Affiliation: University of Oxford
- Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9Yunchuan Ding
Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK
Diabetes 58:1797-806. 2009..Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified...
- Mesenchymal stem-cell immunosuppressive capabilities: therapeutic implications in islet transplantationYunchuan Ding
Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
Transplantation 89:270-3. 2010..This review will discuss the impacts of MSCs on transplant immunity and focus on the potential role of MSCs in protecting islet grafts from both rejection and autoimmune attack...
- Matrix metalloproteinase-9 regulates tumor cell invasion through cleavage of protease nexin-1Danmei Xu
Gray Institute of Radiation Oncology and Biology, University of Oxford, Oxford, UK
Cancer Res 70:6988-98. 2010..This study shows a novel molecular pathway in which MMP-9 regulates uPA activity and tumor cell invasion through cleavage of PN-1...