D H Dockrell
Affiliation: University of Sheffield
- The multiple roles of Fas ligand in the pathogenesis of infectious diseasesD H Dockrell
Division of Genomic Medicine, University of Sheffield, School of Medicine and Biomedical Sciences, Sheffield, UK
Clin Microbiol Infect 9:766-79. 2003..FasL also contributes to the generation and regulation of the inflammatory response in infection. The multiple roles of FasL in infectious disease pathogenesis are discussed in the context of viral, bacterial and parasitic infections...
- Immune-mediated phagocytosis and killing of Streptococcus pneumoniae are associated with direct and bystander macrophage apoptosisD H Dockrell
Division of Genomic Medicine, University of Sheffield Medical School, Sheffield S10 2RX, United Kingdom
J Infect Dis 184:713-22. 2001..This response in vivo may regulate the inflammatory response to infection during a successful host response against S. pneumoniae...
- Apoptotic cell death in the pathogenesis of infectious diseasesD H Dockrell
Division of Genomic Medicine, University of Sheffield Medical School, Department of Infectious Diseases, Royal Hallamshire Hospital, Sheffield, UK
J Infect 42:227-34. 2001....
- Imiquimod and resiquimod as novel immunomodulatorsD H Dockrell
Department of Infectious Diseases, Royal Hallamshire Hospital, Sheffield S10 2RX, UK
J Antimicrob Chemother 48:751-5. 2001..In addition, the imidazoquinolinamines may find roles in the therapy of cancers and as vaccine adjuvants...
- Human herpesvirus 6: molecular biology and clinical featuresD H Dockrell
Division of Genomic Medicine, University of Sheffield School of Medicine and Biomedical Sciences, Beech Hill Road, Sheffield S10 2RX, UK
J Med Microbiol 52:5-18. 2003..Recent advances in quantitative PCR are providing additional insights into the natural history of infection in paediatric populations and immunocompromised hosts...
- Alveolar macrophages in pulmonary host defence the unrecognized role of apoptosis as a mechanism of intracellular bacterial killingJ D Aberdein
Department of Infection and Immunity, University of Sheffield Medical School and Sheffield Teaching Hospitals, Sheffield, UK
Clin Exp Immunol 174:193-202. 2013..Therefore, alveolar macrophages complement canonical microbicidal strategies with an additional level of apoptosis-associated killing to help kill ingested bacteria. ..
- Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunityP Collini
Department of Infection and Immunity, University of Sheffield, Sheffield, UK
Curr Mol Med 10:727-40. 2010..Future research should focus on refining experimental models and on elucidating the physiological mechanisms of monocyte/ Mϕ dysfunction during HIV 1 infection...
- Apoptosis in HIV-1 infectionD J Bell
Communicable Diseases Directorate, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
J Eur Acad Dermatol Venereol 17:178-83. 2003..Apoptosis induction is related to death receptor and mitochondrial-induced pathways in specific circumstances. These events have been linked to individual HIV proteins and have been demonstrated to be altered by antiretroviral therapy...
- Invasive pneumococcal disease and the potential for prevention by vaccination in the United KingdomH K Parsons
Department of Microbiology, Sheffield Teaching Hospitals Trust, Sheffield S10 2RX, UK
J Infect 54:435-8. 2007..The extent of previous exposure to pneumococcal capsular polysaccharide vaccination prior to an episode of IPD in hospitalised adults in the United Kingdom is unclear...
- Improved outcomes associated with advances in therapy for invasive fungal infections in immunocompromised hostsS C Metcalf
Communicable Diseases Directorate, E Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Infect 55:287-99. 2007..Nevertheless, many therapeutic areas of uncertainty remain, including the role of combination therapy, and will provide the focus for future studies...
- Human herpesvirus-6 and -7 in transplantationD H Dockrell
Division of Molecular and Genetic Medicine, University of Sheffield Medical School, F-floor Medical Microbiology, Beechill Road, Sheffield S10 2RX, UK
Rev Med Virol 11:23-36. 2001..For this, sensitive and specific molecular diagnostic techniques allowing for the rapid detection and quantitation of virus and for the analysis of susceptibility to current antiviral agents are required...
- Alopecia in association with severe seborrhoeic dermatitis following combination antiretroviral therapy for acute retroviral syndromeN J Hardcastle
Department of Dermatology, Royal Hallamshire Hospital, Sheffield, UK
J Eur Acad Dermatol Venereol 19:631-3. 2005..We postulate that the eruption could represent a novel manifestation in association with immunological response to antiretroviral therapy...
- Salvage therapy for invasive aspergillosisD H Dockrell
Section of Infection, Inflammation and Immunity, University of Sheffield School of Medicine and Biomedical Sciences, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, UK
J Antimicrob Chemother 61:i41-4. 2008..Further studies are required, ideally comparing newer agents and treatment strategies in randomized clinical trials, to clarify the optimal approach to salvage treatment of IA in this challenging group of patients...
- Human beta-herpesvirus interactions in solid organ transplant recipientsJ C Mendez
Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA
J Infect Dis 183:179-184. 2001..These results suggest that CMV disease in transplant recipients is related to the unique interaction of the 3 beta-herpesviruses and is ultimately reduced after intravenous Gcv treatment...