Mirela Delibegovic

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. ncbi Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance
    Mirela Delibegovic
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Diabetes 52:596-604. 2003
  2. ncbi Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
    Mirela Delibegovic
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7727-34. 2007
  3. ncbi Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
    Mirela Delibegovic
    Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:590-9. 2009
  4. ncbi Neuronal PTP1B regulates body weight, adiposity and leptin action
    Kendra K Bence
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:917-24. 2006
  5. ncbi Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
    Bingzhong Xue
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:4563-73. 2009
  6. ncbi Assay of protein phosphatase 1 complexes
    Patricia T Cohen
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Methods Enzymol 366:135-44. 2003

Collaborators

Detail Information

Publications6

  1. ncbi Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance
    Mirela Delibegovic
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Diabetes 52:596-604. 2003
    ..Our results suggest that dysfunction of PP1-G(M) may contribute to the pathophysiology of human type 2 diabetes...
  2. ncbi Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B
    Mirela Delibegovic
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7727-34. 2007
    ..Therefore, combining PTP1B inhibition with thiazolidinediones should be more effective than either alone for treating insulin-resistant states...
  3. ncbi Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress
    Mirela Delibegovic
    Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:590-9. 2009
    ..Here we studied the role of liver PTP1B in glucose homeostasis and lipid metabolism...
  4. ncbi Neuronal PTP1B regulates body weight, adiposity and leptin action
    Kendra K Bence
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:917-24. 2006
    ..Thus, PTP1B regulates body mass and adiposity primarily through actions in the brain. Furthermore, neuronal PTP1B regulates adipocyte leptin production and probably is essential for the development of leptin resistance...
  5. ncbi Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues
    Bingzhong Xue
    Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 29:4563-73. 2009
    ..Therefore, the mechanism by which PTP1B regulates adiposity and leptin sensitivity likely involves the coordinated regulation of AMPK in hypothalamus and peripheral tissues...
  6. ncbi Assay of protein phosphatase 1 complexes
    Patricia T Cohen
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Methods Enzymol 366:135-44. 2003