C M Dayan

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    Shelley Lindley
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital London SE1 9RT, UK
    Diabetes 54:92-9. 2005
  2. pmc Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412
    C M Dayan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    Clin Exp Immunol 151:231-4. 2008
  3. ncbi request reprint Interpretation of thyroid function tests
    C M Dayan
    University Department of Medicine, Bristol Royal Infirmary, UK
    Lancet 357:619-24. 2001
  4. ncbi request reprint Human monoclonal thyroid-stimulating autoantibody: how useful is a holy grail?
    Colin M Dayan
    University Research Centre for Neuroendocrinology, Department of Medicine, University of Bristol, Bristol Royal Infirmary, BS2 8HW, Bristol, UK
    Lancet 362:92-3. 2003
  5. ncbi request reprint Whose normal thyroid function is better--yours or mine?
    Colin M Dayan
    University Research Centre for Neuroendocrinology, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Lancet 360:353. 2002
  6. ncbi request reprint Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid
    Parth Narendran
    University Department of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Ann N Y Acad Sci 958:170-4. 2002
  7. pmc Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
    C L Falconer
    Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, UK National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Diet and Lifestyle, University of Bristol, UK Electronic address
    Nutr Metab Cardiovasc Dis 24:956-62. 2014
  8. ncbi request reprint An antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA inhibits rat splenocyte proliferation in vitro
    D S Jessop
    Department of Medicine, University of Bristol, UK
    J Neuroimmunol 75:135-40. 1997
  9. ncbi request reprint Reproducibility of individualized coronary heart disease risk calculations in patients with diabetes mellitus
    A P Lambert
    Department of Medicine, Weston General Hospital, Weston Super Mare, UK
    Diabet Med 19:514-7. 2002
  10. pmc Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes
    Parth Narendran
    University Division of Medicine, Bristol Royal Infirmary, Bristol, UK
    Immunology 111:422-9. 2004

Collaborators

  • Parth Narendran
  • A A Montgomery
  • F S Wong
  • D S Jessop
  • Bijay Vaidya
  • J Gallacher
  • B Lozanoska-Ochser
  • M D Williams
  • M Peakman
  • J Evans
  • S Brown
  • D Thompson
  • G Ceresini
  • Bart O Roep
  • Richard J Ellis
  • Timothy I M Tree
  • Luigi Ferrucci
  • A P Lambert
  • A D Dick
  • Vijay Panicker
  • Ponnusamy Saravanan
  • A R Cooper
  • T J Creed
  • P Saravanan
  • C L Falconer
  • S D Hearing
  • T J Peters
  • D J Sharp
  • R C Andrews
  • Sefina Arif
  • Ruben Varela-Calvino
  • L G Petrich de Marquesini
  • S L Thrower
  • Andrew T Hattersley
  • Timothy M Frayling
  • Caroline Baker
  • Ania Skowera
  • Theo J Visser
  • Richard W J Lee
  • Amanda J Bishop
  • Shelley Lindley
  • N A Shepherd
  • C S J Probert
  • M Moorghen
  • C Baker
  • A S Page
  • J P Walhin
  • K Fitzsimons
  • N Jackson
  • S Sebire
  • J Fu
  • A J Bishop
  • C Pope
  • N E McLintock
  • K J Connor
  • Ottar Bjerkeset
  • W Hall
  • L James
  • K M Green
  • L Marquesini
  • S Arif
  • C Van-Krinks
  • J S Allen
  • Trine Bjøro
  • Bjorn O Asvold
  • Anna Zaremba
  • Ferry Ossendorp
  • Dena Hernandez
  • Michael N Weedon
  • Jan W Drijfhout
  • John R B Perry
  • Wendy W Unger
  • Andrew Singleton
  • Liliana G Petrich de Marquesini
  • Claire Durant
  • Beverley Shields
  • David Melzer
  • Chloe Rackham
  • Cassie Van-Krinks
  • Guo Cai Huang
  • Kirstie S Parnell
  • Andrew K Sewell
  • Wendy Unger
  • Anna Murray
  • Min Zhao
  • Alan J Hedges
  • Jennifer S Allen
  • Christie Cluett
  • Thomas J Creed
  • Paul V Newcomb

Detail Information

Publications32

  1. ncbi request reprint Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes
    Shelley Lindley
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, 2nd Floor, New Guy s House, Guy s Hospital London SE1 9RT, UK
    Diabetes 54:92-9. 2005
    ..007) and intracellular CTLA-4 (P = 0.01). These data demonstrate deficiency in function of the CD4(+)CD25(+) Treg population that may influence the pathogenesis of type 1 diabetes...
  2. pmc Preparing for first-in-man studies: the challenges for translational immunology post-TGN1412
    C M Dayan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Bristol, UK
    Clin Exp Immunol 151:231-4. 2008
    ..Here we discuss the critical role for immunologists in ensuring that the development of new immunotherapies continues...
  3. ncbi request reprint Interpretation of thyroid function tests
    C M Dayan
    University Department of Medicine, Bristol Royal Infirmary, UK
    Lancet 357:619-24. 2001
    ..We propose that if assays for thyrotropin, free T3, and free T4 are all done, knowledge of these patterns coupled with clinical details and simple additional tests allow a diagnosis to be made in almost all cases...
  4. ncbi request reprint Human monoclonal thyroid-stimulating autoantibody: how useful is a holy grail?
    Colin M Dayan
    University Research Centre for Neuroendocrinology, Department of Medicine, University of Bristol, Bristol Royal Infirmary, BS2 8HW, Bristol, UK
    Lancet 362:92-3. 2003
  5. ncbi request reprint Whose normal thyroid function is better--yours or mine?
    Colin M Dayan
    University Research Centre for Neuroendocrinology, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Lancet 360:353. 2002
  6. ncbi request reprint Dendritic cell-based proliferative assays of peripheral T cell responses to tetanus toxoid
    Parth Narendran
    University Department of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Ann N Y Acad Sci 958:170-4. 2002
    ....
  7. pmc Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes
    C L Falconer
    Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, UK National Institute for Health Research Bristol Biomedical Research Unit in Nutrition, Diet and Lifestyle, University of Bristol, UK Electronic address
    Nutr Metab Cardiovasc Dis 24:956-62. 2014
    ..We investigated whether objectively measured sedentary time was associated with markers of inflammation in adults with newly diagnosed type 2 diabetes...
  8. ncbi request reprint An antisense oligodeoxynucleotide complementary to corticotropin-releasing hormone mRNA inhibits rat splenocyte proliferation in vitro
    D S Jessop
    Department of Medicine, University of Bristol, UK
    J Neuroimmunol 75:135-40. 1997
    ..This attenuation of the cell proliferative response following reduced expression of splenic ir-CRH provides functional evidence for the involvement of endogenously synthesised immune ir-CRH in splenocyte activation...
  9. ncbi request reprint Reproducibility of individualized coronary heart disease risk calculations in patients with diabetes mellitus
    A P Lambert
    Department of Medicine, Weston General Hospital, Weston Super Mare, UK
    Diabet Med 19:514-7. 2002
    ..To determine prospectively, the reproducibility of individualized coronary heart disease (CHD) risk estimations in a high-risk (diabetic) population...
  10. pmc Dendritic cell-based assays, but not mannosylation of antigen, improves detection of T-cell responses to proinsulin in type 1 diabetes
    Parth Narendran
    University Division of Medicine, Bristol Royal Infirmary, Bristol, UK
    Immunology 111:422-9. 2004
    ..However, they are compromised by high autologous mixed lymphocyte reactions and this requires addressing before they can be used as a routine readout of in vitro peripheral T-cell responses...
  11. ncbi request reprint IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes
    L G Petrich de Marquesini
    Henry Wellcome Laboratory for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Clinical Science at South Bristol, University of Bristol, Whitson St, Bristol, BS1 3NY, UK
    Diabetologia 53:1451-60. 2010
    ..We studied the balance between IFN-gamma (proinflammatory) and IL-10 (regulatory) T cell responses in these participants...
  12. doi request reprint Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery
    Caroline Baker
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Clin Immunol 28:350-60. 2008
    ..In this study, we explored the breadth of CD8 T cell reactivity to preproinsulin (PPI) in type 1 diabetes...
  13. ncbi request reprint Humoral and cellular immune responses to proinsulin in adults with newly diagnosed type 1 diabetes
    Parth Narendran
    University Division of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    Diabetes Metab Res Rev 19:52-9. 2003
    ..The object of this study was to measure antibody and T-cell responses against proinsulin (PI), an islet-derived protein, and to map its dominant T-cell epitopes...
  14. ncbi request reprint Thyroid function and the natural history of depression: findings from the Caerphilly Prospective Study (CaPS) and a meta-analysis
    M D Williams
    Department of Social Medicine, University of Bristol, Bristol, UK
    Clin Endocrinol (Oxf) 70:484-92. 2009
    ..Low thyroid function has been associated with depression in clinical populations. We have examined whether thyroid function in the normal range is associated with minor psychiatric morbidity...
  15. doi request reprint Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 94:1623-9. 2009
    ..We hypothesized that in patients on T(4) common variants in the deiodinase genes might influence baseline psychological well-being and any improvement on combined T(4)/T(3) without necessarily affecting serum thyroid hormone levels...
  16. ncbi request reprint Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes
    A R Cooper
    Centre for Exercise, Nutrition and Health Sciences, School for Policy Studies, University of Bristol, 8 Priory Road, Bristol BS8 1TZ, UK
    Diabetologia 55:589-99. 2012
    ..We investigated whether objectively measured sedentary time and interruptions in sedentary time are associated with metabolic factors in people with type 2 diabetes...
  17. pmc Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study
    S L Thrower
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Clin Exp Immunol 155:156-65. 2009
    ..These studies pave the way for future investigations in new-onset patients designed to examine whether proinsulin peptide immunotherapy has beneficial effects on markers of T cell autoimmunity and preservation of beta cell mass...
  18. ncbi request reprint Thyroid autoantibodies
    P Saravanan
    Division of Medicine, University of Bristol, Bristol, United Kingdom
    Endocrinol Metab Clin North Am 30:315-37, viii. 2001
    ..This article summarizes the immunobiology, assay methodology and prevalence in thyroid diseases of each of the major thyroid autoantibodies before discussing the clinical indications for their use in thyroid diseases...
  19. ncbi request reprint Psychological well-being correlates with free thyroxine but not free 3,5,3'-triiodothyronine levels in patients on thyroid hormone replacement
    Ponnusamy Saravanan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, University of Bristol, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 91:3389-93. 2006
    ..An association between mood disorders and overt thyroid dysfunction is well established, but there are few data on the potential for thyroid hormone levels closer to the reference range to correlate with psychological well-being...
  20. ncbi request reprint In vitro measurement of lymphocyte steroid sensitivity: lack of agreement between whole blood culture and separated lymphocyte culture
    S D Hearing
    Bristol University, Division of Medicine, Bristol Royal Infirmary, UK
    Immunopharmacol Immunotoxicol 21:41-53. 1999
    ..Using the whole blood culture this steroid resistance would not be demonstrated. Hence the use of a whole blood assay can not be recommended...
  21. ncbi request reprint Basiliximab for the treatment of steroid-resistant ulcerative colitis: further experience in moderate and severe disease
    T J Creed
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, Dorothy Hodgkin Building, Bristol, UK
    Aliment Pharmacol Ther 23:1435-42. 2006
    ..We have previously reported a small case series demonstrating the potential of basiliximab as a novel agent for the treatment of steroid-resistant ulcerative colitis...
  22. ncbi request reprint Twenty-four hour hormone profiles of TSH, Free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy
    P Saravanan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    Exp Clin Endocrinol Diabetes 115:261-7. 2007
    ..Although no immediate cardiovascular effects were seen, the long-term consequences for patients on combined therapy are unknown...
  23. ncbi request reprint Basiliximab (anti-CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
    T J Creed
    University Research Centre for Neuroendocrinology, Bristol Royal Infirmary, Bristol, UK
    Aliment Pharmacol Ther 18:65-75. 2003
    ..Steroid resistance represents a major clinical problem in the treatment of ulcerative colitis. In vitro, interleukin-2 renders lymphocytes steroid resistant...
  24. ncbi request reprint Corticotropin-releasing hormone immunoreactivity in human T and B cells and macrophages: colocalization with arginine vasopressin
    C Baker
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, UK
    J Neuroendocrinol 15:1070-4. 2003
    ..These data also confirm that CRH-ir in human PBMC is not urocortin because the antiserum used in the CRH RIA does not bind to urocortin...
  25. ncbi request reprint Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial
    Ponnusamy Saravanan
    Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    J Clin Endocrinol Metab 90:805-12. 2005
    ..They also emphasize the large and sustained placebo effect that can follow changes in thyroid hormone administration...
  26. pmc A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, United Kingdom
    J Clin Endocrinol Metab 93:3075-81. 2008
    ..We aimed to thoroughly examine the role of common variation across the three deiodinase genes in relation to thyroid hormones...
  27. doi request reprint Novel insights into thyroid hormones from the study of common genetic variation
    Colin M Dayan
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Whitson Street, Bristol, UK
    Nat Rev Endocrinol 5:211-8. 2009
    ....
  28. doi request reprint A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study
    Vijay Panicker
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Whitson Street, Bristol, United Kingdom
    Clin Endocrinol (Oxf) 71:574-80. 2009
    ..There have been conflicting reports on the relationship between thyroid function and mood between studies in subjects on T4 and the general population not on T4. We investigated this relationship in a large catchment area-based study...
  29. ncbi request reprint CD4+CD25(int) T cells in inflammatory diseases refractory to treatment with glucocorticoids
    Richard W J Lee
    Academic Unit of Ophthalmology, Department of Clinical Science at South Bristol, University of Bristol, Bristol, UK
    J Immunol 179:7941-8. 2007
    ..As a result, we propose a new paradigm for SR disease in which glucocorticoid therapy positively selects SR cells, generating a population of drug-resistant lymphocytes that perpetuate on-going inflammation...
  30. pmc Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
    Sefina Arif
    Department of Immunobiology, Guy s, King s and St Thomas School of Medicine, King s College London, Guy s Campus, London, United Kingdom
    J Clin Invest 113:451-63. 2004
    ..We conclude that development of T1DM depends on the balance of autoreactive Th1 and Treg cells, which may be open to favorable manipulation by immune intervention...
  31. ncbi request reprint Characterization of the T-cell response to coxsackievirus B4: evidence that effector memory cells predominate in patients with type 1 diabetes
    Ruben Varela-Calvino
    Department of Immunology, Guy s, King s and St Thomas School of Medicine, London, UK
    Diabetes 51:1745-53. 2002
    ..The data are consistent with the notion that the diagnosis of type 1 diabetes is associated with recent or persistent exposure to EV antigens...
  32. pmc CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope
    Ania Skowera
    Department of Immunobiology, King s College London, London, United Kingdom
    J Clin Invest 118:3390-402. 2008
    ..Our findings suggest that autoreactive CTLs are important targets for immune-based interventions in type 1 diabetes and argue for early, aggressive insulin therapy to preserve remaining beta cells...