S W G Derbyshire

..In any case, current evidence does not support efforts to inform women of the potential for fetal pain. Any policy to mitigate fetal pain could expose women to inappropriate intervention, risk and distress...

..These findings provide convincing evidence that some people can readily experience both the emotional and sensory components of pain during observation of other's pain resulting in a shared physical pain experience...

..It is therefore a mistake to draw an equivalence between foetal pain and pain in the older infant or adult...

..These findings provide strong evidence that offset analgesia engages an endogenous inhibitory mechanism originating in the PAG/RVM region, which inhibits pain experience and activation of the pain neuromatrix...

..These findings extend beyond the general proposal of a neural network for pain by providing direct evidence that regions involved in pain experience are actively involved in the generation of fibromyalgia pain...

..It is possible that offset analgesia and attenuation are mediated by inter-related mechanisms. Further studies might investigate whether offset analgesia involves inhibitory structures such as the PAG-RVM...

..Capturing that process inside a brain scan is problematic. Resolving this problem requires an approach to imaging that transgress the boundaries of physical and social concepts...

..Future use of brain imaging to examine chronic visceral pain and other pain disorders will be more likely to succeed by describing clear theoretical and clinical endpoints...

..Subjects reported reduced fear but no change in pain. Consequently, the authors reevaluate the Motivational Priming Hypothesis and emphasize evolutionarily determined threat values...

..The findings emphasise the efficacy of the visual dot probe task as a method of priming and provide a possible method for probing hypervigilance in chronic pain patients...

..In conclusion, we have demonstrated that the reduced contact heat evoked potentials amplitude seen for fixed location stimulation can be improved with single-trial averaging...

..With these insights, new therapeutic interventions are being developed in the treatment of acute and chronic pain conditions...

..A recent exciting study extends this understanding to include the anterior cingulate as a center for endogenous opioid activation specific to negative pain affect...

..The MCC dichotomy suggests that two circuits differentially regulate the two cingulate motor areas, and involvement of aMCC in pain and fear make it selectively vulnerable to chronic pain and stress syndromes...

..The differences in reported activation during esophageal and lower GI sensation imply altered motor, autonomic, and affect response during distension at opposite ends of the GI tract that may be explored in future studies...

..The aim of this study was to determine possible sex-related differences in brain responses to a visceral and a psychological stressor in IBS...

..Future use of functional imaging to examine IBS and other functional disorders will be more likely to succeed by describing clear theoretical and clinical endpoints...

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..This study demonstrates that the location of the cingulate source of LEPs is highly consistent across subjects, when analysed in this way, and supports the involvement of caudal cingulate regions in pain processing...