Research Topics
Genomes and Genes | Hal DrakesmithSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportinHal Drakesmith
Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, United Kingdom
Blood 106:1092-7. 2005..FPN-linked hemochromatosis may have a variable pathogenesis depending on the causative FPN mutant...
HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasisHal Drakesmith
Molecular Immunology Group and Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
Proc Natl Acad Sci U S A 102:11017-22. 2005..We conclude that, through Nef and HFE, HIV-1 directly regulates cellular iron metabolism, possibly benefiting viral growth...
Viral infection and iron metabolismHal Drakesmith
Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and Oxford University, Oxford OX3 9DS, UK
Nat Rev Microbiol 6:541-52. 2008..Understanding how iron metabolism and viral infection interact might suggest new methods to control disease...- In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutationsLisa M Schimanski
Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Headley Way, Oxford, OX3 9DS, United Kingdom
Blood 105:4096-102. 2005..Because FPN is a target for negative feedback in iron homeostasis, we postulate that the latter group of mutants may resist inhibition, resulting in a permanently "turned on" iron exporter... - The hemochromatosis protein HFE inhibits iron export from macrophagesHal Drakesmith
Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
Proc Natl Acad Sci U S A 99:15602-7. 2002..We conclude that HFE has two mutually exclusive functions, binding to TfR1 in competition with Tf, or inhibition of iron release... - HIV-1 down-regulates the expression of CD1d via NefNan Chen
MRC Human Immunology Unit and Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
Eur J Immunol 36:278-86. 2006.... - Localisation of proteins of iron metabolism in the human placenta and liverJudy Bastin
Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital
Br J Haematol 134:532-43. 2006..FPN was also most strongly expressed by CD68+ Kupffer cells. These findings contribute to understanding how iron is transported and stored in the human placenta and liver... - Ferroportin: lack of evidence for multimersLisa M Schimanski
Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK OX3 9DS, UK
Blood Cells Mol Dis 40:360-9. 2008..These data suggest that dominantly inherited ferroportin disease does not result from the direct action of a mutated protein inhibiting a wild-type protein within multimers. We propose other possible mechanisms of disease... - Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overloadAlain Townsend
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DS, UK
Lancet 359:786-90. 2002..In our model, mutations in HFE result in over absorption of dietary iron, and patterns of tissue iron deposition in agreement with clinical observations of hereditary haemochromatosis... - Hepcidin and the iron-infection axisHal Drakesmith
Molecular Immunology Group and Medical Research Council MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Science 338:768-72. 2012..We describe how hepcidin integrates signals from diverse physiological inputs, forming a key molecular bridge between iron trafficking and response to infection... - Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replicationAshleigh Hodges
Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Nat Immunol 8:569-77. 2007..Activation of LARG in DCs exposed to HIV was required for the formation of virus-T cell synapses. Thus, HIV sequestration by and stimulation of DC-SIGN helps HIV evade immune responses and spread to cells... - Hepcidin regulation by innate immune and infectious stimuliAndrew E Armitage
Molecular Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
Blood 118:4129-39. 2011..Together, these results indicate that hepcidin induction represents a component of the innate immune response to acute infection, with the potential to affect disease pathogenesis... - Reflecting on a quarter century of HIV researchAndrew E Armitage
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
Nat Immunol 9:823-6. 2008 - Multifactorial iron manKathryn J H Robson
Digestion 72:22-4. 2005