A J Doherty

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Structural and mechanistic conservation in DNA ligases
    A J Doherty
    Structural Medicine Unit, Department of Haematology, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Nucleic Acids Res 28:4051-8. 2000
  2. ncbi request reprint DNA repair: how Ku makes ends meet
    A J Doherty
    Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Curr Biol 11:R920-4. 2001
  3. ncbi request reprint Nick recognition by DNA ligases
    A J Doherty
    Structural Medicine Unit Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease Cambridge Institute for Medical Research, and Department of Haematology, University of Cambridge, Hills Rd, Cambridge, CB2 2XY, UK
    J Mol Biol 296:43-56. 2000
  4. pmc Conversion of a DNA ligase into an RNA capping enzyme
    A J Doherty
    Structural Medicine Unit, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Nucleic Acids Res 27:3253-8. 1999

Collaborators

Detail Information

Publications4

  1. pmc Structural and mechanistic conservation in DNA ligases
    A J Doherty
    Structural Medicine Unit, Department of Haematology, Wellcome Trust Centre for Molecular Mechanisms in Disease, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Nucleic Acids Res 28:4051-8. 2000
    ..Recently, the crystal structures of a number of DNA ligases have been reported. It is the purpose of this review to summarise the current knowledge of the structure and catalytic mechanism of DNA ligases...
  2. ncbi request reprint DNA repair: how Ku makes ends meet
    A J Doherty
    Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Curr Biol 11:R920-4. 2001
    ..The recently determined crystal structure of the Ku heterodimer, in both DNA-bound and unbound forms, has shed new light on the mechanism by which this protein fulfills its key role in the repair of DNA double-strand breaks...
  3. ncbi request reprint Nick recognition by DNA ligases
    A J Doherty
    Structural Medicine Unit Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease Cambridge Institute for Medical Research, and Department of Haematology, University of Cambridge, Hills Rd, Cambridge, CB2 2XY, UK
    J Mol Biol 296:43-56. 2000
    ..The implications of these results on the ligation mechanism are discussed...
  4. pmc Conversion of a DNA ligase into an RNA capping enzyme
    A J Doherty
    Structural Medicine Unit, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, and Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2XY, UK
    Nucleic Acids Res 27:3253-8. 1999
    ..This is the first observation of ATP-dependent RNA capping. These results suggest that nucleotidyltransferases may have evolved from a common ancestral gene...