I J Deary

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Intelligence
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK Electronic address
    Curr Biol 23:R673-6. 2013
  2. doi request reprint Looking for 'system integrity' in cognitive epidemiology
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Gerontology 58:545-53. 2012
  3. doi request reprint Cohort profile: the Lothian Birth Cohorts of 1921 and 1936
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Int J Epidemiol 41:1576-84. 2012
  4. pmc Profiles of physical, emotional and psychosocial wellbeing in the Lothian birth cohort 1936
    Andrea R Zammit
    Department of Psychology, Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, Scotland, UK
    BMC Geriatr 12:64. 2012
  5. doi request reprint Personality traits and inflammation in men and women in their early 70s: the Lothian Birth Cohort 1936 study of healthy aging
    René Mõttus
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK
    Psychosom Med 75:11-9. 2013
  6. ncbi request reprint 125 years of intelligence in the American Journal of Psychology
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Scotland, UK
    Am J Psychol 125:145-54. 2012
  7. doi request reprint Predicting mortality from human faces
    Dominika Dykiert
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Psychosom Med 74:560-6. 2012
  8. doi request reprint Genetic contributions to stability and change in intelligence from childhood to old age
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Nature 482:212-5. 2012
  9. pmc All-cause mortality in the Aberdeen 1921 birth cohort: effects of socio-demographic, physical and cognitive factors
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    BMC Public Health 8:307. 2008
  10. pmc Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability
    Blair H Smith
    University of Aberdeen, Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen, UK
    BMC Med Genet 7:74. 2006

Detail Information

Publications172 found, 100 shown here

  1. doi request reprint Intelligence
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK Electronic address
    Curr Biol 23:R673-6. 2013
    ....
  2. doi request reprint Looking for 'system integrity' in cognitive epidemiology
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Gerontology 58:545-53. 2012
    ..This field of research is known as cognitive epidemiology. The causes of these associations are not understood...
  3. doi request reprint Cohort profile: the Lothian Birth Cohorts of 1921 and 1936
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, UK
    Int J Epidemiol 41:1576-84. 2012
    ..The LBC1936 participants also have a detailed structural magnetic resonance imaging (MRI) brain scan. A range of scientific findings is described, to illustrate the possible uses of the cohorts...
  4. pmc Profiles of physical, emotional and psychosocial wellbeing in the Lothian birth cohort 1936
    Andrea R Zammit
    Department of Psychology, Centre for Cognitive Aging and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, Scotland, UK
    BMC Geriatr 12:64. 2012
    ....
  5. doi request reprint Personality traits and inflammation in men and women in their early 70s: the Lothian Birth Cohort 1936 study of healthy aging
    René Mõttus
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK
    Psychosom Med 75:11-9. 2013
    ..Findings, however, have been inconsistent. This study investigates these associations in individuals who ranged in age from approximately 70 to 73 years...
  6. ncbi request reprint 125 years of intelligence in the American Journal of Psychology
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Scotland, UK
    Am J Psychol 125:145-54. 2012
    ..There are periods of time--especially the 1970s--during which almost no articles appeared on intelligence. The key articles and themes on intelligence differences are discussed in detail...
  7. doi request reprint Predicting mortality from human faces
    Dominika Dykiert
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Psychosom Med 74:560-6. 2012
    ..To investigate whether and to what extent mortality is predictable from facial photographs of older people...
  8. doi request reprint Genetic contributions to stability and change in intelligence from childhood to old age
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Nature 482:212-5. 2012
    ..62. These estimates, derived from rarely available data on lifetime cognitive measures, warrant the search for genetic causes of cognitive stability and change...
  9. pmc All-cause mortality in the Aberdeen 1921 birth cohort: effects of socio-demographic, physical and cognitive factors
    John M Starr
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    BMC Public Health 8:307. 2008
    ..Childhood intelligence predicts mortality throughout most of the life span. However, it is unknown whether its effect persists into advanced old age...
  10. pmc Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability
    Blair H Smith
    University of Aberdeen, Department of General Practice and Primary Care, Foresterhill Health Centre, Westburn Road, Aberdeen, UK
    BMC Med Genet 7:74. 2006
    ....
  11. pmc Maximum (prior) brain size, not atrophy, correlates with cognition in community-dwelling older people: a cross-sectional neuroimaging study
    Susan D Shenkin
    Geriatric Medicine, Division of Clinical and Surgical Sciences, University of Edinburgh, Edinburgh, UK
    BMC Geriatr 9:12. 2009
    ..However, an association between brain size and intelligence may be due to the persistence of this relationship from earlier life...
  12. pmc A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition
    Sarah E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    BMC Genet 8:43. 2007
    ..Non-pathological cognitive ageing is a distressing condition affecting an increasing number of people in our 'ageing society'. Oxidative stress is hypothesised to have a major role in cellular ageing, including brain ageing...
  13. doi request reprint Genetic foundations of human intelligence
    Ian J Deary
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Hum Genet 126:215-32. 2009
    ..Here, we describe the human intelligence phenotype, summarise the evidence for its heritability, provide an overview of and comment on molecular genetic studies, and comment on future progress in the field...
  14. doi request reprint Are processing speed tasks biomarkers of cognitive aging?
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, United Kingdom
    Psychol Aging 25:219-28. 2010
    ..Inspection time, the marker that was least dependent on childhood intelligence, should be considered further as one biomarker of cognitive aging...
  15. ncbi request reprint Searching for genetic influences on normal cognitive ageing
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Trends Cogn Sci 8:178-84. 2004
    ..However, current progress in genetic knowledge, technology and informatics will contribute to progress in this important area...
  16. ncbi request reprint Sensory discrimination and intelligence: testing Spearman's other hypothesis
    Ian J Deary
    Department of Psychology, University of Edinburgh, Scotland
    Am J Psychol 117:1-18. 2004
    ..68 in men and women. One hundred years after its conception, Spearman's other hypothesis achieves some confirmation. The association between general intelligence and general sensory ability remains to be replicated and explained...
  17. doi request reprint Age-associated cognitive decline
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK
    Br Med Bull 92:135-52. 2009
    ..The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences...
  18. doi request reprint The neuroscience of human intelligence differences
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, Scotland, UK
    Nat Rev Neurosci 11:201-11. 2010
    ..There is also evidence that brain efficiency correlates positively with intelligence...
  19. ncbi request reprint Apolipoprotein e gene variability and cognitive functions at age 79: a follow-up of the Scottish mental survey of 1932
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    Psychol Aging 19:367-71. 2004
    ..Neither nonverbal reasoning nor verbal fluency were affected. In this sample, APOE genotype contributed to verbal memory in old age...
  20. ncbi request reprint The functional anatomy of inspection time: an event-related fMRI study
    Ian J Deary
    Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, EH8 9JZ, UK
    Neuroimage 22:1466-79. 2004
    ..fMRI can thus reveal information about the neural correlates of mental events which occur over very short durations...
  21. ncbi request reprint The cognitive cost of being a twin: two whole-population surveys
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
    Twin Res Hum Genet 8:376-83. 2005
    ..The same mental ability difference of about 5 IQ points was found, and was not accounted for by father's occupation, overcrowding in the childhood home, childhood height, school attendance or the number of people in the family...
  22. ncbi request reprint Genetics of intelligence
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Eur J Hum Genet 14:690-700. 2006
    ..After an overview of candidate gene associations with intelligence test scores, there is a discussion of whole-genome linkage and association studies, the first of which have only recently appeared...
  23. doi request reprint Smarter in middle age, faster in old age: a cross-lagged panel analysis of reaction time and cognitive ability over 13 years in the West of Scotland Twenty-07 Study
    Ian J Deary
    Medical Research Council Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom
    Psychol Aging 24:40-7. 2009
    ....
  24. ncbi request reprint KLOTHO genotype and cognitive ability in childhood and old age in the same individuals
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 378:22-7. 2005
    ..Variation in the KLOTHO gene is a possible contributor to life-long reasoning differences in humans and/or to the ageing of non-verbal reasoning, especially in women...
  25. doi request reprint More intelligent, more dependable children live longer: a 55-year longitudinal study of a representative sample of the Scottish nation
    Ian J Deary
    Medical Research Council Centre for Cognitive Ageing and Cognitive Epidemiology, Departmentof Psychology, University of Edinburgh, 7 George Square, Edinburgh EH89JZ, Scotland, United Kingdom
    Psychol Sci 19:874-80. 2008
    ..41). Studied together for the first time in a representative sample, these two psychological variables are independent life-course risk factors for mortality. It is important to discover the mechanisms by which they influence survival...
  26. ncbi request reprint The principles of cognition and the abilities of man: a natural collaboration
    Ian J Deary
    Department of Psychology, University of Edinburgh
    Cortex 41:225-7. 2005
  27. ncbi request reprint Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, UK
    Neurosci Lett 393:74-7. 2006
    ..91) and rs846910-A/G (p=.90) between the groups. We conclude that these variants in HSD11B1 are not significant contributors to the range of cognitive ageing examined here...
  28. ncbi request reprint Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH89JZ, UK
    Neurosci Lett 373:110-4. 2005
    ..The possibility that this result might be a selection effect was not supported by the samples being in Hardy-Weinberg equilibrium with respect to the distribution of NCSTN genotypes...
  29. ncbi request reprint The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland
    J Pers Soc Psychol 86:130-47. 2004
    ....
  30. doi request reprint Intelligence and education: causal perceptions drive analytic processes and therefore conclusions
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology and Department of Psychology, University of Edinburgh, Scotland, UK
    Int J Epidemiol 39:1362-9. 2010
    ..Researchers' different and often unstated causal assumptions can lead to very different analytical approaches and thus to very different results and interpretations...
  31. doi request reprint A free, easy-to-use, computer-based simple and four-choice reaction time programme: the Deary-Liewald reaction time task
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ Scotland, UK
    Behav Res Methods 43:258-68. 2011
    ..The new task's parameters are reliable, and have very high correlations with the existing task. We also provide instructions for downloading and using the new reaction time programme, and we encourage other researchers to use it...
  32. pmc Cognitive epidemiology
    Ian J Deary
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    J Epidemiol Community Health 61:378-84. 2007
    ..A short guide is given to the main statistical techniques used by differential psychologists in the study of human mental abilities. There is a discussion of common epidemiological concepts in the context of cognitive epidemiology...
  33. ncbi request reprint Physical fitness and lifetime cognitive change
    Ian J Deary
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK
    Neurology 67:1195-200. 2006
    ..To test the hypothesis that physical fitness is associated with more successful cognitive aging...
  34. ncbi request reprint Reaction time explains IQ's association with death
    Ian J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    Psychol Sci 16:64-9. 2005
    ..Finding the mechanisms that relate psychometric intelligence to mortality might help in formulating effective interventions to reduce inequalities in health...
  35. ncbi request reprint Individual differences in cognition: British contributions over a century
    I J Deary
    Department of Psychology, University of Edinburgh, UK
    Br J Psychol 92:217-37. 2001
    ..The new century is likely to see a continuation of this re-emphasis on explaining human ability differences...
  36. doi request reprint From dysphonia to dysphoria: Mokken scaling shows a strong, reliable hierarchy of voice symptoms in the Voice Symptom Scale questionnaire
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, UK
    J Psychosom Res 68:67-71. 2010
    ....
  37. pmc The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    BMC Geriatr 7:28. 2007
    ..A limitation of many studies is the lack of a sufficiently long period between cognitive assessments to examine determinants. Here, the aim is to examine influences on cognitive ageing between childhood and old age...
  38. doi request reprint Bright children become enlightened adults
    Ian J Deary
    Department of Psychology, University of Edinburgh, UK
    Psychol Sci 19:1-6. 2008
    ..This study confirms social attitudes as a major, novel field of adult human activity that is related to childhood intelligence differences...
  39. doi request reprint Intelligence
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, United Kingdom
    Annu Rev Psychol 63:453-82. 2012
    ..More generally, the degree to which intelligence has become a part of broader research in neuroscience, health, and social science is discussed...
  40. ncbi request reprint Commentary: pre-morbid IQ and later health--the rapidly evolving field of cognitive epidemiology
    Ian J Deary
    Department of Psychology, University of Edinburgh, UK
    Int J Epidemiol 35:670-2. 2006
  41. ncbi request reprint VoiSS: a patient-derived Voice Symptom Scale
    Ian J Deary
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    J Psychosom Res 54:483-9. 2003
    ..The aim of this series of studies was to devise and validate a patient-derived inventory of voice symptoms for use as a sensitive assessment tool of (i) baseline pathology and (ii) response to change in adult dysphonia clinics...
  42. ncbi request reprint The dysphonic voice heard by me, you and it: differential associations with personality and psychological distress
    I J Deary
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Clin Otolaryngol Allied Sci 28:374-8. 2003
    ..This suggests that it is in part the patients' perception of their own voice quality which accounts for the association of voice production and psychological factors in subjects presenting to voice clinics...
  43. ncbi request reprint White matter integrity and cognition in childhood and old age
    I J Deary
    Department of Psychology, School of Philosophy, Psychology, and Language Sciences, University of Edinburgh, UK
    Neurology 66:505-12. 2006
    ..To test the hypothesis that white matter integrity, as measured by diffusion tensor and magnetization transfer MRI is significantly associated with cognitive ability measured in youth and old age...
  44. ncbi request reprint Cerebral white matter abnormalities and lifetime cognitive change: a 67-year follow-up of the Scottish Mental Survey of 1932
    Ian J Deary
    Department of Psychology, University of Edinburgh, Scotland
    Psychol Aging 18:140-8. 2003
    ..Some of this effect might be due to hypertension. This contribution is independent of mental function in early life and is associated with general cognitive ability...
  45. doi request reprint Losing one's grip: a bivariate growth curve model of grip strength and nonverbal reasoning from age 79 to 87 years in the Lothian Birth Cohort 1921
    Ian J Deary
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    J Gerontol B Psychol Sci Soc Sci 66:699-707. 2011
    ..Grip strength and reasoning are associated in old age. This is one of the few longitudinal studies addressing whether aging of one causes decline in the other or whether they share causal influences...
  46. doi request reprint Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936
    L M Houlihan
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Genes Brain Behav 8:238-47. 2009
    ..All results are also presented so that they are valuable for future meta-analyses of candidate genes for cognition...
  47. doi request reprint Severe hypoglycaemia and late-life cognitive ability in older people with Type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    P P Aung
    Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Diabet Med 29:328-36. 2012
    ..To determine the association between lifetime severe hypoglycaemia and late-life cognitive ability in older people with Type 2 diabetes...
  48. doi request reprint Reverse causation in the association between C-reactive protein and fibrinogen levels and cognitive abilities in an aging sample
    Michelle Luciano
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Psychosom Med 71:404-9. 2009
    ..Blood inflammatory markers have been shown to predict late-life cognition, although the mechanism through which this occurs is unknown...
  49. ncbi request reprint Acute hypoglycemia impairs the functioning of the central but not peripheral nervous system
    M W Strachan
    Department of Diabetes, Royal Infirmary of Edinburgh, Scotland, Edinburgh, UK
    Physiol Behav 72:83-92. 2001
    ....
  50. pmc Birth weight and cognitive function at age 11 years: the Scottish Mental Survey 1932
    S D Shenkin
    Geriatric Medicine, Department of Clinical and Surgical Sciences, University of Edinburgh, 21 Chalmers Street, Edinburgh EH3 9EW, UK
    Arch Dis Child 85:189-96. 2001
    ..CONCLUSION: In this 1921 birth cohort, social class and birth weight have independent effects on cognitive function at age 11. Future research will relate these childhood data to health and cognition in old age...
  51. doi request reprint DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder
    W Hennah
    Medical Genetics Section, University of Edinburgh, Edinburgh EH4 2XU, Scotland
    Mol Psychiatry 14:865-73. 2009
    ....
  52. doi request reprint Associations between polymorphisms in five inflammation-related genes and cognitive ability in older persons
    R E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Genes Brain Behav 9:348-52. 2010
    ..048). There is little evidence to suggest an association between SNPs in the inflammation-related genes IL-1alpha, IL-1beta, IL-6, TCF-1 and F13A1 and cognition in an elderly population of community-dwelling Scottish citizens...
  53. ncbi request reprint Cognitive function and information processing in type 2 diabetes
    R Cosway
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Diabet Med 18:803-10. 2001
    ..However, other diabetes-related factors, such as macrovascular disease, hypertension and depression, may contribute more to previously observed cognitive decrements in Type 2 diabetes...
  54. doi request reprint Blood rheology and cognition in the Edinburgh Type 2 Diabetes Study
    Riccardo E Marioni
    Centre for Population Health Sciences, University of Edinburgh, Scotland, UK
    Age Ageing 39:354-9. 2010
    ..This study tested the contemporaneous associations between these two markers of rheology and cognitive ability and estimated lifetime cognitive change in an elderly population with type 2 diabetes...
  55. ncbi request reprint Child and parental mental ability and glycaemic control in children with Type 1 diabetes
    L A Ross
    Department of Child Life and Health, University of Edinburgh, Edinburgh, UK
    Diabet Med 18:364-9. 2001
    ..Many psycho-social factors can affect the glycaemic control of children with Type 1 diabetes, but the influence of the intelligence of the child and their parents has not been reported...
  56. ncbi request reprint The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills
    S E Harris
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 11:505-13. 2006
    ..This study indicates that BDNF genotype contributes to age-related changes in reasoning skills, which are closely related to general intelligence...
  57. doi request reprint Variation in the dysbindin gene and normal cognitive function in three independent population samples
    M Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK
    Genes Brain Behav 8:218-27. 2009
    ..Our results therefore support involvement of the dysbindin gene in cognitive function, but further work is needed to clarify the specific functional variants involved and the cognitive abilities with which they are associated...
  58. doi request reprint Apolipoprotein E is not related to memory abilities at 70 years of age
    Michelle Luciano
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK
    Behav Genet 39:6-14. 2009
    ..04) in the analysis not controlling for IQ. Neither of these tests was significant when a correction for multiple testing was applied. APOE e4 does not influence memory abilities in a normal population of 70-year-olds...
  59. ncbi request reprint Acute hypoglycemia in humans causes attentional dysfunction while nonverbal intelligence is preserved
    V McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh, Scotland, UK
    Diabetes Care 24:1745-50. 2001
    ..On the basis of these results, it can be surmised that many complex attention tasks relevant to everyday life are impaired during moderate hypoglycemia...
  60. ncbi request reprint Symptoms of hypoglycaemia in people with diabetes
    V McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh, UK
    Diabet Med 18:690-705. 2001
    ..In addition, the routine assessment of hypoglycaemia symptoms in the diabetic clinic is emphasized as an important part of the regular review of people with diabetes who are treated with insulin...
  61. ncbi request reprint The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds
    Sarah E Harris
    Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
    Neurosci Lett 385:1-6. 2005
    ..Therefore, COMT genotype may contribute to differences in normal cognitive aging and to differences in some of the major personality traits in old age...
  62. doi request reprint Cognitive ability at age 11 and 70 years, information processing speed, and APOE variation: the Lothian Birth Cohort 1936 study
    Michelle Luciano
    Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, Scotland
    Psychol Aging 24:129-38. 2009
    ..05): The correlation between childhood ability and speed was lower in e4 allele carriers. APOE has an influence on nonverbal cognition in old age and interacts with childhood IQ to influence processing speed...
  63. ncbi request reprint Childhood IQ, smoking, and cognitive change from age 11 to 64 years
    Lawrence J Whalley
    Department of Mental Health, University of Aberdeen, Aberdeen, Scotland, UK
    Addict Behav 30:77-88. 2005
    ..In this sample, smoking makes a small (<1% variance) independent negative contribution to cognitive aging...
  64. doi request reprint Caffeine consumption and cognitive function at age 70: the Lothian Birth Cohort 1936 study
    Janie Corley
    Department of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland, UK
    Psychosom Med 72:206-14. 2010
    ..To investigate the association between caffeine consumption and cognitive outcomes in later life...
  65. doi request reprint Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
    A M McIntosh
    Division of Psychiatry, University of Edinburgh, UK
    Psychol Med 43:1197-206. 2013
    ..We tested whether depressive symptoms were related to reduced white-matter tract fractional anisotropy (FA), a measure of integrity, and then examined whether high neuroticism or low extraversion mediated this relationship...
  66. doi request reprint Brain white matter tract integrity as a neural foundation for general intelligence
    L Penke
    Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 17:1026-30. 2012
    ....
  67. pmc Childhood mental ability and smoking cessation in adulthood: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies
    M D Taylor
    Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, UK
    J Epidemiol Community Health 57:464-5. 2003
  68. ncbi request reprint Attentional functioning is impaired during acute hypoglycaemia in people with Type 1 diabetes
    V McAulay
    Department of Diabetes, Royal Infirmary, Edinburgh and Department of Psychology, University of Edinburgh, Edinburgh, UK
    Diabet Med 23:26-31. 2006
    ..To examine the effects of acute insulin-induced hypoglycaemia on different aspects of attention and on general non-verbal reasoning in people with Type 1 diabetes...
  69. ncbi request reprint The effects of acute hypoglycaemia on memory acquisition and recall and prospective memory in type 1 diabetes
    R E Warren
    Department of Diabetes, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, EH16 4SA, UK
    Diabetologia 50:178-85. 2007
    ..This study assessed whether moderate hypoglycaemia disrupts learning and recall in isolation, and utilised a novel test of prospective memory which may better reflect the role of memory in daily life than conventional tests...
  70. doi request reprint Symptoms of depression but not anxiety are associated with central obesity and cardiovascular disease in people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study
    J Labad
    Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Diabetologia 53:467-71. 2010
    ..The aim of the study was to identify risk factors for depression and anxiety in a well-characterised cohort of individuals with type 2 diabetes mellitus...
  71. pmc Childhood mental ability and adult alcohol intake and alcohol problems: the 1970 British cohort study
    G David Batty
    UK Medical Research Council Social and Public Health Sciences Unit, University of Glasgow, Glasgow, Scotland, UK
    Am J Public Health 98:2237-43. 2008
    ..We examined the potential relation of mental ability test scores at age 10 years with alcohol problems and alcohol intake at age 30 years...
  72. ncbi request reprint Apolipoprotein-e influences aspects of intellectual ability in type 1 diabetes
    Stewart C Ferguson
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh, Scotland, U K
    Diabetes 52:145-8. 2003
    ..The APOE epsilon4 genotype is associated with specific cognitive disadvantage in young women with type 1 diabetes. APOE epsilon4 is unlikely to mediate susceptibility to hypoglycemia-induced cognitive disadvantage...
  73. doi request reprint Cognition and mortality from the major causes of death: the Health and Lifestyle Survey
    Beverly A Shipley
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, EH8 9JZ, Scotland, UK
    J Psychosom Res 65:143-52. 2008
    ..To investigate the influence of reaction time and cognition on the risk of death from cause-specific mortality and to examine whether any association found remains after adjustment for available socioeconomic, lifestyle, and health factors...
  74. pmc Childhood IQ in relation to risk factors for premature mortality in middle-aged persons: the Aberdeen Children of the 1950s study
    G David Batty
    MRC Social and Public Health Sciences Unit, University of Glasgow, 4 Lilybank Gardens, Glasgow G12 8RZ, UK
    J Epidemiol Community Health 61:241-7. 2007
    ..This study examines the association between childhood IQ and a range of established physiological and behavioural risk factors for premature mortality in adulthood. Design,..
  75. ncbi request reprint Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes
    Andrew J Sommerfield
    Department of Diabetes, Royal Infirmary of Edinburgh, Edinburgh EH16 4ES, Scotland, U K
    Diabetes Care 27:2335-40. 2004
    ..To examine the effects of acute hyperglycemia on cognitive function and mood in people with type 2 diabetes...
  76. ncbi request reprint Hypoglycaemic symptoms reported by children with type 1 diabetes mellitus and by their parents
    L A Ross
    Department of Child Life and Health, University of Edinburgh, UK
    Diabet Med 15:836-43. 1998
    ..These findings have important implications for the education of parents and children with Type 1 diabetes regarding the symptoms and signs of hypoglycaemia...
  77. doi request reprint Cognitive visual perceptual deficits in patients with delirium
    L J E Brown
    Geriatric Medicine Unit, University of Edinburgh, Edinburgh, UK
    J Neurol Neurosurg Psychiatry 80:594-9. 2009
    ..Psychiatric symptoms of perceptual disturbance--such as hallucinations, illusions and misperceptions--are common in delirium, suggesting that patients may have deficits in the cognitive systems underlying visual perception...
  78. doi request reprint Association of retinal arteriolar dilatation with lower verbal memory: the Edinburgh Type 2 Diabetes Study
    J Ding
    Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
    Diabetologia 54:1653-62. 2011
    ....
  79. ncbi request reprint Pronunciation of irregular words is preserved in dementia, validating premorbid IQ estimation
    B McGurn
    Department of Geriatric Medicine, University of Edinburgh, UK
    Neurology 62:1184-6. 2004
    ..63, p < 0.001) and without (r = 0.60, p < 0.001) dementia. These findings validate the NART as an estimator of premorbid ability in mild to moderate dementia...
  80. ncbi request reprint Optimising outcome assessment of voice interventions, I: Reliability and validity of three self-reported scales
    A L Webb
    Department of Speech and Language Therapy, Institute of Health and Society, Scotland, UK
    J Laryngol Otol 121:763-7. 2007
    ..There is an increasing choice of voice outcome research tools, but good comparative data are lacking...
  81. ncbi request reprint Cognition and all-cause mortality across the entire adult age range: health and lifestyle survey
    Beverly A Shipley
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, Scotland
    Psychosom Med 68:17-24. 2006
    ..To investigate the association of reaction time and brief measures of memory and spatial ability with all-cause mortality...
  82. doi request reprint Mental ability in childhood and cognitive aging
    Alan J Gow
    Department of Psychology, University of Edinburgh, Edinburgh, UK
    Gerontology 54:177-86. 2008
    ..Identifying the determinants of cognitive aging is a research priority; however, few studies are able to examine the influence of pre-morbid cognitive ability on later changes in cognitive function...
  83. ncbi request reprint Renal function and cognition in the 1932 Scottish Mental Survey Lothian cohort
    Latana Munang
    Royal Victoria Hospital, Edinburgh, UK
    Age Ageing 36:323-5. 2007
  84. ncbi request reprint Large, consistent estimates of the heritability of cognitive ability in two entire populations of 11-year-old twins from Scottish mental surveys of 1932 and 1947
    Beben Benyamin
    School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    Behav Genet 35:525-34. 2005
    ..More generally for studies in genetics, the methodological innovation developed here implies that large (national) data collections can provide sufficient information on twin pairs to estimate genetic parameters, even without zygosity...
  85. ncbi request reprint Childhood IQ, social class, deprivation, and their relationships with mortality and morbidity risk in later life: prospective observational study linking the Scottish Mental Survey 1932 and the Midspan studies
    Carole L Hart
    Public Health and Health Policy, Division of Community Based Sciences, University of Glasgow, Glasgow, Scotland
    Psychosom Med 65:877-83. 2003
    ..To investigate how childhood mental ability (IQ) is related to mortality and morbidity risk, when socioeconomic factors are also considered...
  86. pmc Brain white matter lesions detected by magnetic resonance [correction of resosnance] imaging are associated with balance and gait speed
    J M Starr
    Geriatric Medicine Unit, University of Edinburgh, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, Scotland, UK
    J Neurol Neurosurg Psychiatry 74:94-8. 2003
    ..To investigate the relations between premorbid and current mental ability, mood, and white matter signal abnormalities detected by T2 weighted brain magnetic resonance imaging (MRI) and impairment of balance and mobility in older adults...
  87. ncbi request reprint Plasma cortisol levels, brain volumes and cognition in healthy elderly men
    Alasdair M J MacLullich
    Geriatric Medicine, University of Edinburgh, Room SU220, The Chancellor s Building, 49 Little France Crescent, Edinburgh EH16 4SB, UK
    Psychoneuroendocrinology 30:505-15. 2005
    ..This study examined the hypotheses that higher plasma cortisol levels and altered sensitivity to glucocorticoids are associated with worse cognition and more brain atrophy in elderly men...
  88. ncbi request reprint Neuroticism, extraversion, and mortality in the UK Health and Lifestyle Survey: a 21-year prospective cohort study
    Beverly A Shipley
    Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, 7, George Square, Edinburgh EH8 9JZ, Scotland
    Psychosom Med 69:923-31. 2007
    ..To examine the influence of neuroticism and extraversion on all-cause and cause-specific mortality over 21 years after controlling for risk factors...
  89. doi request reprint Childhood cognitive ability and risk of late-onset Alzheimer and vascular dementia
    Brian McGurn
    Geriatric Medicine Unit, University of Edinburgh, UK
    Neurology 71:1051-6. 2008
    ..We investigated differential effects of premorbid cognitive ability on dementia subtypes to clarify which causal pathway was predominant...
  90. ncbi request reprint Glycosylated hemoglobin levels in healthy elderly nondiabetic men are negatively associated with verbal memory
    Alasdair M J MacLullich
    J Am Geriatr Soc 52:848-9. 2004
  91. pmc Mental ability across childhood in relation to risk factors for premature mortality in adult life: the 1970 British Cohort Study
    G David Batty
    MRC Social and Public Health Sciences Unit, University of Glasgow, 4 Lilybank Gardens, Glasgow G12 8RZ, UK
    J Epidemiol Community Health 61:997-1003. 2007
    ..To examine the relation of scores on tests of mental ability across childhood with established risk factors for premature mortality at the age of 30 years...
  92. ncbi request reprint Cognitive correlates of cerebral white matter lesions and water diffusion tensor parameters in community-dwelling older people
    S D Shenkin
    Department of Geriatric Medicine, University of Edinburgh, UK
    Cerebrovasc Dis 20:310-8. 2005
    ..Here the relationships between WML load, DT-MRI parameters and cognition in a large cohort of elderly subjects with a very narrow age range were investigated...
  93. ncbi request reprint Association between genotype at an exonic SNP in DISC1 and normal cognitive aging
    P A Thomson
    Medical Genetics Section, Department of Medical Sciences, University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, UK
    Neurosci Lett 389:41-5. 2005
    ..034 and 0.043, respectively). Women homozygous for the Cys allele had significantly lower cognitive ability scores than men at age 79, p = 0.003. Variation in DISC1 may therefore affect cognitive aging especially in women...
  94. doi request reprint Effects of acute insulin-induced hypoglycaemia on psychomotor function: people with type 1 diabetes are less affected than non-diabetic adults
    J Geddes
    Department of Diabetes, The Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh, UK
    Diabetologia 51:1814-21. 2008
    ..We examined the effects of acute insulin-induced hypoglycaemia on psychomotor function in non-diabetic volunteers and in adults with type 1 diabetes...
  95. doi request reprint Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial
    F Gerald R Fowkes
    Centre for Population Health Sciences, University of Edinburgh, Scotland
    JAMA 303:841-8. 2010
    ..Screening for a low ABI can identify an asymptomatic higher risk group potentially amenable to preventive treatments...
  96. doi request reprint Blood pressure, socio-economic status and health in the Lothian 1921 birth cohort: a longitudinal study
    J M Starr
    Centre for Cognitive Ageing and Cognitive Epidemiology, Geriatric Medicine Unit, University of Edinburgh, Royal Victoria Hospital, Craigleith Road, Edinburgh EH4 2DN, Scotland, UK
    Public Health 125:196-200. 2011
    ..To test whether socio-economic status and disease burden influence blood pressure in older adults...
  97. doi request reprint Five Factor Model personality traits and all-cause mortality in the Edinburgh Artery Study cohort
    Michelle D Taylor
    Psychology, University of Edinburgh, Edinburgh, Scotland
    Psychosom Med 71:631-41. 2009
    ..To examine whether personality traits are related to all-cause mortality in a general adult population in Scotland...
  98. doi request reprint Haemorheological predictors of cognitive decline: the Edinburgh Artery Study
    Snorri Rafnsson
    Public Health Sciences, Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Age Ageing 39:217-22. 2010
    ..vascular risk factors and diseases can negatively impact cognitive function. Determinants of blood flow are implicated in thrombogenesis and ischaemic events, yet little is known about their relationship with cognition...
  99. doi request reprint Variation in the uric acid transporter gene (SLC2A9) and memory performance
    Lorna M Houlihan
    Department of Psychology, The University of Edinburgh, Centre for Cognitive Ageing and Cognitive Epidemiology, 7 George Square, Edinburgh EH8 9JZ, UK
    Hum Mol Genet 19:2321-30. 2010
    ..These associations were not replicated in ET2DS (all P > 0.1). If the positive associations withstand, then this study could suggest that higher uric acid levels may be associated with increased performance on memory-related tasks...
  100. ncbi request reprint Childhood IQ and social factors on smoking behaviour, lung function and smoking-related outcomes in adulthood: linking the Scottish Mental Survey 1932 and the Midspan studies
    Michelle D Taylor
    Department of Psychology, University of Edinburgh, UK
    Br J Health Psychol 10:399-410. 2005
    ..To investigate the associations of childhood IQ and adult social factors, and smoking behaviour, lung function (forced expiratory volume in one second; FEV(1)), and smoking-related outcomes in adulthood...
  101. ncbi request reprint Is the PASAT past it? Testing attention and concentration without numbers
    Alan J Gow
    Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom
    J Clin Exp Neuropsychol 26:723-36. 2004
    ..Performing the PASOT was significantly less aversive; teh PASAT induced more negative feelings of Tense Arousal (t38 = -4.52, p < .001)...