Jessica A Downs

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage
    Elizabeth Bilsland
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, United Kingdom
    DNA Repair (Amst) 6:1471-84. 2007
  2. ncbi Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
    Jessica A Downs
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    Mol Cell 16:979-90. 2004
  3. ncbi Dynamics of chromatin during the repair of DNA double-strand breaks
    Jessica A Downs
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Cell Cycle 4:1373-6. 2005
  4. ncbi Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locus
    Nicholas A Kent
    Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    J Biol Chem 282:27693-701. 2007
  5. ncbi Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair
    Anne C Harvey
    Department of Biochemistry, University of Cambridge, UK
    Genetics 170:543-53. 2005
  6. ncbi Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation
    Elinor R Foster
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, England, UK
    J Cell Biol 184:631-8. 2009
  7. ncbi Tails of histones in DNA double-strand break repair
    Elizabeth Bilsland
    Department of Biochemistry, Cambridge University, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Mutagenesis 20:153-63. 2005
  8. ncbi Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone
    Jessica A Downs
    The Wellcome Trust Cancer Research UK Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Mol Cell 11:1685-92. 2003
  9. ncbi Histone H2A phosphorylation in DNA double-strand break repair
    Elinor R Foster
    Department of Biochemistry, Cambridge University, UK
    FEBS J 272:3231-40. 2005
  10. ncbi A means to a DNA end: the many roles of Ku
    Jessica A Downs
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nat Rev Mol Cell Biol 5:367-78. 2004

Collaborators

Detail Information

Publications14

  1. ncbi The Bre5/Ubp3 ubiquitin protease complex from budding yeast contributes to the cellular response to DNA damage
    Elizabeth Bilsland
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, United Kingdom
    DNA Repair (Amst) 6:1471-84. 2007
    ..Additionally, we have generated mutants of Bre5 that are specifically defective in DNA damage responses...
  2. ncbi Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
    Jessica A Downs
    The Wellcome Trust Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, United Kingdom
    Mol Cell 16:979-90. 2004
    ..Thus, phosphorylation of H2A at DNA damage sites creates a mark recognized by different chromatin modifiers. This interaction leads to stepwise chromatin reconfiguration, allowing efficient DNA repair...
  3. ncbi Dynamics of chromatin during the repair of DNA double-strand breaks
    Jessica A Downs
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Cell Cycle 4:1373-6. 2005
    ..Here, we summarize a number of key findings, largely from studies performed in budding yeast, highlighting the role of chromatin in DNA DSB responses...
  4. ncbi Dual chromatin remodeling roles for RSC during DNA double strand break induction and repair at the yeast MAT locus
    Nicholas A Kent
    Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, United Kingdom
    J Biol Chem 282:27693-701. 2007
    ..The RSC complex therefore has chromatin remodeling roles both before and after DSB induction at MAT, promoting both DNA cleavage and subsequent repair...
  5. ncbi Saccharomyces cerevisiae histone H2A Ser122 facilitates DNA repair
    Anne C Harvey
    Department of Biochemistry, University of Cambridge, UK
    Genetics 170:543-53. 2005
    ....
  6. ncbi Methylation of H3 K4 and K79 is not strictly dependent on H2B K123 ubiquitylation
    Elinor R Foster
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, England, UK
    J Cell Biol 184:631-8. 2009
    ..Finally, we show that strains lacking the ubiquitin ligase Bre1 are defective for H3 methylation, suggesting that there is an additional Bre1 substrate that in combination with H2B K123 facilitates H3 methylation...
  7. ncbi Tails of histones in DNA double-strand break repair
    Elizabeth Bilsland
    Department of Biochemistry, Cambridge University, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Mutagenesis 20:153-63. 2005
    ..Here, we briefly review some of the most common techniques in studying DNA DSB responses in vivo, and focus on the contributions of covalent modifications of core histone proteins to these DNA DSB responses...
  8. ncbi Suppression of homologous recombination by the Saccharomyces cerevisiae linker histone
    Jessica A Downs
    The Wellcome Trust Cancer Research UK Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Mol Cell 11:1685-92. 2003
    ..Finally, we show that Hho1p is inhibitory to the recombination-dependent mechanism of telomere maintenance. The role of linker histones in genome stability, aging, and tumorigenesis is discussed...
  9. ncbi Histone H2A phosphorylation in DNA double-strand break repair
    Elinor R Foster
    Department of Biochemistry, Cambridge University, UK
    FEBS J 272:3231-40. 2005
    ..Here, we review the proteins and protein complexes that have been identified as H2AS129ph (budding yeast) or H2AXS139ph (human) binding partners and discuss the implications of these interactions...
  10. ncbi A means to a DNA end: the many roles of Ku
    Jessica A Downs
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nat Rev Mol Cell Biol 5:367-78. 2004
  11. ncbi What functions do linker histones provide?
    Anne C Harvey
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Mol Microbiol 53:771-5. 2004
    ..We highlight recent developments pointing towards linker histone involvement in DNA repair and ageing, which raise the possibility that the biological functions of linker histones are more varied than previously imagined...
  12. ncbi A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae
    Christopher M Titman
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Mol Biosyst 5:1913-24. 2009
    ..Finally, predictive models were built for distinguishing the genotoxic carcinogens from the control group according to the metabolic profile of the cell culture media...
  13. ncbi Chromatin dynamics and the preservation of genetic information
    Jessica A Downs
    MRC Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK
    Nature 447:951-8. 2007
    ..Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage...
  14. ncbi Cancer: protective packaging for DNA
    Jessica A Downs
    Nature 424:732-4. 2003