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Genomes and Genes | Albena T Dinkova-KostovaSummaryAffiliation: University of Dundee Country: UK Publications
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Publications
Chemoprotection against cancer by isothiocyanates: a focus on the animal models and the protective mechanismsAlbena T Dinkova-Kostova
Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, DD1 9SY, UK
Top Curr Chem 329:179-201. 2013..Because the isothiocyanates affect the function of transcription factors and ultimately the expression of networks of genes, such protection is comprehensive and long-lasting...- Glucosinolates and isothiocyanates in health and diseaseAlbena T Dinkova-Kostova
Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Trends Mol Med 18:337-47. 2012.... - Direct and indirect antioxidant properties of inducers of cytoprotective proteinsAlbena T Dinkova-Kostova
Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, MD, USA
Mol Nutr Food Res 52:S128-38. 2008.... 
Rapid body weight gain increases the risk of UV radiation-induced skin carcinogenesis in SKH-1 hairless miceAlbena T Dinkova-Kostova
Department of Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD 21205, USA
Nutr Res 28:539-43. 2008..Considering the escalating numbers of individuals worldwide who are overweight or obese, our findings provide further impetus for advocating healthier diets and maintenance of constant body weight in adults...- Phytochemicals as protectors against ultraviolet radiation: versatility of effects and mechanismsAlbena T Dinkova-Kostova
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
Planta Med 74:1548-59. 2008..Such protection is comprehensive, long-lasting, and unlikely to cause pro-oxidant effects or interfere with the synthesis of vitamin D... - Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless miceAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
Photochem Photobiol Sci 9:597-600. 2010.... 
Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extractsAlbena T Dinkova-Kostova
The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 N. Wolfe Street, Baltimore, MD 21205, USA
Cancer Lett 240:243-52. 2006..Thus, topical application of sulforaphane-containing broccoli sprout extracts is a promising strategy for protecting against skin tumor formation after exposure to UV radiation...- Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 99:11908-13. 2002..These residues are located in the intervening region between BTB and Kelch repeat domains of Keap1 and probably are the direct sensors of inducers of the phase 2 system... - Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapySukirti Kalra
Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, UK
Cancer Prev Res (Phila) 5:973-81. 2012..Moreover, their potential skin patch incorporation for transdermal delivery is an exciting possibility... - Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathwaySukirti Kalra
Biomedical Research Institute, University of Dundee, Scotland, United Kingdom
Cancer Prev Res (Phila) 4:1665-74. 2011..Our findings suggest that activation of the Keap1/Nrf2/ARE pathway could reduce the risk for skin cancer in patients receiving long-term azathioprine therapy... - A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated miceAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 N Wolfe Street, WBSB Room 406, Baltimore, MD 21205, USA
Biochem Biophys Res Commun 367:859-65. 2008.... - Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I studyTheresa A Shapiro
Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Nutr Cancer 55:53-62. 2006..No significant or consistent subjective or objective abnormal events (toxicities) associated with any of the sprout extract ingestions were observed... - Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducersNobunao Wakabayashi
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 101:2040-5. 2004.... - Electrophilic tuning of the chemoprotective natural product sulforaphaneYoung Hoon Ahn
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 107:9590-5. 2010..We further show in living cells that a sulfoxythiocarbamate analog can label Keap1 on several key cysteine residues as well as other cellular proteins offering new insights into the mechanism of chemoprotection... - Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extractsAlbena T Dinkova Kostova
Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Epidemiol Biomarkers Prev 16:847-51. 2007..5- and 4.5-fold after application of 150 nmol doses, once or three times (at 24 h-intervals), respectively, thus providing direct evidence for induction of the phase 2 response in humans... - The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stressAndrea L Benedict
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Carcinogenesis 33:2457-66. 2012..Thus, our findings support the development of Nrf2 activators as protectors against drug-mediated photooxidative stress and encourage future clinical trials in populations at high risk for cutaneous photodamage and photocarcinogenesis... - An exceptionally potent inducer of cytoprotective enzymes: elucidation of the structural features that determine inducer potency and reactivity with Keap1Albena T Dinkova-Kostova
Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 285:33747-55. 2010.... - Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathwayJohn D Hayes
Biomedical Research Institute, Ninewells Hospital, University of Dundee, Scotland, United Kingdom
Antioxid Redox Signal 13:1713-48. 2010.... - Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiationPaul Talalay
Department of Pharmacology and Molecular Sciences, Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:17500-5. 2007..7% (range 8.37-78.1%; P = 0.025). This protection against a carcinogen in humans is catalytic and long lasting... - Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloproteinAlbena T Dinkova-Kostova
The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, The Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Biochemistry 44:6889-99. 2005..Keap1 is a zinc-thiol protein endowed with a delicate switch controlled by both metal-binding and thiol reactivity... - HSF1-dependent upregulation of Hsp70 by sulfhydryl-reactive inducers of the KEAP1/NRF2/ARE pathwayYing Zhang
Divison of Cancer Research, Medical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, UK
Chem Biol 18:1355-61. 2011..This uncovered duality undoubtedly contributes to the cytoprotective effects of such molecules in models of carcinogenesis, cardiovascular disease, and neurodegeneration... - Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genesJed W Fahey
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205 2185, USA
Carcinogenesis 26:1247-55. 2005.... - Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducersW David Holtzclaw
The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Adv Enzyme Regul 44:335-67. 2004 - Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stressAlbena T Dinkova-Kostova
The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:4584-9. 2005..91) over 6 orders of magnitude of concentration. Thus, in addition to blocking inflammation and promoting differentiation, these TP exhibit another very important protective property: the induction of the phase 2 response... - Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breastBrian S Cornblatt
Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
Carcinogenesis 28:1485-90. 2007..These findings provide a strong rationale for evaluating the protective effects of a broccoli sprout preparation in clinical trials of women at risk for breast cancer... - Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectorsZachary R Healy
Department of Pharmacology and Molecular Sciences, Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Photodermatol Photoimmunol Photomed 25:45-50. 2009..These methods have permitted evaluation of the efficacy of protectors, such as sulforaphane from crucifers, that defend cells through induction of cytoprotective (phase 2) genes... - Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humansLingxiang Ye
Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA
Clin Chim Acta 316:43-53. 2002.... - Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinonesXiu Jun Wang
Cancer Research UK Molecular Pharmacology Unit, Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
Chem Biol 17:75-85. 2010..Thus, the oxidation of para- and ortho-hydroquinones to quinones represents the rate-limiting step in the activation of Nrf2... - The cytoprotective role of the Keap1-Nrf2 pathwayLiam Baird
Biomedical Research Institute, University of Dundee, Dundee, Scotland, UK
Arch Toxicol 85:241-72. 2011..Cross-talks with other signalling pathways broadens the role of the Keap1-Nrf2 pathway in determining the fate of the cell, impacting fundamental biological processes such as proliferation, apoptosis, angiogenesis and metastasis... - Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophilesHua Liu
Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 105:15926-31. 2008..These studies identify suppression of inflammation as a consistent property of inducers of the phase 2 response and strongly suggest that this property is a central aspect of their chemoprotective actions... - NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotectorAlbena T Dinkova-Kostova
Biomedical Research Institute, University of Dundee, Dundee, Scotland, UK
Arch Biochem Biophys 501:116-23. 2010.... - Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplexMichelle L Kerns
Department of Biological Chemistry, 725 North Wolfe Street, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 104:14460-5. 2007..Nrf2 induction is brought about by treatment with sulforaphane, a natural product. Sulforaphane thus represents an attractive option for the prevention of skin blistering associated with K14 mutations in EBS... - Role of nicotinamide quinone oxidoreductase 1 (NQO1) in protection against toxicity of electrophiles and reactive oxygen intermediatesPaul Talalay
Department of Pharmacology and Molecular Science, Lewis B. and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Methods Enzymol 382:355-64. 2004 - Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitisSudhir Chowdhry
Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
Free Radic Biol Med 48:357-71. 2010..Thus, impairment of Nrf2 activity may represent a major risk factor for the evolution of NAFLD to NASH... - Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenolsAlbena T Dinkova-Kostova
Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
Chem Biol Interact 192:101-6. 2011..Thus, based on theoretical and experimental evidence, the oxidation of para- and ortho-hydroquinones to their corresponding electrophilic quinones is a requisite step for the activation of the Keap1/Nrf2/ARE pathway... - The role of Keap1 in cellular protective responsesAlbena T Dinkova-Kostova
The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, The Johns Hopkins University, Baltimore, Maryland 21205, USA
Chem Res Toxicol 18:1779-91. 2005 - Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1)Albena T Dinkova-Kostova
Department of Pharmacology and Molecular Science, Lewis B. and Dorothy Cullman Cancer Center Chemoprotection Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Methods Enzymol 382:423-48. 2004 - Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathwayAlbena T Dinkova-Kostova
Division of Clinical Pharmacology, Department of Medicine, The Lewis B and Dorothy Cullman Cancer Chemoprotection Center, School of Medicine, Johns Hopkins University, 725 North Wolfe Street, Baltimore, MD 21205, USA
Cancer Lett 245:341-9. 2007..The concentration-dependent differential effects on these two pathways should be carefully considered in mechanistic explanations and strategic designs... - Neuroprotective effects of sulforaphane after contusive spinal cord injuryAndrea L Benedict
Lewis B and Dorothy Cullman Chemoprotection Center, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
J Neurotrauma 29:2576-86. 2012..These findings demonstrate that SF provides neuroprotective effects in the spinal cord after injury, and could be a candidate for therapy of SCI... - The "Prochaska" microtiter plate bioassay for inducers of NQO1Jed W Fahey
Department of Pharmacology and Molecular Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Methods Enzymol 382:243-58. 2004 - Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesisPaul Talalay
Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Adv Enzyme Regul 43:121-34. 2003 - Diffusion dynamics of the Keap1-Cullin3 interaction in single live cellsLiam Baird
Jacqui Wood Cancer Centre, Division of Cancer Research, Medical Research Institute, University of Dundee, Dundee, Scotland, UK
Biochem Biophys Res Commun 433:58-65. 2013..As inducers cause conformational changes in Keap1, we conclude that changes in conformation rather than dissociation from Cul3 inactivate the repressor function of Keap1 leading to Nrf2 stabilization... - Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activitiesKaren Liby
Dartmouth Medical School, Hanover, NH 03755, USA
Mol Cancer Ther 6:2113-9. 2007..These results suggest that BA is a useful platform for drug development, and the enhanced potency and varied biological activities of CBA-Im make it a promising candidate for further chemoprevention or chemotherapeutic studies... - Chemoprotection against cancer: an idea whose time has comeAlbena T Dinkova-Kostova
Department of Pharmacology, Johns Hopkins Medical School, USA
Altern Ther Health Med 13:S122-7. 2007