Simon P Dawson

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome
    Simon Dawson
    Laboratory of Intracellular Proteolysis, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 277:10893-902. 2002
  2. doi request reprint Hepatocellular carcinoma and the ubiquitin-proteasome system
    Simon P Dawson
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
    Biochim Biophys Acta 1782:775-84. 2008
  3. ncbi request reprint The alpha4 and alpha7 subunits and assembly of the 20S proteasome
    Géraud Sébastien Apcher
    Laboratory of Intracellular Proteolysis, School of Biomedical Sciences, University of Nottingham, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    FEBS Lett 569:211-6. 2004
  4. ncbi request reprint The ubiquitin-proteasome pathway of intracellular proteolysis
    Fergus J Doherty
    Laboratory of Intracellular Proteolysis, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, U K
    Essays Biochem 38:51-63. 2002
  5. ncbi request reprint Gankyrin: a new oncoprotein and regulator of pRb and p53
    Simon Dawson
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trends Cell Biol 16:229-33. 2006
  6. ncbi request reprint MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity
    Toshikazu Nagao
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Japan
    J Biol Chem 278:10668-74. 2003
  7. ncbi request reprint Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome
    Szymon Krzywda
    Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 59:1294-5. 2003
  8. ncbi request reprint The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53
    Szymon Krzywda
    Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 279:1541-5. 2004
  9. ncbi request reprint The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
    Hiroaki Higashitsuji
    Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Cell 8:75-87. 2005
  10. ncbi request reprint The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity
    Hiroaki Higashitsuji
    Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 363:879-84. 2007

Collaborators

  • R J Mayer
  • Hiroaki Higashitsuji
  • Yu Liu
  • Szymon Krzywda
  • Jun Fujita
  • Frank P Marx
  • Géraud Sébastien Apcher
  • Andrzej M Brzozowski
  • Anthony J Wilkinson
  • Rebecca Welchman
  • Toshikazu Nagao
  • Fergus J Doherty
  • Jorg B Schulz
  • Daniela Berg
  • Karsten M Strauss
  • Sabine Kautzmann
  • Mira Lang
  • Carola Schiesling
  • Simone Engelender
  • Rejko Kruger
  • Olaf Riess
  • Thomas Franck
  • Christian Melle
  • Jens Pahnke
  • Anne S Soehn
  • Ferdinand von Eggeling
  • Joanne Maitland
  • Paul Sheppard
  • Roisin Al-Safty
  • Katsuhiko Itoh
  • Toshiharu Sakurai
  • Maureen Mee
  • Kohsuke Nonoguchi

Detail Information

Publications11

  1. ncbi request reprint Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome
    Simon Dawson
    Laboratory of Intracellular Proteolysis, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Biol Chem 277:10893-902. 2002
    ..The proteasomal ATPases are part of the AAA (ATPases associated with diverse cellular activities) family, members of which are molecular chaperones; gankyrin complexes may therefore influence CDK4 function during oncogenesis...
  2. doi request reprint Hepatocellular carcinoma and the ubiquitin-proteasome system
    Simon P Dawson
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Clifton Boulevard, Nottingham, NG7 2UH, UK
    Biochim Biophys Acta 1782:775-84. 2008
    ....
  3. ncbi request reprint The alpha4 and alpha7 subunits and assembly of the 20S proteasome
    Géraud Sébastien Apcher
    Laboratory of Intracellular Proteolysis, School of Biomedical Sciences, University of Nottingham, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    FEBS Lett 569:211-6. 2004
    ..The unexpected interaction between alpha4 and alpha7 may provide a molecular basis for the formation of previously reported 13S and 16S assembly intermediates...
  4. ncbi request reprint The ubiquitin-proteasome pathway of intracellular proteolysis
    Fergus J Doherty
    Laboratory of Intracellular Proteolysis, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, U K
    Essays Biochem 38:51-63. 2002
    ..The ubiquitin-proteasome pathway is implicated in numerous diseases including cancer and neurodegenerative diseases...
  5. ncbi request reprint Gankyrin: a new oncoprotein and regulator of pRb and p53
    Simon Dawson
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Trends Cell Biol 16:229-33. 2006
    ..Here, we discuss the activities of gankyrin and present a model for its function in the regulation of pRb and p53...
  6. ncbi request reprint MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity
    Toshikazu Nagao
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Japan
    J Biol Chem 278:10668-74. 2003
    ..So far, the major focus of studies on the MAGE proteins has been on their potential for cancer immunotherapy. Our results may also shed light on novel functions for MAGE-A proteins...
  7. ncbi request reprint Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome
    Szymon Krzywda
    Department of Chemistry, University of York, York YO10 5YW, England
    Acta Crystallogr D Biol Crystallogr 59:1294-5. 2003
    ..Gankyrin has been crystallized from polyethylene glycol solutions and diffraction data have been obtained from these crystals that extend to 2.1 A spacing...
  8. ncbi request reprint The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53
    Szymon Krzywda
    Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 279:1541-5. 2004
    ..Comparison with the structures of other ankyrin repeat proteins suggests that interactions with partner proteins are mediated by residues situated on this concave surface...
  9. ncbi request reprint The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
    Hiroaki Higashitsuji
    Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Cell 8:75-87. 2005
    ..Downregulation of gankyrin reduced amounts of Mdm2 and p53 associated with the 26S proteasome. Thus, gankyrin is a cofactor that increases the activities of Mdm2 on p53 and probably targets polyubiquitylated p53 into the 26S proteasome...
  10. ncbi request reprint The oncoprotein gankyrin interacts with RelA and suppresses NF-kappaB activity
    Hiroaki Higashitsuji
    Department of Clinical Molecular Biology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 363:879-84. 2007
    ..Thus, gankyrin binds to NF-kappaB and suppresses its activity at the transcription level by modulating acetylation via SIRT1...
  11. ncbi request reprint The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
    Frank P Marx
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    FASEB J 21:1759-67. 2007
    ..Our data suggest a direct interaction of synphilin-1 with the regulatory complex of the proteasome modulating proteasomal function...