Harminder S Dua

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Quest for limbal stem cells
    Harminder S Dua
    Clin Experiment Ophthalmol 34:1-2. 2006
  2. ncbi request reprint Alcohol delamination of the corneal epithelium: an alternative in the management of recurrent corneal erosions
    Harminder S Dua
    Division of Ophthalmology, University Hospital, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
    Ophthalmology 113:404-11. 2006
  3. pmc Validation of endogenous control genes for gene expression studies on human ocular surface epithelium
    Bina Kulkarni
    Division of Ophthalmology and Visual Sciences, Queen s Medical Centre, Nottingham, United Kingdom
    PLoS ONE 6:e22301. 2011
  4. pmc Optimised laser microdissection of the human ocular surface epithelial regions for microarray studies
    Bina B Kulkarni
    Division of Ophthalmology and Visual Sciences, B Floor, Eye and ENT Building, Queen s Medical Centre, Derby Road, Nottingham, UK
    BMC Ophthalmol 13:62. 2013
  5. ncbi request reprint Human corneal anatomy redefined: a novel pre-Descemet's layer (Dua's layer)
    Harminder S Dua
    Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, Division of Histopathology, University of Nottingham, United Kingdom
    Ophthalmology 120:1778-85. 2013
  6. doi request reprint Management of postkeratoplasty astigmatism by paired arcuate incisions with compression sutures
    Usama Fares
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 97:438-43. 2013
  7. doi request reprint The effect of gravitational force on limbal stem cell growth
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 96:1034-7. 2012
  8. doi request reprint In vivo confocal microscopic findings in patients with limbal stem cell deficiency
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 96:523-9. 2012
  9. ncbi request reprint Stem cell differentiation and the effects of deficiency
    H S Dua
    Division of Ophthalmology and Visual Sciences, School of Clinical Laboratory Sciences, University of Nottingham, Nottingham, UK
    Eye (Lond) 17:877-85. 2003
  10. doi request reprint Contemporary limbal stem cell transplantation - a review
    Harminder S Dua
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham NG7 2UH, England, UK
    Clin Experiment Ophthalmol 38:104-17. 2010

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Quest for limbal stem cells
    Harminder S Dua
    Clin Experiment Ophthalmol 34:1-2. 2006
  2. ncbi request reprint Alcohol delamination of the corneal epithelium: an alternative in the management of recurrent corneal erosions
    Harminder S Dua
    Division of Ophthalmology, University Hospital, Queens Medical Centre, University of Nottingham, Nottingham, United Kingdom
    Ophthalmology 113:404-11. 2006
    ..To investigate the efficacy of alcohol delamination in the management of recurrent corneal erosions (RCEs)...
  3. pmc Validation of endogenous control genes for gene expression studies on human ocular surface epithelium
    Bina Kulkarni
    Division of Ophthalmology and Visual Sciences, Queen s Medical Centre, Nottingham, United Kingdom
    PLoS ONE 6:e22301. 2011
    ....
  4. pmc Optimised laser microdissection of the human ocular surface epithelial regions for microarray studies
    Bina B Kulkarni
    Division of Ophthalmology and Visual Sciences, B Floor, Eye and ENT Building, Queen s Medical Centre, Derby Road, Nottingham, UK
    BMC Ophthalmol 13:62. 2013
    ..0 ST arrays...
  5. ncbi request reprint Human corneal anatomy redefined: a novel pre-Descemet's layer (Dua's layer)
    Harminder S Dua
    Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, Division of Histopathology, University of Nottingham, United Kingdom
    Ophthalmology 120:1778-85. 2013
    ..To define and characterize a novel pre-Descemet's layer in the human cornea...
  6. doi request reprint Management of postkeratoplasty astigmatism by paired arcuate incisions with compression sutures
    Usama Fares
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 97:438-43. 2013
    ..To analyse the efficacy of paired arcuate incisions and compression sutures technique in the management of post penetrating keratoplasty (PK) astigmatism...
  7. doi request reprint The effect of gravitational force on limbal stem cell growth
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 96:1034-7. 2012
    ..To evaluate the effect of gravity on corneal epithelial cell migration in vitro...
  8. doi request reprint In vivo confocal microscopic findings in patients with limbal stem cell deficiency
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 96:523-9. 2012
    ..To describe in vivo confocal microscopy (IVCM) findings in patients with limbal stem cell deficiency (LSCD)...
  9. ncbi request reprint Stem cell differentiation and the effects of deficiency
    H S Dua
    Division of Ophthalmology and Visual Sciences, School of Clinical Laboratory Sciences, University of Nottingham, Nottingham, UK
    Eye (Lond) 17:877-85. 2003
    ..Conjunctivalisation and vascularisation of the corneal surface and persistent or recurring epithelial defects are hallmarks of limbal deficiency...
  10. doi request reprint Contemporary limbal stem cell transplantation - a review
    Harminder S Dua
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham NG7 2UH, England, UK
    Clin Experiment Ophthalmol 38:104-17. 2010
    ..Despite its complexities limbal transplantation does significantly improve vision related quality of life. Autografts give the best results and living related donor grafts are next best. Majority of cadaver grafts fail in 5 years...
  11. doi request reprint The role of limbal stem cells in corneal epithelial maintenance: testing the dogma
    Harminder S Dua
    Division of Ophthalmology and Visual Sciences, Queens Medical Centre, University Hospital, Derby Road, Nottingham, UK
    Ophthalmology 116:856-63. 2009
    ....
  12. ncbi request reprint Limbal stem cells of the corneal epithelium
    H S Dua
    Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Surv Ophthalmol 44:415-25. 2000
    ..With the latter option, systemic immunosuppression is required. Amniotic membrane transplantation is a useful adjunct to the above procedures in some instances...
  13. pmc Limbal epithelial crypts: a novel anatomical structure and a putative limbal stem cell niche
    H S Dua
    The Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University of Nottingham, UK
    Br J Ophthalmol 89:529-32. 2005
    ..The authors undertook to re-evaluate the microanatomy of the limbus in order to identify possible sites that may represent a stem cell niche...
  14. ncbi request reprint Protection of corneal endothelium from irrigation damage: a comparison of sodium hyaluronate and hydroxypropylmethylcellulose
    H S Dua
    Department of Ophthalmology, Queen s Medical Centre, University Hospital Nottingham, UK
    Eye (Lond) 14:88-92. 2000
    ..To compare the endothelial protection of sodium hyaluronate and hydroxypropylmethylcellulose against endothelial damage induced by irrigation...
  15. ncbi request reprint Histologic features of transplanted amniotic membrane: implications for corneal wound healing
    Dalia G Said
    Division of Ophthalmology, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham, England
    Ophthalmology 116:1287-95. 2009
    ..To evaluate the histologic changes occurring in the transplanted amniotic membrane in human eyes...
  16. pmc Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics
    Bina B Kulkarni
    Division of Ophthalmology and Visual Sciences, Eye and ENT Building Queen s Medical Centre, Derby Road, Nottingham, UK
    BMC Genomics 11:526. 2010
    ..The purpose of this microarray study was to characterise the transcriptional profile of the LEC and compare with other ocular surface epithelial regions to support our hypothesis that LEC preferentially harbours stem cells (SC)...
  17. ncbi request reprint Optimization of amniotic membrane (AM) denuding for tissue engineering
    Andrew Hopkinson
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom
    Tissue Eng Part C Methods 14:371-81. 2008
    ..We compare the effects of the main denuding procedures, and propose a highly effective standardized alternative...
  18. ncbi request reprint Long-term outcomes of autolimbal and allolimbal transplants
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, England
    Ophthalmology 117:1207-13. 2010
    ..To evaluate the long-term results of limbal stem cell transplantation (LSCT) in patients with ocular surface (OS) disease...
  19. doi request reprint Increased expression of hepcidin and toll-like receptors 8 and 10 in viral keratitis
    Imran Mohammed
    Larry A Donoso Laboratory for Eye Research, Academic Division of Ophthalmology, ENT Centre, University of Nottingham, Nottingham, United Kingdom
    Cornea 30:899-904. 2011
    ..Evidence suggests that pathogen recognition by TLR releases AMPs, altering AMP-TLR profiles in pathological states. This study investigated ocular surface expression of AMP-TLRs in health and disease...
  20. doi request reprint Histological and confocal microscopy changes in chronic corneal edema: implications for endothelial transplantation
    Thaer S Alomar
    Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 52:8193-207. 2011
    ..To report in vivo confocal microscopic (IVCM) features in corneal edema supported by histopathologic correlation...
  21. doi request reprint Localization and gene expression of human beta-defensin 9 at the human ocular surface epithelium
    Imran Mohammed
    Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, The University of Nottingham, Queens Medical Centre, University Hospital, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 51:4677-82. 2010
    ....
  22. ncbi request reprint The collagen matrix of the human trabecular meshwork is an extension of the novel pre-Descemet's layer (Dua's layer)
    Harminder S Dua
    The Larry A Donoso Laboratory, Academic Ophthalmology, University of Nottingham, UK
    Br J Ophthalmol 98:691-7. 2014
    ..A novel layer in the posterior part of the human cornea has recently been reported (the pre-Descemet's layer (Dua's layer (PDL)). We examined the peripheral part of this layer in relation to the origin of the TM...
  23. pmc Morphological characteristics of the limbal epithelial crypt
    Vijay A Shanmuganathan
    The Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University of Nottingham, United Kingdom
    Br J Ophthalmol 91:514-9. 2007
    ..The purpose of this study was to further evaluate the distribution, immunophenotypical, and ultra structural characteristics of the LEC as a putative niche of stem cells...
  24. doi request reprint Wavefront-optimized excimer laser in situ keratomileusis for myopia and myopic astigmatism: refractive outcomes and corneal densitometry
    Usama Fares
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom
    J Cataract Refract Surg 38:2131-8. 2012
    ..To determine the refractive outcomes of wavefront-optimized laser in situ keratomileusis (LASIK) treatments, in particular to measure corneal densitometry after LASIK using the densitometry function of the Pentacam Scheimpflug system...
  25. doi request reprint Variable expression of human Beta defensins 3 and 9 at the human ocular surface in infectious keratitis
    Ahmad Muneer Otri
    Division of Ophthalmology and Visual Sciences, The University of Nottingham, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 53:757-61. 2012
    ..These play an important role in infection and inflammation. In the present study, the authors studied the gene expression levels of hBD3 and hBD9 in healthy subjects and during and after healing of infectious keratitis...
  26. doi request reprint Organization of the regenerated nerves in human corneal grafts
    Mouhamed Ali Al-Aqaba
    School of Clinical Sciences, Division of Ophthalmology and Visual Sciences, University of Nottingham, United Kingdom
    Am J Ophthalmol 153:29-37.e4. 2012
    ..To examine by histopathology the degree of nerve regeneration in human corneal grafts and to determine the anatomic organization and morphology of the regenerated nerves...
  27. doi request reprint Profile of sight-threatening infectious keratitis: a prospective study
    Ahmad M Otri
    Division of Ophthalmology and Visual Sciences, Queens Medical Centre, Nottingham, UKDepartment of Ophthalmology, Aleppo University Hospital, Aleppo University, Aleppo, Syria
    Acta Ophthalmol 91:643-51. 2013
    ..To prospectively study patients presenting with sight-threatening corneal ulcers with a view to identify the predisposing factors, causative organisms, clinical signs and treatment outcomes...
  28. doi request reprint Tissue transglutaminase (TG-2) modified amniotic membrane: a novel scaffold for biomedical applications
    David Y S Chau
    Allergy Research Group, School of Molecular Medical Sciences, Queen s Medical Centre, The University of Nottingham, Nottingham NG7 2UH, UK
    Biomed Mater 7:045011. 2012
    ....
  29. doi request reprint Donor site complications in autolimbal and living-related allolimbal transplantation
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, UK
    Ophthalmology 118:1265-71. 2011
    ..To study the long-term changes at donor sites and safety implications for donor eyes used for harvesting tissue for autologous and living-related donor limbal transplants...
  30. doi request reprint The effect of standard and transepithelial ultraviolet collagen cross-linking on human corneal nerves: an ex vivo study
    Mouhamed Al-Aqaba
    Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, University of Nottingham, United Kingdom
    Am J Ophthalmol 153:258-266.e2. 2012
    ..To evaluate the early effect of standard and transepithelial collagen cross-linking on human corneal nerves in donor eyes by ex vivo confocal microscopy and acetylcholinesterase staining...
  31. doi request reprint The morphologic characteristics of corneal nerves in advanced keratoconus as evaluated by acetylcholinesterase technique
    Mouhamed Ali Al-Aqaba
    Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom
    Am J Ophthalmol 152:364-376.e1. 2011
    ..To study the morphologic characteristics of corneal nerves in patients with advanced keratoconus using the acetylcholinesterase technique in corneal whole mounts...
  32. doi request reprint In vivo confocal microscopic features of normal limbus
    Ammar Miri
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, England, UK
    Br J Ophthalmol 96:530-6. 2012
    ..To describe in vivo confocal microscopy (IVCM) features of the limbus in normal eyes as related to the palisades of Vogt's...
  33. doi request reprint Outcomes of deep anterior lamellar keratoplasty following successful and failed 'big bubble'
    Uday K Bhatt
    Department of Ophthalmology, Queens Medical Centre, Nottingham, UK
    Br J Ophthalmol 96:564-9. 2012
    ..Manual dissection is then required to complete the procedure. The aim of the study is to compare these two groups, successful BB versus failed bubble (FB) dissection to determine whether the clinical outcomes were different...
  34. pmc Alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome: a prospective study of efficacy and safety
    Ravinder P Singh
    Division of Ophthalmology and Visual Sciences, University of Nottingham, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Ophthalmol 91:908-11. 2007
    ..To investigate the safety and efficacy of alcohol delamination of the corneal epithelium for recalcitrant recurrent corneal erosion syndrome (RCE) in a prospective non-comparative interventional case series...
  35. ncbi request reprint Amniotic membrane transplantation for ocular surface reconstruction: indications and outcomes
    V Senthil Maharajan
    Division of Ophthalmology and Visual Sciences, Eye, Ear, Nose and Throat Centre, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Clin Experiment Ophthalmol 35:140-7. 2007
    ..Herein, the authors' results of amniotic membrane transplantation (AMT) in ocular surface reconstruction against defined outcome measures are reported...
  36. doi request reprint Limbal epithelial crypt: a model for corneal epithelial maintenance and novel limbal regional variations
    Aaron Ming Hon Yeung
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, England
    Arch Ophthalmol 126:665-9. 2008
    ..To determine the distribution of cell membrane proteins and extracellular matrix proteins around the limbal epithelial crypt (LEC) compared with adjacent limbus and corneal epithelium...
  37. doi request reprint A novel antimicrobial peptide on the ocular surface shows decreased expression in inflammation and infection
    Asiya Abedin
    Larry A Donoso Laboratory for Eye Research, Academic Division of Ophthalmology, University of Nottingham, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 49:28-33. 2008
    ..In the present study, a beta-defensin AMP gene was isolated from the ocular surface for the first time, and its expression was characterized in the presence of ocular inflammation and/or infection...
  38. doi request reprint Epidermal growth factor variations in amniotic membrane used for ex vivo tissue constructs
    Jean Jacques Gicquel
    Division of Ophthalmology and Visual Sciences, Hospital Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Tissue Eng Part A 15:1919-1927.. 2009
    ..This study investigated EGF content in AM in relation to intra- and inter-donor variations and the effect of processing and preservation (handling)...
  39. doi request reprint Diffuse keratoconjunctival proliferation: a novel clinical manifestation
    Dalia G Said
    Division of Ophthalmology and Visual Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, England
    Arch Ophthalmol 126:1226-32. 2008
    ..To report a previously unrecognized benign bilateral widespread conjunctival and corneal proliferative condition with a potential to affect vision...
  40. ncbi request reprint Proteomic analysis of amniotic membrane prepared for human transplantation: characterization of proteins and clinical implications
    Andrew Hopkinson
    Division of Ophthalmology and Visual Sciences, University of Nottingham, United Kingdom
    J Proteome Res 5:2226-35. 2006
    ..Without standardization, there will be inter-membrane variation, which may compromise the desired therapeutic effect of transplant ready amniotic membrane...
  41. ncbi request reprint The spectrum of antimicrobial peptide expression at the ocular surface
    Richard S McIntosh
    Larry A Donoso Laboratory for Eye Research, University of Nottingham Division of Ophthalmology and Visual Sciences, Eye, Ear, Nose, and Throat Centre, University Hospital, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 46:1379-85. 2005
    ..In the present study, a survey was made of antimicrobial peptide expression, including 17 previously described members of the beta-defensin family, at the surface of the human eye...
  42. doi request reprint Efficacy, predictability, and safety of wavefront-guided refractive laser treatment: metaanalysis
    Usama Fares
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom
    J Cataract Refract Surg 37:1465-75. 2011
    ..To compare the efficacy, predictability, safety, and induced higher-order aberrations (HOAs) between wavefront-guided and non-wavefront-guided ablations...
  43. doi request reprint Corneal densitometry as an indicator of corneal health
    Ahmad Muneer Otri
    School of Clinical Sciences, Division of Ophthalmology and Visual Sciences, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
    Ophthalmology 119:501-8. 2012
    ..Wetzlar, Germany) and to investigate alteration in corneal density during active and healed stages of bacterial keratitis...
  44. doi request reprint Signalling pathways involved in ribonuclease-7 expression
    Imran Mohammed
    Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University Hospital, Nottingham NG7 2UH, UK
    Cell Mol Life Sci 68:1941-52. 2011
    ..However, RNase-7 induction by IL-1β was not affected by inhibiting the NF-κB signalling pathway. In conclusion, our results indicate that RNase-7 expression is specifically mediated via MAPKs but not NF-κB signalling pathways...
  45. ncbi request reprint Atypical hydrops in keratoconus
    Dalia G Said
    Department of Ophthalmology, Queens Medical Centre, Nottingham University Hospitals, University of Nottingham, Derby Road, Nottingham, NG7 2UH, UK
    Int Ophthalmol 34:951-5. 2014
    ....
  46. ncbi request reprint Architecture and distribution of human corneal nerves
    Mouhamed A Al-Aqaba
    Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, University of Nottingham Medical School, Nottingham, UK
    Br J Ophthalmol 94:784-9. 2010
    ..To comprehensively study the gross anatomy of human corneal innervation...
  47. doi request reprint Management of post-keratoplasty astigmatism
    Usama Fares
    Division of Ophthalmology and Visual Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, United Kingdom
    J Cataract Refract Surg 38:2029-39. 2012
    ..In this review, we discuss the etiology and management of post-keratoplasty astigmatism and provide recommendations and tips to minimize it...
  48. doi request reprint Correlation of central and peripheral corneal thickness in healthy corneas
    Usama Fares
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Eye Ear Nose Throat Centre, University Hospital, Nottingham, United Kingdom
    Cont Lens Anterior Eye 35:39-45. 2012
    ..To study the thickness profile of the normal cornea in order to establish any correlation between central and peripheral points...
  49. doi request reprint Corneal intraepithelial neoplasia: in vivo confocal microscopic study with histopathologic correlation
    Thaer S Alomar
    Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom
    Am J Ophthalmol 151:238-47. 2011
    ..To ascertain in vivo confocal microscopic features of corneal/conjunctival intraepithelial neoplasia (CIN) and correlate these with histology of the same lesions...
  50. doi request reprint Corneal nerve aberrations in bullous keratopathy
    Mouhamed Al-Aqaba
    School of Clinical Sciences, Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, United Kingdom
    Am J Ophthalmol 151:840-849.e1. 2011
    ..To study the corneal nerves in patients with chronic bullous keratopathy...
  51. ncbi request reprint Effect of refractive and topographic astigmatic axis on LASIK correction of myopic astigmatism
    Mohamed A Bragheeth
    Division of Ophthalmology and Visual Sciences, University of Nottingham, United Kingdom
    J Refract Surg 21:269-75. 2005
    ..To evaluate whether agreement or disagreement between the axis of astigmatism as determined by refraction and corneal topography has any influence on the outcome of laser in situ keratomileusis (LASIK) correction of astigmatism...
  52. ncbi request reprint Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues
    Andrew Hopkinson
    University of Nottingham Division of Ophthalmology and Visual Sciences, EENT Centre, UK
    Proteomics 5:1967-79. 2005
    ..Samples were either cup-loaded onto rehydrated HED-containing strips or rebuffered into HED-containing buffer followed by in-gel rehydration...
  53. pmc S antigen specific effector T cell activation detected by cytokine flow cytometry
    J P Morgan
    The Larry Donoso Research Laboratory, Division of Ophthalmology and Visual Sciences, Eye Ear Nose and Throat Centre, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Br J Ophthalmol 86:517-20. 2002
    ..This pilot study seeks to demonstrate activation of human peripheral effector T cells in response to the uveitis candidate autoantigen, retinal S antigen (SAg), using cytokine flow cytometry (CFC)...
  54. pmc Epithelial proliferative potential of organ cultured corneoscleral rims; implications for allo-limbal transplantation and eye banking
    V A Shanmuganathan
    Division of Ophthalmology and Visual Sciences, University Hospital, Nottingham NG7 2UH, UK
    Br J Ophthalmol 90:55-8. 2006
    ..To determine the epithelial proliferative capacity of organ cultured limbal tissue and correlate this with various donor and eye banking factors...
  55. ncbi request reprint Malignant glaucoma after diode laser cyclophotocoagulation
    A Azuara-Blanco
    Department of Ophthalmology, Queen s Medical Centre, University of Nottingham, England
    Am J Ophthalmol 127:467-9. 1999
    ..To report a case of malignant glaucoma after diode laser cyclophotocoagulation...
  56. ncbi request reprint Alcohol debridement of the corneal epithelium in PRK and LASEK: an electron microscopic study
    Andrew C Browning
    Division of Ophthalmology and Visual Sciences, University Hospital, University of Nottingham, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 44:510-3. 2003
    ..To determine the plane of cleavage of the corneal epithelium and smoothness of underlying stroma, after alcohol debridement in photorefractive keratectomy (PRK) and laser subepithelial keratectomy (LASEK)...
  57. ncbi request reprint Expression of CD34 and L-selectin on human corneal keratocytes
    Annie Joseph
    Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, Eye, Ear, Nose, and Throat Centre, University of Nottingham, Queen s Medical Centre, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 44:4689-92. 2003
    ..To investigate the expression of CD34, a hematopoietic stem cell marker and an adhesion molecule, and its ligand L-selectin in the human cornea...
  58. ncbi request reprint Concise review: evidence for CD34 as a common marker for diverse progenitors
    Laura E Sidney
    Academic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Queen s Medical Centre Campus, Nottingham, United Kingdom
    Stem Cells 32:1380-9. 2014
    ..A common function of CD34 has yet to be elucidated, but by analyzing and understanding links between CD34(+) cells, we hope to be able to offer an insight into the overlapping properties of cells that express CD34...
  59. ncbi request reprint Apoptosis in proliferative vitreoretinopathy
    Ibraheem El Ghrably
    Division of Ophthalmology and Visual Sciences, University Hospital, Nottingham, United Kingdom
    Invest Ophthalmol Vis Sci 45:1473-9. 2004
    ..To study the involvement of apoptosis using different apoptosis markers in PVR pathogenesis...
  60. doi request reprint Localized conjunctival extra-nodal marginal zone B cell lymphoma with presumed Paraproteinic Crystalline Keratopathy
    Thaer S Alomar
    Division of Ophthalmology and Visual Sciences, School of Clinical Sciences, Eye ENT Centre, University Hospital, Queens Medical Centre, University of Nottingham, B Floor, Derby Road, Nottingham, NG7 2UH, UK
    Int Ophthalmol 33:561-5. 2013
    ..This is the first report of corneal deposits in a case of localised conjunctival B-cell Lymphoma without paraproteinaemia/hyper-gammaglobulinemia, hence called 'Presumed Paraproteinic Crystalline Keratopathy'. ..
  61. pmc The visualisation of vitreous using surface modified poly(lactic-co-glycolic acid) microparticles
    David Y S Chau
    Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Br J Ophthalmol 94:648-53. 2010
    ..This method may provide a distinct alternative for the visualisation of vitreous whilst eliminating the pharmacological effects of triamcinolone acetonide suspension...
  62. ncbi request reprint Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts
    C M Sloper
    Department of Ophthalmology, Queen's Medical Centre, Nottingham, England
    Ophthalmology 108:1838-44. 2001
    ..Eight patients remain on treatment, and all have clear grafts. CONCLUSIONS: Tacrolimus (FK506) is effective in prevention of rejection in patients with high-risk corneal and limbal grafts...
  63. doi request reprint Kinetics of immune cell migration at the human ocular surface
    J H Chan
    Larry A Donoso Laboratory for Eye Research, Department of Opthalmology, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 92:970-5. 2008
    ..These cells play an active part in ocular surface defence and disease. Our aim was to study the migration of immune cells in the human conjunctiva, across the basement membrane and to characterize their phenotypes...
  64. pmc Augmented dried versus cryopreserved amniotic membrane as an ocular surface dressing
    Claire L Allen
    Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 8:e78441. 2013
    ..This study was established to investigate the biochemical and structural effects of drying AM in the absence and presence of saccharide lyoprotectants and its biocompatibility compared to cryopreserved material...
  65. ncbi request reprint Infliximab in the treatment of refractory posterior uveitis
    Annie Joseph
    Department of Ophthalmology and Visual Sciences, B Floor, Eye and ENT Block, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    Ophthalmology 110:1449-53. 2003
    ..To determine the efficacy and safety of infliximab in the treatment of refractory posterior uveitis...
  66. ncbi request reprint The amniotic membrane in ophthalmology
    Harminder S Dua
    Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham, UK
    Surv Ophthalmol 49:51-77. 2004
    ..Further studies will undoubtedly reveal the true potential of the membrane, its mechanism(s) of action, and the effective use of this tissue in ophthalmology...
  67. pmc Impression cytology of the ocular surface
    R Singh
    Division of Ophthalmology, B Floor, Eye ENT Centre, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Br J Ophthalmol 89:1655-9. 2005
    ..Major ophthalmic centres should develop and introduce this technique into routine clinical practice. This is best achieved with a team approach including the ophthalmologist, pathologist, microbiologist, and the immunologist...
  68. pmc The effect of corneal thickness on intraocular pressure measurement in patients with corneal pathology
    A C Browning
    Division of Ophthalmology and Visual Sciences, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Br J Ophthalmol 88:1395-9. 2004
    ....
  69. pmc A novel use of amniotic membrane in the management of tube exposure following glaucoma tube shunt surgery
    G Ainsworth
    Department of Ophthalmology, B Floor, Eye ENT Centre, Queens Medical Centre, Derby Road, Nottingham NG7 2UH, UK
    Br J Ophthalmol 90:417-9. 2006
    ..To report a novel technique using amniotic membrane to cover exposed glaucoma tube shunts...
  70. pmc Failure of amniotic membrane transplantation in the treatment of acute ocular burns
    A Joseph
    Division of Ophthalmology and Visual Sciences, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK
    Br J Ophthalmol 85:1065-9. 2001
    ..This inadequacy of the classification system probably also explains the difference between outcomes of management of grade IV burns (with AMT) in this series, compared with others...
  71. pmc Epithelial cell characteristics of cultured human limbal explants
    A Joseph
    Larry A Donoso Laboratory for Eye Research, Division of Ophthalmology and Visual Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Br J Ophthalmol 88:393-8. 2004
    ..To determine the immunohistochemical characteristics of putative corneal epithelial stem cells remaining on limbal explants maintained in culture...
  72. doi request reprint Re-treatment after laser in situ keratomileusis for correction of myopia and myopic astigmatism
    M A Bragheeth
    Division of Ophthalmology and Visual Sciences, B Floor, Eye Ear Nose Throat Centre, University Hospital, Queen s Medical Centre, Nottingham, UK
    Br J Ophthalmol 92:1506-10. 2008
    ..To evaluate the results of laser in situ keratomileusis (LASIK) re-treatment for under correction or regression after primary LASIK procedures for myopia and myopic astigmatism...
  73. doi request reprint Antimicrobial peptides expression by ocular surface cells in response to Acanthamoeba castellanii: an in vitro study
    A M Otri
    Division of Ophthalmology and Visual SciencesNottingham University Hospitals NHS Trust, Nottingham, UK
    Br J Ophthalmol 94:1523-7. 2010
    ..The aim of the study was to comprehensively study the gene expression of the ocular AMPs in human corneal limbal epithelial cells stimulated with Acanthamoeba castellanii (AC)...
  74. pmc A protocol for low contamination risk of autologous serum drops in the management of ocular surface disorders
    R Lagnado
    Division of Ophthalmology and Visual Sciences, Eye Ear Nose Throat Centre, University of Nottingham, University Hospital, Queens Medical Centre, Nottingham NG7 2UH, UK
    Br J Ophthalmol 88:464-5. 2004
    ..To assess microbial contamination of 20% autologous serum (AS) eye drops used in a hospital inpatient setting...
  75. pmc The efficacy of sirolimus in the treatment of patients with refractory uveitis
    V A Shanmuganathan
    Division of Ophthalmology and Visual Science, B Floor, Eye and ENT Centre, Queens Medical Centre, Nottingham NG7 2UH, UK
    Br J Ophthalmol 89:666-9. 2005
    ..To determine the efficacy of sirolimus in the treatment of patients with severe non-infectious uveitis...
  76. pmc Effect of ABO blood group mismatching on corneal epithelial cells: an in vitro study
    J H Chan
    Department of Ophthalmology, School of Clinical and Laboratory Sciences, University of Nottingham, UK
    Br J Ophthalmol 85:1104-9. 2001
    ..The variability in the outcome may reflect the levels of antibodies gaining access to the corneal cells and not the mismatching alone...
  77. pmc Tacrolimus immunosuppression in high-risk corneal grafts
    A Joseph
    Department of Ophthalmology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK
    Br J Ophthalmol 91:51-5. 2007
    ..Systemic immunosuppression reduces the risk of rejection in high-risk corneal grafts...
  78. ncbi request reprint Cataract extraction and intraocular lens implantation in anterior megalophthalmos
    H S Dua
    Department of Ophthalmology, Queen s Medical Centre, University Hospital, Nottingham, England
    J Cataract Refract Surg 25:716-9. 1999
    ..Extracapsular cataract extraction with a posterior chamber IOL sutured to the posterior surface of the iris and anterior capsule is a useful option in patients with anterior megalophthalmos and cataract...
  79. ncbi request reprint Limbal stem cell transplantation
    Merle Fernandes
    Cornea and Anterior Segment Service, L V Prasad Eye Institute, Hyderabad, India
    Indian J Ophthalmol 52:5-22. 2004
    ..The short and long-term outcomes of the various modalities reported in the literature are also described...
  80. ncbi request reprint Amniotic membrane use in ophthalmology
    Jose A P Gomes
    Advanced Ocular Surface Center, Brazil
    Curr Opin Ophthalmol 16:233-40. 2005
    ..The purpose of this review is to describe the most recent and relevant clinical and experimental data about the use of amniotic membrane in ophthalmology...
  81. pmc Postoperative subconjunctival 5-fluorouracil in the management of recurring pterygium
    Anupama Pherwani
    Br J Ophthalmol 91:398-9. 2007
  82. doi request reprint Stitched up: full thickness corneal grafts
    Harminder S Dua
    Br J Ophthalmol 92:869-70. 2008
  83. ncbi request reprint Amniotic membrane for ocular surface reconstruction: donor variations and the effect of handling on TGF-beta content
    Andrew Hopkinson
    Division of Ophthalmology and Visual Sciences and
    Invest Ophthalmol Vis Sci 47:4316-22. 2006
    ....