Jacobus C de Roode

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections
    J C De Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Parasitology 127:411-8. 2003
  2. pmc Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections
    Jacobus C de Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 271:1073-80. 2004
  3. pmc Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections
    Jacobus C de Roode
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3 JT, Scotland, United Kingdom
    Malar J 3:33. 2004
  4. pmc Virulence and competitive ability in genetically diverse malaria infections
    Jacobus C de Roode
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Proc Natl Acad Sci U S A 102:7624-8. 2005
  5. ncbi request reprint The role of immune-mediated apparent competition in genetically diverse malaria infections
    Lars Raberg
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom
    Am Nat 168:41-53. 2006
  6. ncbi request reprint Real-time quantitative PCR for analysis of genetically mixed infections of malaria parasites: technique validation and applications
    Sandra J Cheesman
    Division of Biological Sciences, Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 131:83-91. 2003
  7. pmc Transmission stage investment of malaria parasites in response to in-host competition
    Andrew R Wargo
    Institutes of Evolution, Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 274:2629-38. 2007
  8. ncbi request reprint Within-host competition in genetically diverse malaria infections: parasite virulence and competitive success
    Andrew S Bell
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, Kings Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 60:1358-71. 2006
  9. ncbi request reprint Dynamics of multiple infection and within-host competition in genetically diverse malaria infections
    Jacobus C de Roode
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom
    Am Nat 166:531-42. 2005
  10. pmc Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model
    Andrew R Wargo
    Institutes of Evolutionary Biology and Immunology and Infection Research, Ashworth Laboratories, School of Biological Science, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 104:19914-9. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Rodent malaria parasites suffer from the presence of conspecific clones in three-clone Plasmodium chabaudi infections
    J C De Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Parasitology 127:411-8. 2003
    ..These results suggest that in-host competition reduces both growth rate and probability of transmission for individual parasite clones...
  2. pmc Host heterogeneity is a determinant of competitive exclusion or coexistence in genetically diverse malaria infections
    Jacobus C de Roode
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 271:1073-80. 2004
    ..Host genotype and resistance could therefore play a key role in the outcome of within-host competition between parasite clones and in the evolution of parasite virulence...
  3. pmc Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections
    Jacobus C de Roode
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3 JT, Scotland, United Kingdom
    Malar J 3:33. 2004
    ..Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance...
  4. pmc Virulence and competitive ability in genetically diverse malaria infections
    Jacobus C de Roode
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    Proc Natl Acad Sci U S A 102:7624-8. 2005
    ..Our results imply that within-host competition is a major factor driving the evolution of virulence and can explain why many parasites harm their hosts...
  5. ncbi request reprint The role of immune-mediated apparent competition in genetically diverse malaria infections
    Lars Raberg
    Institutes of Evolution, Immunology, and Infection Research, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom
    Am Nat 168:41-53. 2006
    ..As far as we are aware, this is the first direct experimental evidence of immune-mediated apparent competition in any host-parasite system...
  6. ncbi request reprint Real-time quantitative PCR for analysis of genetically mixed infections of malaria parasites: technique validation and applications
    Sandra J Cheesman
    Division of Biological Sciences, Institute of Cell, Animal and Population Biology, Ashworth Laboratories, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Biochem Parasitol 131:83-91. 2003
    ....
  7. pmc Transmission stage investment of malaria parasites in response to in-host competition
    Andrew R Wargo
    Institutes of Evolution, Immunology and Infection Research, Ashworth Laboratories, School of Biological Sciences, University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 274:2629-38. 2007
    ..This study supports much of the current literature, which predicts that conspecific in-host competition will result in a competitive advantage and positive selection for virulent clones and thus the evolution of higher virulence...
  8. ncbi request reprint Within-host competition in genetically diverse malaria infections: parasite virulence and competitive success
    Andrew S Bell
    Institutes of Evolution, Immunology and Infection Research, School of Biological Sciences, Kings Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Evolution 60:1358-71. 2006
    ....
  9. ncbi request reprint Dynamics of multiple infection and within-host competition in genetically diverse malaria infections
    Jacobus C de Roode
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, United Kingdom
    Am Nat 166:531-42. 2005
    ..These results are discussed in the light of strain-specific immunity, drug resistance, and virulence evolution theory...
  10. pmc Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model
    Andrew R Wargo
    Institutes of Evolutionary Biology and Immunology and Infection Research, Ashworth Laboratories, School of Biological Science, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Proc Natl Acad Sci U S A 104:19914-9. 2007
    ..This finding raises the prospect of harnessing in-host ecology to slow the spread of drug resistance...