J W Dear

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Quantification of human urinary exosomes by nanoparticle tracking analysis
    Wilna Oosthuyzen
    J W Dear University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Physiol 591:5833-42. 2013
  2. doi request reprint Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling
    James W Dear
    University, British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Proteomics 13:1572-80. 2013
  3. pmc Identification and proteomic profiling of exosomes in human cerebrospinal fluid
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Transl Med 10:5. 2012
  4. ncbi request reprint Estimated glomerular filtration rate results are misleading in acute kidney disease
    J W Dear
    Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh
    Scott Med J 52:54. 2007
  5. doi request reprint New marker for paracetamol poisoning-revolution or evolution?
    James W Dear
    NPIS Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 48:785-6. 2010
  6. doi request reprint Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury
    James W Dear
    University British Heart Foundation Centre for Cardiovascular Science, Edinburgh University, Edinburgh, EH16 4TJ United Kingdom
    J Immunol 187:3347-52. 2011
  7. pmc Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, UK
    J Physiol 589:6119-27. 2011
  8. doi request reprint Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: the recent United Kingdom experience
    D N Bateman
    National Poisons Information Service Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 52:868-72. 2014
  9. doi request reprint The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose
    K Al-Hourani
    National Poisons Information Service Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 106:541-6. 2013

Collaborators

Detail Information

Publications9

  1. pmc Quantification of human urinary exosomes by nanoparticle tracking analysis
    Wilna Oosthuyzen
    J W Dear University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Physiol 591:5833-42. 2013
    ..In conclusion, with appropriate sample storage, NTA has potential as a tool for the characterization and quantification of extracellular vesicles in human urine...
  2. doi request reprint Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling
    James W Dear
    University, British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Proteomics 13:1572-80. 2013
    ....
  3. pmc Identification and proteomic profiling of exosomes in human cerebrospinal fluid
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Transl Med 10:5. 2012
    ..The objective of this study was to determine: 1) whether human CSF contains exosomes and 2) the variability in exosomal protein content across individuals...
  4. ncbi request reprint Estimated glomerular filtration rate results are misleading in acute kidney disease
    J W Dear
    Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh
    Scott Med J 52:54. 2007
  5. doi request reprint New marker for paracetamol poisoning-revolution or evolution?
    James W Dear
    NPIS Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 48:785-6. 2010
    ..This commentary discusses the use of biomarkers in the context of the management of paracetamol-induced liver injury. New biomarkers should allow better triage and management of & "at risk" patients...
  6. doi request reprint Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury
    James W Dear
    University British Heart Foundation Centre for Cardiovascular Science, Edinburgh University, Edinburgh, EH16 4TJ United Kingdom
    J Immunol 187:3347-52. 2011
    ..In summary, CypA is a DAMP that mediates acetaminophen poisoning. This mechanistic insight presents an opportunity for a new therapeutic approach to a disease that currently has inadequate treatment options...
  7. pmc Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, UK
    J Physiol 589:6119-27. 2011
    ..Exosomes can transfer functional AQP2 between cells and this represents a novel physiological mechanism for cell-to-cell communication within the kidney...
  8. doi request reprint Impact of reducing the threshold for acetylcysteine treatment in acute paracetamol poisoning: the recent United Kingdom experience
    D N Bateman
    National Poisons Information Service Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 52:868-72. 2014
    ..Here we report the impact of this change in the UK on the management of patients with acute overdose in different paracetamol concentration ranges...
  9. doi request reprint The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose
    K Al-Hourani
    National Poisons Information Service Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 106:541-6. 2013
    ..Nonetheless, ALT is measured at hospital presentation; we investigated its value in predicting hepatotoxicity...