Research Topics
Species | D J DijkSummaryAffiliation: University of Surrey Country: UK Publications
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Detail Information
Publications
Peak of circadian melatonin rhythm occurs later within the sleep of older subjectsJeanne F Duffy
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Physiol Endocrinol Metab 282:E297-303. 2002..In healthy older subjects, the relative timing of the melatonin rhythm with respect to sleep may not play a causal role in sleep disruption...- Sleep of aging women and men: back to basicsDerk-Jan Dijk
Sleep 29:12-3. 2006 
Plasma melatonin rhythms in young and older humans during sleep, sleep deprivation, and wakeJamie M Zeitzer
Department of Psychiatry, Stanford University, Palo Alto, CA 94304, USA
Sleep 30:1437-43. 2007..To determine the effects of sleep and sleep deprivation on plasma melatonin concentrations in humans and whether these effects are age-dependent...
Enhanced slow wave sleep and improved sleep maintenance after gaboxadol administration during seven nights of exposure to a traffic noise model of transient insomniaD J Dijk
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
J Psychopharmacol 26:1096-107. 2012..05). Gaboxadol enhanced SWS and reduced the disruptive effects of noise on sleep initiation and maintenance...- Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatoninSibah Hasan
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
FASEB J 26:2414-23. 2012..05) at baseline and with diurnal preference (P<0.05). Individual circadian rhythms can be reliably assessed in fibroblasts but may not correlate with physiological rhythms driven by the central circadian pacemaker... - Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humansDerk Jan Dijk
Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 7:e30037. 2012..The extent to which the phase and amplitude of multiple rhythms are similarly affected during altered timing of light exposure and the sleep-wake cycle has not been fully characterized... - PERIOD3, circadian phenotypes, and sleep homeostasisDerk Jan Dijk
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XP, UK
Sleep Med Rev 14:151-60. 2010..These findings highlight the interrelatedness of circadian rhythmicity and sleep homeostasis... - Age-related increase in awakenings: impaired consolidation of nonREM sleep at all circadian phasesD J Dijk
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
Sleep 24:565-77. 2001.... - Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flightsD J Dijk
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol Regul Integr Comp Physiol 281:R1647-64. 2001..Crewmembers on these flights experienced circadian rhythm disturbances, sleep loss, decrements in neurobehavioral performance, and postflight changes in REM sleep... - Sex differences and the effect of gaboxadol and zolpidem on EEG power spectra in NREM and REM sleepD J Dijk
Surrey Sleep Research Centre, University of Surrey, Guildford, UK
J Psychopharmacol 24:1613-8. 2010..These sex dependent and differential effects of GBX and ZOL may be related to their differential affinity for GABA(A) receptor subtypes and their modulation by neurosteroids... - Fatigue and performance models: general background and commentary on the circadian alertness simulator for fatigue risk assessment in transportationDerk Jan Dijk
Surrey Sleep Research Centre, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
Aviat Space Environ Med 75:A119-21. 2004..However, statistical evaluation is usually based on group data, with few performance metrics. As in other models, there is no substantive theory to connect the alertness computation with specific cognitive or psychomotor functions... - Slow-wave sleep, diabetes, and the sympathetic nervous systemDerk-Jan Dijk
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XP, United Kingdom
Proc Natl Acad Sci U S A 105:1107-8. 2008 - Integration of human sleep-wake regulation and circadian rhythmicityDerk Jan Dijk
Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford GU27XH, United Kingdom
J Appl Physiol 92:852-62. 2002..Recent findings on the physiological and molecular-genetic correlates of circadian sleep disorders suggest that the timing of the sleep-wake cycle and circadian rhythms is closely integrated but is, in part, regulated differentially... - Age-related reduction in daytime sleep propensity and nocturnal slow wave sleepDerk Jan Dijk
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Sleep 33:211-23. 2010..To investigate whether age-related and experimental reductions in SWS and sleep continuity are associated with increased daytime sleep propensity... - Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleepD J Dijk
Circadian, Neuroendocrine, and Sleep Disorders Section, Brigham and Women s Hospital, Harvard Medical School, USA
Chronobiol Int 17:285-311. 2000..Quantification of the interaction between sleep homeostasis and circadian rhythmicity contributes to understanding age-related changes in sleep timing and quality... - Slow-wave sleep deficiency and enhancement: implications for insomnia and its managementDerk Jan Dijk
Surrey Sleep Research Centre, University of Surrey, Guildford, UK
World J Biol Psychiatry 11:22-8. 2010..Pharmacological enhancement of SWS has also been observed in insomnia. The effects of SWS enhancement on other sleep parameters will be discussed... - Microgravity reduces sleep-disordered breathing in humansA R Elliott
Department of Medicine, University of California, San Diego, La Jolla, California 92093-0931, USA
Am J Respir Crit Care Med 164:478-85. 2001..This is the first direct demonstration that gravity plays a dominant role in the generation of apneas, hypopneas, and snoring in healthy subjects... - Circadian temperature and melatonin rhythms, sleep, and neurobehavioral function in humans living on a 20-h dayJ K Wyatt
Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol 277:R1152-63. 1999..The data demonstrate the exquisite sensitivity of many neurobehavioral functions to circadian phase and the accumulation of homeostatic drive for sleep... - Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythmsD J Dijk
Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Physiol 516:611-27. 1999.... - Time course of sleep inertia dissipation in human performance and alertnessM E Jewett
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Sleep Res 8:1-8. 1999..These findings allow for the refinement of models of alertness and performance, and have important implications for the scheduling of work immediately upon awakening in many occupational settings... - Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake scheduleT Klein
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02138
Sleep 16:333-43. 1993..2-0.3 hours from 24 hours, cannot be entrained by periodic daily exposure to nonphotic time cues, including a very regular 24-hour sleep-wake schedule... - Frontal predominance of a relative increase in sleep delta and theta EEG activity after sleep loss in humansC Cajochen
Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Sleep Res Online 2:65-9. 1999..The data demonstrate that the enhancement of slow wave EEG activity during sleep following extended wakefulness is most pronounced in frontal cortical areas... - Variation of electroencephalographic activity during non-rapid eye movement and rapid eye movement sleep with phase of circadian melatonin rhythm in humansD J Dijk
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
J Physiol 505:851-8. 1997..The changes in non-REM sleep EEG spectra are dissimilar from the spectral changes induced by sleep deprivation and exhibit a close temporal association with the melatonin rhythm and the endogenous circadian phase of sleep consolidation... - EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep lossC Cajochen
Circadian, Neuroendocrine and Sleep Disorders Section, Endocrine Hypertension Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Physiol 277:R640-9. 1999..Frontal EEG activity and ocular parameters may be used to monitor and predict changes in neurobehavioral performance associated with sleep loss and circadian misalignment... - Circadian regulation of human sleep and age-related changes in its timing, consolidation and EEG characteristicsD J Dijk
Circadian, Neuroendocrine and Sleep Disorders Section, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Ann Med 31:130-40. 1999..Putative mediators and modulators of circadian sleep regulation are discussed... - Use of transdermal melatonin delivery to improve sleep maintenance during daytimeD Aeschbach
Division of Sleep Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin Pharmacol Ther 86:378-82. 2009..Transdermal MEL may have advantages over fast-release oral MEL in improving sleep maintenance during adverse circadian phases... - Circadian phase resetting in older people by ocular bright light exposureE B Klerman
Circadian, Neuroendocrine, and Sleep Disorders Section, Division of Endocrinology Hypertension, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Mass, USA
J Investig Med 49:30-40. 2001.... - Separation of circadian and wake duration-dependent modulation of EEG activation during wakefulnessC Cajochen
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neuroscience 114:1047-60. 2002.... - Circadian variation of EEG power spectra in NREM and REM sleep in humans: dissociation from body temperatureD J Dijk
Circadian, Neuroendocrine and Sleep Disorders Section, Division of Endocrinology, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA 02115, USA
J Sleep Res 8:189-95. 1999.... - Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humansK P Wright
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:14027-32. 2001..Either exposure to very dim light and/or the scheduled sleep-wake cycle itself can entrain this near-24-h intrinsic period of the human circadian pacemaker to the 24-h day... - Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertnessC Cajochen
Department of Medicine, Circadian, Neuroendocrine and Sleep Disorders Section, Endocrinology and Hypertension Division, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
Behav Brain Res 115:75-83. 2000.... - Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertnessM E Jewett
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Mass, USA
Sleep 22:171-9. 1999.... - PER3 polymorphism predicts sleep structure and waking performanceAntoine U Viola
Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
Curr Biol 17:613-8. 2007..The data show that this polymorphism in PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that this differential susceptibility may be mediated by its effects on sleep homeostasis... - Low-dose repeated caffeine administration for circadian-phase-dependent performance degradation during extended wakefulnessJames K Wyatt
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Sleep 27:374-81. 2004.... - Getting through to circadian oscillators: why use constant routines?Jeanne F Duffy
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Biol Rhythms 17:4-13. 2002.... - Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activitiesKay H S Jones
Surrey Sleep Research Centre, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
J Sleep Res 16:12-6. 2007..They also demonstrate that diurnal preference in young people is more closely associated with this polymorphism than it is in other age groups... - Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillatorsDerk Jan Dijk
Surrey Sleep Research Centre and Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, United Kingdomd
J Biol Rhythms 20:279-90. 2005..Molecular genetic correlates, including polymorphisms in clock genes, of some of these interindividual differences are emerging... - Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytesSimon N Archer
Surrey Sleep Research Centre, Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Sleep 31:608-17. 2008..The study objective was to determine whether the endogenous phase of these rhythms, assessed in the absence of the sleep-wake and light-dark cycle, correlates with habitual sleep-wake timing... - Nonphotic entrainment of the human circadian pacemakerE B Klerman
Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Physiol 274:R991-6. 1998..We conclude that nonphotic stimuli can entrain the human circadian pacemaker in some individuals lacking ocular circadian photoreception... - Melatonin phase-shifts human circadian rhythms with no evidence of changes in the duration of endogenous melatonin secretion or the 24-hour production of reproductive hormonesShantha M W Rajaratnam
Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom
J Clin Endocrinol Metab 88:4303-9. 2003.... - Interindividual variation in sleep duration and its association with sleep debt in young adultsElizabeth B Klerman
Division of Sleep Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Sleep 28:1253-9. 2005..To determine whether variation in sleep duration reflects variation in sleep need or self-imposed sleep restriction... - Melatonin advances the circadian timing of EEG sleep and directly facilitates sleep without altering its duration in extended sleep opportunities in humansShantha M W Rajaratnam
School of Biomedical and Molecular Sciences, University of Surrey, UK
J Physiol 561:339-51. 2004.... - Sleep-facilitating effect of exogenous melatonin in healthy young men and women is circadian-phase dependentJames K Wyatt
Division of Sleep Medicine, Department of Medicine, Brigham and Women a Hospital and Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA
Sleep 29:609-18. 2006..To investigate the effects of a physiologic and a pharmacologic dose of exogenous melatonin on sleep latency and sleep efficiency in sleep episodes initiated across a full range of circadian phases... - Older people awaken more frequently but fall back asleep at the same rate as younger peopleElizabeth B Klerman
Division of Sleep Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Sleep 27:793-8. 2004.... - Alertness, mood and performance rhythm disturbances associated with circadian sleep disorders in the blindSteven W Lockley
School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
J Sleep Res 17:207-16. 2008..Treatment for circadian rhythm disorders should be targeted in normalizing these phase relationships... - Sleep quantity, sleep difficulties and their perceived consequences in a representative sample of some 2000 British adultsJ A Groeger
Surrey Sleep Research Centre, University of Surrey, Guildford, UK
J Sleep Res 13:359-71. 2004..Although we may not sleep less than four decades ago, when we report sleeping less we also tend to associate that lack of sleep with poor performance and quality of life... - Robust circadian rhythm in heart rate and its variability: influence of exogenous melatonin and photoperiodGilles Vandewalle
Surrey Sleep Research Centre, University of Surrey, Guildford, UK
J Sleep Res 16:148-55. 2007.... - Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivationChristian Cajochen
Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, USA
J Pineal Res 35:149-57. 2003..The data indicate that under conditions of reduced zeitgeber strength, the phase of the human circadian pacemaker, using plasma melatonin as a marker, can be phase delayed by one night of SD and the associated dim light exposure... - Age-related reduction in the maximal capacity for sleep--implications for insomniaElizabeth B Klerman
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 18:1118-23. 2008..Thus, in the absence of social and circadian constraints, both daytime sleep propensity and the maximal capacity for sleep are reduced in older people. These data have important implications for understanding age-related insomnia... - Sleep- and circadian-dependent modulation of REM densitySat Bir S Khalsa
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Sleep Res 11:53-9. 2002.... - The selective extrasynaptic GABAA agonist, gaboxadol, improves traditional hypnotic efficacy measures and enhances slow wave activity in a model of transient insomniaJames K Walsh
St Johns Hospital, St Louis, MO, USA
Sleep 30:593-602. 2007..Evaluate the hypnotic efficacy of gaboxadol, a selective extrasynaptic GABAA agonist (SEGA), in a phase advance model of transient insomnia... - Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performanceJo Phipps-Nelson
School of Psychology, Psychiatry and Psychological Medicine, Monash University, Victoria, Australia
Sleep 26:695-700. 2003.... - The suitability of actigraphy, diary data, and urinary melatonin profiles for quantitative assessment of sleep disturbances in schizophrenia: a case reportKatharina Wulff
Department of Visual Neuroscience, Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College London, Charing Cross Hospital, London, UK
Chronobiol Int 23:485-95. 2006..These circadian abnormalities may reinforce the altered sleep patterns and the problems of cognitive function and social engagement associated with schizophrenic... - Nonvisual responses to light exposure in the human brain during the circadian nightFabien Perrin
Centre de Recherches du Cyclotron (B30, , Sart Tilman, , Belgium
Curr Biol 14:1842-6. 2004..Activity in the hypothalamus decreased in proportion to previous illumination. These findings have important implications for understanding the effects of light on human behavior...