Research Topics
| D H DockrellSummaryAffiliation: University of Sheffield Country: UK Publications
| Collaborators
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Detail Information
Publications
Virulence factors in pneumococcal respiratory pathogenesisJulie A Preston
Section of Infection, Inflammation and Immunity, L Floor, University of Sheffield School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
Future Microbiol 3:205-21. 2008..Further appreciation of the molecular basis of pneumococcal pathogenesis will lead to more effective strategies for the prevention and management of pneumococcal disease...
Interleukin-1β regulates CXCL8 release and influences disease outcome in response to Streptococcus pneumoniae, defining intercellular cooperation between pulmonary epithelial cells and macrophagesHelen M Marriott
Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom
Infect Immun 80:1140-9. 2012..They also highlight a potential clinical role for anti-IL-1 treatment to limit excessive neutrophilic inflammation in the lung...- Evolving controversies and challenges in the management of opportunistic infections in HIV-seropositive individualsDavid H Dockrell
Department of Infection and Immunity, The University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK Sheffield Teaching Hospitals, UK
J Infect 63:177-86. 2011..Key areas of when to safely stop prophylaxis against opportunistic infection and when to start antiretroviral therapy after treatment of an opportunistic infection are discussed... 
Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infectionDavid H Dockrell
Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
J Immunol 171:5380-8. 2003..These results suggest that AM play a key role in clearance of bacteria from the lung during subclinical infection and that induction of AM apoptosis contributes to the microbiologic host defense against pneumococci...- Salvage therapy for invasive aspergillosisD H Dockrell
Section of Infection, Inflammation and Immunity, University of Sheffield School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Antimicrob Chemother 61:i41-4. 2008..Further studies are required, ideally comparing newer agents and treatment strategies in randomized clinical trials, to clarify the optimal approach to salvage treatment of IA in this challenging group of patients... - Alopecia in association with severe seborrhoeic dermatitis following combination antiretroviral therapy for acute retroviral syndromeN J Hardcastle
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK
J Eur Acad Dermatol Venereol 19:631-3. 2005..We postulate that the eruption could represent a novel manifestation in association with immunological response to antiretroviral therapy... - Identifying and hurdling obstacles to translational researchIan Sabroe
Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
Nat Rev Immunol 7:77-82. 2007..The purpose of this Opinion article is to examine the nature of these hurdles and to provide food for thought on the main obstacles that impede this process... - Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and miceSarah R Walmsley
Academic Unit of Respiratory Medicine, The Medical School, University of Sheffield, Sheffield, United Kingdom
J Clin Invest 121:1053-63. 2011..These data support what we believe to be a novel function for PHD3 in regulating neutrophil survival in hypoxia and may enable the development of new therapeutics for inflammatory disease... - Targeting the networks that underpin contiguous immunity in asthma and chronic obstructive pulmonary diseaseIan Sabroe
Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, L Floor, Royal Hallamshire Hospital, Sheffield, UK
Am J Respir Crit Care Med 175:306-11. 2007.... - Toll-like receptors in health and disease: complex questions remainIan Sabroe
Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
J Immunol 171:1630-5. 2003 - Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunityP Collini
Department of Infection and Immunity, University of Sheffield, Sheffield, UK
Curr Mol Med 10:727-40. 2010..Future research should focus on refining experimental models and on elucidating the physiological mechanisms of monocyte/ Mϕ dysfunction during HIV 1 infection... - Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosisD H Dockrell
Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom
J Infect Dis 184:713-22. 2001..This response in vivo may regulate the inflammatory response to infection during a successful host response against S. pneumoniae... - Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumoniaHelen M Marriott
Section of Infection and Inflammation, School of Medicine and Biomedical Sciences, University of Sheffield, LU107, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
Am J Respir Crit Care Med 177:887-95. 2008..The relative importance of each role remains poorly defined in community-acquired pneumonia... - Streptococcus pneumoniae-associated human macrophage apoptosis after bacterial internalization via complement and Fcgamma receptors correlates with intracellular bacterial loadFarzana Ali
Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, United Kingdom
J Infect Dis 188:1119-31. 2003..A dynamic interaction between live intracellular bacteria and the host cell is necessary for induction of apoptosis in MDMs, and induction of apoptosis contributes to the host defense against S. pneumoniae... - Regulation of phagocyte lifespan in the lung during bacterial infectionDavid H Dockrell
Academics Units of Respiratory Medicine and Infectious Diseases, University of Sheffield, Sheffield, UK
J Leukoc Biol 79:904-8. 2006..Apoptosis clearly plays a critical role in reconciling these physiological requirements... - Dynamic changes in Mcl-1 expression regulate macrophage viability or commitment to apoptosis during bacterial clearanceHelen M Marriott
Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
J Clin Invest 115:359-68. 2005..Mcl-1 transgenic mice clear pneumococci from the lung less efficiently than nontransgenic mice. Dynamic changes in Mcl-1 expression determine macrophage viability as well as antibacterial host defense... - The burden of invasive pneumococcal disease and the potential for reduction by immunisationHelena K Parsons
Division of Genomic Medicine, University of Sheffield Medical School, Beech Hill Road, S10 2RX, Sheffield, UK
Int J Antimicrob Agents 19:85-93. 2002..This review discusses the burden of invasive pneumococcal disease, identifies high-risk patients and analyses evidence for vaccine efficacy and cost-effectiveness... - Nitric oxide levels regulate macrophage commitment to apoptosis or necrosis during pneumococcal infectionHelen M Marriott
Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, UK
FASEB J 18:1126-8. 2004..These results illustrate important roles for NO in the integration of host defense and regulation of inflammation in human macrophages... - The role of the macrophage in lung disease mediated by bacteriaHelen M Marriott
Section of Infection, Inflammation and Immunity, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, UK
Exp Lung Res 33:493-505. 2007.... - Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosaStephen M Bianchi
Academic Unit of Respiratory Medicine, School of Medicine and Biomedical Sciences, University of Sheffield, Sheffield S10 2JF, UK
Am J Respir Crit Care Med 177:35-43. 2008..Whether these metabolites, particularly pyocyanin, can also modulate apoptotic cell engulfment is unknown... - Improved outcomes associated with advances in therapy for invasive fungal infections in immunocompromised hostsS C Metcalf
Communicable Diseases Directorate, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Infect 55:287-99. 2007..Nevertheless, many therapeutic areas of uncertainty remain, including the role of combination therapy, and will provide the focus for future studies... - Apoptosis in HIV-1 infectionD J Bell
Communicable Diseases Directorate, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
J Eur Acad Dermatol Venereol 17:178-83. 2003..Apoptosis induction is related to death receptor and mitochondrial-induced pathways in specific circumstances. These events have been linked to individual HIV proteins and have been demonstrated to be altered by antiretroviral therapy... - Apoptotic cell death in the pathogenesis of infectious diseasesD H Dockrell
Division of Genomic Medicine, University of Sheffield Medical School, Department of Infectious Diseases, Royal Hallamshire Hospital, Sheffield, UK
J Infect 42:227-34. 2001.... - Group G streptococcal bacteraemia: an opportunistic infection associated with immune senescencePenny Lewthwaite
Department of Infectious Diseases, Royal Hallamshire Hospital, Sheffield, UK
Scand J Infect Dis 34:83-7. 2002.... - Pneumolysin: a double-edged sword during the host-pathogen interactionHelen M Marriott
Section of Infection, Inflammation and Immunity, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, UK
Curr Mol Med 8:497-509. 2008.... - Acceleration of human neutrophil apoptosis by TRAILStephen A Renshaw
Respiratory Medicine Unit, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, United Kingdom
J Immunol 170:1027-33. 2003..The susceptibility of neutrophils to TRAIL-mediated apoptosis suggests a role for TRAIL in the regulation of inflammation and may provide a mechanism for clearance of neutrophils from sites of inflammation... - Pyocyanin production by Pseudomonas aeruginosa induces neutrophil apoptosis and impairs neutrophil-mediated host defenses in vivoLucy Allen
Division of Clinical Sciences (North, University of Sheffield, Sheffield, United Kingdom
J Immunol 174:3643-9. 2005..aeruginosa suppresses the acute inflammatory response by pathogen-driven acceleration of neutrophil apoptosis and by reducing local inflammation, and that this is advantageous for bacterial survival... - Streptococcus pneumoniae: the role of apoptosis in host defense and pathogenesisHelen M Marriott
Division of Genomic Medicine, F-Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
Int J Biochem Cell Biol 38:1848-54. 2006..Apoptosis induction may be harmful or potentially beneficial during pneumococcal infection and understanding its function in each setting is essential to allow specific therapeutic intervention... - Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumoniaHelen M Marriott
School of Medicine and Biomedical Sciences, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, United Kingdom
J Immunol 177:6480-8. 2006.... - Contrasting roles for reactive oxygen species and nitric oxide in the innate response to pulmonary infection with Streptococcus pneumoniaeHelen M Marriott
School of Medicine and Biomedical Sciences, L Floor, University of Sheffield, Beech Hill Road, Sheffield S10 2RX, UK
Vaccine 25:2485-90. 2007..iNOS(-/-) mice recruit neutrophils and generate TNF-alpha to compensate for impaired AM competence but ROS deficiency has no apparent effect on AM function in this model...