K Dheda

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Utility of the antigen-specific interferon-gamma assay for the management of tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and UCL Medical School, London, UK
    Curr Opin Pulm Med 11:195-202. 2005
  2. pmc Implementation of British Thoracic Society guidelines for acute exacerbation of chronic obstructive pulmonary disease: impact on quality of life
    K Dheda
    Chest Clinic, Whipps Cross University Hospital, Leytonstone, London E11 1NR, UK
    Postgrad Med J 80:169-71. 2004
  3. ncbi request reprint The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, London, UK
    Tuberculosis (Edinb) 87:237-41. 2007
  4. ncbi request reprint Lung remodeling in pulmonary tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Thoracic and HIV Medicine, Royal Free Hospital, London, United Kingdom
    J Infect Dis 192:1201-9. 2005
  5. ncbi request reprint Assessments for oxygen therapy in COPD: are we under correcting arterial oxygen tensions?
    K Dheda
    Dept of Respiratory and HIV Medicine, Royal Free Hospital, Pond Street, London, UK
    Eur Respir J 24:954-7. 2004
  6. ncbi request reprint Outcome of HIV-associated tuberculosis in the era of highly active antiretroviral therapy
    Keertan Dheda
    Department of Thoracic and HIV Medicine, Royal Free Hospital, Royal Free and University College London Medical School, London, United Kingdom
    J Infect Dis 190:1670-6. 2004
  7. ncbi request reprint Experience with azathioprine in systemic sclerosis associated with interstitial lung disease
    K Dheda
    Department of Respiratory Medicine, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Clin Rheumatol 23:306-9. 2004
  8. pmc Is virtual bronchoscopy useful for physicians practising in a district general hospital?
    K Dheda
    Chest Unit, Whipps Cross University Hospital NHS Trust, Leytonstone, London E11 1NR, UK
    Postgrad Med J 80:420-3. 2004
  9. ncbi request reprint Expression of a novel cytokine, IL-4delta2, in HIV and HIV-tuberculosis co-infection
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and UCL Medical School, University College London, London, UK
    AIDS 19:1601-6. 2005
  10. ncbi request reprint Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, UK
    AIDS 19:2038-41. 2005

Detail Information

Publications35

  1. ncbi request reprint Utility of the antigen-specific interferon-gamma assay for the management of tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and UCL Medical School, London, UK
    Curr Opin Pulm Med 11:195-202. 2005
    ..More recently, T-cell-based interferon-gamma responses to Mycobacterium tuberculosis - specific antigens have been investigated for their role in diagnosing latent tuberculosis infection...
  2. pmc Implementation of British Thoracic Society guidelines for acute exacerbation of chronic obstructive pulmonary disease: impact on quality of life
    K Dheda
    Chest Clinic, Whipps Cross University Hospital, Leytonstone, London E11 1NR, UK
    Postgrad Med J 80:169-71. 2004
    ..Whether intensive outpatient follow up of COPD patients after acute admission, using these guidelines, improved quality of life compared to the "usual practice" of primary care follow up was investigated...
  3. ncbi request reprint The stability of mRNA encoding IL-4 is increased in pulmonary tuberculosis, while stability of mRNA encoding the antagonistic splice variant, IL-4delta2, is not
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, London, UK
    Tuberculosis (Edinb) 87:237-41. 2007
    ..The differential stability of the Th2 agonist, IL-4, compared to the antagonist IL-4delta2, represents a hitherto undescribed post-transcriptional regulatory mechanism that may modulate the polarisation of Th1/Th2 responses in human TB...
  4. ncbi request reprint Lung remodeling in pulmonary tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Thoracic and HIV Medicine, Royal Free Hospital, London, United Kingdom
    J Infect Dis 192:1201-9. 2005
    ..Further studies are needed to identify and develop specific immunotherapeutic interventions that target immunopathology, since they have the potential to substantially reduce spread...
  5. ncbi request reprint Assessments for oxygen therapy in COPD: are we under correcting arterial oxygen tensions?
    K Dheda
    Dept of Respiratory and HIV Medicine, Royal Free Hospital, Pond Street, London, UK
    Eur Respir J 24:954-7. 2004
    ..The common practice of using wall-oxygen to perform assessments significantly underestimates the required oxygen-concentrator flow rate. This may have implications for the long-term effect of domiciliary oxygen therapy...
  6. ncbi request reprint Outcome of HIV-associated tuberculosis in the era of highly active antiretroviral therapy
    Keertan Dheda
    Department of Thoracic and HIV Medicine, Royal Free Hospital, Royal Free and University College London Medical School, London, United Kingdom
    J Infect Dis 190:1670-6. 2004
    ..The benefit of highly active antiretroviral therapy (HAART) in the treatment of patients coinfected with tuberculosis (TB) and human immunodeficiency virus (HIV) is unclear because of concerns about treatment-related complications...
  7. ncbi request reprint Experience with azathioprine in systemic sclerosis associated with interstitial lung disease
    K Dheda
    Department of Respiratory Medicine, Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Clin Rheumatol 23:306-9. 2004
    ..Our results suggest that azathioprine may have a role in stabilizing lung function and improving symptoms in SSc, although this needs confirmation by a randomized controlled trial...
  8. pmc Is virtual bronchoscopy useful for physicians practising in a district general hospital?
    K Dheda
    Chest Unit, Whipps Cross University Hospital NHS Trust, Leytonstone, London E11 1NR, UK
    Postgrad Med J 80:420-3. 2004
    ..There is limited information on the clinical utility of virtual bronchoscopy and whether it offers any additional information over conventional axial computed tomography in the setting of a busy DGH chest unit...
  9. ncbi request reprint Expression of a novel cytokine, IL-4delta2, in HIV and HIV-tuberculosis co-infection
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and UCL Medical School, University College London, London, UK
    AIDS 19:1601-6. 2005
    ..However data on interleukin (IL)-4 expression in HIV or AIDS are un-interpretable because of failure to distinguish between IL-4 and its splice variant and natural antagonist, IL-4delta2...
  10. ncbi request reprint Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Department of Population Sciences and Primary Care, Royal Free and University College Medical School, University College London, London, UK
    AIDS 19:2038-41. 2005
    ..ELISPOT test performance appears to be independent of HIV-associated immunosuppression...
  11. ncbi request reprint Real-time RT-PCR normalisation; strategies and considerations
    J Huggett
    Centre for Infectious Diseases and International Health, University College London, London, UK
    Genes Immun 6:279-84. 2005
    ..In this review we discuss the relative merits of different normalisation strategies and suggest a method of validation that will enable the measurement of biologically meaningful results...
  12. doi request reprint Trials and tribulations of an African-led research and capacity development programme: the case for EDCTP investments
    A Zumla
    University of Zambia, Lusaka, Zambia
    Trop Med Int Health 15:489-94. 2010
    ..The recent 255 million Euros EDCTP investment in sub-Saharan Africa through south-north partnerships is expected to enhance existing African-led R&D programmes. African governments and scientists must rise to the challenge...
  13. ncbi request reprint Immune systems in developed and developing countries; implications for the design of vaccines that will work where BCG does not
    Graham A W Rook
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, UK
    Tuberculosis (Edinb) 86:152-62. 2006
    ..The development of such vaccines, that might work where BCG does not, will require a greater understanding of the roles of the many types of regulatory T cell in tuberculosis...
  14. ncbi request reprint Expression of IL-4 mRNA in peripheral blood mononuclear cells from normal donors in relation to expression of TLR2
    Jung Su Chang
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Immunol Lett 106:194-7. 2006
    ..We conclude that in T cell populations from normal donors, expression of IL-4 (but not of its antagonist, IL-4delta2, or of IL-10) is associated with high TLR2 and low TLR1...
  15. ncbi request reprint World TB Day 2010: Eradicating tuberculosis in sub-Saharan Africa needs effective and committed north-south partnerships
    Ben Marais
    University College London Medical School
    S Afr Med J 100:153-4. 2010
    ..World TB Day provides an opportunity to reflect on the poor state of TB control globally, particularly in sub-Saharan African countries (SSA)...
  16. ncbi request reprint IL-4 in tuberculosis: implications for vaccine design
    Graham A W Rook
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, Royal Free and University College Medical School, 46 Cleveland Street, London, UK
    Trends Immunol 25:483-8. 2004
    ..If this is important, effective vaccines will need to suppress pre-existing Th2-like activity. Such vaccines are feasible and are active therapeutically in mouse TB...
  17. ncbi request reprint Immune responses to tuberculosis in developing countries: implications for new vaccines
    Graham A W Rook
    Centre for Infectious Diseases and International Health, Windeyer Institute for Medical Sciences, University College London, London W1T 4JF, UK
    Nat Rev Immunol 5:661-7. 2005
    ..We propose that a successful vaccine needs to block this immunopathology, because it is not the quantity of T(H)1-cell activity that matters but, rather, its context...
  18. ncbi request reprint Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?
    Graham A W Rook
    Centre for Infectious Disease and International Health, University College London, Windeyer Institute of Medical Sciences, London W1T 4JF, UK
    Vaccine 23:2115-20. 2005
    ..A successful vaccine, rather than driving a Th1 response, might need to suppress this pre-existing subversive Th2-like component...
  19. doi request reprint Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs
    D J B Marks
    Centre for Molecular Medicine, University College London, London, UK
    Int J STD AIDS 20:339-45. 2009
    ..008). The treatment completion did not differ significantly between the two groups (76.6% and 84.2%, P = 0.08)...
  20. ncbi request reprint In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis
    Keertan Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, 46 Cleveland Street, London W1T 4JF, United Kingdom
    Am J Respir Crit Care Med 172:501-8. 2005
    ..A putative explanation is the simultaneous presence of a subversive Th2 response. However, interpretation is confounded by interleukin 4delta2 (IL-4delta2), a splice variant and inhibitor of IL-4...
  21. ncbi request reprint Myobacterium tuberculosis induces selective up-regulation of TLRs in the mononuclear leukocytes of patients with active pulmonary tuberculosis
    Jung Su Chang
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, London, United Kingdom
    J Immunol 176:3010-8. 2006
    ..We conclude that M. tuberculosis exerts direct effects on patterns of TLR expression, partly via changes in mRNA half-life. The significance of these changes in the pathogenesis of disease deserves further investigation...
  22. pmc The pathogen recognition sensor, NOD2, is variably expressed in patients with pulmonary tuberculosis
    Sanjay Lala
    Centre for Gastroenterology, Royal Free and University College Medical School and Royal Free Hospital NHS Trust, London, UK
    BMC Infect Dis 7:96. 2007
    ..To further define a role for NOD2 in disease pathogenesis, we analysed NOD2 transcriptional responses in pulmonary leucocytes and mononuclear cells harvested from patients with pulmonary tuberculosis (PTB)...
  23. ncbi request reprint The implications of using an inappropriate reference gene for real-time reverse transcription PCR data normalization
    K Dheda
    Centre for Infectious Diseases and International Health, Royal Free and University College Medical School, and Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
    Anal Biochem 344:141-3. 2005
  24. pmc Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
    Anil Pooran
    Division of Infection and Immunity, Centre for Infectious Diseases and International Health, University College London Medical School, University College London, 43 Cleveland Street, London W1T 4JF, UK
    BMC Pulm Med 10:7. 2010
    ..tb...
  25. ncbi request reprint Immune reconstitution inflammatory syndrome in HIV-infected patients receiving antiretroviral therapy : pathogenesis, clinical manifestations and management
    Devesh J Dhasmana
    Department of Respiratory Medicine, Harefield Hospital, Middlesex, UK
    Drugs 68:191-208. 2008
    ..In this review, we discuss research relating to pathogenesis, the range of clinical manifestations, treatment options and prevention issues...
  26. doi request reprint Tuberculosis in association with HIV/AIDS emerges as a major nonobstetric cause of maternal mortality in Sub-Saharan Africa
    John Grange
    Department of Infection, Centre for Infectious Diseases and International Health, University College London Medical School, London, UK
    Int J Gynaecol Obstet 108:181-3. 2010
    ..Maternal deaths from tuberculosis are now on the increase in the UK, and due diligence and watchful surveillance are required in European prenatal services...
  27. ncbi request reprint Validation of housekeeping genes for normalizing RNA expression in real-time PCR
    Keertan Dheda
    Royal Free Medical School, London, UK
    Biotechniques 37:112-4, 116, 118-9. 2004
    ..Validations of housekeeping genes are highly specific for a particular experimental model and are a crucial component in assessing any new model...
  28. ncbi request reprint T-cell assays for the diagnosis of latent tuberculosis infection: moving the research agenda forward
    Madhukar Pai
    McGill University, Department of Epidemiology, Biostatistics and Occupational Health, Montreal, Quebec, Canada
    Lancet Infect Dis 7:428-38. 2007
    ..Ultimately, if adequately financed, the research findings will inform appropriate use of novel latent tuberculosis infection diagnostics in global tuberculosis control...
  29. ncbi request reprint New tools and emerging technologies for the diagnosis of tuberculosis: part II. Active tuberculosis and drug resistance
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:423-32. 2006
    ..Latent TB is discussed in Part I; 413-422 of this issue...
  30. ncbi request reprint New tools and emerging technologies for the diagnosis of tuberculosis: part I. Latent tuberculosis
    Madhukar Pai
    University of California, Berkeley and San Francisco, Berkeley Division of Epidemiology, 140, Warren Hall, Berkeley, CA 94720, USA
    Expert Rev Mol Diagn 6:413-22. 2006
    ..The review concludes by highlighting areas where evidence is lacking, and provides an agenda for future research. Active TB and drug resistance are discussed in Part II; 423-432 of this issue...
  31. ncbi request reprint Peripheral T cell interferon-gamma responses and latent tuberculosis
    Keertan Dheda
    Am J Respir Crit Care Med 170:97-8; author reply 98. 2004
  32. ncbi request reprint Lethal interaction: the colliding epidemics of tobacco and tuberculosis
    Madhukar Pai
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Canada
    Expert Rev Anti Infect Ther 5:385-91. 2007
    ..Since tobacco control will have multiple health benefits, it is likely to be a highly cost-effective intervention from a societal perspective...
  33. ncbi request reprint Type 2 cytokines in respiratory syncytial virus bronchiolitis
    Keertan Dheda
    Am J Respir Crit Care Med 169:1167-8; author reply 1168. 2004
  34. ncbi request reprint Interferon gamma assays for tuberculosis
    Keertan Dheda
    Lancet Infect Dis 5:324-5; author reply 325-7. 2005
  35. ncbi request reprint Smoking is not beneficial for tuberculosis
    Keertan Dheda
    Am J Respir Crit Care Med 170:821; author reply 821. 2004