Research Topics
Genomes and GenesSpecies | Jenny L DonovanSummaryAffiliation: University of Bristol Country: UK Publications
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Publications
Presenting treatment options to men with clinically localized prostate cancer: the acceptability of active surveillance/monitoringJenny L Donovan
School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, UK
J Natl Cancer Inst Monogr 2012:191-6. 2012....
A review of reporting of participant recruitment and retention in RCTs in six major journalsMerran Toerien
Department of Sociology, The University of York, Heslington, York, YO10 4PS, UK
Trials 10:52. 2009..This paper aims: (i) to update and extend previous reviews evaluating reporting of participant recruitment and retention in RCTs; (ii) to quantify the level of participation throughout RCTs...
Public involvement in suicide prevention: understanding and strengthening lay responses to distressChristabel Owens
Peninsula Medical School Universities of Exeter and Plymouth, Wonford House, Dryden Road, Exeter, Devon, EX2 5AF, UK
BMC Public Health 9:308. 2009....
Screening for prostate cancer. The case againstJenny L Donovan
University of Bristol, UK
Ann R Coll Surg Engl 87:90-1; discussion 88. 2005
Development of a complex intervention improved randomization and informed consent in a randomized controlled trialJenny L Donovan
Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
J Clin Epidemiol 62:29-36. 2009..Systematic reviews failed to identify robust strategies to improve recruitment. We developed and evaluated a complex intervention to increase levels of randomization and informed consent...
The case againstJenny L Donovan
University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
Ann R Coll Surg Engl 87:90-1. 2005
Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trialJ Athene Lane
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 332:199-204. 2006..To determine the impact of a community based Helicobacter pylori screening and eradication programme on the incidence of dyspepsia, resource use, and quality of life, including a cost consequences analysis...
Predictors of attendance for prostate-specific antigen screening tests and prostate biopsyKerry N L Avery
School of Social and Community Medicine, University of Bristol, Bristol, UK
Eur Urol 62:649-55. 2012..Little is known about factors influencing men's decisions to undergo screening and diagnostic tests for prostate cancer (PCa)...
Do the risk factors of age, family history of prostate cancer or a higher prostate specific antigen level raise anxiety at prostate biopsy?Rhiannon C Macefield
Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
Eur J Cancer 45:2569-73. 2009....
Who can best recruit to randomized trials? Randomized trial comparing surgeons and nurses recruiting patients to a trial of treatments for localized prostate cancer (the ProtecT study)Jenny L Donovan
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
J Clin Epidemiol 56:605-9. 2003..In a randomized trial nested within a trial of treatments for localized prostate cancer, we investigated the comparative effectiveness and cost-effectiveness of nurses and surgeons in recruiting patients...
Prostate-specific antigen testing and prostate biopsy: are self-reported lower urinary tract symptoms and health-related quality of life associated with the decision to undergo these investigations?Kerry N L Avery
Department of Social Medicine, University of Bristol, Bristol, UK
BJU Int 102:1629-33. 2008..To investigate whether men's self-reported health-related quality of life and lower urinary tract symptoms (LUTS) are associated with acceptance of prostate-specific antigen (PSA) testing and subsequent prostate biopsy...
Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysisSimon M Collin
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Cancer Epidemiol Biomarkers Prev 19:1632-42. 2010..Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determine whether blood levels of folate, vitamin B(12), and related metabolites were associated with prostate cancer risk...
A comparison of socio-demographic and psychological factors between patients consenting to randomisation and those selecting treatment (the ProtecT study)Nicola Mills
Department of Social Medicine, University of Bristol, UK
Contemp Clin Trials 27:413-9. 2006..Moreover, randomising patients with a preference may affect treatment efficacy and threaten internal validity...
Associations of sexual dysfunction symptoms with PSA-detected localised and advanced prostate cancer: a case-control study nested within the UK population-based ProtecT (Prostate testing for cancer and Treatment) studySimon M Collin
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PS, UK
Eur J Cancer 45:3254-61. 2009..Conversely, among men with raised prostate-specific antigen (PSA) levels, a negative association might be expected if sexual dysfunction was symptomatic of benign, rather than malignant, prostatic disease...
Factors distinguishing general practitioners who more readily participated in a large randomized trial were identifiedLiz Down
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
J Clin Epidemiol 62:67-73. 2009..To investigate factors associated with the successful recruitment of general practices to a randomized controlled trial...
Associations of lifestyle factors and anthropometric measures with repeat PSA levels during active surveillance/monitoringAnya J Burton
MRC Centre for Causal Analysis in Translational Epidemiology, University of Bristol, Bristol, UK
Cancer Epidemiol Biomarkers Prev 21:1877-85. 2012..Factors that influence PSA growth, however, are unclear. We evaluated associations of anthropometric and lifestyle factors with age-related PSA growth...
Psychological distress and prostate specific antigen levels in men with and without prostate cancerEmma L Turner
Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
Brain Behav Immun 23:1073-8. 2009..These analyses highlight the need for further investigations into the possible role of depressed mood in the onset of prostate cancer and, in particular, research examining the biological basis for these relationships...
Exploring treatment preferences facilitated recruitment to randomized controlled trialsNicola Mills
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
J Clin Epidemiol 64:1127-36. 2011..To explore how patients' treatment preferences were expressed and justified during recruitment to a randomized controlled trial (RCT) and how they influenced participation and treatment decisions...
It's not just what you say, it's also how you say it: opening the 'black box' of informed consent appointments in randomised controlled trialsJulia Wade
Department of Social Medicine, University of Bristol, 39 Whatley Road, Clifton, Bristol BS8 2PS, United Kingdom
Soc Sci Med 68:2018-28. 2009..Use of these techniques is necessary to make potential participants' understanding of key issues and their position regarding equipoise explicit in order to facilitate truly informed consent...
Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trialJ Athene Lane
Department of Social Medicine, University of Bristol
BMJ 335:1139. 2007..To investigate the feasibility of testing for prostate cancer and the prevalence and characteristics of the disease in unselected young men...
Decision-making about PSA testing and prostate biopsies: a qualitative study embedded in a primary care randomised trialKerry N L Avery
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Eur Urol 53:1186-93. 2008..The overall aim was to increase understanding of men's decision-making about prostate-specific antigen (PSA) testing and subsequent biopsy...
Men with prostate cancer make positive dietary changes following diagnosis and treatmentKerry N L Avery
School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Clifton, Bristol, BS8 2PS, UK
Cancer Causes Control 24:1119-28. 2013..This study examined dietary changes in men before and after treatment for PC within the prostate testing for cancer and treatment randomized trial...
Young adults' perceptions of GPs as a help source for mental distress: a qualitative studyLucy Biddle
Department of Social Medicine, University of Bristol, Bristol, UK
Br J Gen Pract 56:924-31. 2006..Few young adults with mental disorder seek help from a GP.Aim:To explore young adults' perceptions of GPs as a source of help for mental distress...
Alcohol consumption and PSA-detected prostate cancer risk--a case-control nested in the ProtecT studyLuisa Zuccolo
MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
Int J Cancer 132:2176-85. 2013....
Seasonal variation in prostate-specific antigen levels: a large cross-sectional study of men in the UKLiz Down
School of Social and Community Medicine, University of Bristol, Bristol, Oncology Centre, Addenbrooke s Hospital, Cambridge, and Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
BJU Int 108:1409-14. 2011..To assess whether a seasonal change in prostate specific antigen (PSA) levels can be detected in men recruited to a large clinical trial...
A Peer Review Intervention for Monitoring and Evaluating sites (PRIME) that improved randomized controlled trial conduct and performanceJ Athene Lane
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
J Clin Epidemiol 64:628-36. 2011..We aimed to develop a site monitoring process using peer reviewers to improve staff training, site performance, data collection, and GCP compliance...
Development of a new method for monitoring prostate-specific antigen changes in men with localised prostate cancer: a comparison of observational cohortsKate Tilling
Department of Social Medicine, Bristol University, Canynge Hall, Bristol, UK
Eur Urol 57:446-52. 2010..Prostate-specific antigen (PSA) measurements are increasingly used to monitor men with localised prostate cancer (PCa), but there is little consensus about the method to use...
Population-based prostate-specific antigen testing in the UK leads to a stage migration of prostate cancerAlison L Moore
Department of Social Medicine, University of Bristol, Bristol, UK
BJU Int 104:1592-8. 2009..To determine, within the UK, the stage and grade of prostate cancers that would be found through population-based prostate specific antigen (PSA) testing and biopsy...
Association of diabetes mellitus with prostate cancer: nested case-control study (Prostate testing for cancer and treatment study)Emma L Turner
Department of Social Medicine, University of Bristol, Bristol, UK
Int J Cancer 128:440-6. 2011..95). Diabetes is associated with a decreased risk of PSA-detected prostate cancer. These data add to the evidence of the association of diabetes with prostate cancer in the PSA era...
Transurethral prostate resection, noncontact laser therapy or conservative management in men with symptoms of benign prostatic enlargement? An economic evaluationSian M Noble
Department of Social Medicine, Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, United Kingdom
J Urol 168:2476-82. 2002..We evaluated the cost-effectiveness of noncontact laser therapy compared with transurethral prostate resection and conservative treatment in men with symptoms associated with benign prostatic enlargement...
Associations of aspirin, nonsteroidal anti-inflammatory drug and paracetamol use with PSA-detected prostate cancer: findings from a large, population-based, case-control study (the ProtecT study)Ali S Murad
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Int J Cancer 128:1442-8. 2011..Our conclusions are unlikely to be influenced by PSA detection bias because the inverse associations of aspirin, NSAID and paracetamol use with serum PSA would have attenuated (not generated) the observed positive associations...
Associations of adiponectin and leptin with stage and grade of PSA-detected prostate cancer: the ProtecT studyAnya Burton
School of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
Cancer Causes Control 24:323-34. 2013..We examined associations of the adipokines leptin and adiponectin with the stage and grade of PSA-detected prostate cancer...
Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancerSimon M Collin
School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
Cancer Epidemiol Biomarkers Prev 19:2833-8. 2010..We investigated whether these and other elements of folate metabolism were associated with prostate-specific antigen (PSA) velocity (PSAV) as a proxy measure of prostate cancer progression in men with localized prostate cancer...
Key issues in recruitment to randomised controlled trials with very different interventions: a qualitative investigation of recruitment to the SPARE trial (CRUK/07/011)Sangeetha Paramasivan
School of Social and Community Medicine, University of Bristol, 39 Canynge Hall, Whatley Road, Bristol BS8 2PS, UK
Trials 12:78. 2011....
Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT studyNicola Mills
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
Control Clin Trials 24:272-82. 2003..A priority for future research is to focus on the provision and presentation of suitable and effective trial information, concentrating in particular on the neglected concept of clinical equipoise...
Very low PSA concentrations and deletions of the KLK3 geneSantiago Rodriguez
MRC Centre for Causal Analyses in Translational Epidemiology CAiTE and Bristol Genetic Epidemiology Laboratories BGEL, University of Bristol, Bristol, UK
Clin Chem 59:234-44. 2013..We hypothesized that very low PSA concentrations might reflect gene-inactivating mutations in KLK3 that lead to abnormally reduced gene expression...
Satisfaction with care: an independent outcome measure in surgical oncologyKerry N L Avery
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol Royal Infirmary, BS8 2PR, United Kingdom
Ann Surg Oncol 13:817-22. 2006..34). CONCLUSIONS: Patient satisfaction with hospital care is independent of morbidity, treatment type, and QOL outcomes. It may be used to feed back information to providers of health care to improve patients' experiences of treatment...
Behavior theory for dietary interventions for cancer prevention: a systematic review of utilization and effectiveness in creating behavior changeKerry N L Avery
School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol BS8 2PS, UK
Cancer Causes Control 24:409-20. 2013..This systematic review examined application of behavior theory to dietary interventions aimed at preventing cancer to improve the design and interpretation of trials...
A scored form of the Bristol Female Lower Urinary Tract Symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinenceSara T Brookes
Department of Social Medicine, University of Bristol, UK
Am J Obstet Gynecol 191:73-82. 2004..This paper describes development and validation of a scored form BFLUTS questionnaire...
Using genetic proxies for lifecourse sun exposure to assess the causal relationship of sun exposure with circulating vitamin d and prostate cancer riskCarolina Bonilla
School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
Cancer Epidemiol Biomarkers Prev 22:597-606. 2013....
Supporting adolescent emotional health in schools: a mixed methods study of student and staff views in EnglandJudi Kidger
Department of Social Medicine, University of Bristol, Canynge Hall, 39, Whatley Road, Bristol BS8 2PS, UK
BMC Public Health 9:403. 2009..Relatively little is known about student and staff views regarding current school-based emotional health provision and what they would like to see in the future, and this is what this study explored...
Relationship between lower urinary tract symptoms and erectile dysfunction: results from the Boston Area Community Health SurveySara T Brookes
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
J Urol 179:250-5; discussion 255. 2008..We explored the association of lower urinary tract symptoms and erectile dysfunction in a racially and ethnically diverse random sample of men...
Unstated factors in orthopaedic decision-making: a qualitative studyRachael Gooberman-Hill
University of Bristol, School of Clinical Sciences, Southmead Hospital, Westbury on Trym, Bristol BS10 5NB, UK
BMC Musculoskelet Disord 11:213. 2010..However, we do not know what happens within orthopaedic practice and whether this reflects the shared model. Our study examined how decisions are made about TJR in orthopaedic consultations...
Sexual dysfunction in men after treatment for lower urinary tract symptoms: evidence from randomised controlled trialSara T Brookes
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR
BMJ 324:1059-61. 2002..To examine the impact on sexual function of treatments for lower urinary tract symptoms in men...
Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinomaJane M Blazeby
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Cancer 103:1791-9. 2005..The current study examined HRQL during preoperative chemotherapy/chemoradiotherapy treatment and compared postoperative recovery of HRQL in patients undergoing combined treatment with patients undergoing surgery alone...
Research in black and whiteJoy Adamson
Joint Medical Research Council, Department of Health, University of Bristol, UK
Qual Health Res 12:816-25. 2002..The authors believe that qualitative research should be judged by the plausibility of the findings and by a critical evaluation of the way in which the research was conducted and the reflexivity of the researcher...
A placebo-controlled randomized trial of eradication of Helicobacter pylori in the general population: study design and response rates of the Bristol Helicobacter ProjectJ Athene Lane
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Control Clin Trials 23:321-32. 2002..In the Bristol Helicobacter Project the rate of participation varied inversely with both social deprivation and the prevalence of the infection...
Factors influencing help seeking in mentally distressed young adults: a cross-sectional surveyLucy Biddle
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
Br J Gen Pract 54:248-53. 2004..Young adults, especially men, are among those least likely to consult healthcare professionals when mentally distressed or suicidal...
"Why don't they just tell me straight, why allocate it?" The struggle to make sense of participating in a randomised controlled trialKatie Featherstone
Cardiff School of Social Sciences, Cardiff University, Wales, UK
Soc Sci Med 55:709-19. 2002..The provision of clearer written information or time to discuss the trial with particular individuals might be beneficial, although greater public understanding of trials is also needed...
Inverse relationship between alcohol consumption and active Helicobacter pylori infection: the Bristol Helicobacter projectLiam J Murray
The Queen's University of Belfast, United Kingdom
Am J Gastroenterol 97:2750-5. 2002..83, 95% CI = 0.75-0.91). CONCLUSIONS: This study indicates that modest consumption of wine and beer (approximately 7 units/wk) protects against H. pylori infection, presumably by facilitating eradication of the organism...
Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter projectRichard F Harvey
Frenchay Hospital, North Bristol NHS Trust, Bristol BS16 1LE
BMJ 328:1417. 2004..To investigate the effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux...
Measuring the psychosocial impact of population-based prostate-specific antigen testing for prostate cancer in the UKLucy A Brindle
School of Nursing and Midwifery, University of Southampton, Southampton, UK
BJU Int 98:777-82. 2006....
Remapping the body: learning to eat again after surgery for esophageal cancerDavid Wainwright
University of Bath, United Kingdom
Qual Health Res 17:759-71. 2007..The authors report findings from in-depth interviews with 11 esophageal cancer patients, documenting their experiences as they struggle to achieve a process of adaptation that is at once physiological, psychological, and social...
Contribution of a single repeat PSA test to prostate cancer risk assessment: experience from the ProtecT studyDerek J Rosario
University of Sheffield, Sheffield, United Kingdom
Eur Urol 53:777-84. 2008..To examine whether a single repeat prostate-specific antigen (PSA) helps discriminate cancer from non-cancer-related PSA elevation...
Multiple loci with different cancer specificities within the 8q24 gene desertMaya Ghoussaini
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
J Natl Cancer Inst 100:962-6. 2008..We conclude that there are at least five separate functional variants in this region...
Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancerSteven E Oliver
Department of Health Sciences, University of York, and The Hull York Medical School, Heslington, York, UK
Cancer Epidemiol Biomarkers Prev 13:163-5. 2004..Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders...
Ethics of clinical trials from bayesian perspective: randomisation to clinical trials may solve dilemma of treatment choice in prostate cancerFreddie C Hamdy
BMJ 326:1456. 2003
A patient-centered approach to developing a comprehensive symptom and quality of life assessment of anal incontinenceNikki Cotterill
Bristol Urological Institute, Southmead Hospital, Westbury on Trym, Bristol, United Kingdom
Dis Colon Rectum 51:82-7. 2008..This study was designed to identify question items required for a comprehensive symptom and quality of life assessment for individuals with anal incontinence...
Multiple newly identified loci associated with prostate cancer susceptibilityRosalind A Eeles
The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Nat Genet 40:316-21. 2008..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3...
