Gwenaelle Douaud

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
    Gwenaelle Douaud
    Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 110:9523-8. 2013
  2. doi request reprint Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease
    Gwenaelle Douaud
    Functional MRI of the Brain FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 33:2147-55. 2013
  3. ncbi request reprint Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study
    G Douaud
    URA CNRS CEA 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91 401 Orsay, and Département de Neurologie, CHU Angers, France
    Neuroimage 32:1562-75. 2006
  4. ncbi request reprint Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia
    Gwenaelle Douaud
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 130:2375-86. 2007
  5. doi request reprint In vivo evidence for the selective subcortical degeneration in Huntington's disease
    Gwenaelle Douaud
    URA CEA CNRS 2210, SHFJ, Orsay, France
    Neuroimage 46:958-66. 2009
  6. doi request reprint Schizophrenia delays and alters maturation of the brain in adolescence
    Gwenaelle Douaud
    Department of Clinical Neurology, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 132:2437-48. 2009
  7. doi request reprint DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease
    Gwenaelle Douaud
    FMRIB Centre, University of Oxford, UK
    Neuroimage 55:880-90. 2011
  8. doi request reprint Structural and functional bases of visuospatial associative memory in older adults
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing OPTIMA, Experimental Medicine Division of Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Neurobiol Aging 34:961-72. 2013
  9. doi request reprint Resting functional connectivity reveals residual functional activity in Alzheimer's disease
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing, University of Oxford, United Kingdom
    Biol Psychiatry 74:375-83. 2013
  10. pmc Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner
    Karla L Miller
    FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Neuroimage 57:167-81. 2011

Detail Information

Publications20

  1. pmc Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
    Gwenaelle Douaud
    Functional Magnetic Resonance Imaging of the Brain FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 110:9523-8. 2013
    ..Further B-vitamin supplementation trials focusing on elderly subjets with high homocysteine levels are warranted to see if progression to dementia can be prevented...
  2. doi request reprint Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease
    Gwenaelle Douaud
    Functional MRI of the Brain FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 33:2147-55. 2013
    ....
  3. ncbi request reprint Distribution of grey matter atrophy in Huntington's disease patients: a combined ROI-based and voxel-based morphometric study
    G Douaud
    URA CNRS CEA 2210, Service Hospitalier Frederic Joliot, 4, place du General Leclerc, 91 401 Orsay, and Département de Neurologie, CHU Angers, France
    Neuroimage 32:1562-75. 2006
    ..Finally, VBM provided results consistent with previous post mortem results and proved to be a sensitive biomarker capable of correctly managing subcortical distortions throughout HD patients' brains...
  4. ncbi request reprint Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia
    Gwenaelle Douaud
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 130:2375-86. 2007
    ..Together, our observations suggest that the neuropathology of adolescent-onset schizophrenia involves larger and widespread changes than in the adult form, consistent with the greater clinical severity...
  5. doi request reprint In vivo evidence for the selective subcortical degeneration in Huntington's disease
    Gwenaelle Douaud
    URA CEA CNRS 2210, SHFJ, Orsay, France
    Neuroimage 46:958-66. 2009
    ....
  6. doi request reprint Schizophrenia delays and alters maturation of the brain in adolescence
    Gwenaelle Douaud
    Department of Clinical Neurology, FMRIB Centre, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Brain 132:2437-48. 2009
    ..Taken together, these results suggest common aetiological mechanisms for adolescent- and adult-onset schizophrenia with an altered neurodevelopmental time course in the schizophrenic patients that is particularly salient in adolescence...
  7. doi request reprint DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease
    Gwenaelle Douaud
    FMRIB Centre, University of Oxford, UK
    Neuroimage 55:880-90. 2011
    ....
  8. doi request reprint Structural and functional bases of visuospatial associative memory in older adults
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing OPTIMA, Experimental Medicine Division of Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Neurobiol Aging 34:961-72. 2013
    ....
  9. doi request reprint Resting functional connectivity reveals residual functional activity in Alzheimer's disease
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing, University of Oxford, United Kingdom
    Biol Psychiatry 74:375-83. 2013
    ..We combined resting fMRI and task fMRI to examine the correspondence between these methods in individuals with cognitive impairment...
  10. pmc Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner
    Karla L Miller
    FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Neuroimage 57:167-81. 2011
    ..Despite these alterations, diffusion tractography of several major tracts is successfully demonstrated at both resolutions. We also report novel findings of cortical anisotropy and partial volume effects...
  11. pmc Diffusion tractography of post-mortem human brains: optimization and comparison of spin echo and steady-state free precession techniques
    Karla L Miller
    FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK
    Neuroimage 59:2284-97. 2012
    ..These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data...
  12. doi request reprint High resolution diffusion-weighted imaging in fixed human brain using diffusion-weighted steady state free precession
    Jennifer A McNab
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Neuroimage 46:775-85. 2009
    ....
  13. doi request reprint Evidence for abnormalities of cortical development in adolescent-onset schizophrenia
    Natalie L Voets
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, UK
    Neuroimage 43:665-75. 2008
    ..Evidence for changes in local surface area (as opposed to simply cortical thinning) is consistent with a neurodevelopmental contribution to the underlying neuropathology of the disease...
  14. pmc Structural and functional bases for individual differences in motor learning
    Valentina Tomassini
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, United Kingdom
    Hum Brain Mapp 32:494-508. 2011
    ....
  15. ncbi request reprint Brain morphometry and cognitive performance in detoxified alcohol-dependents with preserved psychosocial functioning
    Sandra Chanraud
    Inserm U 797, CEA INSERM Research Unit Neuroimaging and Psychiatry, Institute for Health and Medical Research and Atomic Energy Commission Hospital Department Frédéric Joliot, IFR49, Univ Paris Sud, Univ Paris 5, Orsay, France
    Neuropsychopharmacology 32:429-38. 2007
    ..Besides involving frontal regions, these findings are consistent with a cerebello-thalamo-cortical model of impaired executive functions in alcohol-dependent individuals...
  16. pmc Resting-state fMRI in the Human Connectome Project
    Stephen M Smith
    FMRIB Oxford Centre for Functional MRI of the Brain, Oxford University, Oxford, UK
    Neuroimage 80:144-68. 2013
    ....
  17. doi request reprint Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study
    Stephen E Gwilym
    University of Oxford, Oxford, UK
    Arthritis Rheum 62:2930-40. 2010
    ..From this previous work, it appears that chronic pain is associated with altered brain morphology. The present study was undertaken to assess these potential alterations in patients with painful hip osteoarthritis (OA)...
  18. doi request reprint Benefits of multi-modal fusion analysis on a large-scale dataset: life-span patterns of inter-subject variability in cortical morphometry and white matter microstructure
    Adrian R Groves
    FMRIB Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, OX3 9DU, UK
    Neuroimage 63:365-80. 2012
    ..This exploratory approach automatically generates models to explain structure in the data, and may prove especially powerful for large-scale studies, where the population variability can be explored in increased detail...
  19. doi request reprint Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease
    Paul M Matthews
    Department of Medicine, Division of Brain Sciences, Imperial College, London, UK
    J Alzheimers Dis 33:S163-72. 2013
    ..Together, our studies and related work are helping to establish the exciting potential of a new range of MRI methods as neuropathological measures and as biomarkers of disease progression...
  20. doi request reprint Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis
    Gwenaelle Douaud
    Oxford Centre for Functional Magnetic Resonance of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Brain 134:3470-9. 2011
    ....