Simon J Draper

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Utilizing poxviral vectored vaccines for antibody induction-progress and prospects
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Vaccine 31:4223-30. 2013
  2. pmc The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19)
    Jianguo Shi
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    BMC Biotechnol 11:77. 2011
  3. ncbi request reprint Effective induction of high-titer antibodies by viral vector vaccines
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Nat Med 14:819-21. 2008
  4. pmc Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
    Cell Host Microbe 5:95-105. 2009
  5. ncbi request reprint Viruses as vaccine vectors for infectious diseases and cancer
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
    Nat Rev Microbiol 8:62-73. 2010
  6. doi request reprint Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines
    Simon J Draper
    Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
    J Immunol 185:7583-95. 2010
  7. pmc Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection
    Sean C Elias
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 190:1135-47. 2013
  8. pmc Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection
    Sean C Elias
    The Jenner Institute, University of Oxford, Oxford, UK
    Immunology 141:628-44. 2014
  9. pmc The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
    Anna L Goodman
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Sci Rep 3:1706. 2013
  10. pmc T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e44943. 2012

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Utilizing poxviral vectored vaccines for antibody induction-progress and prospects
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Vaccine 31:4223-30. 2013
    ....
  2. pmc The generation and evaluation of recombinant human IgA specific for Plasmodium falciparum merozoite surface protein 1-19 (PfMSP1 19)
    Jianguo Shi
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    BMC Biotechnol 11:77. 2011
    ..Although human serum immunoglobulin A (IgA) is the second most abundant class of antibody in the circulation, its contribution, if any, to protective responses against malaria is not clear...
  3. ncbi request reprint Effective induction of high-titer antibodies by viral vector vaccines
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Nat Med 14:819-21. 2008
    ..Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro...
  4. pmc Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford OX3 7DQ, UK
    Cell Host Microbe 5:95-105. 2009
    ..Multistage immunity against malaria can thus be achieved by using viral vectors recombinant for MSP-1...
  5. ncbi request reprint Viruses as vaccine vectors for infectious diseases and cancer
    Simon J Draper
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
    Nat Rev Microbiol 8:62-73. 2010
    ....
  6. doi request reprint Enhancing blood-stage malaria subunit vaccine immunogenicity in rhesus macaques by combining adenovirus, poxvirus, and protein-in-adjuvant vaccines
    Simon J Draper
    Jenner Institute, University of Oxford, Oxford, OX3 7DQ, United Kingdom
    J Immunol 185:7583-95. 2010
    ..These data encourage the further clinical development and coadministration of protein and viral vector vaccine platforms in an attempt to induce broad cellular and humoral immune responses against blood-stage malaria Ags in humans...
  7. pmc Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection
    Sean C Elias
    The Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 190:1135-47. 2013
    ..We also show that controlled infection with 3D7 strain P. falciparum parasites neither boosts existing 3D7-specific T cell responses nor appears to "immune divert" cellular responses toward the Wellcome allele...
  8. pmc Analysis of human B-cell responses following ChAd63-MVA MSP1 and AMA1 immunization and controlled malaria infection
    Sean C Elias
    The Jenner Institute, University of Oxford, Oxford, UK
    Immunology 141:628-44. 2014
    ..These CHMI data confirm that mBC and antibody responses can be induced and boosted by blood-stage parasite exposure, in support of epidemiological studies on low-level parasite exposure. ..
  9. pmc The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
    Anna L Goodman
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Sci Rep 3:1706. 2013
    ..An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum...
  10. pmc T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e44943. 2012
    ..The oligomerization domain of C4 bp can thus adjuvant T cell responses induced by AdHu5 vectors against selected antigens and its clinical utility as well as mechanism of action warrant further investigation...
  11. pmc Phase Ia clinical evaluation of the Plasmodium falciparum blood-stage antigen MSP1 in ChAd63 and MVA vaccine vectors
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
    Mol Ther 19:2269-76. 2011
    ..Further studies are required to assess whether this strategy can achieve protective efficacy against blood-stage malaria infection...
  12. pmc Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5
    Alexander D Douglas
    Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 192:245-58. 2014
    ..These data provide important insight into the mechanisms of broadly neutralizing anti-malaria Abs and further encourage anti-PfRH5-based malaria prevention efforts. ..
  13. pmc Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1
    Sumi Biswas
    The Jenner Institute, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS ONE 6:e20977. 2011
    ..Here we describe the pre-clinical development and optimization of recombinant human and simian adenoviral (AdHu5 and ChAd63) and orthopoxviral (MVA) vectors encoding transgene inserts for Plasmodium falciparum AMA1 (PfAMA1)...
  14. pmc Recombinant viral-vectored vaccines expressing Plasmodium chabaudi AS apical membrane antigen 1: mechanisms of vaccine-induced blood-stage protection
    Sumi Biswas
    Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 188:5041-53. 2012
    ....
  15. pmc ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
    Mol Ther 20:2355-68. 2012
    ..These data call into question the utility of T cell-inducing blood-stage malaria vaccines and suggest that the focus should remain on high-titer antibody induction against susceptible antigen targets...
  16. pmc Phase Ia clinical evaluation of the safety and immunogenicity of the Plasmodium falciparum blood-stage antigen AMA1 in ChAd63 and MVA vaccine vectors
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, United Kingdom
    PLoS ONE 7:e31208. 2012
    ..falciparum. The development of a vaccine that could induce both cell-mediated and humoral immune responses would enable important proof-of-concept efficacy studies to be undertaken to address this question...
  17. pmc Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference
    Emily K Forbes
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    J Immunol 187:3738-50. 2011
    ..These data have important implications for the development of a multistage or multicomponent viral vectored malaria vaccine for use in humans...
  18. ncbi request reprint Prime-boost vectored malaria vaccines: progress and prospects
    Adrian V S Hill
    The Jenner Institute, University of Oxford, Oxford, UK
    Hum Vaccin 6:78-83. 2010
    ..These viral vectors now provide a major option for inclusion in a high efficacy multi-stage malaria vaccine that should achieve deployable levels of efficacy in endemic settings...
  19. pmc Fusion of the Mycobacterium tuberculosis antigen 85A to an oligomerization domain enhances its immunogenicity in both mice and non-human primates
    Alexandra J Spencer
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 7:e33555. 2012
    ..This report demonstrates that antigen multimerization using IMX313 is a simple and effective cross-species method to improve vaccine immunogenicity with potentially broad applicability...
  20. pmc The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
    Alexander D Douglas
    Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Nat Commun 2:601. 2011
    ..falciparum is a degenerate process involving a series of parallel redundant pathways...
  21. pmc Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1
    Alexander D Douglas
    Jenner Institute, Oxford University, Oxford, UK
    Vaccine 28:7167-78. 2010
    ....
  22. pmc Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome
    David Llewellyn
    1 University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
    J Leukoc Biol 95:369-82. 2014
    ..falciparum arises following repeated natural exposure. ..
  23. pmc Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
    Katie J Ewer
    1 The Jenner Institute Laboratories, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK 2
    Nat Commun 4:2836. 2013
    ..005). Vaccine-induced CD8(+) T cells provide protection against human malaria, suggesting that a major limitation of previous vaccination approaches has been the insufficient magnitude of induced T cells...
  24. pmc Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens
    Andrew R Williams
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 8:e1002991. 2012
    ..falciparum antigens and should help to guide the rational development of future multi-antigen vaccines...
  25. pmc The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    Simone C de Cassan
    The Jenner Institute, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:2602-16. 2011
    ....
  26. pmc Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors
    Matthew N Davies
    The Jenner Institute, University of Oxford, Newbury, Berkshire, United Kingdom
    PLoS ONE 4:e8084. 2009
    ..An antagonist of the chemokine CCR4 receptor can display adjuvant-like properties by diminishing the ability of CD4+CD25+ regulatory T cells (Tregs) to down-regulate immune responses...
  27. pmc Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection
    Alexander D Douglas
    Jenner Institute, University of Oxford, UK
    J Infect Dis 208:340-5. 2013
    ..We find that the parameters estimated by these models are closely correlated, and their predictive accuracy for omitted data points was similar. We propose that future studies include the linear model...
  28. pmc Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909
    Christopher J A Duncan
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e22271. 2011
    ..Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria...
  29. doi request reprint Recent advances in antibody-inducing poxviral and adenoviral vectored vaccine delivery platforms for difficult disease targets
    Simone C de Cassan
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, UK
    Expert Rev Vaccines 12:365-78. 2013
    ..Future studies in this area are needed to guide the rational design of antibody-inducing subunit vaccine strategies...
  30. pmc A viral vectored prime-boost immunization regime targeting the malaria Pfs25 antigen induces transmission-blocking activity
    Anna L Goodman
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e29428. 2011
    ....
  31. ncbi request reprint Anti-CD25 antibody enhancement of vaccine-induced immunogenicity: increased durable cellular immunity with reduced immunodominance
    Anne C Moore
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, United Kingdom
    J Immunol 175:7264-73. 2005
    ..Vaccine strategies incorporating anti-CD25 lead to improved protection against pre-erythrocytic malaria challenge. These data underpin new strategies for the design and development of more efficacious vaccines in clinical settings...
  32. pmc Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes
    Andrew R Williams
    Jenner Institute, University of Oxford, Roosevelt Drive, Oxford, UK
    Int J Parasitol 43:869-74. 2013
    ..Therefore, this approach of targeting regulatory molecules of the mosquito immune system may represent a novel approach to transmission-blocking malaria vaccines. ..
  33. pmc Controlled human blood stage malaria infection: current status and potential applications
    Christopher J A Duncan
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    Am J Trop Med Hyg 86:561-5. 2012
    ..We summarize clinical, parasitologic, and immunologic data from all BSP challenges to date, explore differences between the BSP and sporozoite models, and propose future applications for BSP challenge...
  34. pmc In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination
    Jagadeesh Bayry
    The Edward Jenner Institute for Vaccine Research, University of Oxford, Compton, United Kingdom
    Proc Natl Acad Sci U S A 105:10221-6. 2008
    ..The significant adjuvant activity observed provides good evidence supporting our hypothesis that CCR4 is a viable target for rational adjuvant design...
  35. pmc Accelerating vaccine development and deployment: report of a Royal Society satellite meeting
    Migena Bregu
    Jenner Institute, University of Oxford, Oxford, UK
    Philos Trans R Soc Lond B Biol Sci 366:2841-9. 2011
    ....