Michael Doherty

....

..We sought to compare the QALY gains, and incremental cost per QALY estimates, predicted on the basis of mapping to those based on actual EQ-5D scores...

..This suggests that it is more appropriate to use the EQ-5D in future cost-effectiveness analyses of interventions which are designed to alleviate knee pain. TRIAL REGISTRATION: Current Controlled Trials ISRCTN93206785...

..Gout appears to be an independent risk factor for all-cause mortality and cardiovascular mortality and morbidity, additional to the risk conferred by its association with traditional cardiovascular risk factors...

..New knowledge of the modifiable risk factors for gout can be integrated into the management strategy to optimize long-term patient outcomes...

..To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain...

..To determine whether 2-dimensional measures of femoral head shape and angle are associated with hip osteoarthritis (OA)...

....

..Such ongoing work and subsequent gene-gene and gene-environment interaction studies are likely to give important, perhaps unexpected, insights into the pathogenesis of hand OA...

..The following important factors were discussed: Genetics, Age, Gender, Obesity, HRT (hormone replacement therapy), Physical activity/trauma...

..2) To investigate the associations between CC and individual radiographic features of osteoarthritis (OA) at the tibiofemoral joint (TFJ) and patellofemoral joint (PFJ)...

..To determine if self-reported current and early adult life knee malalignment is associated with knee chondrocalcinosis (CC)...

..To determine whether self-reported early adult life malalignment of knees or feet are risk factors for knee or hip osteoarthritis (OA)...

..To assess whether three health-related quality-of-life (HRQL) measures (the EQ-5Dindex, SF-6D, and EQ VAS) can discriminate between the HRQL of different groups of individuals...

..To assess concordance of the management of chronic gout in UK primary care with the European League Against Rheumatism (EULAR) gout recommendations...

....

..CONCLUSION: This discordance in symmetry suggests that the relative importance of biomechanical factors in the pathogenesis of OA is site-specific and may be discordant for cartilage and bone...

..The purpose of this study was to develop a new method of determining SOR, incorporating both research evidence and expert opinion...

..1) To develop risk prediction models for knee osteoarthritis (OA) and (2) to estimate the risk reduction that results from modification of potential risk factors...

..To determine the population prevalence and examine factors associated with hallux valgus in a primary care population...

..To determine whether joints affected by gout are also affected by osteoarthritis (OA)...

..This increase, however, did not result in improvements in proprioception or static postural stability, suggesting that other mechanisms play a part in these functions, at least in this acute model...

..To determine whether mild variation in acetabular depth (AD) and shape is a risk factor for osteoarthritis (OA) of the hip...

..However, detection of SF monosodium urate and calcium pyrophosphate dihydrate crystals, even from un-inflamed joints during intercritical periods, allow a precise diagnosis of gout and of calcium pyrophosphate crystal-related arthritis...

..The heritability estimate for knee OA was 0.62. CONCLUSIONS: Siblings are at increased risk of knee OA in comparison with the general population. This is likely to be due to genetic factors...

..The effectiveness and cost effectiveness of these recommendations were evaluated and the strength of recommendation was scored...

..Cartilage factors predisposing to CPPD and CPP-crystal-induced inflammation and current treatment options for the management of CPPD are also described...

..To determine whether dietary intervention or knee strengthening exercise, or both, can reduce knee pain and improve knee function in overweight and obese adults in the community...

..To compare the efficacy of aerobic walking and home based quadriceps strengthening exercises in patients with knee osteoarthritis...

..To assess the cost effectiveness of a 2-year home exercise program for the treatment of knee pain...

....

..Estimating the HRQL effects of obesity on a (common) utility scale enables the relative cost-effectiveness of interventions designed to alleviate obesity to be estimated...

..To develop evidence based recommendations for the management of gout...

..To develop evidence based recommendations for the diagnosis of gout...

..To develop evidence-based recommendations for the diagnosis of hand osteoarthritis (OA)...

..To develop evidence based recommendations for the management of hand osteoarthritis (OA)...

..To determine the relationship between the index to ring finger (2D:4D) length ratio and the risk of knee and hip osteoarthritis (OA)...

..To compare quality of life (QOL) between gout cases and controls in a primary care population and to investigate whether impaired QOL in gout is secondary to co-morbid factors or to intrinsic factors related to gout itself...

..Many unanswered questions remain, however, concerning the practical delivery of exercise therapy. We have produced evidence-based recommendations to guide health-care practitioners...

..CONCLUSIONS: In subjects with knee OA application of an elastic bandage around the knee can reduce knee pain and improve static postural sway. This outcome depends on the size of applied bandage...

..The restricted generalizability of the research data could be improved by improvements in study design and methods of reporting. Current published guidelines on management of OA are critically reviewed and compared...

..To develop evidence-based recommendations for management of calcium pyrophosphate deposition (CPPD)...

..To agree terminology and to develop recommendations for the diagnosis of calcium pyrophosphate deposition (CPPD)...

..To investigate the relative impact of radiographic osteoarthritis (ROA) and current knee pain on lower limb physical function, quadriceps strength, knee joint proprioception, and postural sway...

..To investigate whether ibuprofen was as well-regarded by patients as other non-steroidal anti-inflammatory drugs (NSAIDs)...

..To determine whether the magnitude of the genetic influence on the development of hip osteoarthritis (OA) varies according to the radiographic phenotype within families...

..To develop evidence-based recommendations for the diagnosis of knee osteoarthritis (OA)...

..To assess the best available evidence for efficacy of paracetamol (acetaminophen) in the treatment of osteoarthritis (OA)...

..To update evidence for available therapies in the treatment of hip and knee osteoarthritis (OA) and to examine whether research evidence has changed from 31 January 2006 to 31 January 2009...

..To examine whether beta2-adrenergic agonist-induced hypertrophy of the quadriceps skeletal muscle can modulate the severity of osteoarthritis (OA) in the rodent meniscectomy (MNX) model...

..To investigate the pharmacoepidemiology of NSAID usage in Nottingham general practices...

..To examine the genetic contribution to common, apparently sporadic, radiographic knee chondrocalcinosis (CC) and pyrophosphate arthropathy (PA)...

..Our discussion focuses predominantly on knee OA, to which most of the evidence relates but refers to other sites where appropriate...

..To summarize the overall relative risk of knee osteoarthritis (OA) associated with body mass index, and to estimate the potential risk reduction due to the control of this risk factor...

..001), whereas less healthy individuals had higher mean scores on the SF-6D (individuals with knee pain, osteoarthritis, back pain, rheumatoid arthritis, and hip pain had significantly lower mean scores on the EQ-5D, p<0.001)...

..After two weeks there was no evidence of efficacy superior to placebo. No trial data support the long term use of topical NSAIDs in osteoarthritis...

..Pain and muscle strength may particularly influence postural sway. The interaction between physiological, structural, and functional abnormalities in knee OA deserves further study...

..The lack of improvement in patients who received only telephone contact suggests that improvements are not just due to psychosocial effects because of contact with the therapist...

..CONCLUSIONS: Nurse-based intervention can reduce chronic NSAID usage and costs in primary care and would be cost-effective if maintained in the long term. This intervention package would be readily applicable in primary care...

..To explore patient and provider illness perceptions and barriers to effective management of gout in general practice...

..To replicate, in a Northern Irish population, the previously reported association between a locus on chromosome 6 and hip osteoarthritis (OA)...

..The study objectives were to develop and validate two novel instruments for self-reported knee malalignment and foot rotation suitable for use in questionnaire studies of knee pain and osteoarthritis...

..To determine whether smoking is protective against the development of osteoarthritis (OA)...

..The aim of this study was to determine whether changes in joint space width occur with age, and whether there are sex differences, in asymptomatic subjects without hip OA...

..The justification for these indications, the success rate and the technical aspects related to this procedure are presented in this article...

..47) than JSN (OR = 1.62, 95% CI 1.37 to 1.91). CONCLUSION: There is a positive relationship between HN/BN and underlying radiographic changes of OA, especially OST. Nodes do appear to link pathologically to OA in interphalangeal joints...

..Following the dissemination of guidelines for the management of OA, emphasis should now be placed on discussion and implementation of the recommendations and subsequent revision of guidelines as new evidence comes to light...

..The use of other intra-articular injections including osmic acid, radioisotopes and hyaluronic acid, which are less universally utilised than intra-articular corticosteroid, will also be addressed...

..To (a) develop further logically derived line drawing atlases (LDAs) for grading radiographic knee osteoarthritis (OA); and (b) determine which is superior using metrological criteria...

....

..Although there are problems in assessing severity of a predominantly subjective condition, this essentially negative finding is of interest in respect to the pathogenesis of PFS...

..If radiographs are used for this purpose, we recommend the metacarpal ratio with measurement of a single index hand or an average of both as it is least affected by bias from malpositioning, trauma or common joint disease...

..To validate an instrument for self-reported hallux valgus (HV)...

..We aimed to answer whether carrying several genetic variants associated with knee OA could result in a greater risk of OA...

..Very few studies have evaluated the association of articular hypermobility and radiographic osteoarthritis (OA) in humans. We assessed hypermobility and its relationship to radiographic hand OA in a family-based study...

..Although there is biomechanical evidence that such angulation alters load transmission through the joints of the lower limb, it is not clear whether it can eventually lead to osteoarthritis...

....

....

..Because most of our knowledge surrounds management of knee osteoarthritis, this is the focus of our discussion, with reference being made to other sites as appropriate...

..Although a large number of treatment options for knee OA exist, the evidence based format of the EULAR Recommendations continues to identify key clinical questions that currently are unanswered...

....

..Here we describe the study design and phenotype of the 2728 participants from the 1145 families recruited for this study...

..To reach consensus with recommendations made by an OMERACT Special Interest Group (SIG)...

..The presence of the A(136)H(154)Q(171) allele in the flocks examined resulted in a decreased risk of developing scrapie compared to the presence of the A(136)R(154)Q(171)...

....

..To examine whether time of day significantly affects salivary cortisol and IgA levels before and after submaximal swimming...

..Our results show that SHIP2 is a potent negative regulator of insulin signalling and insulin sensitivity in vivo...

..Chondrocalcinosis is associated with osteophytosis throughout the joint. These data suggest that both local biomechanical and constitutional factors influence the size and direction of osteophyte formation in knee OA...

....

..To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA)...

..Further research is required to identify the specific mechanisms underpinning the observations reported in the present study relating to the interaction between crank rate, workload, and exercise efficiency during arm crank ergometry...

..96 - 0.99. It is concluded that in moderately trained subjects, the 3-min combination test provides reliable data and could therefore be used for short-term, high-intensity cycling intervention studies...

..0000008). These results may help to explain the genome-wide scan linkage data and functional observations concerning association between IL-1 and OA...

..Furthermore, the final document of the Italian Consensus clearly indicated the need that the specialists involved in the management of hip OA strongly encourage the dissemination of the EULAR 2005 recommendations also in Italy...

..In conclusion, measures of performance (maximal speed and average force) can provide reliable results in a repeated sprint protocol but the reliability of fatigue measures appears to be low...