Susan A Deuchars

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc GABA(B) Mediated Regulation of Sympathetic Preganglionic Neurons: Pre- and Postsynaptic Sites of Action
    Lihua Wang
    Institute of Membrane and Systems Biology, University of Leeds Leeds, UK
    Front Neurol 1:142. 2010
  2. pmc Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice
    M L Pierce
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Neuroscience 170:827-38. 2010
  3. pmc Multi-tasking in the spinal cord--do 'sympathetic' interneurones work harder than we give them credit for?
    Susan A Deuchars
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, West Yorkshire, LS2 9JT, UK
    J Physiol 580:723-9. 2007
  4. ncbi request reprint Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, United Kingdom
    J Neurosci 21:6308-20. 2001
  5. ncbi request reprint GABAergic neurons in the central region of the spinal cord: a novel substrate for sympathetic inhibition
    Susan A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 25:1063-70. 2005
  6. ncbi request reprint Properties of interneurones in the intermediolateral cell column of the rat spinal cord: role of the potassium channel subunit Kv3.1
    S A Deuchars
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    Neuroscience 106:433-46. 2001
  7. ncbi request reprint Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin
    Mark L Dallas
    School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Brain Res 1189:51-7. 2008
  8. doi request reprint Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control
    Lihua Wang
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 28:12445-52. 2008
  9. ncbi request reprint Spinal cord interneurones labelled transneuronally from the adrenal gland by a GFP-herpes virus construct contain the potassium channel subunit Kv3.1b
    Ruth E Brooke
    School of Biomedical Sciences, University of Leeds, UK
    Auton Neurosci 98:45-50. 2002
  10. doi request reprint Modulation of potassium ion channel proteins utilising antibodies
    Mark L Dallas
    School of Medicine, University of Leeds, UK
    Methods Mol Biol 491:247-55. 2008

Collaborators

Detail Information

Publications25

  1. pmc GABA(B) Mediated Regulation of Sympathetic Preganglionic Neurons: Pre- and Postsynaptic Sites of Action
    Lihua Wang
    Institute of Membrane and Systems Biology, University of Leeds Leeds, UK
    Front Neurol 1:142. 2010
    ..The data also indicate that there is heterogeneity in the postsynaptic responses of SPNs...
  2. pmc Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice
    M L Pierce
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Neuroscience 170:827-38. 2010
    ..This work questions the assumption that sympathetic rhythms are dependent on supraspinal pacemaker circuits, by highlighting a surprisingly strong rhythmogenic capability of the reduced sympathetic networks of the spinal cord slice...
  3. pmc Multi-tasking in the spinal cord--do 'sympathetic' interneurones work harder than we give them credit for?
    Susan A Deuchars
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, West Yorkshire, LS2 9JT, UK
    J Physiol 580:723-9. 2007
    ..The locations of these neurones and their local axonal ramifications suggest that they play a more widespread function than previously thought. Therefore the data to support such a theory are also examined...
  4. ncbi request reprint Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, United Kingdom
    J Neurosci 21:6308-20. 2001
    ..These data show that activating A1Rs reduces fast excitatory, but not inhibitory, transmission onto SPNs and interneurons in the IML and that A1Rs may play a protective role on neurons involved in the control of sympathetic outflow...
  5. ncbi request reprint GABAergic neurons in the central region of the spinal cord: a novel substrate for sympathetic inhibition
    Susan A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 25:1063-70. 2005
    ....
  6. ncbi request reprint Properties of interneurones in the intermediolateral cell column of the rat spinal cord: role of the potassium channel subunit Kv3.1
    S A Deuchars
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    Neuroscience 106:433-46. 2001
    ..These studies provide electrophysiological and morphological data on interneurones in the IML and indicate that the channels containing the Kv3.1 subunit are important in setting the firing pattern of these neurones...
  7. ncbi request reprint Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin
    Mark L Dallas
    School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Brain Res 1189:51-7. 2008
    ..Given the role of the Kv3 proteins in shaping neuronal excitability, these data highlight a role for homomeric Kv3.4 channels in spike timing and neurotransmitter release in low frequency firing neurons of the DVN...
  8. doi request reprint Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control
    Lihua Wang
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 28:12445-52. 2008
    ..These data indicate a novel influence for controlling the activity of SPNs regardless of their function...
  9. ncbi request reprint Spinal cord interneurones labelled transneuronally from the adrenal gland by a GFP-herpes virus construct contain the potassium channel subunit Kv3.1b
    Ruth E Brooke
    School of Biomedical Sciences, University of Leeds, UK
    Auton Neurosci 98:45-50. 2002
    ..In conjunction with our electrophysiological data, this highlights a role for the Kv3.1b subunit in shaping the activity of intemeurones involved in sympathetic control...
  10. doi request reprint Modulation of potassium ion channel proteins utilising antibodies
    Mark L Dallas
    School of Medicine, University of Leeds, UK
    Methods Mol Biol 491:247-55. 2008
    ..We provide some useful control experiments in order to help validate this method. We conclude that antibodies can be extremely valuable in determining the functions of specific proteins in living neurones in neuroscience research...
  11. ncbi request reprint Subdivision-specific responses of neurons in the nucleus of the tractus solitarius to activation of mu-opioid receptors in the rat
    Sarah L Poole
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Neurophysiol 98:3060-71. 2007
    ..These data demonstrate site specific responses of neurons to activation of MORs and KORs, which may underlie their ability to modulate different autonomic reflexes...
  12. ncbi request reprint The neurochemically diverse intermedius nucleus of the medulla as a source of excitatory and inhibitory synaptic input to the nucleus tractus solitarii
    Ian J Edwards
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 27:8324-33. 2007
    ..These data provide a novel pathway that may underlie possible reflex changes in autonomic variables after neck muscle spindle afferent activation...
  13. ncbi request reprint Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors
    Ruth E Brooke
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 24:127-37. 2004
    ..Simultaneous activation of A1Rs and A2ARs therefore could facilitate inhibition of the postsynaptic neuron, leading to an overall reduction of sympathetic nervous activity...
  14. ncbi request reprint Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons
    Carol J Milligan
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 24:7241-50. 2004
    ..Taken together these separate lines of evidence suggest that the effects of GABA in central neurons can be mediated by heteromeric complexes of GABA(A) and GABA(C) receptor subunits...
  15. pmc Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii
    Mark L Dallas
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    J Physiol 562:655-72. 2005
    ..Synaptic inputs evoked by stimulation of a region lacking Kv3.1b-IR neurones were not affected, correlating the presence of Kv3.1b in the TS with the pharmacological effects...
  16. ncbi request reprint Histamine depolarizes neurons in the dorsal vagal complex
    Sarah L Poole
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Neurosci Lett 432:19-24. 2008
    ..These data indicate that histamine has a restricted but profound effect on neurons in the dorsal vagal complex...
  17. doi request reprint A simple method to fluorescently label pericytes in the CNS and skeletal muscle
    Ian J Edwards
    School of Biomedical Sciences, University of Leeds, LS29JT, UK
    Microvasc Res 89:164-8. 2013
    ..This simple method could therefore be applied for labelling pericytes in a wide variety of studies, including live cell imaging or immunohistochemistry. ..
  18. pmc Na+/K+ ATPase α1 and α3 isoforms are differentially expressed in α- and γ-motoneurons
    Ian J Edwards
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 33:9913-9. 2013
    ..The selective expression of NKAα3 in γ-motoneurons and muscle spindle afferents, which may affect excitability of these neurons, has implications in motor control and disease states associated with NKAα3 dysfunction...
  19. ncbi request reprint The intermedius nucleus of the medulla: a potential site for the integration of cervical information and the generation of autonomic responses
    Ian J Edwards
    Institute of Membrane and Systems Biology, Garstang Building, University of Leeds, Leeds, LS2 9JT, United Kingdom
    J Chem Neuroanat 38:166-75. 2009
    ..Outputs from the InM to the NTS and hypoglossal nucleus suggest a possible role in the coordination of tongue movements and autonomic responses to changes in posture...
  20. ncbi request reprint Immunopharmacology--antibodies for specific modulation of proteins involved in neuronal function
    Mark Dallas
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Neurosci Methods 146:133-48. 2005
    ..Some suggestions for control experiments are made to help validate the method. We conclude that antibodies can be extremely valuable in determining the functions of specific proteins in living neurones in neuroscience research...
  21. pmc GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord
    Laura F Corns
    School of Biomedical Sciences, University of Leeds, Leeds, United Kingdom
    Neurosci Lett 553:57-62. 2013
    ..The ability of ependymal cells to respond to GABA suggests that GABA could be capable of influencing the proliferation and differentiation of cells within the neurogenic niche of the postnatal spinal cord...
  22. doi request reprint Anodal Transcranial Direct Current Stimulation (tDCS) Over the Motor Cortex Increases Sympathetic Nerve Activity
    Jennifer A Clancy
    School of Biomedical Sciences, University of Leeds, Garstang Building, Leeds LS2 9JT, UK
    Brain Stimul 7:97-104. 2014
    ..tDCS affects not only the area underlying the electrodes but also other areas of the cortex and subcortical structures. This could lead to unintended alteration in brain functions such as autonomic control...
  23. pmc The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat
    Varinder K Lall
    School of Biomedical Sciences, University of Leeds, Leeds, UK
    J Biomed Sci 19:103. 2012
    ..MF was added to the perfusate at 1 μM to examine its effects on baseline parameters as well as baroreceptor and chemoreceptor reflexes...
  24. doi request reprint The wonders of the Wanderer
    Jennifer A Clancy
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 98:38-45. 2013
    ..g. reducing activation of vagal respiratory afferents to treat chronic cough. This review discusses evidence underlying some current and potential therapeutic applications of vagal modulation, illustrating the wonders of the Wanderer...
  25. ncbi request reprint Immunopharmacology: utilizing antibodies as ion channel modulators
    Mark L Dallas
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Worsley Building, Leeds LS2 9JT, UK
    Expert Rev Clin Pharmacol 3:281-9. 2010
    ..In addition, we will review some recent studies looking into clinical applications of immunopharmacology and intrabodies...