A C Dolphin


Affiliation: University College London
Country: UK


  1. Nieto Rostro M, Ramgoolam K, Pratt W, Kulik A, Dolphin A. Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo. Proc Natl Acad Sci U S A. 2018;: pubmed publisher
    ..There was no effect of α2δ-1 knockout on other dorsal horn pre- and postsynaptic markers, indicating the primary afferent pathways are not otherwise affected by α2δ-1 ablation. ..
  2. Dahimene S, Page K, Kadurin I, Ferron L, Ho D, Powell G, et al. The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1. Cell Rep. 2018;25:1610-1621.e5 pubmed publisher
    ..2. Cachd1 also competes with α2δ-1 for effects on trafficking. Thus, Cachd1 influences both CaV2.2 trafficking and function and can inhibit responses to α2δ-1. ..
  3. Heyes S, Pratt W, Rees E, Dahimene S, Ferron L, Owen M, et al. Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders. Prog Neurobiol. 2015;134:36-54 pubmed publisher
  4. Dolphin A. The ?2? subunits of voltage-gated calcium channels. Biochim Biophys Acta. 2013;1828:1541-9 pubmed publisher
    ..These proteins are largely extracellular, membrane-associated proteins which influence the trafficking, localization, and biophysical properties of the channels. This article is part of a Special Issue entitled: Calcium channels. ..
  5. Dahimene S, Page K, Nieto Rostro M, Pratt W, D Arco M, Dolphin A. A CaV2.1 N-terminal fragment relieves the dominant-negative inhibition by an Episodic ataxia 2 mutant. Neurobiol Dis. 2016;93:243-56 pubmed publisher
    ..1, which prevents the correct folding of the wild-type channel. In agreement with this, we were able to disrupt the interaction between EA2 and the full length channel by co-expressing a free N-terminal peptide. ..
  6. Dolphin A. Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol. 2016;594:5369-90 pubmed publisher
    ..This review will provide a general introduction and then concentrate particularly on the role of auxiliary ?2 ? subunits in both physiological and pathological processes involving calcium channels, and as a therapeutic target. ..
  7. Margas W, Ferron L, Nieto Rostro M, Schwartz A, Dolphin A. Effect of knockout of α2δ-1 on action potentials in mouse sensory neurons. Philos Trans R Soc Lond B Biol Sci. 2016;371: pubmed publisher
    ..This article is part of the themed issue 'Evolution brings Ca(2+) and ATP together to control life and death'. ..
  8. Zamponi G, Striessnig J, Koschak A, Dolphin A. The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential. Pharmacol Rev. 2015;67:821-70 pubmed publisher
    ..Use-dependent N-type calcium channel blockers are likely to be of therapeutic use in chronic pain conditions. Thus, more selective calcium channel blockers hold promise for therapeutic intervention. ..
  9. Dolphin A. Calcium channel auxiliary ?2? and ? subunits: trafficking and one step beyond. Nat Rev Neurosci. 2012;13:542-55 pubmed publisher
    ..The aim of this Review is to examine both the classic and novel roles for these auxiliary subunits in voltage-gated calcium channel function and beyond. ..

More Information


  1. Lana B, Schlick B, Martin S, Pratt W, Page K, Gonçalves L, et al. Differential upregulation in DRG neurons of an ?2?-1 splice variant with a lower affinity for gabapentin after peripheral sensory nerve injury. Pain. 2014;155:522-33 pubmed publisher
    ..This variant could therefore play a role in determining the efficacy of gabapentin in neuropathic pain. ..
  2. Nieto Rostro M, Sandhu G, Bauer C, Jiruska P, Jefferys J, Dolphin A. Altered expression of the voltage-gated calcium channel subunit α₂δ-1: a comparison between two experimental models of epilepsy and a sensory nerve ligation model of neuropathic pain. Neuroscience. 2014;283:124-37 pubmed publisher
  3. Macabuag N, Dolphin A. Alternative Splicing in Ca(V)2.2 Regulates Neuronal Trafficking via Adaptor Protein Complex-1 Adaptor Protein Motifs. J Neurosci. 2015;35:14636-52 pubmed publisher
    ..2 containing exon 37b, but not exon 37a, and activation by the agonist quinpirole reversed the effect of the D2R. Our work thus reveals key mechanisms involved in the trafficking of N-type calcium channels. ..
  4. Page K, Rothwell S, Dolphin A. The CaV? Subunit Protects the I-II Loop of the Voltage-gated Calcium Channel CaV2.2 from Proteasomal Degradation but Not Oligoubiquitination. J Biol Chem. 2016;291:20402-16 pubmed publisher
    ..We propose that targeting to the plasma membrane requires a conformational change in the I-II loop that is induced by binding of the CaV? subunit. ..
  5. Cassidy J, Ferron L, Kadurin I, Pratt W, Dolphin A. Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits. Proc Natl Acad Sci U S A. 2014;111:8979-84 pubmed publisher
    ..2 and α2δ-1 is not disrupted by gabapentin. Altogether, these results demonstrate that CaV2.2 and α2δ-1 are intimately associated at the plasma membrane and allow us to infer a region of interaction. ..