Ratko Djukanovic

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Persistence of oxidant and protease burden in the airways after smoking cessation
    Noora Louhelainen
    Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, Finland
    BMC Pulm Med 9:25. 2009
  2. pmc Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study
    Noora Louhelainen
    Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, Helsinki, Finland
    BMC Pulm Med 10:13. 2010
  3. doi request reprint Montelukast added to fluticasone propionate does not alter inflammation or outcomes
    Ratko Djukanovic
    University of Southampton, Southampton, UK
    Respir Med 104:1425-35. 2010
  4. ncbi request reprint Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
    Ratko Djukanovic
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
    Am J Respir Crit Care Med 170:583-93. 2004
  5. doi request reprint Prosurvival activity for airway neutrophils in severe asthma
    Mohib Uddin
    Southampton NIHR Respiratory Biomedical Research Unit, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK
    Thorax 65:684-9. 2010
  6. pmc Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease
    Benjamin L Nicholas
    Inflammatory Cell Biology Group, Division of Infection, Inflammation, and Immunity, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK
    Am J Respir Crit Care Med 181:1049-60. 2010
  7. ncbi request reprint Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease
    Pandurangan Vijayanand
    Division of Infection, Inflammation, and Repair, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    N Engl J Med 356:1410-22. 2007
  8. doi request reprint Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients
    Pandurangan Vijayanand
    Division of Infection, Southampton National Institute of Health Research Respiratory Biomedical Research Unit, University of Southampton School of Medicine, Southampton, United Kingdom
    J Immunol 184:4568-74. 2010
  9. ncbi request reprint From proteomics to prescription-the search for COPD biomarkers
    Benjamin L Nicholas
    Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    COPD 6:298-303. 2009
  10. ncbi request reprint Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease
    Takahiro Yoshikawa
    Allergy and Inflammation Research, Division of Infection, Inflammation, and Repair, Mailpoint 810, Level F, South Block, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Respir Crit Care Med 175:473-9. 2007

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc Persistence of oxidant and protease burden in the airways after smoking cessation
    Noora Louhelainen
    Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, Finland
    BMC Pulm Med 9:25. 2009
    ..Oxidative stress is associated with the pathogenesis of cigarette smoke related lung diseases, but longitudinal effects of smoking cessation on oxidant markers in the airways are unknown...
  2. pmc Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study
    Noora Louhelainen
    Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, Helsinki, Finland
    BMC Pulm Med 10:13. 2010
    ..This prospective study evaluated the effects of smoking cessation on induced sputum (IS) neutrophils, matrix metalloproteinases (MMP-7, -8, -9) and tissue inhibitor of metalloproteinase-1 (TIMP-1)...
  3. doi request reprint Montelukast added to fluticasone propionate does not alter inflammation or outcomes
    Ratko Djukanovic
    University of Southampton, Southampton, UK
    Respir Med 104:1425-35. 2010
    ..Airway inflammation is a key pathological feature of asthma which underlies its clinical presentation...
  4. ncbi request reprint Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma
    Ratko Djukanovic
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK
    Am J Respir Crit Care Med 170:583-93. 2004
    ..The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to methacholine in mild to moderate asthma...
  5. doi request reprint Prosurvival activity for airway neutrophils in severe asthma
    Mohib Uddin
    Southampton NIHR Respiratory Biomedical Research Unit, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK
    Thorax 65:684-9. 2010
    ..Evidence for factors present in airway secretions that prolong neutrophil survival has been sought and it has been hypothesised that these might be augmented in neutrophilic asthma...
  6. pmc Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease
    Benjamin L Nicholas
    Inflammatory Cell Biology Group, Division of Infection, Inflammation, and Immunity, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK
    Am J Respir Crit Care Med 181:1049-60. 2010
    ..Much effort is being made to discover noninvasive biomarkers of chronic airway disease that might enable better management, predict prognosis, and provide new therapeutic targets...
  7. ncbi request reprint Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease
    Pandurangan Vijayanand
    Division of Infection, Inflammation, and Repair, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    N Engl J Med 356:1410-22. 2007
    ..We also studied whether an increased number of these cells is a feature of chronic obstructive pulmonary disease (COPD)...
  8. doi request reprint Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients
    Pandurangan Vijayanand
    Division of Infection, Southampton National Institute of Health Research Respiratory Biomedical Research Unit, University of Southampton School of Medicine, Southampton, United Kingdom
    J Immunol 184:4568-74. 2010
    ..This study also provides wider proof of concept for using tissue explants to study immunomodulatory drugs for asthma...
  9. ncbi request reprint From proteomics to prescription-the search for COPD biomarkers
    Benjamin L Nicholas
    Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    COPD 6:298-303. 2009
    ..Cutting edge technology used for biomarker discovery, quantitation in biofluids and imaging biomarkers in whole body systems is reviewed...
  10. ncbi request reprint Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease
    Takahiro Yoshikawa
    Allergy and Inflammation Research, Division of Infection, Inflammation, and Repair, Mailpoint 810, Level F, South Block, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Respir Crit Care Med 175:473-9. 2007
    ..The mechanisms responsible for neutrophil accumulation are poorly understood, but they could involve increased influx and/or survival of these cells...
  11. ncbi request reprint Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke
    Audrey Richter
    Respiratory Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, United Kingdom
    Am J Respir Cell Mol Biol 27:85-90. 2002
    ..Our data indicate that secretion of IL-8 in response to CSE is dependent on EGFR activation and that autocrine production of TGF-alpha makes a substantial contribution to this response...
  12. ncbi request reprint Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum
    Gordon Dent
    Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton, United Kingdom
    Am J Respir Crit Care Med 169:1110-7. 2004
    ..This activity is inhibited significantly by CAT-213...
  13. ncbi request reprint Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    Fabio Bucchieri
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 27:179-85. 2002
    ..This susceptibility may contribute to the rising trends in asthma associated with air pollution and diets low in antioxidants...
  14. doi request reprint Induced sputum: a window to lung pathology
    Ben Nicholas
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton SO16 6YD, UK
    Biochem Soc Trans 37:868-72. 2009
    ..This paper describes the basic constituents of induced sputum and how these influence the quantification and identification of novel biomarkers of chronic lung diseases using techniques such as proteomics...
  15. ncbi request reprint Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium
    Sarah M Puddicombe
    The Brooke Laboratory, Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 28:61-8. 2003
    ..We conclude that p21(waf) overexpression in asthma influences cell proliferation and survival. This may cause abnormal repair responses that contribute to airway inflammation and remodeling...
  16. ncbi request reprint Shotgun proteomic analysis of human-induced sputum
    Ben Nicholas
    Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK
    Proteomics 6:4390-401. 2006
    ..Taken together, these data represent the first extensive survey of the proteome of induced sputum and provide a platform for future identification of biomarkers of lung disease...

Research Grants4

  1. A proteomics approach in the study of novel COPD markers
    Ratko Djukanovic; Fiscal Year: 2005
    ..Finally, applying the antibodies to archival lung tissue samples we will be able to localize the COPD-selective proteins to the airway and alveoli, adding valuable knowledge to our understanding of COPD mechanisms. ..