A D Dick

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Use of infliximab in juvenile onset rheumatological disease-associated refractory uveitis: efficacy in joint and ocular disease
    Srilakshmi M Sharma
    Ann Rheum Dis 66:840-1. 2007
  2. pmc Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice
    Jian Liu
    Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e72935. 2013
  3. pmc CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization
    Shintaro Horie
    1 Academic Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, UK 2 Department of Ophthalmology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan 3
    Sci Rep 3:3072. 2013
  4. pmc Local therapies for inflammatory eye disease in translation: past, present and future
    Shenzhen Tempest-Roe
    Faculty of Medicine, Imperial College London, London, UK
    BMC Ophthalmol 13:39. 2013
  5. pmc Diagnostic techniques for inflammatory eye disease: past, present and future: a review
    Stephen C Teoh
    National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    BMC Ophthalmol 13:41. 2013
  6. pmc Systemic therapies for inflammatory eye disease: past, present and future
    Alastair K Denniston
    Ophthalmology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK
    BMC Ophthalmol 13:18. 2013
  7. doi Secukinumab in the treatment of noninfectious uveitis: results of three randomized, controlled clinical trials
    Andrew D Dick
    School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
    Ophthalmology 120:777-87. 2013
  8. doi Road to fulfilment: taming the immune response to restore vision
    Andrew D Dick
    School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
    Ophthalmic Res 48:43-9. 2012
  9. pmc CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF)
    Debra A Carter
    Academic Unit of Ophthalmology, Department of Clinical Sciences South Bristol, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS12LX, UK
    BMC Ophthalmol 9:1. 2009
  10. ncbi Control of myeloid activity during retinal inflammation
    Andrew D Dick
    Division of Ophthalmology, University of Bristol, United Kingdom
    J Leukoc Biol 74:161-6. 2003

Collaborators

Detail Information

Publications91

  1. pmc Use of infliximab in juvenile onset rheumatological disease-associated refractory uveitis: efficacy in joint and ocular disease
    Srilakshmi M Sharma
    Ann Rheum Dis 66:840-1. 2007
  2. pmc Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice
    Jian Liu
    Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 8:e72935. 2013
    ....
  3. pmc CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization
    Shintaro Horie
    1 Academic Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol, UK 2 Department of Ophthalmology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan 3
    Sci Rep 3:3072. 2013
    ..Local delivery of a CD200R agonist mAb to target myeloid infiltrate alters macrophage phenotype and inhibits pro-angiogenic gene expression, which suppresses pathological angiogenesis and CNV development. ..
  4. pmc Local therapies for inflammatory eye disease in translation: past, present and future
    Shenzhen Tempest-Roe
    Faculty of Medicine, Imperial College London, London, UK
    BMC Ophthalmol 13:39. 2013
    ....
  5. pmc Diagnostic techniques for inflammatory eye disease: past, present and future: a review
    Stephen C Teoh
    National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore
    BMC Ophthalmol 13:41. 2013
    ....
  6. pmc Systemic therapies for inflammatory eye disease: past, present and future
    Alastair K Denniston
    Ophthalmology Department, University Hospitals Birmingham NHS Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK
    BMC Ophthalmol 13:18. 2013
    ..Although there are challenges, these are exciting opportunities as we seek to develop safe and effective treatments for patients with inflammatory eye disease...
  7. doi Secukinumab in the treatment of noninfectious uveitis: results of three randomized, controlled clinical trials
    Andrew D Dick
    School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
    Ophthalmology 120:777-87. 2013
    ..To determine the efficacy and safety of different doses of secukinumab, a fully human monoclonal antibody for targeted interleukin-17A blockade, in patients with noninfectious uveitis...
  8. doi Road to fulfilment: taming the immune response to restore vision
    Andrew D Dick
    School of Clinical Sciences and School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
    Ophthalmic Res 48:43-9. 2012
    ..Understanding the mechanisms has gained potential therapeutic opportunities not only to suppress on-going inflammation, but also to restore homeostasis and prevent recrudescence...
  9. pmc CD133+ adult human retinal cells remain undifferentiated in Leukaemia Inhibitory Factor (LIF)
    Debra A Carter
    Academic Unit of Ophthalmology, Department of Clinical Sciences South Bristol, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS12LX, UK
    BMC Ophthalmol 9:1. 2009
    ..We used CD133 to purify adult human retinal cells and aimed to determine what effect LIF had on these cultures and whether they still had the ability to generate neurospheres...
  10. ncbi Control of myeloid activity during retinal inflammation
    Andrew D Dick
    Division of Ophthalmology, University of Bristol, United Kingdom
    J Leukoc Biol 74:161-6. 2003
    ..Thus, when mice lack CD200, they show increased susceptibility to and accelerated onset of tissue-specific autoimmunity...
  11. ncbi Influence of microglia on retinal progenitor cell turnover and cell replacement
    A D Dick
    Department of Clinical Sciences South Bristol, Academic Unit of Ophthalmology, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
    Eye (Lond) 23:1939-45. 2009
    ....
  12. ncbi The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU)
    Andrew D Dick
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
    Prog Retin Eye Res 23:617-37. 2004
    ....
  13. ncbi Cytokines and immunopathogenesis of intraocular posterior segment inflammation
    Andrew D Dick
    Division of Ophthalmology, University of Bristol, Bristol, UK
    Ocul Immunol Inflamm 11:17-28. 2003
  14. pmc Single dose intranasal administration of retinal autoantigen generates a rapid accumulation and cell activation in draining lymph node and spleen: implications for tolerance therapy
    A D Dick
    Division of Ophthalmology, University of Aberdeen, UK
    Br J Ophthalmol 85:1001-6. 2001
    ..To further unravel underlying mechanisms the authors wished to determine, firstly, the kinetics of antigen delivery and, secondly, the early cellular responses involved in the initial stages of nasal mucosal tolerance induction...
  15. ncbi Distribution of OX2 antigen and OX2 receptor within retina
    A D Dick
    Division of Ophthalmology, University of Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 42:170-6. 2001
    ..The purpose of this study was to determine the distribution and extent of expression of OX2 and its receptor within the retina, a tissue developed to restrain immune-mediated inflammatory damage...
  16. pmc Neural progenitor cells from postmortem adult human retina
    E J Mayer
    Department of Clinical Sciences, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
    Br J Ophthalmol 89:102-6. 2005
    ..A resident population of NPC suggests that the retina may constitutively replace neurons, photoreceptors, and glia...
  17. ncbi Neutralizing TNF-alpha activity modulates T-cell phenotype and function in experimental autoimmune uveoretinitis
    A D Dick
    Department of Ophthalmology, University of Aberdeen, UK
    J Autoimmun 11:255-64. 1998
    ..Although in both animal groups, comparable numbers of T cells were isolated, neutralizing TNF activity suppressed Th1 effector mechanisms protecting against target organ damage...
  18. pmc Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis
    Cathryn Broderick
    Department of Ophthalmology, University of Aberdeen, United Kingdom
    Am J Pathol 161:1669-77. 2002
    ....
  19. ncbi CD69 expression on peripheral CD4+ T cells parallels disease activity and is reduced by mycophenolate mofetil therapy in uveitis
    D J Kilmartin
    Department of Ophthalmology, University of Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 42:1285-92. 2001
    ..The frequency of CD69-positive CD4 T cells is a measure of activity in posterior uveitis and may guide adequate immunosuppression...
  20. pmc Systemic CD4(+) T cell phenotype and activation status in intermediate uveitis
    C C Murphy
    Division of Ophthalmology, University of Bristol, UK
    Br J Ophthalmol 88:412-6. 2004
    ..To investigate peripheral blood lymphocyte phenotype in patients with intermediate uveitis using CD69, chemokine receptor, and cytokine expression...
  21. ncbi Neutralizing tumor necrosis factor-alpha activity suppresses activation of infiltrating macrophages in experimental autoimmune uveoretinitis
    Morag Robertson
    Department of Ophthalmology, University of Aberdeen, Aberdeen, Scotland, United Kingdom
    Invest Ophthalmol Vis Sci 44:3034-41. 2003
    ....
  22. ncbi Kinetics of leukocyte and myeloid cell traffic in the murine corneal allograft response
    L Kuffova
    Department of Ophthalmology, Medical School Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, United Kingdom
    Transplantation 72:1292-8. 2001
    ..This study reports on changes in the cornea and the draining lymph node (DLN) from the time of graft emplacement...
  23. ncbi CD200 maintains microglial potential to migrate in adult human retinal explant model
    Debra A Carter
    University of Bristol, Bristol Eye Hospital, Bristol, UK
    Curr Eye Res 28:427-36. 2004
    ....
  24. pmc Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis
    David A Copland
    Division of Infection and Immunity, Department of Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom
    Am J Pathol 171:580-8. 2007
    ..These experiments demonstrate that promoting CD200R-mediated signaling can successfully prevent full expression of IFNgamma-mediated macrophage activation and protect against tissue damage during autoimmune responses...
  25. pmc Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis
    D A Copland
    Academic Unit of Ophthalmology, Department of Clinical Sciences South Bristol, Bristol, UK
    Clin Exp Immunol 159:303-14. 2010
    ..This presents great therapeutic potential to protect against tissue damage during autoimmune responses in the retina or inflammation-induced degenerative disease...
  26. pmc Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats
    S Banerjee
    Division of Ophthalmology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Br J Ophthalmol 87:1515-22. 2003
    ..To investigate the development of lymphoid aggregates in the conjunctiva after corneal transplantation in rats...
  27. doi The effect on visual function of Hydroview intraocular lens opacification: a cross-sectional study
    M S J Blundell
    Department of Clinical Sciences at South Bristol, Academic Unit of Ophthalmology, University of Bristol, Bristol, UK
    Eye (Lond) 24:1590-8. 2010
    ..This study's purpose was to investigate the impact of IOL opacification on objective measurements of visual function, including glare, and on vision-related quality of life...
  28. doi TNFR1-dependent regulation of myeloid cell function in experimental autoimmune uveoretinitis
    Ben J E Raveney
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    J Immunol 183:2321-9. 2009
    ..Thus, in TNFR1 knock out mice, the amplification of autoimmunity is limited, leading to resistance to experimental autoimmune uveoretinitis induction...
  29. ncbi Anti-TNFalpha therapy modulates the phenotype of peripheral blood CD4+ T cells in patients with posterior segment intraocular inflammation
    Kathrin Greiner
    Department of Ophthalmology, University of Aberdeen, Aberdeen, United Kingdom
    Invest Ophthalmol Vis Sci 45:170-6. 2004
    ..Previous studies implicated an efficacy of anti-TNFalpha therapies in patients with PSII. This study investigated the immunomodulatory effect of anti-TNFalpha therapy to find predictors of effective immunosuppression in PSII...
  30. ncbi Retinal microenvironment controls resident and infiltrating macrophage function during uveoretinitis
    Morag J Robertson
    Department of Ophthalmology, University of Aberdeen, Aberdeen, Scotland, UK
    Invest Ophthalmol Vis Sci 43:2250-7. 2002
    ....
  31. ncbi Mechanisms for inducing nasal mucosal tolerance in experimental autoimmune uveoretinitis
    Claudia J Calder
    Department of Pathology and Microbiology, University of Bristol, UK
    Methods 38:69-76. 2006
    ....
  32. pmc Lentiviral-vector-mediated expression of murine IL-1 receptor antagonist or IL-10 reduces the severity of endotoxin-induced uveitis
    P Trittibach
    Division of Molecular Therapy, Institute of Ophthalmology, University College London, London, UK
    Gene Ther 15:1478-88. 2008
    ....
  33. pmc Tumour necrosis factor-mediated macrophage activation in the target organ is critical for clinical manifestation of uveitis
    T K Khera
    School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
    Clin Exp Immunol 168:165-77. 2012
    ..We conclude that sTNF is required for inflammatory cell infiltration into target tissue, but at the tissue site inhibition of both sTNF and tmTNF is required to inhibit macrophage activation and to protect from tissue damage...
  34. pmc Choroidal dendritic cells require activation to present antigen and resident choroidal macrophages potentiate this response
    J V Forrester
    Department of Ophthalmology, University of Aberdeen, Foresterhill, Aberdeen AB9 2ZD, UK
    Br J Ophthalmol 89:369-77. 2005
    ..These cells are now recognised to have a role in many ocular pathologies. The aim of this study was to isolate, characterise, and compare the function of ciliary body/choroid dendritic cells and macrophages from the normal eye...
  35. doi The B subunit of Escherichia coli heat-labile enterotoxin inhibits Th1 but not Th17 cell responses in established experimental autoimmune uveoretinitis
    Ben J E Raveney
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 49:4008-17. 2008
    ..EtxB is a potent immune modulator that ameliorates other Th1-mediated autoimmune diseases, enhancing regulatory T-cell activity...
  36. ncbi Blocking CD200-CD200 receptor axis augments NOS-2 expression and aggravates experimental autoimmune uveoretinitis in Lewis rats
    Debatri Banerjee
    Department of Ophthalmology, University of Bristol, UK
    Ocul Immunol Inflamm 12:115-25. 2004
    ..Our interests were to investigate whether blocking CD200 receptor (CD200R) signalling in vivo results in macrophage activation and thus aggravation of EAU in Lewis rats...
  37. ncbi Mapping immune responses to mRBP-3 1-16 peptide with altered peptide ligands
    Carly J Guyver
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 47:2027-35. 2006
    ..This study of a truncated murine peptide (mRBP-3 1-16) was conducted to determine its pathogenic potential and to characterize partially its interaction with specific T cells...
  38. pmc Nestin positive cells in adult human retina and in epiretinal membranes
    E J Mayer
    University Division of Ophthalmology, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
    Br J Ophthalmol 87:1154-8. 2003
    ..Nestin is an intermediate filament marker for neural progenitor cells. The authors aimed to identify nestin positive cells in adult human retina and within surgically removed epiretinal membranes...
  39. ncbi Cytopathological analysis of vitreous in intraocular lymphoma
    L Intzedy
    Department of Pathology, Bristol Royal Infirmary, Bristol, UK
    Eye (Lond) 22:289-93. 2008
    ..To describe the cytopathological method used in the analysis of vitreous samples in the diagnosis of primary intraocular lymphoma (PIOL)...
  40. pmc Lipopolysaccharide/interferon-gamma and not transforming growth factor beta inhibits retinal microglial migration from retinal explant
    D A Carter
    Division of Ophthalmology, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
    Br J Ophthalmol 87:481-7. 2003
    ..The aims of this study are to investigate changes in human microglia phenotype, migration, and activation status in response to pro-inflammatory and anti-inflammatory stimulation...
  41. ncbi Fragile X-related protein FXR1 controls post-transcriptional suppression of lipopolysaccharide-induced tumour necrosis factor-alpha production by transforming growth factor-beta1
    Tarnjit K Khera
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, Bristol, UK
    FEBS J 277:2754-65. 2010
    ..In summary, TGF-beta1 opposes LPS-induced stabilization of TNF-alpha mRNA and reduces the amount of TNF-alpha protein, through induction of expression of the mRNA-binding protein FXR1...
  42. doi Mechanisms of TNF╬▒ regulation in uveitis: focus on RNA-binding proteins
    Tarnjit K Khera
    School of Cellular and Molecular Medicine, University Walk, Bristol, UK
    Prog Retin Eye Res 29:610-21. 2010
    ..The study of mRNA stability remains essential for the understanding of intracellular regulatory pathways and molecular mechanisms of pathology for infection, inflammation and degeneration...
  43. doi The dynamics of leukocyte infiltration in experimental autoimmune uveoretinitis
    Emma C Kerr
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Prog Retin Eye Res 27:527-35. 2008
    ....
  44. doi The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation
    David A Copland
    Academic Unit of Ophthalmology, Department of Clinical Sciences at South Bristol, UK
    Invest Ophthalmol Vis Sci 49:5458-65. 2008
    ....
  45. doi Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations
    Emma C Kerr
    Department of Cellular and Molecular Medicine, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Autoimmun 31:354-61. 2008
    ..Instead, fluctuations in infiltrating leukocyte numbers and changes to their relative composition continue, indicating that clinical recovery does not equate to the restoration of a normal retinal leukocyte population...
  46. ncbi Cyclosporine vs tacrolimus therapy for posterior and intermediate uveitis
    Conor C Murphy
    Division of Ophthalmology, University of Bristol, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, England
    Arch Ophthalmol 123:634-41. 2005
    ..To compare the efficacy and tolerability of tacrolimus and cyclosporine therapy for noninfectious posterior segment intraocular inflammation and to evaluate their effect on peripheral blood CD4(+) T-cell phenotype and activation status...
  47. ncbi Cytokine polymorphism in noninfectious uveitis
    Denize Atan
    Clinical Sciences at South Bristol, Bristol Eye Hospital, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4133-42. 2010
    ..TNFA and IL10 are strong candidate genes, given the influence of these cytokines on inflammation, immune tolerance, and apoptosis...
  48. doi Dendritic cell physiology and function in the eye
    John V Forrester
    Section of Immunology and Infection, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Immunol Rev 234:282-304. 2010
    ..This approach has considerable potential for use in translational clinical therapy to prevent sight-threatening disease caused by ocular inflammation...
  49. ncbi Predicting endothelial cell loss and long-term corneal graft survival
    W John Armitage
    Division of Ophthalmology, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 44:3326-31. 2003
    ..To evaluate a biexponential decay model for describing the loss of corneal endothelial cells with age as well as the increased loss of cells after cataract surgery and penetrating keratoplasty...
  50. doi Microglia derived IL-6 suppresses neurosphere generation from adult human retinal cell suspensions
    Balini Balasubramaniam
    Academic Unit of Ophthalmology, Department of Clinical Sciences South Bristol, University of Bristol, Bristol Eye Hospital BEH, Lower Maudlin Street, Bristol BS1 2LX, UK
    Exp Eye Res 89:757-66. 2009
    ..Even in the presence of high levels of IL-6, those few NS that did form demonstrated a capacity to differentiate. The data supports activated MG-derived IL-6 influence retinal cell turnover...
  51. ncbi Turnover of resident retinal microglia in the normal adult mouse
    Heping Xu
    Department of Ophthalmology, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Glia 55:1189-98. 2007
    ..The complete replacement of retinal microglia/macrophages takes about 6 months. In situ proliferation was predominantly of nonhemopoetic retinal cells...
  52. ncbi Cytokine gene polymorphism in sympathetic ophthalmia
    Denize Atan
    Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
    Invest Ophthalmol Vis Sci 46:4245-50. 2005
    ..The purpose of this study was to determine whether polymorphisms in the cytokine genes are important markers for disease severity and outcome in patients with SO...
  53. ncbi A selective role for the TNF p55 receptor in autocrine signaling following IFN-gamma stimulation in experimental autoimmune uveoretinitis
    Claudia J Calder
    Department of Pathology and Microbiology, University of Bristol, Bristol, United Kingdom
    J Immunol 175:6286-93. 2005
    ....
  54. pmc Quality of life and visual function in patients with intermediate uveitis
    C C Murphy
    Division of Ophthalmology, University of Bristol, Bristol BS1 2LX, UK
    Br J Ophthalmol 89:1161-5. 2005
    ..To assess visual function, vision related quality of life (VR-QOL), and general health related quality of life (HR-QOL) in intermediate uveitis (IU)...
  55. doi Perioperative socialization, care and monitoring of National Institutes of Health miniature swine undergoing ocular surgery and sampling of peripheral blood
    S M Nicholls
    Unit of Ophthalmology, School of Clinical Sciences, University of Bristol, Bristol BS8 1TD, UK
    Lab Anim 46:59-64. 2012
    ..We conclude that NIH minipigs are fully compliant with anaesthetic and postoperative experimental procedures provided they are well-socialized to project personnel before surgery...
  56. ncbi Emulsification of Densiron-68 used in inferior retinal detachment surgery
    M A Majid
    Department of Ophthalmology, University of Bristol, Bristol, UK
    Eye (Lond) 22:152-7. 2008
    ..To report the clinical features of eight patients presenting with emulsification of the heavier than water vitreous substitute, Densiron-68...
  57. doi Does orally administered doxycycline reach the tear film?
    V A Smith
    University of Bristol, Academic Unit of Ophthalmology, Lower Maudlin Street, Bristol BS1 2LX, UK
    Br J Ophthalmol 92:856-9. 2008
    ..Since these functions are concentration-dependent, the aim of this project was to determine whether sufficient doxycycline reached the tear film to fulfil these roles in vivo...
  58. doi Lack of IFN-gamma synthesis in aqueous humor during corneal graft rejection correlates with suppressed nitric oxide production by macrophages
    Susan M Nicholls
    Department of Clinical Science, Academic Unit of Ophthalmology, School of Medical Sciences, South Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 49:4923-30. 2008
    ..To investigate cytokine production by leukocytes in aqueous humor (AH) during corneal graft rejection and nitric oxide (NO) production by macrophages as a potential mediator of graft damage...
  59. ncbi Differences in leukocyte phenotype and interferon-gamma expression in stroma and endothelium during corneal graft rejection
    Susan M Nicholls
    Unit of Ophthalmology, Department of Clinical Science at South Bristol, School of Medical Sciences, University Walk, Bristol, BS8 1TD, UK
    Exp Eye Res 83:339-47. 2006
    ..The restricted endothelial cell profile and lack of IFN-gamma suggests that the anti-endothelial response may be modulated by the anterior chamber environment...
  60. pmc Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation
    R W J Lee
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Eye (Lond) 26:17-28. 2012
    ....
  61. ncbi The pathology and pathogenesis of retinal vasculitis
    E H Hughes
    University of Bristol, Bristol Eye Hospital, Bristol, UK
    Neuropathol Appl Neurobiol 29:325-40. 2003
    ..The growing understanding of the cellular mechanisms involved in the effector immune response is already providing a rationale for more specific therapeutic approaches...
  62. ncbi Generation of activated sialoadhesin-positive microglia during retinal degeneration
    Edward H Hughes
    Division of Ophthalmology, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 44:2229-34. 2003
    ..The results may have relevance to similar degeneration in humans (retinitis pigmentosa)...
  63. pmc The effect of postmortem time, donor age and sex on the generation of neurospheres from adult human retina
    Debra A Carter
    Department of Clinical Sciences South Bristol, University of Bristol, Bristol Eye Hospital, Bristol, UK
    Br J Ophthalmol 91:1216-8. 2007
    ..Postmortem adult human retina contains pluripotent progenitor cells capable of forming neurospheres with different retinal cell types. The authors examine whether this is the case at all ages and at different postmortem times...
  64. ncbi Murine respiratory tract dendritic cells: isolation, phenotyping and functional studies
    Claudia J Calder
    Division of Ophthalmology, University of Bristol, UK
    J Immunol Methods 287:67-77. 2004
    ..Using such modified isolation procedures for RTDCs, we have developed a consistent method of RTDC enrichment, which maintains the immature phenotype and functional antigen presenting capability...
  65. doi Steroid refractory CD4+ T cells in patients with sight-threatening uveitis
    Richard W J Lee
    Bristol Eye Hospital, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 50:4273-8. 2009
    ..As interleukin (IL)-2 experimentally mediates the SR phenotype, the combined effects of dexamethasone (Dex) and a range of IL-2 targeting immunosuppressive agents were also investigated...
  66. ncbi Recovery from macular phototoxicity after corneal triple procedure
    Nathaniel E Knox Cartwright
    Department of Ophthalmology, University of Bristol, Bristol Eye Hospital, Bristol, United Kingdom
    Cornea 26:102-4. 2007
    ..Visual recovery from macular phototoxicity in 2 cases after prolonged exposure to operating microscope light from uncomplicated corneal triple-procedure surgery. Recovery is discussed in the context of repair and regeneration...
  67. doi Gene therapy for noninfectious uveitis
    C J Chu
    University of Bristol, School of Clinical Sciences, Bristol Eye Hospital, Lower Maudlin Street, Bristol, BS1 2LX, UK
    Ocul Immunol Inflamm 20:394-405. 2012
    ..This review evaluates these preclinical studies, considers the route to clinical application, and explores future targets and approaches...
  68. doi Switching biologic agents for uveitis
    N Dhingra
    Academic Unit of Ophthalmology, Bristol Eye Hospital, Bristol, UK
    Eye (Lond) 23:1868-70. 2009
    ..To observe whether switching between biological agents helps to gain or maintain uveitis remission in cases with sight-threatening refractory uveitis...
  69. pmc Tissue inhibitor of metalloproteinase-3 differentially binds to components of Bruch's membrane
    M A Majid
    Academic Unit of Ophthalmology, University of Bristol, Bristol Eye Hospital, Bristol, UK
    Br J Ophthalmol 90:1310-5. 2006
    ..The pathological features of this condition relate to the accumulation of TIMP-3 in Bruch's membrane...
  70. ncbi Reduced mortality compared with national averages following phacoemulsification cataract surgery: a retrospective observational study
    M S J Blundell
    Clinical Research Unit, Bristol Eye Hospital, Lower Maudlin Street, Bristol BS1 2LX, UK
    Br J Ophthalmol 93:290-5. 2009
    ..Higher or equal rates of mortality are associated with cataract surgery compared with the general population. Cataract surgery has advanced, and the clinical characteristics of the patient undergoing cataract surgery have changed...
  71. pmc Immunogenetics and clinical phenotype of sympathetic ophthalmia in British and Irish patients
    D J Kilmartin
    Department of Ophthalmology, University of Aberdeen, Scotland, UK
    Br J Ophthalmol 85:281-6. 2001
    ..This study sought to assess HLA genetic polymorphism in British and Irish patients with SO, and to assess whether HLA gene variants are associated with clinical phenotype or disease severity...
  72. ncbi Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism
    Edward H Hughes
    University Division of Ophthalmology, Bristol Eye Hospital, University of Bristol, Lower Maudlin St, Bristol BS1 2LX, UK
    Exp Eye Res 78:1077-84. 2004
    ....
  73. doi Clinical review: Anti-TNFalpha therapies in uveitis: perspective on 5 years of clinical experience
    Srilakshmi M Sharma
    Academic Unit of Ophthalmology, Bristol Eye Hospital, Bristol, UK
    Ocul Immunol Inflamm 17:403-14. 2009
    ..Given their cost and the potential for significant adverse events, this review highlights the evidence for their continued use, possibilities for switching anti-TNF agents, and ways of reducing the risk of therapy...
  74. doi Differential patterning of neuronal, glial and neural progenitor cells on phosphorus-doped and UV irradiated diamond-like carbon
    Edward M Regan
    Henry Wellcome L I N E, Clinical Sciences South Bristol, University of Bristol, UK
    Biomaterials 31:207-15. 2010
    ..We conclude that DLC is a well-suited candidate material for coating implantable devices in the human nervous system...
  75. ncbi Biologics in the treatment of uveitis
    Fraser R Imrie
    Academic Unit of Ophthalmology, University of Bristol and Bristol Eye Hospital, Bristol, UK
    Curr Opin Ophthalmol 18:481-6. 2007
    ..This review summarizes the current evidence for biologic therapies in the treatment of uveitis. The review emphasizes published research in this field since 2005...
  76. ncbi Neutralizing tumor necrosis factor activity leads to remission in patients with refractory noninfectious posterior uveitis
    Conor C Murphy
    Division of Ophthalmology, University of Bristol, Bristol, England
    Arch Ophthalmol 122:845-51. 2004
    ..To evaluate the efficacy and safety of tumor necrosis factor (TNF) inhibition with the p55 TNF receptor fusion protein (TNFr-Ig) for severe sight-threatening noninfectious posterior segment intraocular inflammation...
  77. ncbi CD4+CD25(int) T cells in inflammatory diseases refractory to treatment with glucocorticoids
    Richard W J Lee
    Academic Unit of Ophthalmology, Department of Clinical Science at South Bristol, University of Bristol, Bristol, UK
    J Immunol 179:7941-8. 2007
    ..As a result, we propose a new paradigm for SR disease in which glucocorticoid therapy positively selects SR cells, generating a population of drug-resistant lymphocytes that perpetuate on-going inflammation...
  78. ncbi Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis
    Fraser R Imrie
    Academic Unit of Ophthalmology, University of Bristol and Bristol Eye Hospital, Lower Maudlin Street, Bristol, UK
    Curr Opin Ophthalmol 18:212-9. 2007
    ..This review summarizes current nonsteroidal drug therapies for noninfectious posterior and intermediate uveitis...
  79. pmc Inflammatory choroidal neovascular membrane in posterior uveitis-pathogenesis and treatment
    Narendra Dhingra
    Department of Academic Ophthalmology, Bristol Eye Hospital, Bristol, United Kingdom
    Indian J Ophthalmol 58:3-10. 2010
    ..Though significant advances have occurred in the understanding of the pathogenesis and management of this condition, optimizing therapeutic regimens will require further well-constructed prospective cohort series...
  80. ncbi Glucocorticoids and the emerging importance of T cell subsets in steroid refractory diseases
    Lauren P Schewitz
    Department of Clinical Science at South Bristol, University of Bristol, United Kingdom
    Immunopharmacol Immunotoxicol 31:1-22. 2009
    ..These mechanisms are discussed, with emphasis on recent evidence for the role of the CD4(+)CD25(int) and GC-induced T regulatory cell subsets in perpetrating SR disease...
  81. ncbi Non-infectious pediatric uveitis: an update on immunomodulatory management
    Srilakshmi M Sharma
    Bristol Eye Hospital, Bristol, UK
    Paediatr Drugs 11:229-41. 2009
    ..Successful outcomes may be achieved with appropriate immunosuppressant therapy given early in the disease, although clinical trials are required to define the true efficacy of this strategy...
  82. doi Mycophenolate mofetil for the treatment of uveitis
    Stephen C Teoh
    Bristol Eye Hospital, University of Bristol, Bristol, UK
    Am J Ophthalmol 146:752-60, 760.e1-3. 2008
    ....
  83. ncbi Changes in the balance of the tissue inhibitor of matrix metalloproteinases (TIMPs)-1 and -3 may promote keratocyte apoptosis in keratoconus
    Fiona J Matthews
    University of Bristol, Academic Unit of Ophthalmology, Bristol Eye Hospital, Lower Maudlin Street, Bristol, BS1 2LX, UK
    Exp Eye Res 84:1125-34. 2007
    ....
  84. ncbi Long-term efficacy and tolerance of tacrolimus for the treatment of uveitis
    Aideen C Hogan
    Bristol Eye Hospital, Bristol, United Kingdom
    Ophthalmology 114:1000-6. 2007
    ..To evaluate the long-term efficacy and tolerance of tacrolimus for the treatment of uveitis...
  85. doi Cataract surgery with primary intraocular lens implantation in children with chronic uveitis
    Anthony G Zaborowski
    Arch Ophthalmol 126:583-4. 2008
  86. doi Fingolimod (FTY720) as an acute rescue therapy for intraocular inflammatory disease
    Ben J E Raveney
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Arch Ophthalmol 126:1390-5. 2008
    ..To examine the efficacy of the immunomodulatory drug fingolimod (FTY720) as a rescue therapy for noninfectious intraocular inflammation...
  87. ncbi Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis
    Cathryn A Broderick
    Division of Molecular Therapy, Institute of Ophthalmology, University College, London, 11 43 Bath Street, London EC1V 9EL, UK
    Mol Ther 12:369-73. 2005
    ....
  88. ncbi Cataract surgery in pediatric uveitis
    Anthony G Zaborowski
    West of England Eye Unit, Royal Devon and Exeter Hospital, Exeter, United Kingdom
    J Pediatr Ophthalmol Strabismus 45:270-8. 2008
    ..The authors review the available evidence base for the treatment of these children...
  89. ncbi Are we still reluctant to immunosuppress?
    Andrew D Dick
    Clin Experiment Ophthalmol 33:1-2. 2005
  90. pmc Validity of using vision-related quality of life as a treatment end point in intermediate and posterior uveitis
    Conor C Murphy
    Department of Ophthalmology, Royal Perth Hospital, Victoria Square, Perth, WA 6000, Australia
    Br J Ophthalmol 91:154-6. 2007
    ....
  91. doi Patterned growth of neuronal cells on modified diamond-like carbon substrates
    Stephen Kelly
    Henry Wellcome L I N E, Clinical Sciences South Bristol, University of Bristol, UK
    Biomaterials 29:2573-80. 2008
    ..This study reports the generation of nerve cell patterns via patterned deposition of DLC...