Paul D Dobson

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Integration of metabolic databases for the reconstruction of genome-scale metabolic networks
    Karin Radrich
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    BMC Syst Biol 4:114. 2010
  2. doi request reprint 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries
    Paul D Dobson
    School of Chemistry and The Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK
    Drug Discov Today 14:31-40. 2009
  3. ncbi request reprint Implications of the dominant role of transporters in drug uptake by cells
    Paul D Dobson
    School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester M17DN, UK
    Curr Top Med Chem 9:163-81. 2009
  4. doi request reprint Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
    Douglas B Kell
    School of Chemistry, The University of Manchester, 131 Princess St, Manchester, M1 7DN, UK
    Drug Discov Today 16:704-14. 2011
  5. doi request reprint The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
    Douglas B Kell
    School of Chemistry, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK
    Drug Discov Today 18:218-39. 2013
  6. doi request reprint Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
    Paul D Dobson
    School of Chemistry and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    Nat Rev Drug Discov 7:205-20. 2008
  7. pmc Further developments towards a genome-scale metabolic model of yeast
    Paul D Dobson
    School of Chemistry, The University of Manchester, Manchester M13 9PL, UK
    BMC Syst Biol 4:145. 2010
  8. ncbi request reprint A simple approach to normalization for spectroscopic data mining
    Paul D Dobson
    Faculty of Life Sciences, The University of Manchester, Sackville Street, P O Box 88, Manchester M60 1QD, UK
    Appl Spectrosc 59:542-4. 2005

Collaborators

Detail Information

Publications8

  1. pmc Integration of metabolic databases for the reconstruction of genome-scale metabolic networks
    Karin Radrich
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
    BMC Syst Biol 4:114. 2010
    ..This process is further complicated by occurrences of missing or conflicting information and the absence of common annotation standards between different data sources...
  2. doi request reprint 'Metabolite-likeness' as a criterion in the design and selection of pharmaceutical drug libraries
    Paul D Dobson
    School of Chemistry and The Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK
    Drug Discov Today 14:31-40. 2009
    ....
  3. ncbi request reprint Implications of the dominant role of transporters in drug uptake by cells
    Paul D Dobson
    School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester M17DN, UK
    Curr Top Med Chem 9:163-81. 2009
    ..Finally, the central importance of computational modelling of transporter substrate preferences by structure-activity relationships is discussed...
  4. doi request reprint Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only
    Douglas B Kell
    School of Chemistry, The University of Manchester, 131 Princess St, Manchester, M1 7DN, UK
    Drug Discov Today 16:704-14. 2011
    ..The recognition that drugs necessarily require carriers for uptake into cells provides many opportunities for improving the effectiveness of the drug discovery process...
  5. doi request reprint The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so
    Douglas B Kell
    School of Chemistry, The University of Manchester, 131 Princess St, Manchester M1 7DN, UK
    Drug Discov Today 18:218-39. 2013
    ..This needs to be acquired in cells that contain the relevant proteins, and we highlight an experimental system for simultaneous genome-wide assessment of carrier-mediated uptake in a eukaryotic cell (yeast)...
  6. doi request reprint Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
    Paul D Dobson
    School of Chemistry and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK
    Nat Rev Drug Discov 7:205-20. 2008
    ....
  7. pmc Further developments towards a genome-scale metabolic model of yeast
    Paul D Dobson
    School of Chemistry, The University of Manchester, Manchester M13 9PL, UK
    BMC Syst Biol 4:145. 2010
    ....
  8. ncbi request reprint A simple approach to normalization for spectroscopic data mining
    Paul D Dobson
    Faculty of Life Sciences, The University of Manchester, Sackville Street, P O Box 88, Manchester M60 1QD, UK
    Appl Spectrosc 59:542-4. 2005