Alexander D Douglas

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection
    Alexander D Douglas
    Jenner Institute, University of Oxford, UK
    J Infect Dis 208:340-5. 2013
  2. pmc Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1
    Alexander D Douglas
    Jenner Institute, Oxford University, Oxford, UK
    Vaccine 28:7167-78. 2010
  3. pmc Substantially reduced pre-patent parasite multiplication rates are associated with naturally acquired immunity to Plasmodium falciparum
    A D Douglas
    Jenner Institute, Nuffield Department of Medicine, University of Oxford, UK
    J Infect Dis 203:1337-40. 2011
  4. pmc The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
    Alexander D Douglas
    Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Nat Commun 2:601. 2011
  5. pmc The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
    Anna L Goodman
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Sci Rep 3:1706. 2013
  6. pmc Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5
    Alexander D Douglas
    Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 192:245-58. 2014
  7. pmc ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
    Mol Ther 20:2355-68. 2012
  8. pmc Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens
    Andrew R Williams
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 8:e1002991. 2012
  9. pmc The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    Simone C de Cassan
    The Jenner Institute, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:2602-16. 2011
  10. pmc Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome
    David Llewellyn
    1 University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
    J Leukoc Biol 95:369-82. 2014

Collaborators

Detail Information

Publications12

  1. pmc Comparison of modeling methods to determine liver-to-blood inocula and parasite multiplication rates during controlled human malaria infection
    Alexander D Douglas
    Jenner Institute, University of Oxford, UK
    J Infect Dis 208:340-5. 2013
    ..We find that the parameters estimated by these models are closely correlated, and their predictive accuracy for omitted data points was similar. We propose that future studies include the linear model...
  2. pmc Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1
    Alexander D Douglas
    Jenner Institute, Oxford University, Oxford, UK
    Vaccine 28:7167-78. 2010
    ....
  3. pmc Substantially reduced pre-patent parasite multiplication rates are associated with naturally acquired immunity to Plasmodium falciparum
    A D Douglas
    Jenner Institute, Nuffield Department of Medicine, University of Oxford, UK
    J Infect Dis 203:1337-40. 2011
    ..This supports the view that a blood-stage vaccine capable of emulating the disease-reducing effect of natural immunity could achieve a detectable effect during the prepatent period...
  4. pmc The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
    Alexander D Douglas
    Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Nat Commun 2:601. 2011
    ..falciparum is a degenerate process involving a series of parallel redundant pathways...
  5. pmc The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment
    Anna L Goodman
    The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK
    Sci Rep 3:1706. 2013
    ..An improved understanding of the mechanisms responsible for protection, or failure of protection, against P. berghei merozoites could guide the development of an efficacious vaccine against P. falciparum...
  6. pmc Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5
    Alexander D Douglas
    Jenner Institute, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Immunol 192:245-58. 2014
    ..These data provide important insight into the mechanisms of broadly neutralizing anti-malaria Abs and further encourage anti-PfRH5-based malaria prevention efforts. ..
  7. pmc ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans
    Susanne H Sheehy
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Churchill Hospital, Oxford, UK
    Mol Ther 20:2355-68. 2012
    ..These data call into question the utility of T cell-inducing blood-stage malaria vaccines and suggest that the focus should remain on high-titer antibody induction against susceptible antigen targets...
  8. pmc Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens
    Andrew R Williams
    The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 8:e1002991. 2012
    ..falciparum antigens and should help to guide the rational development of future multi-antigen vaccines...
  9. pmc The requirement for potent adjuvants to enhance the immunogenicity and protective efficacy of protein vaccines can be overcome by prior immunization with a recombinant adenovirus
    Simone C de Cassan
    The Jenner Institute, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom
    J Immunol 187:2602-16. 2011
    ....
  10. pmc Assessment of antibody-dependent respiratory burst activity from mouse neutrophils on Plasmodium yoelii malaria challenge outcome
    David Llewellyn
    1 University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK
    J Leukoc Biol 95:369-82. 2014
    ..falciparum arises following repeated natural exposure. ..
  11. pmc Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909
    Christopher J A Duncan
    Centre for Clinical Vaccinology and Tropical Medicine, The Jenner Institute, University of Oxford, Oxford, United Kingdom
    PLoS ONE 6:e22271. 2011
    ..Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria...
  12. ncbi request reprint Blood-stage challenge for malaria vaccine efficacy trials: a pilot study with discussion of safety and potential value
    Frances Sanderson
    Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, University of Oxford, Oxford, United Kingdom
    Am J Trop Med Hyg 78:878-83. 2008
    ..This finding may provide greater power to detect partial efficacy of many blood-stage candidate vaccines. We discuss the potential utility of blood-stage challenge studies in accelerating malaria vaccine development...