Mirela Delibegovic

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi request reprint Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance
    Mirela Delibegovic
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Diabetes 52:596-604. 2003
  2. pmc Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
    Nigel Hoggard
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Int J Gen Med 5:403-11. 2012
  3. pmc Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
    Mirela Delibegovic
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7727-34. 2007
  4. pmc Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
    Mirela Delibegovic
    Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:590-9. 2009
  5. pmc Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress
    Abdelali Agouni
    Institute of Biological and Environmental Sciences, College of Life Sciences and Medicine, University of Aberdeen, UK
    Biochem J 438:369-78. 2011
  6. doi request reprint Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism
    Louise Grant
    Institute of Medical Sciences, University of Aberdeen, College of Life Sciences and Medicine, Foresterhill Health Campus, Aberdeen, United Kingdom
    Diabetes 63:456-70. 2014
  7. pmc Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus
    George D McIlroy
    University of Aberdeen, College of Life Sciences and Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
    Diabetes 62:825-36. 2013
  8. doi request reprint In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues
    Abdelali Agouni
    IBES, College of Life Sciences and Medicine, Integrative Physiology, University of Aberdeen, Aberdeen AB242TZ, UK
    Biochem Biophys Res Commun 401:104-11. 2010
  9. pmc Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
    Carl Owen
    Integrative Physiology, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 7:e32700. 2012
  10. pmc Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
    Bingzhong Xue
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:4563-73. 2009

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance
    Mirela Delibegovic
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Diabetes 52:596-604. 2003
    ..Our results suggest that dysfunction of PP1-G(M) may contribute to the pathophysiology of human type 2 diabetes...
  2. pmc Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes
    Nigel Hoggard
    Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, UK
    Int J Gen Med 5:403-11. 2012
    ..In this study we investigated if serum and/or adipose tissue RBP4 protein levels and expression levels of PTP1B and other ER stress-response genes are altered in obese and obese/diabetic men resident in northeast Scotland...
  3. pmc Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
    Mirela Delibegovic
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7727-34. 2007
    ..Therefore, combining PTP1B inhibition with thiazolidinediones should be more effective than either alone for treating insulin-resistant states...
  4. pmc Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
    Mirela Delibegovic
    Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:590-9. 2009
    ..Here we studied the role of liver PTP1B in glucose homeostasis and lipid metabolism...
  5. pmc Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B improves obesity- and pharmacologically induced endoplasmic reticulum stress
    Abdelali Agouni
    Institute of Biological and Environmental Sciences, College of Life Sciences and Medicine, University of Aberdeen, UK
    Biochem J 438:369-78. 2011
    ....
  6. doi request reprint Myeloid-cell protein tyrosine phosphatase-1B deficiency in mice protects against high-fat diet and lipopolysaccharide-induced inflammation, hyperinsulinemia, and endotoxemia through an IL-10 STAT3-dependent mechanism
    Louise Grant
    Institute of Medical Sciences, University of Aberdeen, College of Life Sciences and Medicine, Foresterhill Health Campus, Aberdeen, United Kingdom
    Diabetes 63:456-70. 2014
    ..Our studies implicate myeloid PTP1B in negative regulation of STAT3/IL-10-mediated signaling, highlighting its inhibition as a potential anti-inflammatory and antidiabetic target in obesity. ..
  7. pmc Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus
    George D McIlroy
    University of Aberdeen, College of Life Sciences and Medicine, Institute of Medical Sciences, Foresterhill, Aberdeen, United Kingdom
    Diabetes 62:825-36. 2013
    ..We show that FEN-mediated beneficial effects are through alterations in retinoid homeostasis genes, and these are strong candidates as therapeutic targets for the treatment of obesity and insulin resistance...
  8. doi request reprint In vivo differential effects of fasting, re-feeding, insulin and insulin stimulation time course on insulin signaling pathway components in peripheral tissues
    Abdelali Agouni
    IBES, College of Life Sciences and Medicine, Integrative Physiology, University of Aberdeen, Aberdeen AB242TZ, UK
    Biochem Biophys Res Commun 401:104-11. 2010
    ....
  9. pmc Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
    Carl Owen
    Integrative Physiology, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 7:e32700. 2012
    ..Moreover, PTP1B does not appear to be the major negative regulator of the IR in adipocytes...
  10. pmc Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
    Bingzhong Xue
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:4563-73. 2009
    ..Therefore, the mechanism by which PTP1B regulates adiposity and leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues...
  11. ncbi request reprint Neuronal PTP1B regulates body weight, adiposity and leptin action
    Kendra K Bence
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:917-24. 2006
    ..Thus, PTP1B regulates body mass and adiposity primarily through actions in the brain. Furthermore, neuronal PTP1B regulates adipocyte leptin production and probably is essential for the development of leptin resistance...
  12. ncbi request reprint Assay of protein phosphatase 1 complexes
    Patricia T Cohen
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Methods Enzymol 366:135-44. 2003