Research Topics
| A D de GreySummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Foreseeable pharmaceutical repair of age-related extracellular damageAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Curr Drug Targets 7:1469-77. 2006..In this article, the major types of age-related extracellular damage and promising avenues for their repair are reviewed...- The unfortunate influence of the weather on the rate of ageing: why human caloric restriction or its emulation may only extend life expectancy by 2-3 yearsAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
Gerontology 51:73-82. 2005.... - The 8th International Symposium on the Maillard reaction (Charleston, South Carolina, August 28 to September 1, 2004)Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 7:257-60. 2004 - Regenerate 2004: tissue engineering the human body, June 10-12, 2004, SeattleAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
Rejuvenation Res 7:226-8. 2004 - Mitochondrial mutations in mammalian aging: an over-hasty about-turn?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom
Rejuvenation Res 7:171-4. 2004..However, there are compelling reasons to doubt the relevance of this mouse to normal mammalian aging, and thus to seek further testing of specific mechanistic hypotheses for how mtDNA mutations could cause age-related dysfunction... 
Life extension, human rights, and the rational refinement of repugnanceA D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
J Med Ethics 31:659-63. 2005- Inter-species therapeutic cloning: the looming problem of mitochondrial DNA and two possible solutionsAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 7:95-8. 2004 - Report on the open discussion on the future of life extension researchAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ann N Y Acad Sci 1019:552-3. 2004.... - Biogerontologists' duty to discuss timescales publiclyAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ann N Y Acad Sci 1019:542-5. 2004.... - Forces maintaining organellar genomes: is any as strong as genetic code disparity or hydrophobicity?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Bioessays 27:436-46. 2005.... - Reactive oxygen species production in the mitochondrial matrix: implications for the mechanism of mitochondrial mutation accumulationAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 8:13-7. 2005..quot; It may also prove to explain other recent observations in mitochondrially mutant cells in vivo... - Free radicals in aging: causal complexity and its biomedical implicationsAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
Free Radic Res 40:1244-9. 2006..This has led me to pursue the alternative, "repair and maintenance" approach that sidesteps our ignorance of metabolism and may be feasible relatively soon... - Extrapolaholics anonymous: why demographers' rejections of a huge rise in cohort life expectancy in this century are overconfidentAubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Ann N Y Acad Sci 1067:83-93. 2006.... - International Association of Biomedical Gerontology, 11th Congress (Aarhus, Denmark, August 13-16, 2005)Aubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Rejuvenation Res 8:264-6. 2005 - Appropriating microbial catabolism: a proposal to treat and prevent neurodegenerationAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Neurobiol Aging 27:589-95. 2006..Thus, microbes may exist that can degrade these lysosomal toxins. If so, it should be possible to isolate the genes responsible and modify them for therapeutic activity in the mammalian lysosome... - Medical bioremediation: prospects for the application of microbial catabolic diversity to aging and several major age-related diseasesAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ageing Res Rev 4:315-38. 2005..We discuss how microbes capable of degrading them can be isolated, characterised and their relevant enzymes engineered for this purpose and ways to avoid potential side-effects... - Resistance to debate on how to postpone ageing is delaying progress and costing lives. Open discussions in the biogerontology community would attract public interest and influence funding policyAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
EMBO Rep 6:S49-53. 2005 - Whole-body interdiction of lengthening of telomeres: a proposal for cancer preventionAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, United Kingdom
Front Biosci 10:2420-9. 2005..Here, I describe why WILT might prove to be an exceptionally powerful anti-cancer modality... - Rejuvenation Research 2004: a relaunch with a differenceAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Rejuvenation Res 8:58-60. 2005 - Total deletion of in vivo telomere elongation capacity: an ambitious but possibly ultimate cure for all age-related human cancersAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Ann N Y Acad Sci 1019:147-70. 2004..Hence, given the absence of alternatives with comparable anticancer promise, we advocate working toward such a therapy... - A proposed refinement of the mitochondrial free radical theory of agingA D de Grey
Department of Genetics, University of Cambridge, UK
Bioessays 19:161-6. 1997..The consistency of the hypothesis with known facts is discussed, and technically feasible tests are suggested, of both the proposed mechanism and its overall contribution to mammalian aging... - Is human aging still mysterious enough to be left only to scientists?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Bioessays 24:667-76. 2002..Consequently, we suggest that serious public debate on this subject is now warranted, and we survey here several of the biological, social and political issues relating to it... - HO2*: the forgotten radicalAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
DNA Cell Biol 21:251-7. 2002..It is suggested that a more widespread appreciation of the possible role of HO2* in biological systems would be of considerable benefit to biomedical research... - The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischiefAubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Eur J Biochem 269:2003-9. 2002..In this minireview, recent results relevant to this hypothesis are surveyed and approaches to intervening in the proposed process are discussed... - Time to talk SENS: critiquing the immutability of human agingAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, UK
Ann N Y Acad Sci 959:452-62; discussion 463-5. 2002..Given the major demographic consequences if it came about, this possibility merits urgent debate... - UK research on the biology of agingA D de Grey
Department of Genetics, University of Cambridge, Downing Street, CB2 3EH, Cambridge, UK
Exp Gerontol 37:1-7. 2001..Its one potential Achilles heel is the overemphasis on compression of morbidity as a goal, since further compression is highly unlikely to occur and is anyway inconsistent with the public's demonstrated desires... - Mitochondrial gene therapy: an arena for the biomedical use of inteinsA D de Grey
Department of Genetics, University of Cambridge, Cambridge, UK CB2 3EH
Trends Biotechnol 18:394-9. 2000.... - The reductive hotspot hypothesis: an updateA D de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, United Kingdom
Arch Biochem Biophys 373:295-301. 2000..This model, now known as the "reductive hotspot hypothesis," has recently gained much indirect experimental support; several direct tests of it are also feasible... - Incorporation of transmembrane hydroxide transport into the chemiosmotic theoryA D de Grey
Department of Genetics, University of Cambridge, UK
Bioelectrochem Bioenerg 49:43-50. 1999..The conflicting measurements of delta psi are shown to be consistent with the response of this system to its chemical environment... - Bioremediation meets biomedicine: therapeutic translation of microbial catabolism to the lysosomeAubrey D N J de Grey
Dept of Genetics, University of Cambridge, UK
Trends Biotechnol 20:452-5. 2002..This article examines the feasibility and biomedical potential of such lysosomal enhancement as an approach to retarding or treating age-related physiological decline and disease... - The foreseeability of real anti-aging medicine: focusing the debateAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Exp Gerontol 38:927-34. 2003..It is hoped that, by clearing the debate on future anti-aging advances of these obfuscations, the many aspects of this topic that have hitherto received much less attention than they warrant will be brought to the fore... - Critique of the demographic evidence for 'late-life non-senescence'A D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, U K
Biochem Soc Trans 31:452-4. 2003..Either explanation may therefore be correct... - Falsifying falsifications: the most critical task of theoreticians in biologyAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Med Hypotheses 62:1012-20. 2004.... - An engineer's approach to the development of real anti-aging medicineAubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Sci Aging Knowledge Environ 2003:VP1. 2003..This approach should help to prevent the development of these age-related changes into life-threatening pathologies and possibly, in due course, allow a large increase in healthy human life expectancy... - A hypothesis for the minimal overall structure of the mammalian plasma membrane redox systemAubrey D N J de Grey
Department of Genetics, University of Cambridge, Cambridge, United Kingdom
Protoplasma 221:3-9. 2003.... - Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?Konstantin Khrapko
Gerontology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Aging Cell 5:279-82. 2006..Thus, mtDNA mutations may indeed be relevant to human aging, but they probably differ by origin, type, distribution, and spectra of affected tissues from those observed in mutator mice... - Rejuvenation Research in 2007Aubrey D N J de Grey
Methuslah Foundation, Cambridge, U.K
Rejuvenation Res 11:837-9. 2008 - Mitochondria in homeotherm aging: will detailed mechanisms consistent with the evidence now receive attention?Aubrey D N J de Grey
Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
Aging Cell 3:77. 2004 - SENS survives the challenge: now let's get to workAubrey D N J de Grey
Rejuvenation Res 9:429-30. 2006 - Is SENS a farrago?Aubrey D N J de Grey
Methuselah Foundation, Cambridge, United Kingdom
Rejuvenation Res 9:436-9. 2006..Here I briefly respond to these criticisms... - The natural biogerontology portfolio: "defeating aging" as a multi-stage ultra-grand challengeAubrey D N J de Grey
Methuselah Foundation, P O Box 1143, Lorton, VA 22199, USA
Ann N Y Acad Sci 1100:409-23. 2007.... - Edmonton: a future center for pioneering biomedical gerontology?Aubrey D N J de Grey
Rejuvenation Res 10:345-7. 2007 - The case for prioritizing research on late-onset life-extension interventions in mammalsAubrey D N J de Grey
Rejuvenation Res 10:257-9. 2007 - Retrospective: Rejuvenation Research in 2006Aubrey D N J de Grey
Rejuvenation Res 10:335-8. 2007 - Dissertations: a survey of selected recent theses relevant to combating agingAubrey D N J de Grey
Rejuvenation Res 10:339-43. 2007 - Compression of morbidity: the hype and the reality, part 2Aubrey D N J de Grey
Rejuvenation Res 9:167-8. 2006 - Dissertations: a survey of selected recent theses relevant to combating agingAubrey D N J de Grey
Methuselah Foundation, Cambridge, United Kingdom
Rejuvenation Res 10:641-6. 2007 - Combating the Tithonus error: what works?Aubrey D N J de Grey
Rejuvenation Res 11:713-5. 2008 - Dissertations: a survey of selected recent theses relevant to combating agingAubrey D N J de Grey
Rejuvenation Res 11:689-95. 2008 - Challenging but essential targets for genuine anti-ageing drugsAubrey D N J de Grey
Expert Opin Ther Targets 7:1-5. 2003.... - Man, machines, manufacturing, and maintenance: merits of a much-maligned metaphorAubrey D N J de Grey
Rejuvenation Res 11:277-9. 2008 - Three detailed hypotheses implicating oxidative damage to mitochondria as a major driving force in homeotherm agingAubrey D N J de Grey
Department of Genetics, University of Cambridge, UK
Eur J Biochem 269:1995. 2002 - Antiaging technology and pseudoscienceAubrey D N J de Grey
Science 296:656. 2002 - Like it or not, life-extension research extends beyond biogerontologyAubrey D N J de Grey
EMBO Rep 6:1000. 2005 - Three self-evident life-extension truthsAubrey D N J de Grey
Rejuvenation Res 7:165-7. 2004 - The SENS challenge: 20,000 US dollars says the foreseeable defeat of aging is not laughableAubrey D N J de Grey
Rejuvenation Res 8:207-10. 2005 - Leon Kass: quite substantially rightAubrey D N J de Grey
Rejuvenation Res 7:89-91. 2004 - The need to debalkanize gerontology: a case studyAubrey D N J de Grey
Rejuvenation Res 10:431-4. 2007 
Annotation of the Drosophila melanogaster euchromatic genome: a systematic reviewSima Misra
Department of Molecular and Cell Biology, University of California, Life Sciences Addition, Berkeley, CA 94720 3200, USA
Genome Biol 3:RESEARCH0083. 2002....- Calorie restriction, post-reproductive life span, and programmed aging: a plea for rigorAubrey D N J de Grey
Methuselah Foundation, Cambridge, UK
Ann N Y Acad Sci 1119:296-305. 2007..Greater precision on these points will, I believe, benefit biogerontology at many levels, avoiding confusion among biogerontologists, among other biologists, and among the general public... - Protagonistic pleiotropy: Why cancer may be the only pathogenic effect of accumulating nuclear mutations and epimutations in agingAubrey D N J de Grey
Methuselah Foundation, PO Box 1143, Lorton, VA 22079, USA
Mech Ageing Dev 128:456-9. 2007..If this conclusion is correct, the implications for the feasibility of greatly postponing mammalian (and eventually human) aging and age-related pathology are far-reaching... - Has Hippocrates had his day?Aubrey D N J de Grey
Rejuvenation Res 9:371-3. 2006 - Compression of morbidity: the hype and the reality, part 1Aubrey D N J de Grey
Rejuvenation Res 9:1-2. 2006 - "The rate of aging": a counterproductively undefinable termAubrey D N J de Grey
Rejuvenation Res 8:77-8. 2005 - When and where to publish important findings: a casualty of biogerontology's rise to respectabilityAubrey D N J de Grey
Rejuvenation Res 8:1-2. 2005 - Aging, childlessness, or overpopulation: the future's right to chooseAubrey D N J de Grey
Rejuvenation Res 7:237-8. 2004 - Understanding and tackling aging: two fields communicating (a little) at lastAubrey D N J de Grey
Methuselah Foundation, Cambridge, United Kingdom
Rejuvenation Res 10:637-40. 2007....