De Koning H. Transporters in African trypanosomes: role in drug action and resistance. Int J Parasitol. 2001;31:512-22 pubmed
..Lessons learned from studying the uptake of drugs currently in use may assist the design of a much needed new generation of trypanocides. ..
De Koning H. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by three distinct transporters: implications for cross-resistance with arsenicals. Mol Pharmacol. 2001;59:586-92 pubmed
..Treatment with ionophores revealed that PPT1 may be a proton/pentamidine cotransporter. ..
de Koning H. Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes. Trends Parasitol. 2008;24:345-9 pubmed publisher
De Koning H, Watson C, Sutcliffe L, Jarvis S. Differential regulation of nucleoside and nucleobase transporters in Crithidia fasciculata and Trypanosoma brucei brucei. Mol Biochem Parasitol. 2000;106:93-107 pubmed
..These results show that regulation of the capacity of the purine transporters is common in different protozoa, and that, in T. b. brucei, various purine transporters are under differential control...
De Koning H, Jarvis S. Uptake of pentamidine in Trypanosoma brucei brucei is mediated by the P2 adenosine transporter and at least one novel, unrelated transporter. Acta Trop. 2001;80:245-50 pubmed
..The identity of these transporters was investigated, and their significance for drug uptake and resistance in African trypanosomes is discussed. ..
de Koning H, Al Salabi M, Cohen A, Coombs G, Wastling J. Identification and characterisation of high affinity nucleoside and nucleobase transporters in Toxoplasma gondii. Int J Parasitol. 2003;33:821-31 pubmed
de Koning H, Bridges D, Burchmore R. Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy. FEMS Microbiol Rev. 2005;29:987-1020 pubmed
..Recent studies are increasingly addressing the structure and substrate recognition mechanisms of these vital transport proteins. ..