Jamie Davies

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Engineered renal tissue as a potential platform for pharmacokinetic and nephrotoxicity testing
    Jamie Davies
    University of Edinburgh, United Kingdom Electronic address
    Drug Discov Today 19:725-9. 2014
  2. pmc A novel, low-volume method for organ culture of embryonic kidneys that allows development of cortico-medullary anatomical organization
    David D R Sebinger
    Max Bergmann Center of Biomaterials, Leibniz Institut für Polymerforschung Dresden, Dresden, Germany
    PLoS ONE 5:e10550. 2010
  3. pmc FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique
    Guangping Tai
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Biol Open 2:416-23. 2013
  4. pmc Engineering kidneys from simple cell suspensions: an exercise in self-organization
    Jamie A Davies
    University of Edinburgh, Edinburgh, Scotland, UK
    Pediatr Nephrol 29:519-24. 2014
  5. doi request reprint Disinherited daughters travel by tube
    Jamie A Davies
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK Electronic address
    Dev Cell 27:245-6. 2013
  6. doi request reprint Access and use of the GUDMAP database of genitourinary development
    Jamie A Davies
    University of Edinburgh, Hugh Robson Building, Edinburgh, UK
    Methods Mol Biol 886:185-201. 2012
  7. ncbi request reprint siRNA-mediated RNA interference in embryonic kidney organ culture
    Jamie A Davies
    University of Edinburgh, Hugh Robson Building, Edinburgh, UK
    Methods Mol Biol 886:295-303. 2012
  8. pmc Developmental biologists' choice of subjects approximates to a power law, with no evidence for the existence of a special group of 'model organisms'
    Jamie A Davies
    BMC Dev Biol 7:40. 2007
  9. ncbi request reprint Regulation, necessity, and the misinterpretation of knockouts
    Jamie Davies
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square EH89XB, UK
    Bioessays 31:826-30. 2009
  10. pmc Synthetic morphology: prospects for engineered, self-constructing anatomies
    Jamie A Davies
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, United Kingdom
    J Anat 212:707-19. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Engineered renal tissue as a potential platform for pharmacokinetic and nephrotoxicity testing
    Jamie Davies
    University of Edinburgh, United Kingdom Electronic address
    Drug Discov Today 19:725-9. 2014
    ..More realistic would be a recently developed technique for engineering functioning 'mini-kidneys' from suspensions of stem cells, a technique that works in mouse but that could also be applied to humans. ..
  2. pmc A novel, low-volume method for organ culture of embryonic kidneys that allows development of cortico-medullary anatomical organization
    David D R Sebinger
    Max Bergmann Center of Biomaterials, Leibniz Institut für Polymerforschung Dresden, Dresden, Germany
    PLoS ONE 5:e10550. 2010
    ..In this system, kidneys grow directly on glass, grow larger than in conventional culture and develop a clear anatomical cortico-medullary zonation with extended loops of Henle...
  3. pmc FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique
    Guangping Tai
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Biol Open 2:416-23. 2013
    ..We demonstrate the utility of the screen by using it to identify the FAK-Src-pathway signalling as being important for collecting duct development, specifically for the cell proliferation on which this development depends...
  4. pmc Engineering kidneys from simple cell suspensions: an exercise in self-organization
    Jamie A Davies
    University of Edinburgh, Edinburgh, Scotland, UK
    Pediatr Nephrol 29:519-24. 2014
    ..We hope that this approach might one day be the basis of a clinically useful technique for renal replacement therapy...
  5. doi request reprint Disinherited daughters travel by tube
    Jamie A Davies
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK Electronic address
    Dev Cell 27:245-6. 2013
    ..One daughter inherits its mother's location, whereas the other moves along the lumen and reintegrates there...
  6. doi request reprint Access and use of the GUDMAP database of genitourinary development
    Jamie A Davies
    University of Edinburgh, Hugh Robson Building, Edinburgh, UK
    Methods Mol Biol 886:185-201. 2012
    ..Here, we explain how to run typical queries on the database, by gene or anatomical location, how to view data, how to perform complex queries, and how to submit data...
  7. ncbi request reprint siRNA-mediated RNA interference in embryonic kidney organ culture
    Jamie A Davies
    University of Edinburgh, Hugh Robson Building, Edinburgh, UK
    Methods Mol Biol 886:295-303. 2012
    ..As well as proving instructions for the methods, we provide a brief discussion of necessary controls...
  8. pmc Developmental biologists' choice of subjects approximates to a power law, with no evidence for the existence of a special group of 'model organisms'
    Jamie A Davies
    BMC Dev Biol 7:40. 2007
    ....
  9. ncbi request reprint Regulation, necessity, and the misinterpretation of knockouts
    Jamie Davies
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square EH89XB, UK
    Bioessays 31:826-30. 2009
    ..This logical error threatens to blur the important distinction between regulation and mere necessity and therefore to weaken one of our strongest tools for comprehending how organisms work...
  10. pmc Synthetic morphology: prospects for engineered, self-constructing anatomies
    Jamie A Davies
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, United Kingdom
    J Anat 212:707-19. 2008
    ..The necessary library may therefore be within reach. The paper ends by suggesting a set of challenges, ranging from simple to complex, the achievement of which would provide valuable proofs of concept...
  11. ncbi request reprint A method for cold storage and transport of viable embryonic kidney rudiments
    J A Davies
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh, UK
    Kidney Int 70:2031-4. 2006
    ..It will therefore substantially augment the ability of kidney research labs to perform pilot experiments on large numbers of different transgenic animals and to collaborate in new ways...
  12. ncbi request reprint Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubules
    J A Davies
    Department of Anatomy, University of Edinburgh Medical School, UK
    FEBS Lett 410:378-82. 1997
    ..These results suggest an unsuspected link between the phosphotriesterase enzyme family and resiniferatoxin toxicity and pharmacology...
  13. ncbi request reprint Watching tubules glow and branch
    Jamie A Davies
    Centre for Integrative Physiology, Edinburgh University College of Medicine, Teviot Place, Edinburgh, EH8 9AG, UK
    Curr Opin Genet Dev 15:364-70. 2005
    ....
  14. ncbi request reprint Structural determinants of heparan sulphate modulation of GDNF signalling
    J A Davies
    Anatomy Building, Edinburgh University College of Medicine, Teviot Place, Edinburgh EH8 9AG, UK
    Growth Factors 21:109-19. 2003
    ..These findings may explain the similarities between the phenotypes of transgenic mice lacking GDNF and those lacking heparan sulphate 2-sulphotransferase, the enzyme responsible for achieving 2-O-sulphation of uronic acids in vivo...
  15. ncbi request reprint Mechanisms of epithelial development and neoplasia in the metanephric kidney
    J A Davies
    Centre for Developmental Biology and Department of Anatomy, Edinburgh University, United Kingdom
    Int J Dev Biol 43:473-8. 1999
    ....
  16. ncbi request reprint Genes and proteins in renal development
    Jamie A Davies
    Centre for Developmental Biology, Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    Exp Nephrol 10:102-13. 2002
    ..As nephrons mature, regions of them differentiate to perform specific physiological functions, a process that requires the proteins WT-1, Lmx-1b, Notch-2, Jagged-1, and Hnf-1...
  17. ncbi request reprint Do different branching epithelia use a conserved developmental mechanism?
    Jamie A Davies
    Anatomy Building, Edinburgh University Medical School, Scotland
    Bioessays 24:937-48. 2002
    ..Overall, I come to the tentative conclusion that key mechanisms are highly conserved, at least within vertebrates, but acknowledge that more work needs to be done before the case is proved beyond reasonable doubt...
  18. ncbi request reprint Glycosaminoglycans in the study of mammalian organ development
    J A Davies
    Department of Anatomy, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, U K
    Biochem Soc Trans 29:166-71. 2001
    ..This approach has assisted the identification of four collecting-duct morphogens: hepatocyte growth factor, glial cell line-derived neurotrophic factor, nerturin and persephin...
  19. ncbi request reprint Collecting duct morphogenesis
    J A Davies
    Centre for Developmental Biology, University of Edinburgh Medical School, Scotland
    Pediatr Nephrol 13:535-41. 1999
    ..More information on these internal pathways of control is expected over the next few years...
  20. ncbi request reprint Neurturin: an autocrine regulator of renal collecting duct development
    J A Davies
    Centre for Developmental Biology, University of Edinburgh Medical School, Scotland, UK
    Dev Genet 24:284-92. 1999
    ..This is in marked contrast to previously identified morphogens such as glial cell line derived neurotrophic factor and hepatocyte growth factor, which act in a paracrine manner...
  21. ncbi request reprint The Kidney Development Database
    J A Davies
    Department of Biomedical Sciences, University of Edinburgh Medical School, Scotland, UK
    Dev Genet 24:194-8. 1999
    ..ana.ed.ac.uk/kidhome.html, and http://www.ana.ed.ac.uk/anatomy/database/kidbase/ kidhome.html...
  22. ncbi request reprint Morphogenesis of the metanephric kidney
    Jamie A Davies
    Anatomy Building, Edinburgh University Medical School, Teviot Place, Edinburgh, EH8 9AG
    ScientificWorldJournal 2:1937-50. 2002
    ....
  23. ncbi request reprint Molecular aspects of the epithelial phenotype
    J A Davies
    Department of Anatomy, University of Edinburgh Medical School, UK
    Bioessays 19:699-704. 1997
    ..The epithelial state may therefore be controlled by multiple regulatory genes so that there is no single molecule responsible for all of the diverse types of epithelium that exist in higher animals...
  24. pmc Intracellular and extracellular regulation of ureteric bud morphogenesis
    J Davies
    Department of Anatomy, Edinburgh University Medical School, UK
    J Anat 198:257-64. 2001
    ....
  25. pmc Granulocyte colony-stimulating factor (G-CSF) depresses angiogenesis in vivo and in vitro: implications for sourcing cells for vascular regeneration therapy
    O Tura
    SNBTS Cell Therapy Group, MRC Centre for Regenerative Medicine, The University of Edinburgh, Edinburgh, UK
    J Thromb Haemost 8:1614-23. 2010
    ..It has been proposed that endothelial progenitor cells (EPCs) share precursors with HPCs, and that EPC release may accompany HPC mobilization to the circulation following G-CSF administration...
  26. pmc Pattern and regulation of cell proliferation during murine ureteric bud development
    Lydia Michael
    Genes and Development Group, University of Edinburgh College of Medicine, UK
    J Anat 204:241-55. 2004
    ..Our results suggest that localized proliferation is an important morphogenetic mechanism in kidney development...
  27. doi request reprint Developmental plasticity and regenerative capacity in the renal ureteric bud/collecting duct system
    Derina Sweeney
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
    Development 135:2505-10. 2008
    ..This observation has major implications for models of pattern formation in branching trees, and may also be important for tissue engineering and regenerative medicine...
  28. ncbi request reprint Epithelial branching: the power of self-loathing
    Wen Chin Lee
    Chang Gung Memorial Hospital Kaohsiung Medical Center, Taiwan
    Bioessays 29:205-7. 2007
    ..Such a system would allow a developing tree to arrange itself, without detailed genetic specification, by adaptive self-organization...
  29. pmc The lectin Dolichos biflorus agglutinin is a sensitive indicator of branching morphogenetic activity in the developing mouse metanephric collecting duct system
    Lydia Michael
    Centre for Integrative Physiology, Edinburgh University College of Medicine, Edinburgh, UK
    J Anat 210:89-97. 2007
    ..Similarly, if excess GDNF is provided to growing kidneys, the DBA-free zone expands. DBA-staining status therefore appears to be a sensitive indicator of the morphogenetic activity of the collecting duct system...
  30. ncbi request reprint Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan
    Mark W Barnett
    Edinburgh University Medical School, Teviot Place, Edinburgh EH8 9AG, UK
    J Cell Sci 115:4495-503. 2002
    ..The involvement of heparan sulphates in GDNF signalling raises the possibility that modulation of heparan expression may modulate signalling by GDNF in vivo...
  31. ncbi request reprint The anatomy of organogenesis: novel solutions to old problems
    Jamie A Davies
    Centre for Integrative Physiology, University of Edinburgh College of Medicine, Hugh Robson Building, Edinburgh EH8 9XB, UK
    Prog Histochem Cytochem 40:165-76. 2006
    ..We finish by looking ahead to the prospects of uniting these three technologies to allow accurate, high-throughput screening of mutants and automated comparison of biological data with computer predictions...
  32. ncbi request reprint Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation
    Jamie A Davies
    The Department of Anatomy, Edinburgh University, Edinburgh, UK
    Hum Mol Genet 13:235-46. 2004
    ....
  33. ncbi request reprint A role for microfilament-based contraction in branching morphogenesis of the ureteric bud
    Lydia Michael
    Centre for Integrative Physiology, Edinburgh University College of Medicine, Scotland, UK
    Kidney Int 68:2010-8. 2005
    ..The actin cytoskeleton is a common component of mechanisms of morphogenesis. We have therefore studied the expression of, and requirement for actin filaments in the ureteric bud, a branching epithelium of the mammalian kidney...