Albena T Dinkova-Kostova

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. doi request reprint Chemoprotection against cancer by isothiocyanates: a focus on the animal models and the protective mechanisms
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, DD1 9SY, UK
    Top Curr Chem 329:179-201. 2013
  2. doi request reprint Glucosinolates and isothiocyanates in health and disease
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Trends Mol Med 18:337-47. 2012
  3. doi request reprint Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms
    Albena T Dinkova-Kostova
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Planta Med 74:1548-59. 2008
  4. pmc Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Nutr Res 28:539-43. 2008
  5. pmc Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Photochem Photobiol Sci 9:597-600. 2010
  6. doi request reprint Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, MD, USA
    Mol Nutr Food Res 52:S128-38. 2008
  7. ncbi request reprint Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 240:243-52. 2006
  8. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
  9. pmc Electrophilic tuning of the chemoprotective natural product sulforaphane
    Young Hoon Ahn
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:9590-5. 2010
  10. doi request reprint Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy
    Sukirti Kalra
    Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, UK
    Cancer Prev Res (Phila) 5:973-81. 2012

Collaborators

Detail Information

Publications45

  1. doi request reprint Chemoprotection against cancer by isothiocyanates: a focus on the animal models and the protective mechanisms
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, DD1 9SY, UK
    Top Curr Chem 329:179-201. 2013
    ..Because the isothiocyanates affect the function of transcription factors and ultimately the expression of networks of genes, such protection is comprehensive and long-lasting...
  2. doi request reprint Glucosinolates and isothiocyanates in health and disease
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Trends Mol Med 18:337-47. 2012
    ....
  3. doi request reprint Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanisms
    Albena T Dinkova-Kostova
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Planta Med 74:1548-59. 2008
    ..Such protection is comprehensive, long-lasting, and unlikely to cause pro-oxidant effects or interfere with the synthesis of vitamin D...
  4. pmc Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
    Nutr Res 28:539-43. 2008
    ..Considering the escalating numbers of individuals worldwide who are overweight or obese, our findings provide further impetus for advocating healthier diets and maintenance of constant body weight in adults...
  5. pmc Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Photochem Photobiol Sci 9:597-600. 2010
    ....
  6. doi request reprint Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, MD, USA
    Mol Nutr Food Res 52:S128-38. 2008
    ....
  7. ncbi request reprint Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 240:243-52. 2006
    ..Thus, topical application of sulforaphane-containing broccoli sprout extracts is a promising strategy for protecting against skin tumor formation after exposure to UV radiation...
  8. pmc Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 99:11908-13. 2002
    ..These residues are located in the intervening region between BTB and Kelch repeat domains of Keap1 and probably are the direct sensors of inducers of the phase 2 system...
  9. pmc Electrophilic tuning of the chemoprotective natural product sulforaphane
    Young Hoon Ahn
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:9590-5. 2010
    ..We further show in living cells that a sulfoxythiocarbamate analog can label Keap1 on several key cysteine residues as well as other cellular proteins offering new insights into the mechanism of chemoprotection...
  10. doi request reprint Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy
    Sukirti Kalra
    Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, UK
    Cancer Prev Res (Phila) 5:973-81. 2012
    ..Moreover, their potential skin patch incorporation for transdermal delivery is an exciting possibility...
  11. pmc Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway
    Sukirti Kalra
    Biomedical Research Institute, University of Dundee, Scotland, United Kingdom
    Cancer Prev Res (Phila) 4:1665-74. 2011
    ..Our findings suggest that activation of the Keap1/Nrf2/ARE pathway could reduce the risk for skin cancer in patients receiving long-term azathioprine therapy...
  12. doi request reprint A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB Room 406, Baltimore, MD 21205, USA
    Biochem Biophys Res Commun 367:859-65. 2008
    ....
  13. ncbi request reprint Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    Theresa A Shapiro
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nutr Cancer 55:53-62. 2006
    ..No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed...
  14. pmc Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
    Nobunao Wakabayashi
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 101:2040-5. 2004
    ....
  15. ncbi request reprint Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Epidemiol Biomarkers Prev 16:847-51. 2007
    ..5- and 4.5-fold after application of 150 nmol doses, once or three times (at 24 h-intervals), respectively, thus providing direct evidence for induction of the phase 2 response in humans...
  16. pmc The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress
    Andrea L Benedict
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Carcinogenesis 33:2457-66. 2012
    ..Thus, our findings support the development of Nrf2 activators as protectors against drug-mediated photooxidative stress and encourage future clinical trials in populations at high risk for cutaneous photodamage and photocarcinogenesis...
  17. pmc Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:17500-5. 2007
    ..7% (range 8.37-78.1%; P = 0.025). This protection against a carcinogen in humans is catalytic and long lasting...
  18. doi request reprint Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway
    John D Hayes
    Biomedical Research Institute, Ninewells Hospital, University of Dundee, Scotland, United Kingdom
    Antioxid Redox Signal 13:1713-48. 2010
    ....
  19. pmc An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1
    Albena T Dinkova-Kostova
    Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 285:33747-55. 2010
    ....
  20. ncbi request reprint Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Biochemistry 44:6889-99. 2005
    ..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity...
  21. pmc Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex
    Liam Baird
    Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee DD1 9SY, United Kingdom
    Proc Natl Acad Sci U S A 110:15259-64. 2013
    ..This previously unanticipated dynamism allows rapid transcriptional responses to environmental changes and can accommodate multiple modes of regulation. ..
  22. pmc HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathway
    Ying Zhang
    Divison of Cancer Research, Medical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Chem Biol 18:1355-61. 2011
    ..This uncovered duality undoubtedly contributes to the cytoprotective effects of such molecules in models of carcinogenesis, cardiovascular disease, and neurodegeneration...
  23. ncbi request reprint Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
    Carcinogenesis 26:1247-55. 2005
    ....
  24. pmc Neuroprotective effects of sulforaphane after contusive spinal cord injury
    Andrea L Benedict
    Lewis B and Dorothy Cullman Chemoprotection Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    J Neurotrauma 29:2576-86. 2012
    ..These findings demonstrate that SF provides neuroprotective effects in the spinal cord after injury, and could be a candidate for therapy of SCI...
  25. doi request reprint Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells
    Liam Baird
    Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, UK
    Biochem Biophys Res Commun 433:58-65. 2013
    ..As inducers cause conformational changes in Keap1, we conclude that changes in conformation rather than dissociation from Cul3 inactivate the repressor function of Keap1 leading to Nrf2 stabilization...
  26. ncbi request reprint Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers
    W David Holtzclaw
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Adv Enzyme Regul 44:335-67. 2004
  27. pmc Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 102:4584-9. 2005
    ..91) over 6 orders of magnitude of concentration. Thus, in addition to blocking inflammation and promoting differentiation, these TP exhibit another very important protective property: the induction of the phase 2 response...
  28. pmc Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors
    Zachary R Healy
    Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Photodermatol Photoimmunol Photomed 25:45-50. 2009
    ..These methods have permitted evaluation of the efficacy of protectors, such as sulforaphane from crucifers, that defend cells through induction of cytoprotective (phase 2) genes...
  29. ncbi request reprint Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    Brian S Cornblatt
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 28:1485-90. 2007
    ..These findings provide a strong rationale for evaluating the protective effects of a broccoli sprout preparation in clinical trials of women at risk for breast cancer...
  30. ncbi request reprint Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans
    Lingxiang Ye
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Clin Chim Acta 316:43-53. 2002
    ....
  31. doi request reprint Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones
    Xiu Jun Wang
    Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chem Biol 17:75-85. 2010
    ..Thus, the oxidation of para- and ortho-hydroquinones to quinones represents the rate-limiting step in the activation of Nrf2...
  32. pmc NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
    Albena T Dinkova-Kostova
    Biomedical Research Institute, University of Dundee, Dundee, Scotland, UK
    Arch Biochem Biophys 501:116-23. 2010
    ....
  33. pmc Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles
    Hua Liu
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:15926-31. 2008
    ..These studies identify suppression of inflammation as a consistent property of inducers of the phase 2 response and strongly suggest that this property is a central aspect of their chemoprotective actions...
  34. doi request reprint The cytoprotective role of the Keap1-Nrf2 pathway
    Liam Baird
    Biomedical Research Institute, University of Dundee, Dundee, Scotland, UK
    Arch Toxicol 85:241-72. 2011
    ..Cross-talks with other signalling pathways broadens the role of the Keap1-Nrf2 pathway in determining the fate of the cell, impacting fundamental biological processes such as proliferation, apoptosis, angiogenesis and metastasis...
  35. pmc Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex
    Michelle L Kerns
    Department of Biological Chemistry, 725 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:14460-5. 2007
    ..Nrf2 induction is brought about by treatment with sulforaphane, a natural product. Sulforaphane thus represents an attractive option for the prevention of skin blistering associated with K14 mutations in EBS...
  36. doi request reprint Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
    Sudhir Chowdhry
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Free Radic Biol Med 48:357-71. 2010
    ..Thus, impairment of Nrf2 activity may represent a major risk factor for the evolution of NAFLD to NASH...
  37. ncbi request reprint Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1)
    Albena T Dinkova-Kostova
    Department of Pharmacology and Molecular Science, Lewis B and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 382:423-48. 2004
  38. ncbi request reprint Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Cancer Lett 245:341-9. 2007
    ..The concentration-dependent differential effects on these two pathways should be carefully considered in mechanistic explanations and strategic designs...
  39. ncbi request reprint The role of Keap1 in cellular protective responses
    Albena T Dinkova-Kostova
    The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 18:1779-91. 2005
  40. ncbi request reprint Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediates
    Paul Talalay
    Department of Pharmacology and Molecular Science, Lewis B and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Methods Enzymol 382:355-64. 2004
  41. doi request reprint Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols
    Albena T Dinkova-Kostova
    Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Chem Biol Interact 192:101-6. 2011
    ..Thus, based on theoretical and experimental evidence, the oxidation of para- and ortho-hydroquinones to their corresponding electrophilic quinones is a requisite step for the activation of the Keap1/Nrf2/ARE pathway...
  42. ncbi request reprint The "Prochaska" microtiter plate bioassay for inducers of NQO1
    Jed W Fahey
    Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 382:243-58. 2004
  43. ncbi request reprint Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis
    Paul Talalay
    Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Adv Enzyme Regul 43:121-34. 2003
  44. ncbi request reprint Chemoprotection against cancer: an idea whose time has come
    Albena T Dinkova-Kostova
    Department of Pharmacology, Johns Hopkins Medical School, USA
    Altern Ther Health Med 13:S122-7. 2007
  45. ncbi request reprint Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities
    Karen Liby
    Dartmouth Medical School, Hanover, NH 03755, USA
    Mol Cancer Ther 6:2113-9. 2007
    ..These results suggest that BA is a useful platform for drug development, and the enhanced potency and varied biological activities of CBA-Im make it a promising candidate for further chemoprevention or chemotherapeutic studies...