R J O Davies

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial
    Justin C T Pepperell
    Oxford Sleep Unit and Respiratory Trials Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, OX3 7LJ, Oxford, UK
    Lancet 359:204-10. 2002
  2. pmc Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Crit Care 14:R227. 2010
  3. pmc Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    BMC Med Genet 11:5. 2010
  4. pmc Introduction to the methods used in the generation of the British Thoracic Society guidelines for the management of pleural diseases
    R J O Davies
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ, UK
    Thorax 58:ii1-7. 2003
  5. doi request reprint Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial
    M Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    Thorax 64:67-73. 2009
  6. ncbi request reprint Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients
    G V Robinson
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals NHS Trust, Churchill Hospital Site, Oxford, OX3 7LJ, UK
    Eur Respir J 27:1229-35. 2006
  7. doi request reprint CPAP and measures of cardiovascular risk in males with OSAS
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford, OX3 7LJ, UK
    Eur Respir J 32:1488-96. 2008
  8. pmc Sleep . 6: obstructive sleep apnoea/hypopnoea syndrome and hypertension
    G V Robinson
    Oxford Sleep Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK
    Thorax 59:1089-94. 2004
  9. pmc Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials
    G V Robinson
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK
    Thorax 59:777-82. 2004
  10. pmc NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations
    S J Chapman
    Immunity and Inflammation, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 11:319-25. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial
    Justin C T Pepperell
    Oxford Sleep Unit and Respiratory Trials Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, OX3 7LJ, Oxford, UK
    Lancet 359:204-10. 2002
    ..Our aim was to see whether nCPAP for sleep apnoea reduces blood pressure compared with the most robust control intervention subtherapeutic nCPAP...
  2. pmc Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Crit Care 14:R227. 2010
    ..The possible role of genetic variation in the atypical NF-κB inhibitor IκB-R, encoded by NFKBIL2, in susceptibility to invasive pneumococcal disease has not, to our knowledge, previously been reported upon...
  3. pmc Mannose-binding lectin genotypes: lack of association with susceptibility to thoracic empyema
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    BMC Med Genet 11:5. 2010
    ..The possible role of MBL genotypic deficiency in susceptibility to thoracic empyema has not previously been reported...
  4. pmc Introduction to the methods used in the generation of the British Thoracic Society guidelines for the management of pleural diseases
    R J O Davies
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ, UK
    Thorax 58:ii1-7. 2003
  5. doi request reprint Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial
    M Kohler
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford, UK
    Thorax 64:67-73. 2009
    ..Continuous positive airway pressure (CPAP) is the treatment of choice for OSAS, but the impact of this intervention on systemic inflammation involved in the atherosclerotic process remains unclear...
  6. ncbi request reprint Continuous positive airway pressure does not reduce blood pressure in nonsleepy hypertensive OSA patients
    G V Robinson
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals NHS Trust, Churchill Hospital Site, Oxford, OX3 7LJ, UK
    Eur Respir J 27:1229-35. 2006
    ....
  7. doi request reprint CPAP and measures of cardiovascular risk in males with OSAS
    M Kohler
    Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospitals, Churchill Hospital Campus, Headington, Oxford, OX3 7LJ, UK
    Eur Respir J 32:1488-96. 2008
    ....
  8. pmc Sleep . 6: obstructive sleep apnoea/hypopnoea syndrome and hypertension
    G V Robinson
    Oxford Sleep Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK
    Thorax 59:1089-94. 2004
    ..The use of CPAP to control excessive daytime sleepiness in OSAHS probably also produces a substantial reduction in vascular risk. This is reviewed with particular reference to hypertension...
  9. pmc Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomised controlled trials
    G V Robinson
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospitals, Oxford OX3 7LJ, UK
    Thorax 59:777-82. 2004
    ..Examination of these markers may clarify the increased risk in OSA and contribute to an analysis of the benefits of treatment...
  10. pmc NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations
    S J Chapman
    Immunity and Inflammation, The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 11:319-25. 2010
    ..86). We conclude that multiple NFKBIZ polymorphisms associate with susceptibility to IPD in humans. The study of multiple populations may aid in fine mapping of associations within extensive regions of strong LD ('transethnic mapping')...
  11. pmc Investigating suspected malignant pleural effusion
    N M Rahman
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ
    BMJ 334:206-7. 2007
  12. ncbi request reprint Endocrine effects of nasal continuous positive airway pressure in male patients with obstructive sleep apnoea
    N Meston
    Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Intern Med 254:447-54. 2003
    ..This study aimed to provide controlled data on the interaction between OSA and endocrine axes to establish whether overrepresentation of pathology such as hypertension and hypogonadism in OSA subjects might have an endocrine basis...
  13. pmc Sleep. 1: Obstructive sleep apnoea/hypopnoea syndrome: definitions, epidemiology, and natural history
    J R Stradling
    Oxford Centre for Respiratory Medicine, University of Oxford and Churchill Hospital, Oxford OX3 7LJ, UK
    Thorax 59:73-8. 2004
    ..New approaches are needed to identify those who have "CPAP responsive" disease, enabling more accurate estimates to be made of the prevalence of the sleep apnoea syndrome in the community...
  14. pmc Caffeine levels following treatment of obstructive sleep apnoea
    G V Robinson
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ, UK
    Thorax 58:801-2. 2003
    ....
  15. pmc Selective pulmonary fat aspiration complicating oesophageal achalasia
    G V Robinson
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ, UK
    Thorax 59:180. 2004
  16. ncbi request reprint IkappaB genetic polymorphisms and invasive pneumococcal disease
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, and Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Roosevelt Drive, Oxford, OX3 7BN, UK
    Am J Respir Crit Care Med 176:181-7. 2007
    ..Rare NFKBIA mutations cause immunodeficiency with severe bacterial infection, raising the possibility that common IkappaB gene polymorphisms confer susceptibility to common bacterial disease...
  17. doi request reprint Use of indwelling pleural catheters for chronic pleural infection
    Helen E Davies
    Oxford Pleural Unit, Oxford Centre for Respiratory Medicine, University of Oxford and Oxford Radcliffe NHS Trust, Oxford, OX3 7LJ, UK
    Chest 133:546-9. 2008
    ..Long-term indwelling pleural catheters may have a role in maintaining the drainage of a chronically infected pleural space that is not readily treated in other ways...
  18. pmc A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 39:523-8. 2007
    ..6 x 10(-8)). We found that the Mal S180L variant attenuated TLR2 signal transduction...
  19. doi request reprint Pleural interventions: management of acute and chronic pneumothorax
    Najib M Rahman
    Oxford Pleural Unit and Oxford University, Churchill Hospital, Oxford, United Kingdom
    Semin Respir Crit Care Med 29:427-40. 2008
    ..Radiological intervention techniques are valuable in the treatment of complicated pneumothoraces and in certain clinical situations...
  20. ncbi request reprint Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Mol Immunol 44:3267-70. 2007
    ..Although we are unable to exclude small effects of FCN2 genetic variation on susceptibility to IPD, the result suggests that L-ficolin may not be critical for host defence against pneumococcal infection...
  21. ncbi request reprint Deficiency of a subset of T-cells with immunoregulatory properties in sarcoidosis
    Ling Pei Ho
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 7DS, UK
    Lancet 365:1062-72. 2005
    ..We explored whether abnormalities in these cells are implicated in the pathogenesis of sarcoidosis...
  22. ncbi request reprint Systemic hypertension and obstructive sleep apnoea
    Justin C T Pepperell
    Oxford Sleep Unit, Oxford Centre for Respiratory Medicine, UK
    Sleep Med Rev 6:157-73. 2002
    ..Finally, several studies on the beneficial effects of nasal continuous positive airway pressure in reducing blood pressure in OSA patients have preliminary results in abstract form, with one published in full...
  23. ncbi request reprint Recent advances in parapneumonic effusion and empyema
    Stephen J Chapman
    Oxford Pleural Diseases Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK
    Curr Opin Pulm Med 10:299-304. 2004
    ..This review describes recent advances in this field, as well as areas for future research...
  24. ncbi request reprint U.K. Controlled trial of intrapleural streptokinase for pleural infection
    Nicholas A Maskell
    Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford, United Kingdom
    N Engl J Med 352:865-74. 2005
    ..This use is based on small trials that did not have the statistical power to evaluate accurately important clinical outcomes, including safety. We conducted a trial to clarify the therapeutic role of intrapleural streptokinase...
  25. ncbi request reprint The approach to the patient with a parapneumonic effusion
    Najib M Rahman
    Oxford Pleural Diseases Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital Site, Oxford Radcliffe Hospital, Headington, Oxford OX3 7LJ, UK
    Clin Chest Med 27:253-66. 2006
    ..Recent data suggest that fibrinolytics do not influence outcomes in pleural infection. The optimal type and timing of surgery remain controversial...
  26. ncbi request reprint The management of pleural space infections
    Stephen J Chapman
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Respirology 9:4-11. 2004
    ..The pharmacological treatment of tuberculous pleurisy is the same as for pulmonary tuberculosis; the precise role of steroids in the treatment of tuberculous pleurisy remains uncertain...
  27. pmc Clinically important factors influencing the diagnostic measurement of pleural fluid pH and glucose
    Najib M Rahman
    Oxford Centre for Respiratory Medicine and University of Oxford, Oxford, United Kingdom
    Am J Respir Crit Care Med 178:483-90. 2008
    ..Accurate pleural fluid pH and glucose measurement is a key component in the diagnosis and management of patients with pleural effusion. Standardized methods of pleural fluid collection have not been defined...
  28. ncbi request reprint Familial spontaneous pneumothorax and FBN1 mutations
    Caroline M Cardy
    Am J Respir Crit Care Med 169:1260-2. 2004
  29. ncbi request reprint Randomized trials describing lung inflammation after pleurodesis with talc of varying particle size
    Nick A Maskell
    Oxford Pleural Disease Clinic, Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford Radcliffe NHS Trust, Oxford OX3 7LJ, UK
    Am J Respir Crit Care Med 170:377-82. 2004
    ..46 kPa 5.4 18.5 mm Hg, difference = 1.45; 95% CI, 0.2 to 2.7; p = 0.03) and induced more systemic inflammation than graded talc. We conclude that the routine use of graded talc for pleurodesis would reduce the morbidity of this procedure...
  30. ncbi request reprint Pleurodesis practice for malignant pleural effusions in five English-speaking countries: survey of pulmonologists
    Y C Gary Lee
    University of Oxford and Osler Chest Unit, Churchill Hospital, Oxford OX3 7BN, UK
    Chest 124:2229-38. 2003
    ..Pleurodesis is important in the management of malignant pleural effusions, but no consensus exists on the optimal agent or methods of pleurodesis. How pleurodesis is practiced worldwide has not been studied...
  31. ncbi request reprint A randomized controlled trial of adaptive ventilation for Cheyne-Stokes breathing in heart failure
    Justin C T Pepperell
    Oxford Sleep Unit, Oxford Centre for Respiratory Medicine, Oxford Radcliffe Hospital, Oxford, United Kingdom
    Am J Respir Crit Care Med 168:1109-14. 2003
    ..This study suggests improvements in neurohormonal activation with this treatment...
  32. ncbi request reprint Pleurodesis for malignant pleural effusions: current controversies and variations in practices
    Sophie D West
    Oxford Pleural Diseases Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford, UK
    Curr Opin Pulm Med 10:305-10. 2004
    ..A recent international survey of pleurodesis practice has highlighted variations in how pleurodesis is performed worldwide. Future research should target these areas of variation to determine the best practice protocols...
  33. ncbi request reprint Catheter-tract metastases associated with chronic indwelling pleural catheters
    Sam M Janes
    Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ, UK
    Chest 131:1232-4. 2007
    ..7% of 45 patients treated with indwelling pleural catheters for malignant pleural effusions. Both clinicians and patients should be aware of this potential complication...
  34. ncbi request reprint Pleural effusions
    Stephen J Chapman
    Wellcome Trust Centre for Human Genetics, Oxford University
    Clin Med 4:207-10. 2004
  35. ncbi request reprint Diagnosing pleural effusion: moving beyond transudate-exudate separation
    Y C Gary Lee
    Chest 131:942-3. 2007
  36. ncbi request reprint Diagnostically significant variations in pleural fluid pH in loculated parapneumonic effusions
    Nick A Maskell
    Oxford Centre for Respiratory Medicine, Churchill Hospital, John Radcliffe NHS Trust, Oxford, Oxfordshire, UK
    Chest 126:2022-4. 2004
    ..We therefore set out to test the hypothesis that pH varies significantly between locules in complicated parapneumonic effusions...
  37. ncbi request reprint The bacteriology of pleural infection by genetic and standard methods and its mortality significance
    Nick A Maskell
    Department of Respiratory Medicine, Southmead Hospital, North Bristol NHS Trust, UK
    Am J Respir Crit Care Med 174:817-23. 2006
    ..Antibiotic choices for pleural infection are uncertain as its bacteriology is poorly described...
  38. ncbi request reprint CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
    Nicola Dalbeth
    Division of Medicine, Imperial College London, Commonwealth Building, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    J Immunol 173:6418-26. 2004
    ..Such a positive feedback loop is likely to be important in the pathogenesis of chronic inflammatory conditions such as rheumatoid arthritis...
  39. ncbi request reprint PTPN22 and invasive bacterial disease
    Stephen J Chapman
    Nat Genet 38:499-500. 2006
  40. pmc Intrapleural streptokinase for pleural infection
    Nick Maskell
    BMJ 332:552. 2006
  41. ncbi request reprint Needle-track metastases and prophylactic radiotherapy for mesothelioma
    Sophie D West
    Oxford Pleural Clinic, Oxford Centre for Respiratory Medicine, Churchill Hospital, Headington, Oxford OX3 7LJ, UK
    Respir Med 100:1037-40. 2006
    ..Mesothelioma invades the tracts made by chest instrumentation. Prophylactic radiotherapy is effective at preventing malignant seeding at these sites...
  42. ncbi request reprint Pleural effusion: a structured approach to care
    Najib M Rahman
    Oxford Pleural Diseases Unit, Oxford Centre for Respiratory Medicine, Churchill Hospital Oxford OX3 7LJ, UK
    Br Med Bull 72:31-47. 2004
    ..This review provides a structured approach to the investigation of the patient with a pleural effusion. This should allow an accurate diagnosis to be made with the minimum number of invasive and time-consuming investigations...