A J Drake

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Maternal obesity has little effect on the immediate offspring but impacts on the next generation
    Vicky King
    Medical Research Council University of Edinburgh Centre for Reproductive Health, University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 154:2514-24. 2013
  2. doi request reprint Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects
    Amanda J Drake
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Epigenetics 6:1334-43. 2011
  3. ncbi request reprint Transmission of programming effects across generations
    Amanda J Drake
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Pediatr Endocrinol Rev 9:566-78. 2011
  4. ncbi request reprint The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk
    A J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    J Endocrinol 180:1-16. 2004
  5. doi request reprint Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 151:1581-7. 2010
  6. doi request reprint Intergenerational transmission of programmed effects: public health consequences
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Trends Endocrinol Metab 21:206-13. 2010
  7. doi request reprint Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 150:5055-64. 2009
  8. ncbi request reprint Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 146:913-9. 2005
  9. ncbi request reprint Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
  10. doi request reprint Androgen action in the masculinization programming window and development of male reproductive organs
    D J Macleod
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 33:279-87. 2010

Collaborators

Detail Information

Publications15

  1. doi request reprint Maternal obesity has little effect on the immediate offspring but impacts on the next generation
    Vicky King
    Medical Research Council University of Edinburgh Centre for Reproductive Health, University British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 154:2514-24. 2013
    ..This suggests that the consequences of the current dietary obesity epidemic may also have an impact on the descendants of obese individuals, even when the phenotype of the F1 appears largely unaffected. ..
  2. doi request reprint Multigenerational programming in the glucocorticoid programmed rat is associated with generation-specific and parent of origin effects
    Amanda J Drake
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, Edinburgh, UK
    Epigenetics 6:1334-43. 2011
    ..These findings have implications for the pathogenesis and future attempts to stratify therapies for the "developmental component" of cardiometabolic disease...
  3. ncbi request reprint Transmission of programming effects across generations
    Amanda J Drake
    Endocrinology Unit, University BHF Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Pediatr Endocrinol Rev 9:566-78. 2011
    ..In this review we discuss the evidence for these mechanisms in human and animal studies and the potential importance of this field for child health...
  4. ncbi request reprint The intergenerational effects of fetal programming: non-genomic mechanisms for the inheritance of low birth weight and cardiovascular risk
    A J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU, UK
    J Endocrinol 180:1-16. 2004
    ..This may represent a mechanism for the non-genetic inheritance of a predisposition to low birth weight and adverse cardiovascular risk across a number of generations...
  5. doi request reprint Prenatal dexamethasone programs expression of genes in liver and adipose tissue and increased hepatic lipid accumulation but not obesity on a high-fat diet
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 151:1581-7. 2010
    ..This may be due to depot-specific-programmed alterations in fat metabolism in adipose tissue...
  6. doi request reprint Intergenerational transmission of programmed effects: public health consequences
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Trends Endocrinol Metab 21:206-13. 2010
    ..In this review, we discuss the evidence for these mechanisms in human and animal studies and the potential importance of this field for human health...
  7. doi request reprint Glucocorticoids amplify dibutyl phthalate-induced disruption of testosterone production and male reproductive development
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 150:5055-64. 2009
    ..These findings suggest that exposure to common environmental chemicals in combination with, for example, maternal stress, may increase the risk of common male reproductive abnormalities, with implications for human populations...
  8. ncbi request reprint Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Endocrinology 146:913-9. 2005
    ..Acute exposure to HF diet alters glucocorticoid metabolism, predicting lower hepatic and adipose intracellular glucocorticoid concentrations, which may be a key mechanism protecting against the metabolic complications of obesity...
  9. ncbi request reprint Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats
    Amanda J Drake
    Endocrinology Unit, School of Molecular and Clinical Medicine, University of Edinburgh, Molecular Medicine Center, Western General Hospital, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R34-8. 2005
    ....
  10. doi request reprint Androgen action in the masculinization programming window and development of male reproductive organs
    D J Macleod
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, The Queen s Medical Research Institute, Edinburgh, UK
    Int J Androl 33:279-87. 2010
    ..controls. In conclusion, we show that the size of all male reproductive organs is programmed by androgen exposure in the MPW, but that growth towards this size is dependent on androgen action postnatally...
  11. doi request reprint Relationship between androgen action in the "male programming window," fetal sertoli cell number, and adult testis size in the rat
    Hayley M Scott
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Endocrinology 149:5280-7. 2008
    ..001) with AGD at e21.5, and postnatal d 25 and 90 in animals exposed in utero to vehicle or DBP (e13.5-e21.5). Thus, AGD may predict adult testis size but probably not through a direct relationship with SC number...
  12. doi request reprint Impact of maternal obesity on offspring obesity and cardiometabolic disease risk
    Amanda J Drake
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 6TJ, UK
    Reproduction 140:387-98. 2010
    ..The ultimate aim is to identify potential targets, which may be amenable to prevention or early intervention in order to improve the health of this and future generations...
  13. doi request reprint Altered placental methyl donor transport in the dexamethasone programmed rat
    C S Wyrwoll
    Endocrinology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Placenta 33:220-3. 2012
    ..These data suggest prenatal glucocorticoid overexposure causes complex alterations in the placental transport of key methyl donors which may have important implications for maternal diet and nutrient supplementation in pregnancy...
  14. doi request reprint The effects of an obesogenic diet during pregnancy on fetal growth and placental gene expression are gestation dependent
    V King
    MRC University of Edinburgh Centre for Reproductive Health, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Placenta 34:1087-90. 2013
    ..Differences in maternal weight gain and/or specific dietary components may impact on fetal and placental growth and later disease risk. ..
  15. ncbi request reprint Mechanisms underlying the role of glucocorticoids in the early life programming of adult disease
    Amanda J Drake
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    Clin Sci (Lond) 113:219-32. 2007
    ..These animal observations could have huge implications if extrapolated to humans, where glucocorticoids have extensive therapeutic use in obstetric and neonatal practice...