Rachelle Donn

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis
    Rachelle Donn
    Epidemiology Unit, Arthritis Research Campaign, University of Manchester, Manchester, UK
    Arthritis Rheum 46:2402-9. 2002
  2. ncbi request reprint A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis
    Rachelle Donn
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 50:1604-10. 2004
  3. ncbi request reprint Lack of association between juvenile idiopathic arthritis and fas gene polymorphism
    Rachelle Donn
    ARC Epidemiology Unit, University of Manchester, UK
    J Rheumatol 29:166-8. 2002
  4. doi request reprint Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression
    Laura M Elsby
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:2220-31. 2009
  5. ncbi request reprint Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
  6. ncbi request reprint Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype
    Adam Stevens
    Endocrine Sciences Research Group and Centre for Molecular Medicine, Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 89:892-7. 2004
  7. pmc Rheumatoid arthritis association at 6q23
    Wendy Thomson
    Arthritis Research Campaign ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Nat Genet 39:1431-3. 2007
  8. ncbi request reprint Wnt-1-inducible signaling pathway protein 3 and susceptibility to juvenile idiopathic arthritis
    Rebecca Lamb
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 52:3548-53. 2005
  9. ncbi request reprint Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII
    Rachelle Donn
    Centre for Molecular Medicine, University of Manchester, Oxford Rd, Manchester, M13 9PT, UK
    FASEB J 21:402-14. 2007
  10. pmc Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis
    Rachelle Donn
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:869-74. 2008

Detail Information

Publications26

  1. ncbi request reprint Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis
    Rachelle Donn
    Epidemiology Unit, Arthritis Research Campaign, University of Manchester, Manchester, UK
    Arthritis Rheum 46:2402-9. 2002
    ..To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with juvenile idiopathic arthritis (JIA)...
  2. ncbi request reprint A functional promoter haplotype of macrophage migration inhibitory factor is linked and associated with juvenile idiopathic arthritis
    Rachelle Donn
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 50:1604-10. 2004
    ..To establish linkage and replicate the association of macrophage migration inhibitory factor (MIF) with juvenile idiopathic arthritis (JIA)...
  3. ncbi request reprint Lack of association between juvenile idiopathic arthritis and fas gene polymorphism
    Rachelle Donn
    ARC Epidemiology Unit, University of Manchester, UK
    J Rheumatol 29:166-8. 2002
    ..We investigated whether a polymorphism in the Fas promoter region (-670) confers susceptibility to JIA...
  4. doi request reprint Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression
    Laura M Elsby
    University of Manchester, Manchester, UK
    Arthritis Rheum 60:2220-31. 2009
    ..Macrophage migration inhibitory factor (MIF) is a proinflammatory mediator involved in the pathogenesis of rheumatoid arthritis. This study was undertaken to identify the MIF promoter elements responsible for regulating gene expression...
  5. ncbi request reprint Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: further support that PTPN22 is an autoimmunity gene
    Anne Hinks
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1694-9. 2005
    ....
  6. ncbi request reprint Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype
    Adam Stevens
    Endocrine Sciences Research Group and Centre for Molecular Medicine, Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 89:892-7. 2004
    ..This haplotype may help predetermine variation in clinical response to GC therapy and also assist the understanding of diseases related to GC production...
  7. pmc Rheumatoid arthritis association at 6q23
    Wendy Thomson
    Arthritis Research Campaign ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Nat Genet 39:1431-3. 2007
    ..1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3)...
  8. ncbi request reprint Wnt-1-inducible signaling pathway protein 3 and susceptibility to juvenile idiopathic arthritis
    Rebecca Lamb
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Arthritis Rheum 52:3548-53. 2005
    ..To determine whether Wnt-1-inducible signaling pathway protein 3 (WISP3) polymorphisms are associated with susceptibility to juvenile idiopathic arthritis (JIA)...
  9. ncbi request reprint Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII
    Rachelle Donn
    Centre for Molecular Medicine, University of Manchester, Oxford Rd, Manchester, M13 9PT, UK
    FASEB J 21:402-14. 2007
    ..Furthermore, this combined gene profiling, and functional analysis approach has identified BMPRII as a modulator of Gc signaling...
  10. pmc Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis
    Rachelle Donn
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:869-74. 2008
    ....
  11. ncbi request reprint Regulation of glucocorticoid receptor gamma (GRgamma) by glucocorticoid receptor haplotype and glucocorticoid
    Adam Stevens
    Endocrine Sciences Research Group, Faculty of Medicine, University of Manchester, Manchester, UK
    Clin Endocrinol (Oxf) 61:327-31. 2004
    ..Therefore we proposed that the GR haplotype affects glucocorticoid sensitivity either by influencing GRgamma expression basally, or in response to Gc exposure...
  12. ncbi request reprint Positive association of SLC26A2 gene polymorphisms with susceptibility to systemic-onset juvenile idiopathic arthritis
    Rebecca Lamb
    Arthritis Research Campaign Epidemiology Unit and Centre for Molecular Medicine, University of Manchester, Manchester, UK
    Arthritis Rheum 56:1286-91. 2007
    ..To investigate SLC26A2, the gene that causes diastrophic dysplasia, in juvenile idiopathic arthritis (JIA)...
  13. pmc Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis
    Rachelle Donn
    Arthritis Research Campaign Epidemiology Unit ARC EU and Centre for Molecular Medicine CMM, University of Manchester, Manchester, UK
    Clin Endocrinol (Oxf) 67:342-5. 2007
    ..A defect in hypothalamic-pituitary-adrenal (HPA) axis function has been suggested to contribute to susceptibility to rheumatoid arthritis (RA)...
  14. ncbi request reprint Linkage and association studies of single-nucleotide polymorphism-tagged tumor necrosis factor haplotypes in juvenile oligoarthritis
    Eleftheria Zeggini
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 46:3304-11. 2002
    ..The aim of this study was to examine the association of multiple TNF SNPs with juvenile oligoarthritis and to construct and analyze SNP-tagged TNF haplotypes...
  15. pmc Ultradian cortisol pulsatility encodes a distinct, biologically important signal
    Andrew McMaster
    Endocrine Sciences Research Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom
    PLoS ONE 6:e15766. 2011
    ..Cortisol is released in ultradian pulses. The biological relevance of the resulting fluctuating cortisol concentration has not been explored...
  16. pmc Juvenile idiopathic arthritis genetics - what's new? What's next?
    Wendy Thomson
    Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Stopford Building, Oxford Road, UK
    Arthritis Res 4:302-6. 2002
    ..MHC-, cytokine- and T-cell-related genes have all been positively associated with JIA. Here we review some of the latest genetic data, and discuss ways in which JIA genetic research might proceed...
  17. pmc Ligand modulation of REV-ERBalpha function resets the peripheral circadian clock in a phasic manner
    Qing Jun Meng
    Faculty of Life Sciences, A V Hill Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 121:3629-35. 2008
    ..Therefore, similar regulation of REV-ERBalpha function by endogenous ligands, such as heme, is likely to be an important mechanism for clock resetting. In addition, we identify a new means to generate phasic shifts in the clock...
  18. pmc Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis
    A Hinks
    Arthritis Research Campaign Epidemiology Unit ARC EU, University of Manchester, Manchester, UK
    Genes Immun 11:194-8. 2010
    ..All results require validation in independent JIA data sets. Further characterisation of the specific causal variants will be required before functional studies can be performed...
  19. ncbi request reprint Pediatric perspective on pharmacogenomics
    Adam Stevens
    Institute of Human Development, Medical and Human Sciences, University of Manchester and Royal Manchester Children s Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, 5th Floor Research, Oxford Road, Manchester, M13 9WL, UK
    Pharmacogenomics 14:1889-905. 2013
    ..This review focuses on pharmacogenomic research in pediatrics, providing examples from common pediatric conditions and emphasizing their developmental context. ..
  20. doi request reprint A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility
    Kay Chapman
    Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, University of Oxford, Oxford, UK
    Hum Mol Genet 17:1497-504. 2008
    ..0004, OR = 1.21) and the dominant model (P < 0.0001, OR = 1.48). These findings represent the first highly significant evidence for a risk factor for the development of OA which affects two highly diverse ethnic groups...
  21. doi request reprint Association of the macrophage migration inhibitory factor -173*C allele with childhood nephrotic syndrome
    Marina Vivarelli
    Unita Operativa di Nefrologia e Dialisi, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
    Pediatr Nephrol 23:743-8. 2008
    ....
  22. ncbi request reprint Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis
    Fabrizio De Benedetti
    IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy
    Arthritis Rheum 48:1398-407. 2003
    ....
  23. pmc Macrophage migration inhibitory factor polymorphisms do not predict therapeutic response to glucocorticoids or to tumour necrosis factor alpha-neutralising treatments in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, PO 6525 GA, Nijmegen, The Netherlands
    Ann Rheum Dis 66:1525-30. 2007
    ..Therefore, the question of whether two functional variants in MIF are associated with the response to tumour necrosis factor (TNF)alpha-neutralising and GC treatments in RA was investigated...
  24. ncbi request reprint Genetic variations in ZFP36 and their possible relationship to autoimmune diseases
    Danielle Mercatante Carrick
    Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    J Autoimmun 26:182-96. 2006
    ..The data presented here suggest a tentative association between ZFP36 and RA. This finding, as well as the ZFP36 polymorphisms and haplotypes identified here, should form the basis for future association studies in autoimmune diseases...
  25. ncbi request reprint Correlation of rheumatoid arthritis severity with the genetic functional variants and circulating levels of macrophage migration inhibitory factor
    Timothy R D J Radstake
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 52:3020-9. 2005
    ..To study whether genetic variants of macrophage migration inhibitory factor (MIF), the MIF -173G>C and CATT(5-8) alleles, are associated with disease severity and levels of circulating MIF in patients with rheumatoid arthritis (RA)...
  26. ncbi request reprint Human macrophage migration inhibitory factor: a proven immunomodulatory cytokine?
    Alex Kudrin
    Department of Disease Biology, Rheumatology, and Inflammation and Discovery Research, GlaxoSmithKline, Stevenage SG1 2NY, United Kingdom
    J Biol Chem 281:29641-51. 2006
    ..The potentiating effect of MIF was seen at physiologically relevant concentrations. These data suggest that MIF has no conventional cytokine activity but, rather, acts to modulate and amplify the response to LPS...