Research Topics
Genomes and Genes | Jamie DaviesSummaryAffiliation: University of Edinburgh Country: UK Publications
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Publications
siRNA-mediated RNA interference in embryonic kidney organ cultureJamie A Davies
University of Edinburgh, Hugh Robson Building, Edinburgh, UK
Methods Mol Biol 886:295-303. 2012..As well as proving instructions for the methods, we provide a brief discussion of necessary controls...- Access and use of the GUDMAP database of genitourinary developmentJamie A Davies
University of Edinburgh, Hugh Robson Building, Edinburgh, UK
Methods Mol Biol 886:185-201. 2012..Here, we explain how to run typical queries on the database, by gene or anatomical location, how to view data, how to perform complex queries, and how to submit data... 
Developmental biologists' choice of subjects approximates to a power law, with no evidence for the existence of a special group of 'model organisms'Jamie A Davies
BMC Dev Biol 7:40. 2007....
Structural determinants of heparan sulphate modulation of GDNF signallingJ A Davies
Anatomy Building, Edinburgh University College of Medicine, Teviot Place, Edinburgh EH8 9AG, UK
Growth Factors 21:109-19. 2003..These findings may explain the similarities between the phenotypes of transgenic mice lacking GDNF and those lacking heparan sulphate 2-sulphotransferase, the enzyme responsible for achieving 2-O-sulphation of uronic acids in vivo...- Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubulesJ A Davies
Department of Anatomy, University of Edinburgh Medical School, UK
FEBS Lett 410:378-82. 1997..These results suggest an unsuspected link between the phosphotriesterase enzyme family and resiniferatoxin toxicity and pharmacology... - Watching tubules glow and branchJamie A Davies
Centre for Integrative Physiology, Edinburgh University College of Medicine, Teviot Place, Edinburgh, EH8 9AG, UK
Curr Opin Genet Dev 15:364-70. 2005.... - A method for cold storage and transport of viable embryonic kidney rudimentsJ A Davies
Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, UK
Kidney Int 70:2031-4. 2006..It will therefore substantially augment the ability of kidney research labs to perform pilot experiments on large numbers of different transgenic animals and to collaborate in new ways... 
Synthetic morphology: prospects for engineered, self-constructing anatomiesJamie A Davies
Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, United Kingdom
J Anat 212:707-19. 2008..The necessary library may therefore be within reach. The paper ends by suggesting a set of challenges, ranging from simple to complex, the achievement of which would provide valuable proofs of concept...- Regulation, necessity, and the misinterpretation of knockoutsJamie Davies
Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square EH89XB, UK
Bioessays 31:826-30. 2009..This logical error threatens to blur the important distinction between regulation and mere necessity and therefore to weaken one of our strongest tools for comprehending how organisms work... - Morphogenesis of the metanephric kidneyJamie A Davies
Anatomy Building, Edinburgh University Medical School, Teviot Place, Edinburgh, EH8 9AG
ScientificWorldJournal 2:1937-50. 2002.... - Collecting duct morphogenesisJ A Davies
Centre for Developmental Biology, University of Edinburgh Medical School, Scotland
Pediatr Nephrol 13:535-41. 1999..More information on these internal pathways of control is expected over the next few years... - Do different branching epithelia use a conserved developmental mechanism?Jamie A Davies
Anatomy Building, Edinburgh University Medical School, Scotland
Bioessays 24:937-48. 2002..Overall, I come to the tentative conclusion that key mechanisms are highly conserved, at least within vertebrates, but acknowledge that more work needs to be done before the case is proved beyond reasonable doubt... - Molecular aspects of the epithelial phenotypeJ A Davies
Department of Anatomy, University of Edinburgh Medical School, UK
Bioessays 19:699-704. 1997..The epithelial state may therefore be controlled by multiple regulatory genes so that there is no single molecule responsible for all of the diverse types of epithelium that exist in higher animals... - Genes and proteins in renal developmentJamie A Davies
Centre for Developmental Biology, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
Exp Nephrol 10:102-13. 2002..As nephrons mature, regions of them differentiate to perform specific physiological functions, a process that requires the proteins WT-1, Lmx-1b, Notch-2, Jagged-1, and Hnf-1... - Glycosaminoglycans in the study of mammalian organ developmentJ A Davies
Department of Anatomy, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U K
Biochem Soc Trans 29:166-71. 2001..This approach has assisted the identification of four collecting-duct morphogens: hepatocyte growth factor, glial cell line-derived neurotrophic factor, nerturin and persephin... - Intracellular and extracellular regulation of ureteric bud morphogenesisJ Davies
Department of Anatomy, Edinburgh University Medical School, UK
J Anat 198:257-64. 2001.... - Neurturin: an autocrine regulator of renal collecting duct developmentJ A Davies
Centre for Developmental Biology, University of Edinburgh Medical School, Scotland, UK
Dev Genet 24:284-92. 1999..This is in marked contrast to previously identified morphogens such as glial cell line derived neurotrophic factor and hepatocyte growth factor, which act in a paracrine manner... - The Kidney Development DatabaseJ A Davies
Department of Biomedical Sciences, University of Edinburgh Medical School, Scotland, UK
Dev Genet 24:194-8. 1999..ana.ed.ac.uk/kidhome.html, and http://www.ana.ed.ac.uk/anatomy/database/kidbase/ kidhome.html... - Mechanisms of epithelial development and neoplasia in the metanephric kidneyJ A Davies
Centre for Developmental Biology and Department of Anatomy, Edinburgh University, United Kingdom
Int J Dev Biol 43:473-8. 1999.... - Granulocyte colony-stimulating factor (G-CSF) depresses angiogenesis in vivo and in vitro: implications for sourcing cells for vascular regeneration therapyO Tura
SNBTS Cell Therapy Group, MRC Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK
J Thromb Haemost 8:1614-23. 2010..It has been proposed that endothelial progenitor cells (EPCs) share precursors with HPCs, and that EPC release may accompany HPC mobilization to the circulation following G-CSF administration... - Developmental plasticity and regenerative capacity in the renal ureteric bud/collecting duct systemDerina Sweeney
Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
Development 135:2505-10. 2008..This observation has major implications for models of pattern formation in branching trees, and may also be important for tissue engineering and regenerative medicine... - Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycanMark W Barnett
Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
J Cell Sci 115:4495-503. 2002..The involvement of heparan sulphates in GDNF signalling raises the possibility that modulation of heparan expression may modulate signalling by GDNF in vivo... - Epithelial branching: the power of self-loathingWen Chin Lee
Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
Bioessays 29:205-7. 2007..Such a system would allow a developing tree to arrange itself, without detailed genetic specification, by adaptive self-organization... - The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct systemLydia Michael
Centre for Integrative Physiology, Edinburgh University College of Medicine, Edinburgh, UK
J Anat 210:89-97. 2007..Similarly, if excess GDNF is provided to growing kidneys, the DBA-free zone expands. DBA-staining status therefore appears to be a sensitive indicator of the morphogenetic activity of the collecting duct system... - The anatomy of organogenesis: novel solutions to old problemsJamie A Davies
Centre for Integrative Physiology, University of Edinburgh College of Medicine, Hugh Robson Building, Edinburgh EH8 9XB, UK
Prog Histochem Cytochem 40:165-76. 2006..We finish by looking ahead to the prospects of uniting these three technologies to allow accurate, high-throughput screening of mutants and automated comparison of biological data with computer predictions... - A role for microfilament-based contraction in branching morphogenesis of the ureteric budLydia Michael
Centre for Integrative Physiology, Edinburgh University College of Medicine, Scotland, UK
Kidney Int 68:2010-8. 2005..CONCLUSION: The formation of tension-bearing actin-myosin complexes is essential for branching morphogenesis in the developing kidney... - Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiationJamie A Davies
The Department of Anatomy, Edinburgh University, Edinburgh, UK
Hum Mol Genet 13:235-46. 2004.... - Pattern and regulation of cell proliferation during murine ureteric bud developmentLydia Michael
Genes and Development Group, University of Edinburgh College of Medicine, UK
J Anat 204:241-55. 2004..Our results suggest that localized proliferation is an important morphogenetic mechanism in kidney development...