Paul Dean

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Insights into the pathogenesis of enteropathogenic E. coli using an improved intestinal enterocyte model
    Paul Dean
    Institute of Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e55284. 2013
  2. pmc The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS Pathog 6:e1000961. 2010
  3. pmc The effector repertoire of enteropathogenic E. coli: ganging up on the host cell
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Curr Opin Microbiol 12:101-9. 2009
  4. doi Functional domains and motifs of bacterial type III effector proteins and their roles in infection
    Paul Dean
    Institute of Cell and Molecular Bioscience, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    FEMS Microbiol Rev 35:1100-25. 2011
  5. pmc Cell-surface nucleolin is sequestered into EPEC microcolonies and may play a role during infection
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Microbiology 157:1761-7. 2011
  6. ncbi The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targeting
    Sabine Quitard
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cell Microbiol 8:972-81. 2006
  7. pmc The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-κB activity by targeting TNFα receptor-associated factors
    Marie Hélène Ruchaud-Sparagano
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Pathog 7:e1002414. 2011
  8. pmc Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 103:1876-81. 2006
  9. ncbi EPEC's weapons of mass subversion
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE24HH, UK
    Curr Opin Microbiol 8:28-34. 2005
  10. pmc The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Cell Microbiol 12:1308-21. 2010

Collaborators

Detail Information

Publications13

  1. pmc Insights into the pathogenesis of enteropathogenic E. coli using an improved intestinal enterocyte model
    Paul Dean
    Institute of Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e55284. 2013
    ..Together, this study highlights the many advantages of using TC-7 cells as a small intestinal model to study host-pathogen interactions...
  2. pmc The enteropathogenic E. coli effector EspF targets and disrupts the nucleolus by a process regulated by mitochondrial dysfunction
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    PLoS Pathog 6:e1000961. 2010
    ....
  3. pmc The effector repertoire of enteropathogenic E. coli: ganging up on the host cell
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Curr Opin Microbiol 12:101-9. 2009
    ..Here, we describe the genomic location of effectors and discuss recent advances made on effector cellular function as well as their role in the infection process...
  4. doi Functional domains and motifs of bacterial type III effector proteins and their roles in infection
    Paul Dean
    Institute of Cell and Molecular Bioscience, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    FEMS Microbiol Rev 35:1100-25. 2011
    ..This review provides a snapshot of our current understanding of bacterial effector domains and motifs where a defined role in infection has been demonstrated...
  5. pmc Cell-surface nucleolin is sequestered into EPEC microcolonies and may play a role during infection
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Microbiology 157:1761-7. 2011
    ..Taken together, this work suggests that EPEC exploits two spatially distinct pools of nucleolin during the infection process...
  6. ncbi The enteropathogenic Escherichia coli EspF effector molecule inhibits PI-3 kinase-mediated uptake independently of mitochondrial targeting
    Sabine Quitard
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cell Microbiol 8:972-81. 2006
    ..Moreover, loss of PI-3 kinase-dependent phosphorylation of Akt and gross changes in host phosphotyrosine protein profiles could not be linked to inhibition of the PI-3 kinase-dependent uptake process...
  7. pmc The enteropathogenic E. coli (EPEC) Tir effector inhibits NF-κB activity by targeting TNFα receptor-associated factors
    Marie Hélène Ruchaud-Sparagano
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS Pathog 7:e1002414. 2011
    ..The work not only reveals a second Intimin-independent property for Tir and a novel EPEC effector-mediated NF-κB inhibitory mechanism but also lends itself to speculations on the evolution of EPEC's capacity to inhibit NF-κB function...
  8. pmc Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteins
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 103:1876-81. 2006
    ..Moreover, the identification of effector activities that alter microvilli structure and SGLT-1 function provides new tools for studying the underlying regulatory processes...
  9. ncbi EPEC's weapons of mass subversion
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE24HH, UK
    Curr Opin Microbiol 8:28-34. 2005
    ..Furthermore, new virulence-associated factors are continually being uncovered that are encoded outside the LEE pathogenicity island, some of which are not injected into host cells...
  10. pmc The bacterial effectors EspG and EspG2 induce a destructive calpain activity that is kept in check by the co-delivered Tir effector
    Paul Dean
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Cell Microbiol 12:1308-21. 2010
    ....
  11. ncbi Enteropathogenic Escherichia coli (EPEC) effector-mediated suppression of antimicrobial nitric oxide production in a small intestinal epithelial model system
    Marc Maresca
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE24HH, UK
    Cell Microbiol 7:1749-62. 2005
    ..Our study also provides insights into the nature of NO production in response to bacterial infection as well as the role of the locus of enterocyte effacement (LEE)-encoded effector molecules in inhibiting iNOS expression...
  12. doi Cultured enterocytes internalise bacteria across their basolateral surface for, pathogen-inhibitable, trafficking to the apical compartment
    Paul Dean
    Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Sci Rep 5:17359. 2015
    ..Indeed, studies with Salmonella demonstrated that it's entry-forcing virulence factor (SPI-I) was not required to enter via the basolateral surface but to promote another virulence-associated event (intra-enterocyte accumulation). ..
  13. pmc The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella
    David M Bulmer
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle, United Kingdom
    PLoS Pathog 8:e1002500. 2012
    ..Collectively, these results suggest that expression of virulence genes might be directly coordinated with cytoskeletal integrity, and this regulation is mediated by the two-component system sensor kinase RcsC...