Research Topics
| J L DonovanSummaryAffiliation: University of Bristol Country: UK Publications
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Publications
Who can best recruit to randomized trials? Randomized trial comparing surgeons and nurses recruiting patients to a trial of treatments for localized prostate cancer (the ProtecT study)Jenny L Donovan
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
J Clin Epidemiol 56:605-9. 2003..In a randomized trial nested within a trial of treatments for localized prostate cancer, we investigated the comparative effectiveness and cost-effectiveness of nurses and surgeons in recruiting patients...
Qualitative study of interpretation of reassurance among patients attending rheumatology clinics: "just a touch of arthritis, doctor?"J L Donovan
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 320:541-4. 2000..To examine commonly used methods of reassurance by clinicians and explore their effect on patients...
Capturing users' experiences of participating in cancer trialsJ L Donovan
Department of Social Medicine, University of Bristol, UK
Eur J Cancer Care (Engl) 11:210-4. 2002..In this article, we review the literature in these areas and examine whether users' experiences of participating in cancer trials can be used to assist in the design or conduct of trials...
Impact of prostate cancer testing: an evaluation of the emotional consequences of a negative biopsy resultR C Macefield
Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol BS8 2PS, UK
Br J Cancer 102:1335-40. 2010..When testing for prostate cancer, as many as 75% of men with a raised prostate-specific antigen (PSA) have a benign biopsy result. Little is known about the psychological effect of this result for these men...
Do height-related variations in insulin-like growth factors underlie the associations of stature with adult chronic disease?D Gunnell
Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
J Clin Endocrinol Metab 89:213-8. 2004..The associations of anthropometry with IGFBP-2 merit additional investigation...
Low risk research using routinely collected identifiable health information without informed consent: encounters with the Patient Information Advisory GroupC Metcalfe
Department of Social Medicine, Bristol University, Bristol, UK
J Med Ethics 34:37-40. 2008..We conclude by arguing that many of the current problems could be avoided by returning PIAG's responsibilities to research ethics committees, and by allowing "opt-out" consent for many public health research projects...
Current strategies for monitoring men with localised prostate cancer lack a strong evidence base: observational longitudinal studyC Metcalfe
Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK
Br J Cancer 101:390-4. 2009..However, there is little evidence of the changes in PSA level that should alert to the need for clinical re-assessment...
Development of a questionnaire for measurement of vision-related quality of lifeN A Frost
Department of Ophthalmology, University of Bristol, UK
Ophthalmic Epidemiol 5:185-210. 1998..To define vision-related quality of life, to outline the development of a vision-specific quality of life instrument and to present the characteristics of a 10-item 'core' questionnaire...
Latest results from the UK trials evaluating prostate cancer screening and treatment: the CAP and ProtecT studiesJ A Lane
School of Social and Community Medicine, University of Bristol, Bristol, UK
Eur J Cancer 46:3095-101. 2010..3% (10/442). The CAP and ProtecT trials (ISRCTN92187251 and ISRCTN20141217) will help resolve the prostate cancer screening debate, define the optimum treatment for localised disease and generate evidence to improve men's health...
Outcomes of total knee replacement: a qualitative studyG M Woolhead
Department of Social Medicine, Canynge Hall, University of Bristol, Bristol, BS8 2PR, UK
Rheumatology (Oxford) 44:1032-7. 2005..To investigate patients' experiences of outcome from a total knee replacement (TKR)...
Transurethral prostatic resection or laser therapy for men with acute urinary retention: the ClasP randomized trialK N Chacko
Department of Social Medicine, University of Bristol, United Kingdom
J Urol 166:166-70; discussion 170-1. 2001..CONCLUSIONS: Transurethral prostatic resection was more effective, resulted in fewer failures than laser treatment and remains the procedure of choice for men with acute urinary retention...
Clinical decision-making in a multidisciplinary gynaecological cancer team: a qualitative studyJ Kidger
Department of Social Medicine, University of Bristol, Bristol, UK
BJOG 116:511-7. 2009..To explore the factors that influence treatment decision-making in a gynaecological cancer team (MDT)...
Prostate cancer: screening approachesJ L Donovan
Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR
Br J Hosp Med (Lond) 66:623-6. 2005..Current evidence about the impact and natural history of prostate cancer, screening and diagnostic tests, and the effectiveness of treatments is reviewed below...
Reporting clinical outcomes of breast reconstruction: a systematic reviewS Potter
Surgical Research Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK
J Natl Cancer Inst 103:31-46. 2011..Breast reconstruction after mastectomy for cancer requires accurate evaluation to inform evidence-based participatory decision making, but the standards of outcome reporting after breast reconstruction have not previously been considered...
Analysis of clinical decision-making in multi-disciplinary cancer teamsJ M Blazeby
Department of Social Medicine, Canynge Hall, University of Bristol, Bristol, UK
Ann Oncol 17:457-60. 2006..For upper gastrointestinal cancer, MDTs require more information about co morbid disease and patient choice to truly optimize the implementation of multi-disciplinary expertise...
Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled studyJ A Lane
School of Social and Community Medicine, University of Bristol, 39 Whatley Road, Bristol, UK
Aliment Pharmacol Ther 33:922-9. 2011..Body mass index (BMI) increased following Helicobacter pylori eradication in several Japanese cohorts, which requires further investigation...
Why don't patients do their exercises? Understanding non-compliance with physiotherapy in patients with osteoarthritis of the kneeR Campbell
Department of Social Medicine, University of Bristol, Whiteladies Road, Bristol BS8 4SH, UK
J Epidemiol Community Health 55:132-8. 2001..To understand reasons for compliance and non-compliance with a home based exercise regimen by patients with osteoarthritis of the knee...
Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in healthy middle-aged menD Gunnell
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, UK
Br J Cancer 88:1682-6. 2003..These patterns support the possibility that IGFs may mediate some diet-cancer associations...
The development and validation of a questionnaire to assess visual symptoms/dysfunction and impact on quality of life in cataract patients: the Visual Symptoms and Quality of life (VSQ) QuestionnaireJ L Donovan
Department of Social Medicine, University of Bristol, UK
Ophthalmic Epidemiol 10:49-65. 2003..Two final versions of the VSQ questionnaire have been produced for future use in assessing visual symptoms/dysfunction and impact on vision-specific quality of life: a scoreable short form and more detailed and sensitive long form...
Sexual dysfunction in men with lower urinary tract symptomsS J Frankel
Department of Social Medicine, University of Bristol, United Kingdom
J Clin Epidemiol 51:677-85. 1998..Urinary flow rates were not associated with sexual symptoms. Sexual dysfunction is, therefore, strongly associated with LUTS, is a matter of concern to the men affected, and should be taken into account when managing patients with LUTS...
Who should have priority for a knee joint replacement?G M Woolhead
Medical Research Council Health Services Research Collaboration, Department of Social Medicine, Canynge Hall, University of Bristol, Bristol BS8 2PR, UK
Rheumatology (Oxford) 41:390-4. 2002..To explore patients' views on who should have priority for total knee replacement (TKR)...
"Why don't they just tell me straight, why allocate it?" The struggle to make sense of participating in a randomised controlled trialKatie Featherstone
Cardiff School of Social Sciences, Cardiff University, Wales, UK
Soc Sci Med 55:709-19. 2002..The provision of clearer written information or time to discuss the trial with particular individuals might be beneficial, although greater public understanding of trials is also needed...
A comparison of socio-demographic and psychological factors between patients consenting to randomisation and those selecting treatment (the ProtecT study)Nicola Mills
Department of Social Medicine, University of Bristol, UK
Contemp Clin Trials 27:413-9. 2006..Moreover, randomising patients with a preference may affect treatment efficacy and threaten internal validity...
Ethics of clinical trials from bayesian perspective: randomisation to clinical trials may solve dilemma of treatment choice in prostate cancerFreddie C Hamdy
BMJ 326:1456. 2003
Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT studyNicola Mills
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
Control Clin Trials 24:272-82. 2003..A priority for future research is to focus on the provision and presentation of suitable and effective trial information, concentrating in particular on the neglected concept of clinical equipoise...
Multiple loci with different cancer specificities within the 8q24 gene desertMaya Ghoussaini
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
J Natl Cancer Inst 100:962-6. 2008..We conclude that there are at least five separate functional variants in this region...
Research in black and whiteJoy Adamson
Joint Medical Research Council, Department of Health, University of Bristol, UK
Qual Health Res 12:816-25. 2002..The authors believe that qualitative research should be judged by the plausibility of the findings and by a critical evaluation of the way in which the research was conducted and the reflexivity of the researcher...
Multiple newly identified loci associated with prostate cancer susceptibilityRosalind A Eeles
The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Nat Genet 40:316-21. 2008..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3...
A placebo-controlled randomized trial of eradication of Helicobacter pylori in the general population: study design and response rates of the Bristol Helicobacter ProjectJ Athene Lane
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Control Clin Trials 23:321-32. 2002..In the Bristol Helicobacter Project the rate of participation varied inversely with both social deprivation and the prevalence of the infection...
Contribution of a single repeat PSA test to prostate cancer risk assessment: experience from the ProtecT studyDerek J Rosario
University of Sheffield, Sheffield, United Kingdom
Eur Urol 53:777-84. 2008..To examine whether a single repeat prostate-specific antigen (PSA) helps discriminate cancer from non-cancer-related PSA elevation...
Transurethral prostate resection, noncontact laser therapy or conservative management in men with symptoms of benign prostatic enlargement? An economic evaluationSian M Noble
Department of Social Medicine, Medical Research Council Health Services Research Collaboration, Department of Social Medicine, University of Bristol, United Kingdom
J Urol 168:2476-82. 2002..We evaluated the cost-effectiveness of noncontact laser therapy compared with transurethral prostate resection and conservative treatment in men with symptoms associated with benign prostatic enlargement...
Detection of prostate cancer in unselected young men: prospective cohort nested within a randomised controlled trialJ Athene Lane
Department of Social Medicine, University of Bristol
BMJ 335:1139. 2007..To investigate the feasibility of testing for prostate cancer and the prevalence and characteristics of the disease in unselected young men...
Factors influencing help seeking in mentally distressed young adults: a cross-sectional surveyLucy Biddle
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
Br J Gen Pract 54:248-53. 2004..Young adults, especially men, are among those least likely to consult healthcare professionals when mentally distressed or suicidal...
A scored form of the Bristol Female Lower Urinary Tract Symptoms questionnaire: data from a randomized controlled trial of surgery for women with stress incontinenceSara T Brookes
Department of Social Medicine, University of Bristol, UK
Am J Obstet Gynecol 191:73-82. 2004..This paper describes development and validation of a scored form BFLUTS questionnaire...
Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinomaJane M Blazeby
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Cancer 103:1791-9. 2005..The current study examined HRQL during preoperative chemotherapy/chemoradiotherapy treatment and compared postoperative recovery of HRQL in patients undergoing combined treatment with patients undergoing surgery alone...
Screening for prostate cancer. The case againstJenny L Donovan
University of Bristol, UK
Ann R Coll Surg Engl 87:90-1; discussion 88. 2005
Impact of Helicobacter pylori eradication on dyspepsia, health resource use, and quality of life in the Bristol helicobacter project: randomised controlled trialJ Athene Lane
Department of Social Medicine, University of Bristol, Bristol BS8 2PR
BMJ 332:199-204. 2006..To determine the impact of a community based Helicobacter pylori screening and eradication programme on the incidence of dyspepsia, resource use, and quality of life, including a cost consequences analysis...
Satisfaction with care: an independent outcome measure in surgical oncologyKerry N L Avery
Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol Royal Infirmary, BS8 2PR, United Kingdom
Ann Surg Oncol 13:817-22. 2006..34). CONCLUSIONS: Patient satisfaction with hospital care is independent of morbidity, treatment type, and QOL outcomes. It may be used to feed back information to providers of health care to improve patients' experiences of treatment...
The case againstJenny L Donovan
University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
Ann R Coll Surg Engl 87:90-1. 2005
Measuring the psychosocial impact of population-based prostate-specific antigen testing for prostate cancer in the UKLucy A Brindle
School of Nursing and Midwifery, University of Southampton, Southampton, UK
BJU Int 98:777-82. 2006....
Decision-making about PSA testing and prostate biopsies: a qualitative study embedded in a primary care randomised trialKerry N L Avery
Department of Social Medicine, University of Bristol, Bristol, United Kingdom
Eur Urol 53:1186-93. 2008..The overall aim was to increase understanding of men's decision-making about prostate-specific antigen (PSA) testing and subsequent biopsy...
A patient-centered approach to developing a comprehensive symptom and quality of life assessment of anal incontinenceNikki Cotterill
Bristol Urological Institute, Southmead Hospital, Westbury on Trym, Bristol, United Kingdom
Dis Colon Rectum 51:82-7. 2008..This study was designed to identify question items required for a comprehensive symptom and quality of life assessment for individuals with anal incontinence...
