A D de Grey

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Regenerate 2004: tissue engineering the human body, June 10-12, 2004, Seattle
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Rejuvenation Res 7:226-8. 2004
  2. ncbi Foreseeable pharmaceutical repair of age-related extracellular damage
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Curr Drug Targets 7:1469-77. 2006
  3. ncbi The unfortunate influence of the weather on the rate of ageing: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK
    Gerontology 51:73-82. 2005
  4. ncbi The 8th International Symposium on the Maillard reaction (Charleston, South Carolina, August 28 to September 1, 2004)
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Rejuvenation Res 7:257-60. 2004
  5. ncbi Mitochondrial mutations in mammalian aging: an over-hasty about-turn?
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Rejuvenation Res 7:171-4. 2004
  6. pmc Life extension, human rights, and the rational refinement of repugnance
    A D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    J Med Ethics 31:659-63. 2005
  7. ncbi Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutions
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Rejuvenation Res 7:95-8. 2004
  8. ncbi Report on the open discussion on the future of life extension research
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ann N Y Acad Sci 1019:552-3. 2004
  9. ncbi Biogerontologists' duty to discuss timescales publicly
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ann N Y Acad Sci 1019:542-5. 2004
  10. ncbi Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity?
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Bioessays 27:436-46. 2005

Collaborators

Detail Information

Publications67

  1. ncbi Regenerate 2004: tissue engineering the human body, June 10-12, 2004, Seattle
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Rejuvenation Res 7:226-8. 2004
  2. ncbi Foreseeable pharmaceutical repair of age-related extracellular damage
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Curr Drug Targets 7:1469-77. 2006
    ..In this article, the major types of age-related extracellular damage and promising avenues for their repair are reviewed...
  3. ncbi The unfortunate influence of the weather on the rate of ageing: why human caloric restriction or its emulation may only extend life expectancy by 2-3 years
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK
    Gerontology 51:73-82. 2005
    ....
  4. ncbi The 8th International Symposium on the Maillard reaction (Charleston, South Carolina, August 28 to September 1, 2004)
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Rejuvenation Res 7:257-60. 2004
  5. ncbi Mitochondrial mutations in mammalian aging: an over-hasty about-turn?
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
    Rejuvenation Res 7:171-4. 2004
    ..However, there are compelling reasons to doubt the relevance of this mouse to normal mammalian aging, and thus to seek further testing of specific mechanistic hypotheses for how mtDNA mutations could cause age-related dysfunction...
  6. pmc Life extension, human rights, and the rational refinement of repugnance
    A D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    J Med Ethics 31:659-63. 2005
  7. ncbi Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutions
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Rejuvenation Res 7:95-8. 2004
  8. ncbi Report on the open discussion on the future of life extension research
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ann N Y Acad Sci 1019:552-3. 2004
    ....
  9. ncbi Biogerontologists' duty to discuss timescales publicly
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ann N Y Acad Sci 1019:542-5. 2004
    ....
  10. ncbi Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity?
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Bioessays 27:436-46. 2005
    ....
  11. ncbi Reactive oxygen species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulation
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Rejuvenation Res 8:13-7. 2005
    ..quot; It may also prove to explain other recent observations in mitochondrially mutant cells in vivo...
  12. ncbi Free radicals in aging: causal complexity and its biomedical implications
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK
    Free Radic Res 40:1244-9. 2006
    ..This has led me to pursue the alternative, "repair and maintenance" approach that sidesteps our ignorance of metabolism and may be feasible relatively soon...
  13. ncbi Extrapolaholics anonymous: why demographers' rejections of a huge rise in cohort life expectancy in this century are overconfident
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, UK
    Ann N Y Acad Sci 1067:83-93. 2006
    ....
  14. ncbi International Association of Biomedical Gerontology, 11th Congress (Aarhus, Denmark, August 13-16, 2005)
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, UK
    Rejuvenation Res 8:264-6. 2005
  15. ncbi Appropriating microbial catabolism: a proposal to treat and prevent neurodegeneration
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Neurobiol Aging 27:589-95. 2006
    ..Thus, microbes may exist that can degrade these lysosomal toxins. If so, it should be possible to isolate the genes responsible and modify them for therapeutic activity in the mammalian lysosome...
  16. ncbi Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseases
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ageing Res Rev 4:315-38. 2005
    ..We discuss how microbes capable of degrading them can be isolated, characterised and their relevant enzymes engineered for this purpose and ways to avoid potential side-effects...
  17. pmc Resistance to debate on how to postpone ageing is delaying progress and costing lives. Open discussions in the biogerontology community would attract public interest and influence funding policy
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK
    EMBO Rep 6:S49-53. 2005
  18. ncbi Whole-body interdiction of lengthening of telomeres: a proposal for cancer prevention
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
    Front Biosci 10:2420-9. 2005
    ..Here, I describe why WILT might prove to be an exceptionally powerful anti-cancer modality...
  19. ncbi Rejuvenation Research 2004: a relaunch with a difference
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Rejuvenation Res 8:58-60. 2005
  20. ncbi Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancers
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Ann N Y Acad Sci 1019:147-70. 2004
    ..Hence, given the absence of alternatives with comparable anticancer promise, we advocate working toward such a therapy...
  21. ncbi A proposed refinement of the mitochondrial free radical theory of aging
    A D de Grey
    Department of Genetics, University of Cambridge, UK
    Bioessays 19:161-6. 1997
    ..The consistency of the hypothesis with known facts is discussed, and technically feasible tests are suggested, of both the proposed mechanism and its overall contribution to mammalian aging...
  22. ncbi Is human aging still mysterious enough to be left only to scientists?
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Bioessays 24:667-76. 2002
    ..Consequently, we suggest that serious public debate on this subject is now warranted, and we survey here several of the biological, social and political issues relating to it...
  23. ncbi HO2*: the forgotten radical
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    DNA Cell Biol 21:251-7. 2002
    ..It is suggested that a more widespread appreciation of the possible role of HO2* in biological systems would be of considerable benefit to biomedical research...
  24. ncbi The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, UK
    Eur J Biochem 269:2003-9. 2002
    ..In this minireview, recent results relevant to this hypothesis are surveyed and approaches to intervening in the proposed process are discussed...
  25. ncbi Time to talk SENS: critiquing the immutability of human aging
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 959:452-62; discussion 463-5. 2002
    ..Given the major demographic consequences if it came about, this possibility merits urgent debate...
  26. ncbi UK research on the biology of aging
    A D de Grey
    Department of Genetics, University of Cambridge, Downing Street, CB2 3EH, Cambridge, UK
    Exp Gerontol 37:1-7. 2001
    ..Its one potential Achilles heel is the overemphasis on compression of morbidity as a goal, since further compression is highly unlikely to occur and is anyway inconsistent with the public's demonstrated desires...
  27. ncbi Mitochondrial gene therapy: an arena for the biomedical use of inteins
    A D de Grey
    Department of Genetics, University of Cambridge, Cambridge, UK CB2 3EH
    Trends Biotechnol 18:394-9. 2000
    ....
  28. ncbi The reductive hotspot hypothesis: an update
    A D de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, United Kingdom
    Arch Biochem Biophys 373:295-301. 2000
    ..This model, now known as the "reductive hotspot hypothesis," has recently gained much indirect experimental support; several direct tests of it are also feasible...
  29. ncbi Incorporation of transmembrane hydroxide transport into the chemiosmotic theory
    A D de Grey
    Department of Genetics, University of Cambridge, UK
    Bioelectrochem Bioenerg 49:43-50. 1999
    ..The conflicting measurements of delta psi are shown to be consistent with the response of this system to its chemical environment...
  30. ncbi Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosome
    Aubrey D N J de Grey
    Dept of Genetics, University of Cambridge, UK
    Trends Biotechnol 20:452-5. 2002
    ..This article examines the feasibility and biomedical potential of such lysosomal enhancement as an approach to retarding or treating age-related physiological decline and disease...
  31. ncbi The foreseeability of real anti-aging medicine: focusing the debate
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Exp Gerontol 38:927-34. 2003
    ..It is hoped that, by clearing the debate on future anti-aging advances of these obfuscations, the many aspects of this topic that have hitherto received much less attention than they warrant will be brought to the fore...
  32. ncbi Critique of the demographic evidence for 'late-life non-senescence'
    A D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, U K
    Biochem Soc Trans 31:452-4. 2003
    ..Either explanation may therefore be correct...
  33. ncbi Falsifying falsifications: the most critical task of theoreticians in biology
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Med Hypotheses 62:1012-20. 2004
    ....
  34. ncbi An engineer's approach to the development of real anti-aging medicine
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Sci Aging Knowledge Environ 2003:VP1. 2003
    ..This approach should help to prevent the development of these age-related changes into life-threatening pathologies and possibly, in due course, allow a large increase in healthy human life expectancy...
  35. ncbi A hypothesis for the minimal overall structure of the mammalian plasma membrane redox system
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Cambridge, United Kingdom
    Protoplasma 221:3-9. 2003
    ....
  36. ncbi Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?
    Konstantin Khrapko
    Gerontology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Aging Cell 5:279-82. 2006
    ..Thus, mtDNA mutations may indeed be relevant to human aging, but they probably differ by origin, type, distribution, and spectra of affected tissues from those observed in mutator mice...
  37. doi Rejuvenation Research in 2007
    Aubrey D N J de Grey
    Methuslah Foundation, Cambridge, U K
    Rejuvenation Res 11:837-9. 2008
  38. ncbi Mitochondria in homeotherm aging: will detailed mechanisms consistent with the evidence now receive attention?
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
    Aging Cell 3:77. 2004
  39. ncbi SENS survives the challenge: now let's get to work
    Aubrey D N J de Grey
    Rejuvenation Res 9:429-30. 2006
  40. ncbi Is SENS a farrago?
    Aubrey D N J de Grey
    Methuselah Foundation, Cambridge, United Kingdom
    Rejuvenation Res 9:436-9. 2006
    ..Here I briefly respond to these criticisms...
  41. ncbi The natural biogerontology portfolio: "defeating aging" as a multi-stage ultra-grand challenge
    Aubrey D N J de Grey
    Methuselah Foundation, P O Box 1143, Lorton, VA 22199, USA
    Ann N Y Acad Sci 1100:409-23. 2007
    ....
  42. ncbi Edmonton: a future center for pioneering biomedical gerontology?
    Aubrey D N J de Grey
    Rejuvenation Res 10:345-7. 2007
  43. ncbi The case for prioritizing research on late-onset life-extension interventions in mammals
    Aubrey D N J de Grey
    Rejuvenation Res 10:257-9. 2007
  44. ncbi Retrospective: Rejuvenation Research in 2006
    Aubrey D N J de Grey
    Rejuvenation Res 10:335-8. 2007
  45. ncbi Dissertations: a survey of selected recent theses relevant to combating aging
    Aubrey D N J de Grey
    Rejuvenation Res 10:339-43. 2007
  46. ncbi Compression of morbidity: the hype and the reality, part 2
    Aubrey D N J de Grey
    Rejuvenation Res 9:167-8. 2006
  47. ncbi Dissertations: a survey of selected recent theses relevant to combating aging
    Aubrey D N J de Grey
    Methuselah Foundation, Cambridge, United Kingdom
    Rejuvenation Res 10:641-6. 2007
  48. ncbi Combating the Tithonus error: what works?
    Aubrey D N J de Grey
    Rejuvenation Res 11:713-5. 2008
  49. doi Dissertations: a survey of selected recent theses relevant to combating aging
    Aubrey D N J de Grey
    Rejuvenation Res 11:689-95. 2008
  50. ncbi Challenging but essential targets for genuine anti-ageing drugs
    Aubrey D N J de Grey
    Expert Opin Ther Targets 7:1-5. 2003
    ....
  51. doi Man, machines, manufacturing, and maintenance: merits of a much-maligned metaphor
    Aubrey D N J de Grey
    Rejuvenation Res 11:277-9. 2008
  52. ncbi Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm aging
    Aubrey D N J de Grey
    Department of Genetics, University of Cambridge, UK
    Eur J Biochem 269:1995. 2002
  53. ncbi Antiaging technology and pseudoscience
    Aubrey D N J de Grey
    Science 296:656. 2002
  54. pmc Like it or not, life-extension research extends beyond biogerontology
    Aubrey D N J de Grey
    EMBO Rep 6:1000. 2005
  55. ncbi Three self-evident life-extension truths
    Aubrey D N J de Grey
    Rejuvenation Res 7:165-7. 2004
  56. ncbi The SENS challenge: 20,000 US dollars says the foreseeable defeat of aging is not laughable
    Aubrey D N J de Grey
    Rejuvenation Res 8:207-10. 2005
  57. ncbi Leon Kass: quite substantially right
    Aubrey D N J de Grey
    Rejuvenation Res 7:89-91. 2004
  58. ncbi The need to debalkanize gerontology: a case study
    Aubrey D N J de Grey
    Rejuvenation Res 10:431-4. 2007
  59. pmc Annotation of the Drosophila melanogaster euchromatic genome: a systematic review
    Sima Misra
    Department of Molecular and Cell Biology, University of California, Life Sciences Addition, Berkeley, CA 94720 3200, USA
    Genome Biol 3:RESEARCH0083. 2002
    ....
  60. ncbi Calorie restriction, post-reproductive life span, and programmed aging: a plea for rigor
    Aubrey D N J de Grey
    Methuselah Foundation, Cambridge, UK
    Ann N Y Acad Sci 1119:296-305. 2007
    ..Greater precision on these points will, I believe, benefit biogerontology at many levels, avoiding confusion among biogerontologists, among other biologists, and among the general public...
  61. ncbi Protagonistic pleiotropy: Why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in aging
    Aubrey D N J de Grey
    Methuselah Foundation, PO Box 1143, Lorton, VA 22079, USA
    Mech Ageing Dev 128:456-9. 2007
    ..If this conclusion is correct, the implications for the feasibility of greatly postponing mammalian (and eventually human) aging and age-related pathology are far-reaching...
  62. ncbi Has Hippocrates had his day?
    Aubrey D N J de Grey
    Rejuvenation Res 9:371-3. 2006
  63. ncbi Compression of morbidity: the hype and the reality, part 1
    Aubrey D N J de Grey
    Rejuvenation Res 9:1-2. 2006
  64. ncbi "The rate of aging": a counterproductively undefinable term
    Aubrey D N J de Grey
    Rejuvenation Res 8:77-8. 2005
  65. ncbi When and where to publish important findings: a casualty of biogerontology's rise to respectability
    Aubrey D N J de Grey
    Rejuvenation Res 8:1-2. 2005
  66. ncbi Aging, childlessness, or overpopulation: the future's right to choose
    Aubrey D N J de Grey
    Rejuvenation Res 7:237-8. 2004
  67. ncbi Understanding and tackling aging: two fields communicating (a little) at last
    Aubrey D N J de Grey
    Methuselah Foundation, Cambridge, United Kingdom
    Rejuvenation Res 10:637-40. 2007
    ....