diabetes 1990-96
    J A Edge
    Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Arch Dis Child 81:318-23. 1999
    ..Mortality rates in children with insulin dependent diabetes (IDDM) in the UK are unknown and the causes of death not well documented...
  66. pmc The risk and outcome of cerebral oedema developing during diabetic ketoacidosis
    J A Edge
    Department of Paediatrics, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
    Arch Dis Child 85:16-22. 2001
    ..Cerebral oedema is a major cause of morbidity and mortality in children with insulin dependent diabetes...
  67. ncbi request reprint A longitudinal study of the effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease
    Rakesh Amin
    University Department of Paediatrics, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Care 25:1117-22. 2002
    ..To describe the longitudinal growth characteristics and glycemic control in type 1 diabetic children diagnosed with celiac disease and started on a gluten-free diet (GFD)...
  68. doi request reprint Treatment with recombinant human insulin-like growth factor (rhIGF)-I/rhIGF binding protein-3 complex improves metabolic control in subjects with severe insulin resistance
    Fiona M Regan
    University of Cambridge, Department of Pediatrics, Cambridge, United Kingdom
    J Clin Endocrinol Metab 95:2113-22. 2010
    ..We report clinical and physiological outcomes after adjunctive therapy with rhIGF-I/rhIGFBP-3 in five subjects with SIR...
  69. pmc Earlier mother's age at menarche predicts rapid infancy growth and childhood obesity
    Ken K Ong
    Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
    PLoS Med 4:e132. 2007
    ..As age at menarche is a heritable trait, we hypothesised that age at menarche in the mother may in turn predict her children's early growth and obesity risk...
  70. ncbi request reprint IGF-I treatment of insulin resistance
    Anna McDonald
    University of Cambridge, Department of Paediatrics, Box 116, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2QQ, UK
    Eur J Endocrinol 157:S51-6. 2007
    ....
  71. ncbi request reprint Randomized cross-over trial of insulin glargine plus lispro or NPH insulin plus regular human insulin in adolescents with type 1 diabetes on intensive insulin regimens
    Nuala P Murphy
    Department of Paediatrics, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Diabetes Care 26:799-804. 2003
    ..To compare blood glucose control and incidence of nocturnal hypoglycemia in adolescents with type 1 diabetes on multiple injection regimens managed with either an insulin analog combination or NPH insulin plus regular human insulin...
  72. ncbi request reprint No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility
    Rebecca Pask
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK
    Diabetes Metab Res Rev 22:356-60. 2006
    ..Replication of association in independent, large-sample studies is essential to further identify the genes involved in T1D. Two single nucleotide polymorphisms (SNPs) in the catalase gene have been reported to be associated with T1D...
  73. doi request reprint Short-term administration of pegvisomant improves hepatic insulin sensitivity and reduces soleus muscle intramyocellular lipid content in young adults with type 1 diabetes
    A Thankamony
    Department of Paediatrics A T, P H T, C A, D E, R M W, D B D, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom Wolfson Brain Imaging Centre A S, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom Department of Paediatrics P H T, University of Oulu, 90029 OYS, Oulu, Finland WellChild Laboratory R N D, King s College London, Evelina Children s Hospital, London SE1 7EH, United Kingdom Diabetes and Metabolic Medicine N C J, A M U, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7WG, United Kingdom and National Institute for Health Research Cambridge Comprehensive Biomedical Research Centre D B D, Cambridge, CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 99:639-47. 2014
    ..Unchanged peripheral IS despite reductions in IMCL indicate that GH-induced alterations in IMCL may not be causally linked to glucose metabolism. ..
  74. pmc Measurement delay associated with the Guardian RT continuous glucose monitoring system
    C Wei
    MRC Biostatistics Unit, Institute of Public Health, University of Cambridge, Cambridge, UK
    Diabet Med 27:117-22. 2010
    ..Using compartment modelling, we assessed the time delay between blood glucose and sensor glucose measured by the Guardian RT continuous glucose monitoring system in young subjects with Type 1 diabetes (T1D)...
  75. doi request reprint Reduced endogenous secretory receptor for advanced glycation end products (esRAGE) in young people with Type 1 diabetes developing microalbuminuria
    M L Marcovecchio
    Department of Paediatrics and Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Diabet Med 26:815-9. 2009
    ..The aim of the present study was to perform a longitudinal evaluation of esRAGE in young people with Type 1 diabetes (T1D) in relation to the development of microalbuminuria (MA)...
  76. pmc Growth hormone (GH) provocation tests and the response to GH treatment in GH deficiency
    T J Cole
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    Arch Dis Child 89:1024-7. 2004
    ..To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD)...
  77. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
    ..Our aim was to study the association between the CYP27B1 and CYP24A1 gene polymorphisms and type 1 diabetes...
  78. pmc Ghrelin receptor gene polymorphisms and body size in children and adults
    Edwin A Garcia
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Clin Endocrinol Metab 93:4158-61. 2008
    ..Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth...
  79. doi request reprint Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects
    Burak Salgin
    University Department of Paediatrics, University of Cambridge, Cambridge, U K
    Clin Sci (Lond) 117:111-8. 2009
    ....
  80. pmc Prevalence of abnormal lipid profiles and the relationship with the development of microalbuminuria in adolescents with type 1 diabetes
    M Loredana Marcovecchio
    Department of Paediatrics and the Institute of Metabolic Science, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Care 32:658-63. 2009
    ..To explore the prevalence of lipid abnormalities and their relationship with albumin excretion and microalbuminuria in adolescents with type 1 diabetes...
  81. doi request reprint Heritability of childhood weight gain from birth and risk markers for adult metabolic disease in prepubertal twins
    Kathryn Beardsall
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 0QQ, United Kingdom
    J Clin Endocrinol Metab 94:3708-13. 2009
    ..We utilized a twin model to explore these hypotheses...
  82. ncbi request reprint Individual igf-I responsiveness to a fixed regimen of low-dose growth hormone replacement is increased with less variability in obese compared to non-obese adults with severe growth hormone deficiency
    Kevin C J Yuen
    Department of Endocrinology, Addenbrooke s Hospital, Cambridge, UK, and Division of Endocrinology, Oregon Health and Science University, Portland 97239 3098, USA
    Horm Res 65:6-13. 2006
    ..To address this question, we challenged a cohort of severely GH-deficient non-obese and obese adults with a fixed low GH dose (0.2 mg/day), and examined the relationship of body mass index (BMI) with IGF-I response...
  83. ncbi request reprint Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Growth Horm IGF Res 15:363-8. 2005
    ..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth...
  84. ncbi request reprint Hypoglycemia prevalence in prepubertal children with type 1 diabetes on standard insulin regimen: use of continuous glucose monitoring system
    Rakesh Amin
    University Departments of Paediatrics, Addenbrookes Hospital, Cambridge, UK
    Diabetes Care 26:662-7. 2003
    ..To determine hypoglycemia prevalence in prepubertal children on thrice (TID) and twice (BID) daily insulin regimens, using the Medtronic Minimed Continuous Glucose Monitoring System...
  85. pmc Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    Adrian Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Hum Genet 76:773-9. 2005
    ..3x10(-3); combined P=1.3x10(-10)). These results illustrate the utility of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region...
  86. doi request reprint Association between a common variant near MC4R and change in body mass index develops by two weeks of age
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Horm Res Paediatr 73:275-80. 2010
    ..Our objective was to test the association between rs17782313 and neonatal weight gain in a contemporary population...
  87. ncbi request reprint The relationship between microalbuminuria and glomerular filtration rate in young type 1 diabetic subjects: The Oxford Regional Prospective Study
    Rakesh Amin
    University Department of Paediatrics, Addenbrookes Hospital, Cambridge, UK
    Kidney Int 68:1740-9. 2005
    ..The purpose of this study was to examine the relationship between glomerular filtration rate (GFR) measured at 5 years' diabetes duration and annual urine albumin excretion in a prospective cohort of children with type 1 diabetes (T1DM)...
  88. ncbi request reprint Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..24 x 10(-4); OR 1.43 [95% CI 1.17-1.76]). Taken together, these results indicate a more general association of the PTPN22 locus with autoimmune disease...
  89. doi request reprint Validation of the continuous glucose monitoring sensor in preterm infants
    K Beardsall
    Department of Paediatrics, University of Cambridge, Cambridge University Hospitals NHS Foundation Trust, Hills Road, UK
    Arch Dis Child Fetal Neonatal Ed 98:F136-40. 2013
    ..This study aimed to assess the accuracy of the continuous glucose monitoring sensor (CGMS) across the glucose profile, and to determine whether there was any deterioration over a 7 day period...
  90. ncbi request reprint Developmental aspects in the pathogenesis of type 2 diabetes
    K K Ong
    Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 185:145-9. 2001
    ..Finally, larger early postnatal size is also important for survival and some genotypes may promote infancy growth, but in affluent societies may predispose to obesity and increased risks for adulthood type 2 diabetes...
  91. doi request reprint Prevention and treatment of microvascular disease in childhood type 1 diabetes
    M L Marcovecchio
    Department of Paediatrics and Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    Br Med Bull 94:145-64. 2010
    ..The prevention and treatment of microvascular complications, which include nephropathy, retinopathy and neuropathy, are of paramount importance to decrease the associated mortality and morbidity...
  92. ncbi request reprint Insulin treatment in children and adolescents
    R M Williams
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Acta Paediatr 93:440-6. 2004
    ..CONCLUSION: This review will focus on the particular difficulties of managing diabetes in children and, in particular, the problem of avoiding hypoglycaemia while maintaining adequate glycaemic control...
  93. pmc The continuous glucose monitoring sensor in neonatal intensive care
    K Beardsall
    University of Cambridge, Department of Paediatrics, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Arch Dis Child Fetal Neonatal Ed 90:F307-10. 2005
    ..To determine the feasibility of continuous glucose monitoring in the very low birthweight baby requiring intensive care, as these infants are known to be at high risk of abnormalities of glucose control...
  94. ncbi request reprint Association of aromatase (CYP 19) gene variation with features of hyperandrogenism in two populations of young women
    C J Petry
    Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
    Hum Reprod 20:1837-43. 2005
    ..Aromatase catalyses the conversion of androgens to estrogens and thus variation in the aromatase gene could contribute to female syndromes of androgen excess, such as precocious pubarche (PP) and polycystic ovarian syndrome (PCOS)...
  95. doi request reprint Effect of delay on measurement of blood glucose levels in young subjects with type 1 diabetes
    Daniela Elleri
    Department of Paediatrics, University of Cambridge, Hills Road, Cambridge CB2 0QQ, UK
    Diabetes Res Clin Pract 86:e31-3. 2009
    ..Blood glucose decreased by 0.47 mmol/L despite samples being collected in fluoride tubes and placed on ice. The extent of reduction differs among subjects, prevailing blood glucose and time-of-day of sample withdrawal...
  96. doi request reprint Early insulin therapy in very-low-birth-weight infants
    Kathryn Beardsall
    University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 359:1873-84. 2008
    ..This international randomized, controlled trial aimed to determine whether early insulin replacement reduced hyperglycemia and affected outcomes in such neonates...
  97. pmc Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
    Maria Ban
    Department of Clinical Neuroscience, Addenbrooke s, Hospital, University of Cambridge, Cambridge, UK
    Eur J Hum Genet 17:1309-13. 2009
    ....
  98. ncbi request reprint Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer
    Manjinder S Sandhu
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    J Natl Cancer Inst 94:972-80. 2002
    ..This new evidence for biologic interactions among insulin, IGF-I, and IGFBPs in the context of colorectal carcinogenesis provides a potential mechanism through which diet and associated factors may increase the risk of this cancer...
  99. pmc Closed-loop insulin delivery during pregnancy complicated by type 1 diabetes
    Helen R Murphy
    Institute of Metabolic Science, Metabolic Research Laboratories, University of Cambridge, Hills Road, Cambridge, UK
    Diabetes Care 34:406-11. 2011
    ..This study evaluated closed-loop insulin delivery with a model predictive control (MPC) algorithm during early (12-16 weeks) and late gestation (28-32 weeks) in pregnant women with type 1 diabetes...
  100. doi request reprint Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study
    Ken K Ong
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge, UK
    Am J Clin Nutr 90:156-61. 2009
    ..Formula milk-fed infants show faster rates of growth and weight gain than do breastfed infants, and they have higher concentrations of insulin-like growth factor I (IGF-I)...