J W Dear

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Quantification of human urinary exosomes by nanoparticle tracking analysis
    Wilna Oosthuyzen
    J W Dear University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Physiol 591:5833-42. 2013
  2. doi request reprint Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling
    James W Dear
    University, British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Proteomics 13:1572-80. 2013
  3. pmc Identification and proteomic profiling of exosomes in human cerebrospinal fluid
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Transl Med 10:5. 2012
  4. ncbi request reprint Estimated glomerular filtration rate results are misleading in acute kidney disease
    J W Dear
    Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh
    Scott Med J 52:54. 2007
  5. doi request reprint New marker for paracetamol poisoning-revolution or evolution?
    James W Dear
    NPIS Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 48:785-6. 2010
  6. doi request reprint Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury
    James W Dear
    University British Heart Foundation Centre for Cardiovascular Science, Edinburgh University, Edinburgh, EH16 4TJ United Kingdom
    J Immunol 187:3347-52. 2011
  7. pmc Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, UK
    J Physiol 589:6119-27. 2011
  8. doi request reprint The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose
    K Al-Hourani
    National Poisons Information Service Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 106:541-6. 2013

Collaborators

Detail Information

Publications8

  1. pmc Quantification of human urinary exosomes by nanoparticle tracking analysis
    Wilna Oosthuyzen
    J W Dear University of Edinburgh British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Physiol 591:5833-42. 2013
    ..In conclusion, with appropriate sample storage, NTA has potential as a tool for the characterization and quantification of extracellular vesicles in human urine...
  2. doi request reprint Urinary exosomes: a reservoir for biomarker discovery and potential mediators of intrarenal signalling
    James W Dear
    University, British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK
    Proteomics 13:1572-80. 2013
    ....
  3. pmc Identification and proteomic profiling of exosomes in human cerebrospinal fluid
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    J Transl Med 10:5. 2012
    ..The objective of this study was to determine: 1) whether human CSF contains exosomes and 2) the variability in exosomal protein content across individuals...
  4. ncbi request reprint Estimated glomerular filtration rate results are misleading in acute kidney disease
    J W Dear
    Clinical Pharmacology Unit, Centre for Cardiovascular Science, University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh
    Scott Med J 52:54. 2007
  5. doi request reprint New marker for paracetamol poisoning-revolution or evolution?
    James W Dear
    NPIS Edinburgh, Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh, UK
    Clin Toxicol (Phila) 48:785-6. 2010
    ..This commentary discusses the use of biomarkers in the context of the management of paracetamol-induced liver injury. New biomarkers should allow better triage and management of & "at risk" patients...
  6. doi request reprint Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury
    James W Dear
    University British Heart Foundation Centre for Cardiovascular Science, Edinburgh University, Edinburgh, EH16 4TJ United Kingdom
    J Immunol 187:3347-52. 2011
    ..In summary, CypA is a DAMP that mediates acetaminophen poisoning. This mechanistic insight presents an opportunity for a new therapeutic approach to a disease that currently has inadequate treatment options...
  7. pmc Exosomal transmission of functional aquaporin 2 in kidney cortical collecting duct cells
    Jonathan M Street
    University British Heart Foundation Centre for Cardiovascular Science, The University of Edinburgh, UK
    J Physiol 589:6119-27. 2011
    ..Exosomes can transfer functional AQP2 between cells and this represents a novel physiological mechanism for cell-to-cell communication within the kidney...
  8. doi request reprint The predictive value of hospital admission serum alanine transaminase activity in patients treated for paracetamol overdose
    K Al-Hourani
    National Poisons Information Service Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK
    QJM 106:541-6. 2013
    ..Nonetheless, ALT is measured at hospital presentation; we investigated its value in predicting hepatotoxicity...