Kate E Dingle

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Molecular characterization of Campylobacter jejuni clones: a basis for epidemiologic investigation
    Kate E Dingle
    Department of Zoology, University of Oxford, United Kingdom
    Emerg Infect Dis 8:949-55. 2002
  2. pmc Sequence typing and comparison of population biology of Campylobacter coli and Campylobacter jejuni
    Kate E Dingle
    Nuffield Department of Clinical Sciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 43:340-7. 2005
  3. pmc Multilocus sequence typing of Clostridium difficile
    David Griffiths
    Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 48:770-8. 2010
  4. pmc Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing
    Kate E Dingle
    Nuffield Department of Clinical Medicine, Oxford Biomedical Research Centre, John Radcliffe Hospital, UK
    J Infect Dis 207:675-86. 2013
  5. pmc Clinical Clostridium difficile: clonality and pathogenicity locus diversity
    Kate E Dingle
    Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 6:e19993. 2011
  6. pmc Genetic relationships among reptilian and mammalian Campylobacter fetus strains determined by multilocus sequence typing
    Kate E Dingle
    Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 48:977-80. 2010
  7. pmc Stable and noncompetitive RNA internal control for routine clinical diagnostic reverse transcription-PCR
    Kate E Dingle
    Nuffield Department of Clinical Sciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 42:1003-11. 2004
  8. pmc Mutation in a Lordsdale norovirus epidemic strain as a potential indicator of transmission routes
    Kate E Dingle
    Nuffield Department of Clinical Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom, OX3 9DU
    J Clin Microbiol 42:3950-7. 2004
  9. pmc Predictors of first recurrence of Clostridium difficile infection: implications for initial management
    David W Eyre
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    Clin Infect Dis 55:S77-87. 2012
  10. pmc Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection
    A Sarah Walker
    NIHR Biomedical Research Centre, Oxford, UK
    Clin Infect Dis 56:1589-600. 2013

Collaborators

Detail Information

Publications24

  1. pmc Molecular characterization of Campylobacter jejuni clones: a basis for epidemiologic investigation
    Kate E Dingle
    Department of Zoology, University of Oxford, United Kingdom
    Emerg Infect Dis 8:949-55. 2002
    ..These data demonstrate that the clonal complex, as defined by MLST, is an epidemiologically relevant unit for both long and short-term investigations of C. jejuni epidemiology...
  2. pmc Sequence typing and comparison of population biology of Campylobacter coli and Campylobacter jejuni
    Kate E Dingle
    Nuffield Department of Clinical Sciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 43:340-7. 2005
    ..The use of a common MLST scheme allows direct comparisons of the population biology and molecular epidemiology of these two closely related human pathogens...
  3. pmc Multilocus sequence typing of Clostridium difficile
    David Griffiths
    Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 48:770-8. 2010
    ..difficile in total stool DNA extracts without isolate culture. The direct (nonculture) MLST approach may prove useful as a rapid genotyping method, potentially benefiting individual patients and informing hospital infection control...
  4. pmc Recombinational switching of the Clostridium difficile S-layer and a novel glycosylation gene cluster revealed by large-scale whole-genome sequencing
    Kate E Dingle
    Nuffield Department of Clinical Medicine, Oxford Biomedical Research Centre, John Radcliffe Hospital, UK
    J Infect Dis 207:675-86. 2013
    ..Our purpose was to understand the diversity and evolution of slpA and nearby genes also encoding immunodominant cell surface antigens...
  5. pmc Clinical Clostridium difficile: clonality and pathogenicity locus diversity
    Kate E Dingle
    Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS ONE 6:e19993. 2011
    ....
  6. pmc Genetic relationships among reptilian and mammalian Campylobacter fetus strains determined by multilocus sequence typing
    Kate E Dingle
    Nuffield Department of Clinical Laboratory Sciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 48:977-80. 2010
    ..fetus, and there was evidence of recombination among members of these two groups. The reptile group represents a possible separate genomospecies capable of infecting humans...
  7. pmc Stable and noncompetitive RNA internal control for routine clinical diagnostic reverse transcription-PCR
    Kate E Dingle
    Nuffield Department of Clinical Sciences, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Clin Microbiol 42:1003-11. 2004
    ..During routine testing of 324 consecutive unselected respiratory samples, the presence of the internal control ensured that genuine and false-negative results were distinguishable, thus increasing the diagnostic confidence in the assay...
  8. pmc Mutation in a Lordsdale norovirus epidemic strain as a potential indicator of transmission routes
    Kate E Dingle
    Nuffield Department of Clinical Sciences, Oxford University, John Radcliffe Hospital, Oxford, United Kingdom, OX3 9DU
    J Clin Microbiol 42:3950-7. 2004
    ..4 to 13.6% in the outer P2 domain of the capsid, which also had a single-amino-acid insertion. Alterations to the capsid structure compared to previous noroviruses may explain the increased number of outbreaks during 2002 and 2003...
  9. pmc Predictors of first recurrence of Clostridium difficile infection: implications for initial management
    David W Eyre
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, UK
    Clin Infect Dis 55:S77-87. 2012
    ..Risk factors, including increasing age, initial disease severity, and hospital exposure, predict CDI recurrence and identify patients likely to benefit from enhanced initial CDI treatment...
  10. pmc Relationship between bacterial strain type, host biomarkers, and mortality in Clostridium difficile infection
    A Sarah Walker
    NIHR Biomedical Research Centre, Oxford, UK
    Clin Infect Dis 56:1589-600. 2013
    ..Despite substantial interest in biomarkers, their impact on clinical outcomes and variation with bacterial strain has rarely been explored using integrated databases...
  11. pmc Real-time genomic epidemiological evaluation of human Campylobacter isolates by use of whole-genome multilocus sequence typing
    Alison J Cody
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    J Clin Microbiol 51:2526-34. 2013
    ..The approach is widely applicable to analyses of human bacterial pathogens in real time in clinical laboratories, with little specialist training required. ..
  12. pmc Molecular epidemiology of Clostridium difficile strains in children compared with that of strains circulating in adults with Clostridium difficile-associated infection
    Nicole Stoesser
    Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, Oxford OX3 9DU, UK
    J Clin Microbiol 49:3994-6. 2011
    ..difficile-associated infections studied (n = 83). No children carried hypervirulent PCR ribotype 027. Children could participate in the transmission of some adult disease-causing genotypes...
  13. pmc Clostridium difficile mixed infection and reinfection
    David W Eyre
    NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    J Clin Microbiol 50:142-4. 2012
    ..Of 109 sample pairs taken on the same day, 3 (3%) had different genotypes. Considering samples 0 to 7 days apart as the same CDI, 7% of cases had mixed infections with >1 genotype...
  14. pmc Diverse sources of C. difficile infection identified on whole-genome sequencing
    David W Eyre
    Nuffield Department of Clinical Medicine, University of Oxford, the National Institute for Health Research NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    N Engl J Med 369:1195-205. 2013
    ..However, endemic spread has hampered identification of precise sources of infection and the assessment of the efficacy of interventions...
  15. pmc A longitudinal 6-year study of the molecular epidemiology of clinical campylobacter isolates in Oxfordshire, United kingdom
    Alison J Cody
    Department of Zoology, University of Oxford, Oxford, UK
    J Clin Microbiol 50:3193-201. 2012
    ..These data also demonstrated that detailed surveillance at a single site captures information which reflects that observed nationally...
  16. pmc Characterisation of Clostridium difficile hospital ward-based transmission using extensive epidemiological data and molecular typing
    A Sarah Walker
    National Institute for Health Research Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Med 9:e1001172. 2012
    ..This study aimed to investigate ward-based transmission of C. difficile, by subdividing outbreaks into distinct lineages defined by multi-locus sequence typing (MLST)...
  17. pmc Extended sequence typing of Campylobacter spp., United Kingdom
    Kate E Dingle
    John Radcliffe Hospital, Oxford, UK
    Emerg Infect Dis 14:1620-2. 2008
    ..975 to 0.992 among 620 clinical isolates from Oxfordshire, United Kingdom. This enhanced typing scheme enabled identification of clusters and retained data required for long-range epidemiologic comparisons of isolates...
  18. pmc Evolutionary History of the Clostridium difficile Pathogenicity Locus
    Kate E Dingle
    Nuffield Department of Clinical Medicine, Oxford University, John Radcliffe Hospital, United Kingdom
    Genome Biol Evol 6:36-52. 2014
    ..The evolutionary histories of two contrasting but clinically important genetic elements were thus characterized: the PaLoc, mobilized rarely via homologous recombination, and Tn6218, mobilized frequently through transposition. ..
  19. pmc A modified RNA-Seq approach for whole genome sequencing of RNA viruses from faecal and blood samples
    Elizabeth M Batty
    Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom
    PLoS ONE 8:e66129. 2013
    ....
  20. pmc Host-associated genetic import in Campylobacter jejuni
    Noel D McCarthy
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    Emerg Infect Dis 13:267-72. 2007
    ..Assignment using this signature enables improved prediction of source for pathogens that undergo frequent genetic recombination...
  21. pmc Whole genome sequencing and de novo assembly identifies Sydney-like variant noroviruses and recombinants during the winter 2012/2013 outbreak in England
    T H Nicholas Wong
    Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Virol J 10:335. 2013
    ..We apply these methods to recent English outbreaks, placing them in the wider context of the international norovirus epidemic of winter 2012...
  22. pmc Clonal nature of Campylobacter fetus as defined by multilocus sequence typing
    Marcel A P Van Bergen
    Animal Sciences Group, Division of Infectious Diseases, P O Box 65, 8200 AB Lelystad, The Netherlands
    J Clin Microbiol 43:5888-98. 2005
    ..Congruence was observed among C. fetus subspecies, sap type, and ST; therefore, MLST confirms that mammalian C. fetus is genetically stable, probably as result of the introduction of a single ancestral clone into a mammalian niche...
  23. pmc Molecular evidence for dissemination of unique Campylobacter jejuni clones in Curaçao, Netherlands Antilles
    Birgitta Duim
    Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
    J Clin Microbiol 41:5593-7. 2003
    ..Furthermore, given the observation that C. jejuni-associated diseases appear to be more severe from November to February, it can be speculated that this may be due to the presence of virulent clones with a limited span of circulation...
  24. pmc Comparative genotyping of Campylobacter jejuni by amplified fragment length polymorphism, multilocus sequence typing, and short repeat sequencing: strain diversity, host range, and recombination
    Leo M Schouls
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Clin Microbiol 41:15-26. 2003
    ....