M S Dennis

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke
    F N Doubal
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Neurology 74:1102-7. 2010
  2. pmc Temporal profile of body temperature in acute ischemic stroke: relation to stroke severity and outcome
    Bartosz Karaszewski
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    BMC Neurol 12:123. 2012
  3. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: statistical analysis plan
    Martin Dennis
    Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 14:66. 2013
  4. doi request reprint The effect of graduated compression stockings on long-term outcomes after stroke: the CLOTS trials 1 and 2
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    Stroke 44:1075-9. 2013
  5. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
  6. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: study protocol for a randomized controlled trial
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh Western General Hospital, Edinburgh EH4 2XU, UK
    Trials 13:26. 2012
  7. doi request reprint Determining the modified Rankin score after stroke by postal and telephone questionnaires
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH42XU, UK
    Stroke 43:851-3. 2012
  8. pmc Improving adherence to medication in stroke survivors (IAMSS): a randomised controlled trial: study protocol
    Ronan O'Carroll
    Department of Psychology, Stirling University, Stirling, UK
    BMC Neurol 10:15. 2010
  9. ncbi request reprint Senior physicians' estimates of the likely effects of feeding policies on outcomes prior to the completion of the FOOD trials
    Martin S Dennis
    Clinical Neurosciences, University of Edinburgh, Edinburgh, Scotland, UK
    Age Ageing 35:185-7. 2006
  10. doi request reprint The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials
    M Dennis
    Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 9:2193-200. 2011

Collaborators

Detail Information

Publications77

  1. pmc Fractal analysis of retinal vessels suggests that a distinct vasculopathy causes lacunar stroke
    F N Doubal
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Neurology 74:1102-7. 2010
    ..Altered retinal vessel fractal dimensions may act as a surrogate marker for diseased cerebral vessels. We used a cross-sectional study to investigate fractal properties of retinal vessels in lacunar stroke...
  2. pmc Temporal profile of body temperature in acute ischemic stroke: relation to stroke severity and outcome
    Bartosz Karaszewski
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    BMC Neurol 12:123. 2012
    ..Pyrexia after stroke (temperature ≥37.5°C) is associated with poor prognosis, but information on timing of body temperature changes and relationship to stroke severity and subtypes varies...
  3. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: statistical analysis plan
    Martin Dennis
    Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 14:66. 2013
    ..The CLOTS 3 trial aims to determine whether, compared with best medical care, best medical care plus intermittent pneumatic compression (IPC) in immobile stroke patients reduces the risk of proximal deep vein thrombosis (DVT)...
  4. doi request reprint The effect of graduated compression stockings on long-term outcomes after stroke: the CLOTS trials 1 and 2
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    Stroke 44:1075-9. 2013
    ..We aimed to estimate the effects of graduated compression stockings on venous thromboembolism events, survival, and functional status at 6 months after stroke...
  5. pmc Update on the third international stroke trial (IST-3) of thrombolysis for acute ischaemic stroke and baseline features of the 3035 patients recruited
    Peter Sandercock
    The IST 3 Co ordinating Centre, Neurosciences Trial Unit, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Trials 12:252. 2011
    ..IST-3 sought to improve the external validity and precision of the estimates of the overall treatment effects (efficacy and safety) of rtPA in acute ischaemic stroke, and to determine whether a wider range of patients might benefit...
  6. pmc Does intermittent pneumatic compression reduce the risk of post stroke deep vein thrombosis? The CLOTS 3 trial: study protocol for a randomized controlled trial
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh Western General Hospital, Edinburgh EH4 2XU, UK
    Trials 13:26. 2012
    ..The CLOTS trial 3 aims to determine whether, compared with best medical care, best medical care plus intermittent pneumatic compression in immobile stroke patients reduces the risk of proximal deep vein thrombosis...
  7. doi request reprint Determining the modified Rankin score after stroke by postal and telephone questionnaires
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH42XU, UK
    Stroke 43:851-3. 2012
    ..We tested 2 postal mRS questionnaires and a telephone questionnaire to determine completion rates and intermodality agreement...
  8. pmc Improving adherence to medication in stroke survivors (IAMSS): a randomised controlled trial: study protocol
    Ronan O'Carroll
    Department of Psychology, Stirling University, Stirling, UK
    BMC Neurol 10:15. 2010
    ..We now wish to pilot a brief intervention aimed at (a) helping patients establish a better medication-taking routine, and (b) eliciting and modifying any erroneous beliefs regarding their medication and their stroke...
  9. ncbi request reprint Senior physicians' estimates of the likely effects of feeding policies on outcomes prior to the completion of the FOOD trials
    Martin S Dennis
    Clinical Neurosciences, University of Edinburgh, Edinburgh, Scotland, UK
    Age Ageing 35:185-7. 2006
  10. doi request reprint The timing, extent, progression and regression of deep vein thrombosis in immobile stroke patients: observational data from the CLOTS multicenter randomized trials
    M Dennis
    Division of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 9:2193-200. 2011
    ..Deep vein thrombosis (DVT) is an important complication of stroke, but the evidence to support commonly used prophylactic strategies is conflicting...
  11. ncbi request reprint Routine oral nutritional supplementation for stroke patients in hospital (FOOD): a multicentre randomised controlled trial
    M S Dennis
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 365:755-63. 2005
    ..Undernutrition is common in hospital patients with stroke, can develop or worsen in hospital, and is associated with poor outcomes. We aimed to establish whether routine oral nutritional supplements improve outcome after stroke...
  12. ncbi request reprint Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial
    M S Dennis
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 365:764-72. 2005
    ..Undernutrition is common in patients admitted with stroke. We aimed to establish whether the timing and route of enteral tube feeding after stroke affected patients' outcomes at 6 months...
  13. doi request reprint Can clinical features distinguish between immobile patients with stroke at high and low risk of deep vein thrombosis? Statistical modelling based on the CLOTS trials cohorts
    Martin Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 82:1067-73. 2011
    ..Guidelines recommend that DVT prophylaxis should be guided by an assessment of the individual patient's risk. The authors aimed to develop and test models to predict DVT risk...
  14. pmc Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial
    M Dennis
    Division of Clinical Neurosciences, University of Edinburgh, Bramwell Dott Building, Western General Hospital, Edinburgh EH4 2XU, UK
    Lancet 373:1958-65. 2009
    ..National stroke guidelines extrapolating from these trials recommend their use in patients with stroke despite insufficient evidence. We assessed the effectiveness of thigh-length GCS to reduce DVT after stroke...
  15. ncbi request reprint MR diffusion-weighted imaging and outcome prediction after ischemic stroke
    P J Hand
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK
    Neurology 66:1159-63. 2006
    ..MR diffusion-weighted imaging (DWI) shows acute ischemic lesions early after stroke so it might improve outcome prediction and reduce sample sizes in stroke treatment trials. Previous studies of DWI and outcome produced conflicting results...
  16. ncbi request reprint Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Scotland
    Stroke 29:1618-24. 1998
    ....
  17. ncbi request reprint Is visible infarction on computed tomography associated with an adverse prognosis in acute ischemic stroke?
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital NHS Trust, Edinburgh, Scotland, UK
    Stroke 29:1315-9. 1998
    ..We examined whether visible infarction was associated with a poor outcome after stroke using univariate and multivariate analyses, including easily identifiable clinical baseline variables, and adjusting for time from stroke onset to CT...
  18. doi request reprint Brain choline concentration. Early quantitative marker of ischemia and infarct expansion?
    B Karaszewski
    SFC Brain Imaging Research Centre, SINAPSE Collaboration, Division of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK
    Neurology 75:850-6. 2010
    ....
  19. ncbi request reprint Does feeding alter arterial oxygen saturation in patients with acute stroke?
    A M Rowat
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, UK
    Stroke 31:2134-40. 2000
    ..We measured arterial oxygen saturation (SaO(2)) during eating in acute stroke patients to establish the frequency of any meal-related hypoxemia, which could further damage already vulnerable brain tissue...
  20. ncbi request reprint The influence of randomized trials on the use of anticoagulants for atrial fibrillation
    G E Mead
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Age Ageing 28:441-6. 1999
    ..We therefore investigated their use in patients known to be in AF before a stroke, transient ischaemic attack (either cerebral or ocular) or retinal artery occlusion to assess the influence of trials on clinical practice...
  21. ncbi request reprint Relationship between pattern of intracranial artery abnormalities on transcranial doppler and Oxfordshire Community Stroke Project clinical classification of ischemic stroke
    G E Mead
    Neurosciences Trials Unit, Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Stroke 31:714-9. 2000
    ..We investigated whether the pattern of intracranial vascular abnormalities is related to the clinical syndrome...
  22. ncbi request reprint Towards a national system for monitoring the quality of hospital-based stroke services
    N Weir
    Department of Clinical Neurosciences, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, Scotland
    Stroke 32:1415-21. 2001
    ..More moderate, but still clinically important, variations in stroke care can only be identified by monitoring the process of care directly...
  23. pmc Should computed tomography appearance of lacunar stroke influence patient management?
    G E Mead
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 67:682-4. 1999
    ..Brain imaging should modify the clinical classification and influence patient investigation...
  24. ncbi request reprint What is the best imaging strategy for acute stroke?
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital University of Edinburgh, Edinburgh, UK
    Health Technol Assess 8:iii, ix-x, 1-180. 2004
    ....
  25. ncbi request reprint Do acute diffusion- and perfusion-weighted MRI lesions identify final infarct volume in ischemic stroke?
    C S Rivers
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, EH4 2XU, UK
    Stroke 37:98-104. 2006
    ..quot; It is unclear which "semiquantitative" perfusion parameter most closely identifies final infarct volume...
  26. ncbi request reprint The influence of food ingestion on blood pressure in stroke patients
    A M Rowat
    Department of Clinical Neurosciences, Universtiy of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 12:152-8. 2001
    ....
  27. pmc The impact of delays in computed tomography of the brain on the accuracy of diagnosis and subsequent management in patients with minor stroke
    J M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:77-81. 2003
    ..To determine the proportion of haemorrhagic strokes misdiagnosed as infarcts on computed tomography (CT) in patients with mild stroke, and the implications for health care...
  28. ncbi request reprint Imaging appearance of the symptomatic perforating artery in patients with lacunar infarction: occlusion or other vascular pathology?
    J M Wardlaw
    Department of Clinical Neurosciences, The University of Edinburgh, Western General Hospital, United Kingdom
    Ann Neurol 50:208-15. 2001
    ..We describe the patients' clinical and imaging features, and discuss alternative explanations for the imaging appearance and the implications for gaining insights into the cause of lacunar infarction...
  29. ncbi request reprint Patient positioning influences oxygen saturation in the acute phase of stroke
    A M Rowat
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 12:66-72. 2001
    ..These results may have implications for current practice and for future patient positioning strategies to improve outcome after stroke...
  30. doi request reprint Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke
    Vera Cvoro
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, UK
    Stroke 40:767-72. 2009
    ..We used spectroscopic imaging to measure N-acetyl aspartate (NAA, a marker of normal neurons) and lactate (a marker of ischemia) to compare with diffusion and perfusion values in the diffusion lesion in acute ischemic stroke...
  31. ncbi request reprint Negative attitudes among short-term stroke survivors predict worse long-term survival
    S C Lewis
    Department of Clinical Neurosciences, University of Edinburgh, Scotland
    Stroke 32:1640-5. 2001
    ..These findings need to be confirmed and any causal relationship between attitude and survival further explored in a randomized controlled trial to "improve" the attitude of stroke patients toward their illness...
  32. ncbi request reprint Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?
    J M Wardlaw
    Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Stroke 34:806-12. 2003
    ..The pathogenesis of and relationship between small deep (lacunar) infarcts, cerebral white matter disease (leukoaraiosis or white matter hyperintensities), and progressive cognitive impairment or dementia are much debated...
  33. ncbi request reprint A formal overview of stroke unit trials
    P Langhorne
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, Scotland
    Rev Neurol 23:394-8. 1995
    ..Stroke patients managed within specialist units are more likely to be alive and living at home a year after the stroke than those managed in general wards. Stroke unit care does not apparently increase the time spent in hospital...
  34. pmc No evidence that severity of stroke in internal carotid occlusion is related to collateral arteries
    G E Mead
    Division of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 77:729-33. 2006
    ....
  35. pmc Magnetic resonance brain imaging in patients with acute stroke: feasibility and patient related difficulties
    P J Hand
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 76:1525-7. 2005
    ..To assess organisational and patient specific limitations and safety of magnetic resonance imaging (MRI) as the first line investigation for hospital admitted stroke patients...
  36. pmc Reliability of the variables in a new set of models that predict outcome after stroke
    N U Weir
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:447-51. 2003
    ..The authors have recently reported a set of simple but rigorously developed models that predict outcome after stroke. The aim of this study was to establish the inter-rater reliability of the variables included in the models...
  37. doi request reprint MR diffusion and perfusion parameters: relationship to metabolites in acute ischaemic stroke
    Vera Cvoro
    SFC Brain Imaging Research Centre, SINAPSE Collaboration, Division of Clinical Neuroscience, Western General Hospital, Crewe Rd, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 81:185-91. 2010
    ..The authors compared N-acetyl aspartate (NAA, found in intact neurons) and lactate (anaerobic metabolism) with diffusion/perfusion parameters...
  38. ncbi request reprint Relationship between absolute mean cerebral transit time and absolute mean flow velocity on transcranial Doppler ultrasound after ischemic stroke
    Joanna M Wardlaw
    Department of Clinical Neurosciences, Western General Hospital, University of Edinburgh, Edinburgh, EH4 2XU, United Kingdom
    J Neuroimaging 12:104-11. 2002
    ..However, a simple measure of absolute mean flow velocity might provide a direct assessment of "perfusion reserve" in acute ischemic stroke...
  39. ncbi request reprint Extensive haemorrhagic transformation of infarct: might it be an important cause of primary intracerebral haemorrhage?
    Gillian E Mead
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Age Ageing 31:429-33. 2002
    ....
  40. pmc Research governance impediments to clinical trials: a retrospective survey
    Rustam Al-Shahi Salman
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    J R Soc Med 100:101-4. 2007
    ..We sought to evaluate the delays, between-centre variations in practice, and opportunity costs attributable to delays in research governance approval of clinical trials in the United Kingdom...
  41. doi request reprint Counting cavitating lacunes underestimates the burden of lacunar infarction
    Gillian M Potter
    Division of Clinical Neurosciences and SINAPSE Collaboration, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom
    Stroke 41:267-72. 2010
    ..The proportion of symptomatic lacunar infarcts that progress to lacunes is unknown. Noncavitating lacunar infarcts may continue to resemble white matter lesions...
  42. pmc Retinopathy in ischemic stroke subtypes
    Fergus N Doubal
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 40:389-93. 2009
    ..We hypothesized that there would be higher rates of retinopathy in patients with acute lacunar versus cortical stroke...
  43. ncbi request reprint Outcome after brain haemorrhage
    Martin S Dennis
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 16:9-13. 2003
    ..Pooling of data from community-based studies of haemorrhagic stroke that have used consistent definitions and methods represents the only feasible way to obtain more precise data on prognosis after intracerebral haemorrhage...
  44. doi request reprint Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease
    Fergus N Doubal
    MRCP, Division of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Stroke 41:450-4. 2010
    ..We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensities, markers of established small vessel disease. Materials and..
  45. doi request reprint Differences between ischemic stroke subtypes in vascular outcomes support a distinct lacunar ischemic stroke arteriopathy: a prospective, hospital-based study
    Caroline A Jackson
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU
    Stroke 40:3679-84. 2009
    ..Different risks of recurrent stroke and MI after lacunar versus nonlacunar ischemic stroke may support a distinct lacunar arteriopathy...
  46. pmc Retinal arteriolar geometry is associated with cerebral white matter hyperintensities on magnetic resonance imaging
    Fergus N Doubal
    Division of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Int J Stroke 5:434-9. 2010
    ..Retinal vessels show developmental and pathophysiological similarities to cerebral small vessels and microvessel geometry may influence vascular efficiency...
  47. ncbi request reprint Cerebral microbleeds are associated with lacunar stroke defined clinically and radiologically, independently of white matter lesions
    Joanna M Wardlaw
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH4 2EX, UK
    Stroke 37:2633-6. 2006
    ..An association between microbleeds and clinically defined lacunar stroke might suggest a common causal microangiopathy...
  48. ncbi request reprint Effective prophylaxis for deep vein thrombosis after stroke: low-dose anticoagulation rather than stockings alone: against
    Martin S Dennis
    Neuroscience Trials Unit, University of Edinburgh, Bramwell Dott Building, Western General Hospitals NHS Trust, Crewe Road, Edinburgh, UK
    Stroke 35:2912-3. 2004
  49. pmc Personality change after stroke: some preliminary observations
    J Stone
    Division of Clinical Neurosciences, School of Molecular and Clinical Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 75:1708-13. 2004
    ..To describe changes in personality after stroke and effects on carers...
  50. ncbi request reprint Correlates of informant-rated cognitive decline after stroke
    J M Starr
    Department of Geriatric Medicine, University of Edinburgh, UK
    Cerebrovasc Dis 10:214-20. 2000
    ..60, p = 0.001) and with a general cognitive factor extracted from the mental ability test scores (r = -0.42, p = 0.016). We conclude that informant-rated methods offer a promising approach to measuring cognitive decline after stroke...
  51. ncbi request reprint Recently occluded intracranial and extracranial carotid arteries. Relevance of the unstable atherosclerotic plaque
    G A Lammie
    Department of Pathology, Edinburgh University, Edinburgh, Scotland
    Stroke 30:1319-25. 1999
    ..We therefore describe the clinical and pathological features of recent, symptomatic internal carotid artery occlusion to examine the pathogenetic role of plaque instability at both extracranial and intracranial sites...
  52. ncbi request reprint Performance of a statistical model to predict stroke outcome in the context of a large, simple, randomized, controlled trial of feeding
    C Counsel
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh EH4 2XU, Scotland
    Stroke 34:127-33. 2003
    ..We sought to test the external validity of some recently described models in patients enrolled in the FOOD (Feed Or Ordinary Diet) trial: a large randomized trial evaluating feeding policies in patients with stroke...
  53. pmc Are multiple acute small subcortical infarctions caused by embolic mechanisms?
    D Chowdhury
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    J Neurol Neurosurg Psychiatry 75:1416-20. 2004
    ..To seek evidence of potential embolic sources or other stroke mechanisms in patients who, on chance observation, had several apparently recent small subcortical infarcts on diffusion weighted magnetic resonance imaging (DWI)...
  54. ncbi request reprint Meeting the challenge of stroke
    N U Weir
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    Scott Med J 42:145-7. 1997
    ..In contrast, the high hopes raised by many "high-tech" solutions have largely been dashed or remain promising but unproven...
  55. ncbi request reprint In which patients is diffusion-weighted magnetic resonance imaging most useful in routine stroke care?
    S L Keir
    Division of Clinical Neurosciences, Western General Hospital NHS Trust, Edinburgh, United Kingdom
    J Neuroimaging 14:118-22. 2004
    ....
  56. ncbi request reprint Persistent infarct hyperintensity on diffusion-weighted imaging late after stroke indicates heterogeneous, delayed, infarct evolution
    Carly S Rivers
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 37:1418-23. 2006
    ..We hypothesized that late DWI hyperintensity reflected different infarct evolution compared with areas that were isointense by 1 month...
  57. doi request reprint Differing risk factor profiles of ischemic stroke subtypes: evidence for a distinct lacunar arteriopathy?
    Caroline A Jackson
    Division of Clinical Neurosciences, University of Edinburgh, United Kingdom
    Stroke 41:624-9. 2010
    ..We overcame these by pooling individual data on 2875 patients with first-ever ischemic stroke from 5 collaborating prospective stroke registers that used similar, unbiased methods to define risk factors and classify stroke subtypes...
  58. ncbi request reprint Fractures after stroke: frequency, types, and associations
    M S Dennis
    Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK
    Stroke 33:728-34. 2002
    ..Stroke patients may have an increased risk of fractures because of weak bones or an increased risk of falling. Our goal was to estimate the frequency of fracture after stroke and to identify those at greatest risk...
  59. ncbi request reprint Parental causes of death in primary intracerebral haemorrhage
    J M Starr
    Geriatric Medicine Unit, Edinburgh University, Edinburgh, UK
    Cerebrovasc Dis 12:313-7. 2001
    ..40-1.40). Other forms of vascular disease in parents were not associated with significant risk either (OR 0.93, 95% CI 0.51-1.68). We conclude that familial factors do not contribute substantially to risk in most cases of PICH...
  60. ncbi request reprint Severe ipsilateral carotid stenosis and middle cerebral artery disease in lacunar ischaemic stroke: innocent bystanders?
    G E Mead
    Department of Clinical Neurosciences, Western General Hospital, Edinburgh
    J Neurol 249:266-71. 2002
    ..Therefore, our aim was to compare the severity of ipsilateral with contralateral ICA and MCA disease in patients with lacunar ischaemic stroke...
  61. doi request reprint Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke
    Bartosz Karaszewski
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Crewe Rd, Edinburgh, EH4 2XU, UK
    Brain 132:955-64. 2009
    ..Further studies are required to determine why early brain temperature elevation is highest in potential penumbral tissue...
  62. pmc Abnormal breathing patterns in stroke: relationship with location of acute stroke lesion and prior cerebrovascular disease
    Anne M Rowat
    School of Nursing, Midwifery and Social Care, Napier University, Canaan Lane Campus, Edinburgh EH9 2TB, Scotland, UK
    J Neurol Neurosurg Psychiatry 78:277-9. 2007
    ..To determine whether central periodic breathing (CPB) is associated with acute involvement of any particular part of the brain, or the extent of total damage in patients with acute stroke...
  63. pmc Differences in retinal vessels support a distinct vasculopathy causing lacunar stroke
    F N Doubal
    Western General Hospital, Edinburgh, UK
    Neurology 72:1773-8. 2009
    ..We compared retinal microvessel appearance as a surrogate for cerebral small vessels in patients with lacunar and large artery cortical ischemic stroke...
  64. ncbi request reprint Central periodic breathing observed on hospital admission is associated with an adverse prognosis in conscious acute stroke patients
    Anne M Rowat
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Cerebrovasc Dis 21:340-7. 2006
    ..Central periodic breathing (CPB) is common following acute stroke, but its prognostic significance is uncertain. We determined the frequency of CPB on admission with stroke and assessed whether it was related to outcome...
  65. ncbi request reprint Sleep-disordered breathing as a risk factor for cerebrovascular disease: a case-control study in patients with transient ischemic attacks
    Nigel McArdle
    Department of Medicine, University of Edinburgh, Royal Infirmary, Edinburgh, UK
    Stroke 34:2916-21. 2003
    ..We explored this relationship in transient ischemic attack (TIA) patients because they are less likely than stroke patients to have OSAH as a consequence of cerebrovascular disease...
  66. ncbi request reprint Interobserver agreement for the bedside clinical assessment of suspected stroke
    Peter J Hand
    Division of Clinical Neurosciences, Western General Hospital, Edinburgh, UK
    Stroke 37:776-80. 2006
    ..We aimed to measure inter-rater reliability for the clinical assessment of stroke, with emphasis on items of history, timing of symptom onset, and diagnosis of stroke or mimic. We explored reasons for poor reliability...
  67. ncbi request reprint Study of the relationship between social deprivation and outcome after stroke
    Nicolas U Weir
    Department of Clinical Neurosciences, Western General Hospital, Crewe Road, Edinburgh, Scotland
    Stroke 36:815-9. 2005
    ..This study has investigated the relationship between SES and case fatality, "death or dependency," and "death or institutional care" at 6 months after stroke...
  68. ncbi request reprint Comparison of risk factors in patients with transient and prolonged eye and brain ischemic syndromes
    Gillian E Mead
    Department of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland
    Stroke 33:2383-90. 2002
    ....
  69. doi request reprint Two cases of recurrent stroke in treated giant cell arteritis: diagnostic and therapeutic dilemmas
    Alasdair J Fitzgerald
    Department of Rehabilitation Medicine, Astley Ainslie Hospital, Edinburgh, Scotland
    J Clin Rheumatol 16:225-8. 2010
    ..There is a need to develop effective means of monitoring GCA activity and to determine the most effective treatment approach in this circumstance...
  70. ncbi request reprint Hypoxaemia in acute stroke is frequent and worsens outcome
    Anne M Rowat
    Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK
    Cerebrovasc Dis 21:166-72. 2006
    ..Hypoxaemia in the acute phase of stroke might damage the ischaemic penumbra and worsen clinical outcome. We determined the frequency of hypoxaemia on admission with stroke and assessed whether it was related to outcome...
  71. doi request reprint Changes in background blood-brain barrier integrity between lacunar and cortical ischemic stroke subtypes
    Joanna M Wardlaw
    Stroke 39:1327-32. 2008
    ..Endothelial dysfunction could impair blood-brain barrier integrity. We assessed background blood-brain barrier leakage in patients with lacunar ischemic stroke compared with cortical stroke controls...
  72. ncbi request reprint Measurement of brain temperature with magnetic resonance spectroscopy in acute ischemic stroke
    Bartosz Karaszewski
    Department of Neurology of Adults, Medical University of Gdansk, Gdansk, Poland
    Ann Neurol 60:438-46. 2006
    ..We used magnetic resonance spectroscopic imaging (water-to-N-acetylaspartate frequency shift) to measure cerebral temperature noninvasively in stroke patients...
  73. ncbi request reprint Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092)
    Nikola Sprigg
    Institute of Neuroscience, University of Nottingham, Nottingham, UK
    Stroke 37:2979-83. 2006
    ..We assessed the safety of granulocyte-colony-stimulating factor (G-CSF) after stroke and its effect on circulating CD34+ stem cells...
  74. ncbi request reprint Predicting outcome in hyper-acute stroke: validation of a prognostic model in the Third International Stroke Trial (IST3)
    Steff C Lewis
    J Neurol Neurosurg Psychiatry 79:397-400. 2008
    ..The explanatory variables in the model are age, living alone, independent pre-stroke, Glasgow Coma Scale verbal score, ability to lift arms and ability to walk...
  75. ncbi request reprint Acute ischemic stroke lesion measurement on diffusion-weighted imaging--important considerations in designing acute stroke trials with magnetic resonance imaging
    Carly S Rivers
    Clinical Trials Research Unit, University of Leeds, Leeds, United Kingdom
    J Stroke Cerebrovasc Dis 16:64-70. 2007
    ..Little is known of what factors might affect DWI lesion size measurement. We examined morphologic factors that might affect DWI lesion measurement...
  76. ncbi request reprint The impact of neuroimaging on clinical decisions in minor stroke
    Sarah L Keir
    Age Ageing 33:312-4. 2004
  77. ncbi request reprint Distinguishing between stroke and mimic at the bedside: the brain attack study
    Peter J Hand
    Stroke Centre, Department of Neurology, Royal Melbourne Hospital, Monash University, Victoria, Australia
    Stroke 37:769-75. 2006
    ..We aimed to determine the frequency and nature of stroke mimics and to identify the key clinical features that distinguish between stroke and mimic at the bedside...