Hal Drakesmith

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
    Hal Drakesmith
    Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, United Kingdom
    Blood 106:1092-7. 2005
  2. pmc HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis
    Hal Drakesmith
    Molecular Immunology Group and Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 102:11017-22. 2005
  3. ncbi request reprint Viral infection and iron metabolism
    Hal Drakesmith
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and Oxford University, Oxford OX3 9DS, UK
    Nat Rev Microbiol 6:541-52. 2008
  4. ncbi request reprint In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations
    Lisa M Schimanski
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Headley Way, Oxford, OX3 9DS, United Kingdom
    Blood 105:4096-102. 2005
  5. pmc The hemochromatosis protein HFE inhibits iron export from macrophages
    Hal Drakesmith
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Proc Natl Acad Sci U S A 99:15602-7. 2002
  6. ncbi request reprint HIV-1 down-regulates the expression of CD1d via Nef
    Nan Chen
    MRC Human Immunology Unit and Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Eur J Immunol 36:278-86. 2006
  7. ncbi request reprint Localisation of proteins of iron metabolism in the human placenta and liver
    Judy Bastin
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital
    Br J Haematol 134:532-43. 2006
  8. ncbi request reprint Ferroportin: lack of evidence for multimers
    Lisa M Schimanski
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK OX3 9DS, UK
    Blood Cells Mol Dis 40:360-9. 2008
  9. ncbi request reprint Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload
    Alain Townsend
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DS, UK
    Lancet 359:786-90. 2002
  10. doi request reprint Hepcidin and the iron-infection axis
    Hal Drakesmith
    Molecular Immunology Group and Medical Research Council MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Science 338:768-72. 2012

Detail Information

Publications15

  1. ncbi request reprint Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
    Hal Drakesmith
    Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, United Kingdom
    Blood 106:1092-7. 2005
    ..FPN-linked hemochromatosis may have a variable pathogenesis depending on the causative FPN mutant...
  2. pmc HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis
    Hal Drakesmith
    Molecular Immunology Group and Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom
    Proc Natl Acad Sci U S A 102:11017-22. 2005
    ..We conclude that, through Nef and HFE, HIV-1 directly regulates cellular iron metabolism, possibly benefiting viral growth...
  3. ncbi request reprint Viral infection and iron metabolism
    Hal Drakesmith
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and Oxford University, Oxford OX3 9DS, UK
    Nat Rev Microbiol 6:541-52. 2008
    ..Understanding how iron metabolism and viral infection interact might suggest new methods to control disease...
  4. ncbi request reprint In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations
    Lisa M Schimanski
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Headley Way, Oxford, OX3 9DS, United Kingdom
    Blood 105:4096-102. 2005
    ..Because FPN is a target for negative feedback in iron homeostasis, we postulate that the latter group of mutants may resist inhibition, resulting in a permanently "turned on" iron exporter...
  5. pmc The hemochromatosis protein HFE inhibits iron export from macrophages
    Hal Drakesmith
    Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Proc Natl Acad Sci U S A 99:15602-7. 2002
    ..We conclude that HFE has two mutually exclusive functions, binding to TfR1 in competition with Tf, or inhibition of iron release...
  6. ncbi request reprint HIV-1 down-regulates the expression of CD1d via Nef
    Nan Chen
    MRC Human Immunology Unit and Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK
    Eur J Immunol 36:278-86. 2006
    ....
  7. ncbi request reprint Localisation of proteins of iron metabolism in the human placenta and liver
    Judy Bastin
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital
    Br J Haematol 134:532-43. 2006
    ..FPN was also most strongly expressed by CD68+ Kupffer cells. These findings contribute to understanding how iron is transported and stored in the human placenta and liver...
  8. ncbi request reprint Ferroportin: lack of evidence for multimers
    Lisa M Schimanski
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK OX3 9DS, UK
    Blood Cells Mol Dis 40:360-9. 2008
    ..These data suggest that dominantly inherited ferroportin disease does not result from the direct action of a mutated protein inhibiting a wild-type protein within multimers. We propose other possible mechanisms of disease...
  9. ncbi request reprint Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload
    Alain Townsend
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DS, UK
    Lancet 359:786-90. 2002
    ..In our model, mutations in HFE result in over absorption of dietary iron, and patterns of tissue iron deposition in agreement with clinical observations of hereditary haemochromatosis...
  10. doi request reprint Hepcidin and the iron-infection axis
    Hal Drakesmith
    Molecular Immunology Group and Medical Research Council MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Science 338:768-72. 2012
    ..We describe how hepcidin integrates signals from diverse physiological inputs, forming a key molecular bridge between iron trafficking and response to infection...
  11. ncbi request reprint Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
    Ashleigh Hodges
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Immunol 8:569-77. 2007
    ..Activation of LARG in DCs exposed to HIV was required for the formation of virus-T cell synapses. Thus, HIV sequestration by and stimulation of DC-SIGN helps HIV evade immune responses and spread to cells...
  12. doi request reprint Hepcidin regulation by innate immune and infectious stimuli
    Andrew E Armitage
    Molecular Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Blood 118:4129-39. 2011
    ..Together, these results indicate that hepcidin induction represents a component of the innate immune response to acute infection, with the potential to affect disease pathogenesis...
  13. ncbi request reprint Expression of the iron hormone hepcidin distinguishes different types of anemia in African children
    Sant Rayn Pasricha
    Medical Research Council MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK
    Sci Transl Med 6:235re3. 2014
    ....
  14. doi request reprint Reflecting on a quarter century of HIV research
    Andrew E Armitage
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK
    Nat Immunol 9:823-6. 2008
  15. ncbi request reprint Multifactorial iron man
    Kathryn J H Robson
    Digestion 72:22-4. 2005