S K Dove

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
    S K Dove
    Centre for Clinical Research in Immunology and Signalling, University of Birmingham, UK
    Nature 390:187-92. 1997
  2. ncbi request reprint Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Trends Biochem Sci 31:52-63. 2006
  3. doi request reprint Inositol lipid-dependent functions in Saccharomyces cerevisiae: analysis of phosphatidylinositol phosphates
    Stephen K Dove
    Phosphoinositide Lab, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Methods Mol Biol 462:59-74. 2009
  4. pmc Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham, UK
    EMBO J 23:1922-33. 2004
  5. doi request reprint Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 419:1-13. 2009
  6. ncbi request reprint Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Biol 12:885-93. 2002
  7. ncbi request reprint Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
    R K McEwen
    School of Biochemistry, Centre for Clinical Research in Immunology and Signalling, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 274:33905-12. 1999
  8. ncbi request reprint Morton Medal Lecture. New insights into the roles of phosphoinositides and inositol polyphosphates in yeast
    R H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem Soc Trans 31:11-5. 2003
  9. ncbi request reprint Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast
    Nevin M Perera
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 279:5216-26. 2004
  10. pmc A protein complex that regulates PtdIns(3,5)P2 levels
    Robert H Michell
    School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK
    EMBO J 28:86-7. 2009

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
    S K Dove
    Centre for Clinical Research in Immunology and Signalling, University of Birmingham, UK
    Nature 390:187-92. 1997
    ....
  2. ncbi request reprint Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions
    Robert H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Trends Biochem Sci 31:52-63. 2006
    ....
  3. doi request reprint Inositol lipid-dependent functions in Saccharomyces cerevisiae: analysis of phosphatidylinositol phosphates
    Stephen K Dove
    Phosphoinositide Lab, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK
    Methods Mol Biol 462:59-74. 2009
    ..This chapter describes how to extract and quantify the inositol lipids of S. cerevisiae cells that have been radiolabeled to isotopic equilibrium with [3H]myo-inositol...
  4. pmc Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham, UK
    EMBO J 23:1922-33. 2004
    ..Svp1p is not involved in the contributions of FAB1/PtdIns(3,5)P2 to MVB sorting or to vacuole acidification and so additional PtdIns(3,5)P2 effectors must exist...
  5. doi request reprint Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem J 419:1-13. 2009
    ..We also discuss new evidence linking PtdIns(3,5)P(2) and PtdIns5P to the regulation of exocytosis...
  6. ncbi request reprint Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body
    Stephen K Dove
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Curr Biol 12:885-93. 2002
    ..No regulators of Fab1 were identified until recently...
  7. ncbi request reprint Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases
    R K McEwen
    School of Biochemistry, Centre for Clinical Research in Immunology and Signalling, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 274:33905-12. 1999
    ..These results also suggest that p235 may regulate a step in membrane trafficking in mammalian cells that is analogous to its function in yeast...
  8. ncbi request reprint Morton Medal Lecture. New insights into the roles of phosphoinositides and inositol polyphosphates in yeast
    R H Michell
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
    Biochem Soc Trans 31:11-5. 2003
    ....
  9. ncbi request reprint Hypo-osmotic stress activates Plc1p-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and inositol Hexakisphosphate accumulation in yeast
    Nevin M Perera
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    J Biol Chem 279:5216-26. 2004
    ..This ability routinely to activate Plc1p-catalyzed PtdIns(4,5)P2 hydrolysis in vivo opens up new opportunities for molecular and genetic scrutiny of the regulation and functions of phosphoinositidases C of the delta-subfamily...
  10. pmc A protein complex that regulates PtdIns(3,5)P2 levels
    Robert H Michell
    School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK
    EMBO J 28:86-7. 2009
    ....
  11. ncbi request reprint Analysis of intact phosphoinositides in biological samples
    Trevor R Pettitt
    Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham B15 2TH, UK
    J Lipid Res 47:1588-96. 2006
    ..Data are presented using this approach for the analysis of phosphoinositides in human platelet and yeast samples...
  12. pmc Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium
    Soha Zouwail
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem J 389:207-14. 2005
    ..This implies that localized PLD-regulated synthesis of PtdIns(4,5)P2 is essential for Dictyostelium actin function...
  13. pmc PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49
    Tim R Jeffries
    Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, United Kingdom
    Mol Biol Cell 15:2652-63. 2004
    ..We conclude that WIPI49 is a novel regulatory component of the endosomal and MPR pathway and that this role is dependent upon the PI-binding properties of its WD40 domain...
  14. ncbi request reprint I-proteins - a proposed switch in myotubularin function
    Michael J Clague
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Trends Biochem Sci 29:58-61. 2004
    ..We propose an alternate, or additional, function that is analogous to the G-protein family of phosphatases, which use nucleotide-dependent conformational changes to transduce signals or do mechanical work...
  15. ncbi request reprint Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells
    Gerald R V Hammond
    Molecular Neuropathobiology, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, London WC2A 3PX, UK
    J Cell Sci 119:2084-94. 2006
    ..We propose that a cycle of PtdIns(4,5)P2 synthesis and breakdown is crucial for exocytosis to occur in mast cells, and may have a more general role in all professional secretory cells...
  16. ncbi request reprint Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases
    Julia Schaletzky
    Department of Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, Martinsried, 82152 Germany
    Curr Biol 13:504-9. 2003
    ..These findings highlight the importance of regulated phosphatase activity for the control of phosphoinositide metabolism...