L Djouhri

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Indications for coupling between feline spinocervical tract neurones and midlumbar interneurones
    L Djouhri
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, UK
    Exp Brain Res 119:39-46. 1998
  2. ncbi request reprint Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
  3. ncbi request reprint Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Brain Res Brain Res Rev 46:131-45. 2004
  4. ncbi request reprint Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 TD, United Kingdom
    J Neurosci 21:8722-33. 2001
  5. ncbi request reprint Increased conduction velocity of nociceptive primary afferent neurons during unilateral hindlimb inflammation in the anaesthetised guinea-pig
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, BS8 1TD, Bristol, UK
    Neuroscience 102:669-79. 2001
  6. pmc Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo
    X Fang
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 1TD, UK
    J Physiol 565:927-43. 2005
  7. ncbi request reprint Differences in the size of the somatic action potential overshoot between nociceptive and non-nociceptive dorsal root ganglion neurones in the guinea-pig
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, BS8 TD, Bristol, UK
    Neuroscience 108:479-91. 2001
  8. pmc Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function
    L L Gao
    School of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 590:4691-705. 2012
  9. pmc Immunostaining for the α3 isoform of the Na+/K+-ATPase is selective for functionally identified muscle spindle afferents in vivo
    A Parekh
    Department of Physiology and Pharmacology, Medical School, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 588:4131-43. 2010
  10. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003

Detail Information

Publications14

  1. ncbi request reprint Indications for coupling between feline spinocervical tract neurones and midlumbar interneurones
    L Djouhri
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, UK
    Exp Brain Res 119:39-46. 1998
    ..Thereby these interneurones might contribute to the co-ordination of responses mediated by various populations of supraspinal neurones...
  2. ncbi request reprint Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
  3. ncbi request reprint Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Brain Res Brain Res Rev 46:131-45. 2004
    ..It is important that the existence of Abeta nociceptors is recognised, because assumptions that fast conducting, large diameter afferents are always low threshold mechanoreceptors might lead/have led to misinterpretations of data...
  4. ncbi request reprint Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 TD, United Kingdom
    J Neurosci 21:8722-33. 2001
    ....
  5. ncbi request reprint Increased conduction velocity of nociceptive primary afferent neurons during unilateral hindlimb inflammation in the anaesthetised guinea-pig
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, BS8 1TD, Bristol, UK
    Neuroscience 102:669-79. 2001
    ..These changes, together with the previously described changes in the action potential shape of nociceptive neurons during inflammation, probably reflect alterations in membrane function that contribute to inflammatory hyperalgesia...
  6. pmc Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo
    X Fang
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 1TD, UK
    J Physiol 565:927-43. 2005
    ..These findings indicate both the usefulness and limitations of using electrophysiological criteria for identifying neurones acutely in vitro as nociceptive...
  7. ncbi request reprint Differences in the size of the somatic action potential overshoot between nociceptive and non-nociceptive dorsal root ganglion neurones in the guinea-pig
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, BS8 TD, Bristol, UK
    Neuroscience 108:479-91. 2001
    ..An overshooting action potential coupled with a long afterhyperpolarisation or broad action potential may help in identifying sensory neurones as nociceptive...
  8. pmc Expression and properties of hyperpolarization-activated current in rat dorsal root ganglion neurons with known sensory function
    L L Gao
    School of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 590:4691-705. 2012
    ..g. in chronic/pathological pain states) may influence both nociceptor and LTM excitability.expression and/or properties (e.g. in chronic/pathological pain states) may influence both nociceptor and LTM excitability...
  9. pmc Immunostaining for the α3 isoform of the Na+/K+-ATPase is selective for functionally identified muscle spindle afferents in vivo
    A Parekh
    Department of Physiology and Pharmacology, Medical School, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 588:4131-43. 2010
    ..The high α3 levels in MSAs may enable the greater dynamic firing range in MSAs...
  10. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003
    ..Thus high levels of Nav1.8 protein may contribute to the longer AP durations (especially in A-fibre neurons) and larger AP overshoots that are typical of nociceptors...
  11. pmc Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Physiol 546:565-76. 2003
    ..Since nociceptive units tend overall to have longer duration APs, slower CVs and smaller somata, these correlations may be related to the generally greater expression of Na(v)1.7 in nociceptive units...
  12. ncbi request reprint trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors
    Xin Fang
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:4868-78. 2005
    ..8 are related to, and perhaps limited by, expression levels of trkA. This view is supported by a positive correlation between immuno-intensities of trkA and Nav1.8 in A-fiber, but not C-fiber, nociceptors...
  13. ncbi request reprint The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons
    Xin Fang
    Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:7425-33. 2002
    ..The data provide direct evidence that Na(v)1.9 is expressed selectively in (but not in all) C- and A-fiber nociceptive-type units and suggest that Na(v)1.9 contributes to membrane properties that are typical of nociceptive neurons...
  14. ncbi request reprint Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1.9 expression
    Xin Fang
    Department of Physiology, Medical School, Bristol University, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:7281-92. 2006
    ..We conclude that strongly IB4+ DRG neurons are exclusively C-nociceptor type and that high Nav1.9 expression may contribute to their distinct membrane properties...