J Deuchars

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice
    R J Chapman
    Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Brain Struct Funct 218:751-65. 2013
  2. pmc The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat
    Varinder K Lall
    School of Biomedical Sciences, University of Leeds, Leeds, UK
    J Biomed Sci 19:103. 2012
  3. doi request reprint The wonders of the Wanderer
    Jennifer A Clancy
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 98:38-45. 2013
  4. pmc Dynamic remodelling of synapses can occur in the absence of the parent cell body
    Natalia L Bettini
    University of Leeds, Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Garstang Building, LS2 9JT, UK
    BMC Neurosci 8:79. 2007
  5. ncbi request reprint Morphological and electrophysiological properties of neurones in the dorsal vagal complex of the rat activated by arterial baroreceptors
    J Deuchars
    School of Biomedical Sciences, University of Leeds, United Kingdom
    J Comp Neurol 417:233-49. 2000
  6. ncbi request reprint How much gas does it take to pump up synaptic transmission in the brain?
    Jim Deuchars
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 92:367. 2007
  7. ncbi request reprint Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, United Kingdom
    J Neurosci 21:7143-52. 2001
  8. ncbi request reprint Differential expression of vesicular glutamate transporters by vagal afferent terminals in rat nucleus of the solitary tract: projections from the heart preferentially express vesicular glutamate transporter 1
    E K A Corbett
    School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Neuroscience 135:133-45. 2005
  9. ncbi request reprint Association of potassium channel Kv3.4 subunits with pre- and post-synaptic structures in brainstem and spinal cord
    R E Brooke
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
    Neuroscience 126:1001-10. 2004
  10. ncbi request reprint Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, United Kingdom
    J Neurosci 21:6308-20. 2001

Collaborators

Detail Information

Publications42

  1. pmc Localization of neurones expressing the gap junction protein Connexin45 within the adult spinal dorsal horn: a study using Cx45-eGFP reporter mice
    R J Chapman
    Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Brain Struct Funct 218:751-65. 2013
    ..The implications of these data in the context of the putative role of Cx45 and gap junctions in spinal somatosensory processing and pain are discussed...
  2. pmc The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat
    Varinder K Lall
    School of Biomedical Sciences, University of Leeds, Leeds, UK
    J Biomed Sci 19:103. 2012
    ..MF was added to the perfusate at 1 μM to examine its effects on baseline parameters as well as baroreceptor and chemoreceptor reflexes...
  3. doi request reprint The wonders of the Wanderer
    Jennifer A Clancy
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 98:38-45. 2013
    ..g. reducing activation of vagal respiratory afferents to treat chronic cough. This review discusses evidence underlying some current and potential therapeutic applications of vagal modulation, illustrating the wonders of the Wanderer...
  4. pmc Dynamic remodelling of synapses can occur in the absence of the parent cell body
    Natalia L Bettini
    University of Leeds, Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Garstang Building, LS2 9JT, UK
    BMC Neurosci 8:79. 2007
    ..Here we test the hypothesis that nerve terminals are semi-autonomous and able to rapidly respond to local stimuli in the absence of communication with their parent cell body...
  5. ncbi request reprint Morphological and electrophysiological properties of neurones in the dorsal vagal complex of the rat activated by arterial baroreceptors
    J Deuchars
    School of Biomedical Sciences, University of Leeds, United Kingdom
    J Comp Neurol 417:233-49. 2000
    ..By comparing labelled cells with each other as well as with other unidentified cells, we conclude that NTS arterially baroreceptive neurones are morphologically and physiologically heterogenous...
  6. ncbi request reprint How much gas does it take to pump up synaptic transmission in the brain?
    Jim Deuchars
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 92:367. 2007
  7. ncbi request reprint Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, United Kingdom
    J Neurosci 21:7143-52. 2001
    ..Such a widespread distribution and functional role suggests that the receptor may be involved in the fundamental regulation of synaptic transmission at the presynaptic site...
  8. ncbi request reprint Differential expression of vesicular glutamate transporters by vagal afferent terminals in rat nucleus of the solitary tract: projections from the heart preferentially express vesicular glutamate transporter 1
    E K A Corbett
    School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Neuroscience 135:133-45. 2005
    ..A high proportion of cardiac neurones appear to be glutamatergic, but differ from other vagal afferents in expressing vesicular glutamate transporter 1...
  9. ncbi request reprint Association of potassium channel Kv3.4 subunits with pre- and post-synaptic structures in brainstem and spinal cord
    R E Brooke
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
    Neuroscience 126:1001-10. 2004
    ..Therefore the pre and postsynaptic localization of Kv3.4-IR suggests a role both in the control of transmitter release and in regulating neuronal excitability...
  10. ncbi request reprint Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, United Kingdom
    J Neurosci 21:6308-20. 2001
    ..These data show that activating A1Rs reduces fast excitatory, but not inhibitory, transmission onto SPNs and interneurons in the IML and that A1Rs may play a protective role on neurons involved in the control of sympathetic outflow...
  11. ncbi request reprint Properties of presynaptic P2X7-like receptors at the neuromuscular junction
    T S Moores
    School of Biomedical Sciences, Worsley Building, University of Leeds, LS2 9JT Leeds, UK
    Brain Res 1034:40-50. 2005
    ..We conclude that a P2X7-like receptor is present at mouse motor nerve terminals, and that their activation promotes vesicle release...
  12. ncbi request reprint Subcellular localization of neuronal nitric oxide synthase in the rat nucleus of the solitary tract in relation to vagal afferent inputs
    L Atkinson
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Neuroscience 118:115-22. 2003
    ..The lack of nNOS in vagal afferent terminals in the NTS, yet the presence in some vagal afferent cell bodies, suggests it is selectively targeted to specific regions of the same neurones...
  13. ncbi request reprint P2X(2) receptor immunoreactivity in the dorsal vagal complex and area postrema of the rat
    L Atkinson
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Neuroscience 99:683-96. 2000
    ....
  14. ncbi request reprint Differential co-localisation of the P2X7 receptor subunit with vesicular glutamate transporters VGLUT1 and VGLUT2 in rat CNS
    L Atkinson
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, UK
    Neuroscience 123:761-8. 2004
    ....
  15. ncbi request reprint Properties of interneurones in the intermediolateral cell column of the rat spinal cord: role of the potassium channel subunit Kv3.1
    S A Deuchars
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    Neuroscience 106:433-46. 2001
    ..These studies provide electrophysiological and morphological data on interneurones in the IML and indicate that the channels containing the Kv3.1 subunit are important in setting the firing pattern of these neurones...
  16. pmc Spontaneous rhythmogenic capabilities of sympathetic neuronal assemblies in the rat spinal cord slice
    M L Pierce
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Neuroscience 170:827-38. 2010
    ..This work questions the assumption that sympathetic rhythms are dependent on supraspinal pacemaker circuits, by highlighting a surprisingly strong rhythmogenic capability of the reduced sympathetic networks of the spinal cord slice...
  17. ncbi request reprint Voltage-gated potassium currents within the dorsal vagal nucleus: inhibition by BDS toxin
    Mark L Dallas
    School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Brain Res 1189:51-7. 2008
    ..Given the role of the Kv3 proteins in shaping neuronal excitability, these data highlight a role for homomeric Kv3.4 channels in spike timing and neurotransmitter release in low frequency firing neurons of the DVN...
  18. ncbi request reprint The neurochemically diverse intermedius nucleus of the medulla as a source of excitatory and inhibitory synaptic input to the nucleus tractus solitarii
    Ian J Edwards
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 27:8324-33. 2007
    ..These data provide a novel pathway that may underlie possible reflex changes in autonomic variables after neck muscle spindle afferent activation...
  19. ncbi request reprint Subdivision-specific responses of neurons in the nucleus of the tractus solitarius to activation of mu-opioid receptors in the rat
    Sarah L Poole
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Neurophysiol 98:3060-71. 2007
    ..These data demonstrate site specific responses of neurons to activation of MORs and KORs, which may underlie their ability to modulate different autonomic reflexes...
  20. ncbi request reprint HCN1 ion channel immunoreactivity in spinal cord and medulla oblongata
    Carol J Milligan
    Institute of Membrane and Systems Biology, University of Leeds, LS2 9JT, UK
    Brain Res 1081:79-91. 2006
    ..These data therefore described the first localization of the HCN1 subunit in the spinal cord and extend previous reports from the brainstem...
  21. ncbi request reprint Immunohistochemical localisation of the voltage gated potassium ion channel subunit Kv3.3 in the rat medulla oblongata and thoracic spinal cord
    Ruth E Brooke
    Institute of Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    Brain Res 1070:101-15. 2006
    ..This study provides evidence supporting a role for Kv3.3 subunits in regulating neuronal excitability and in the modulation of excitatory and inhibitory synaptic transmission in the medulla oblongata and spinal cord...
  22. ncbi request reprint Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord
    Ricardo J M Governo
    School of Biomedical Sciences, University of Leeds, UK
    Brain Res 1059:129-38. 2005
    ..The functional significance of ENT1 expression with regard to the homeostatic regulation of adenosine at synapses remains to be established...
  23. doi request reprint Role of olivary electrical coupling in cerebellar motor learning
    Ruben S Van Der Giessen
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Neuron 58:599-612. 2008
    ....
  24. pmc Distinct profiles of REST interactions with its target genes at different stages of neuronal development
    Yuh Man Sun
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Mol Biol Cell 16:5630-8. 2005
    ..These data indicate that the REST regulon is specific to each developmental stage and support the notion that REST plays distinct roles in regulating gene expression in pluripotent ES cells, multipotent NS cells, and mature neurons...
  25. ncbi request reprint Expression of connexin30.2 in interneurons of the central nervous system in the mouse
    Maria M Kreuzberg
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, 53117 Bonn, Germany
    Mol Cell Neurosci 37:119-34. 2008
    ..This suggests that the lack of Cx30.2 in interneurons can be largely compensated by other connexins, most likely Cx36...
  26. ncbi request reprint Transcription of the M1 muscarinic receptor gene in neurons and neuronal progenitors of the embryonic rat forebrain
    Brenda P Williams
    Department of Psychological Medicine, Section of Experimental Neuropathology and Psychiatry, Institute of Psychiatry, London, UK
    J Neurochem 88:70-7. 2004
    ....
  27. ncbi request reprint Angiotensin type 1 receptor immunoreactivity in the thoracic spinal cord
    Zai Ahmad
    School of Biomedical Sciences, The Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    Brain Res 985:21-31. 2003
    ..These data show that the AT1R in the spinal cord is ideally located to influence autonomic outflow and hence participate in the CNS determination of blood pressure...
  28. ncbi request reprint Spinal cord interneurones labelled transneuronally from the adrenal gland by a GFP-herpes virus construct contain the potassium channel subunit Kv3.1b
    Ruth E Brooke
    School of Biomedical Sciences, University of Leeds, UK
    Auton Neurosci 98:45-50. 2002
    ..In conjunction with our electrophysiological data, this highlights a role for the Kv3.1b subunit in shaping the activity of intemeurones involved in sympathetic control...
  29. ncbi request reprint Input-specific modulation of neurotransmitter release in the lateral horn of the spinal cord via adenosine receptors
    Ruth E Brooke
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 24:127-37. 2004
    ..Simultaneous activation of A1Rs and A2ARs therefore could facilitate inhibition of the postsynaptic neuron, leading to an overall reduction of sympathetic nervous activity...
  30. ncbi request reprint Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons
    Carol J Milligan
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 24:7241-50. 2004
    ..Taken together these separate lines of evidence suggest that the effects of GABA in central neurons can be mediated by heteromeric complexes of GABA(A) and GABA(C) receptor subunits...
  31. ncbi request reprint Electron microscopic localisation of P2X4 receptor subunit immunoreactivity to pre- and post-synaptic neuronal elements and glial processes in the dorsal vagal complex of the rat
    Fathia Ashour
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, UK
    Brain Res 1026:44-55. 2004
    ..The P2X(4)R is therefore expressed by neurones and glia in the dorsal vagal complex and may play a role in mediating extracellular signalling by ATP in this region...
  32. pmc Localization and function of the Kv3.1b subunit in the rat medulla oblongata: focus on the nucleus tractus solitarii
    Mark L Dallas
    School of Biomedical Sciences, Worsley Building, University of Leeds, Leeds LS2 9NQ, UK
    J Physiol 562:655-72. 2005
    ..Synaptic inputs evoked by stimulation of a region lacking Kv3.1b-IR neurones were not affected, correlating the presence of Kv3.1b in the TS with the pharmacological effects...
  33. ncbi request reprint Kv3 voltage-gated potassium channels regulate neurotransmitter release from mouse motor nerve terminals
    Ruth E Brooke
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, United Kingdom
    Eur J Neurosci 20:3313-21. 2004
    ..05-1 microM. The combined presynaptic localization of Kv3 subunits and pharmacological enhancement of EPP amplitude indicate that Kv3 channels regulate neurotransmitter release from presynaptic terminals at the NMJ...
  34. ncbi request reprint Ionotropic glutamate receptor subunit immunoreactivity of vagal preganglionic neurones projecting to the rat heart
    Eric K A Corbett
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, LS2 9JT, Leeds, UK
    Auton Neurosci 105:105-17. 2003
    ....
  35. ncbi request reprint GABAergic neurons in the central region of the spinal cord: a novel substrate for sympathetic inhibition
    Susan A Deuchars
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
    J Neurosci 25:1063-70. 2005
    ....
  36. ncbi request reprint Differential increases in P2X receptor levels in rat vagal efferent neurones following a vagal nerve section
    Lucy Atkinson
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
    Brain Res 977:112-8. 2003
    ..Thus the increase in P2XR levels in DVN cells ipsilateral to a nerve section are likely to reflect an increase in expression of functional P2XRs on the cell surface...
  37. ncbi request reprint An ATP-gated ion channel at the cell nucleus
    Lucy Atkinson
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, UK
    Nature 420:42. 2002
  38. ncbi request reprint Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus
    Beata Sperlagh
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    J Neurochem 81:1196-211. 2002
    ..In conclusion, P2X7 Rs are localized to the excitatory terminals in the hippocampus, and their activation regulates the release of glutamate and GABA from themselves and from their target cells...
  39. pmc Purinergic signalling in the medullary mechanisms of respiratory control in the rat: respiratory neurones express the P2X2 receptor subunit
    Alexander V Gourine
    Department of Physiology, Royal Free and University College London Medical School, Rowland Hill Street, London NW3 2PF, U K
    J Physiol 552:197-211. 2003
    ....
  40. ncbi request reprint Immunopharmacology--antibodies for specific modulation of proteins involved in neuronal function
    Mark Dallas
    School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK
    J Neurosci Methods 146:133-48. 2005
    ..Some suggestions for control experiments are made to help validate the method. We conclude that antibodies can be extremely valuable in determining the functions of specific proteins in living neurones in neuroscience research...
  41. ncbi request reprint An evaluation of antibody detection of the P2X1 receptor subunit in the CNS of wild type and P2X1-knockout mice
    Fathia Ashour
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Neurosci Lett 397:120-5. 2006
    ..Thus the P2X1 subunit antibodies cross-react with non-P2X1 receptor proteins in the CNS. Antibody specificity tests should therefore be conducted in the specific tissue to be examined and on KO tissue where available...
  42. doi request reprint A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells
    Kerstin Wellershaus
    Institute of Genetics, Division of Molecular Genetics, University of Bonn, Roemerstrasse 164, Bonn, Germany
    Exp Cell Res 314:997-1012. 2008
    ..Cell type specific deletion of Cx36 in the CNS by suitable Cre recombinases should also help to elucidate the functional role of Cx36 in different neuronal subtypes...