Donald J Davidson

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells
    Donald J Davidson
    Child and Family Research Institute and Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    J Immunol 177:8202-11. 2006
  2. pmc Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
    Robert D Gray
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, Scotland, UK
    J Inflamm (Lond) 10:12. 2013
  3. pmc Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
    Kelly L Brown
    Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Transl Med 8:6. 2010
  4. pmc Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37
    Y Elaine Lau
    Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, BC V6T 1Z4 Canada
    Am J Respir Cell Mol Biol 34:399-409. 2006
  5. pmc Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells
    Y Elaine Lau
    The Department of Microbiology and Immunology, University of British Columbia, 6174 University Blvd, Vancouver, British Columbia, Canada
    Infect Immun 73:583-91. 2005
  6. pmc Immunomodulatory activities of small host defense peptides
    Dawn M E Bowdish
    Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Road, Vancouver, British Columbia, Canada V6T 1Z4
    Antimicrob Agents Chemother 49:1727-32. 2005
  7. ncbi request reprint Impact of LL-37 on anti-infective immunity
    Dawn M E Bowdish
    Centre for Microbial Diseases and Immunity Research, Vancouver, British Columbia, Canada
    J Leukoc Biol 77:451-9. 2005
  8. pmc The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium
    Peter G Barlow
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, W2 05, 47 Little France Crescent, Edinburgh, Scotland, UK
    Am J Respir Cell Mol Biol 43:692-702. 2010
  9. ncbi request reprint A re-evaluation of the role of host defence peptides in mammalian immunity
    Dawn M E Bowdish
    Department of Microbiology, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Protein Pept Sci 6:35-51. 2005
  10. ncbi request reprint Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
    Aaron F Hirschfeld
    Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Clin Immunol 122:271-8. 2007

Collaborators

Detail Information

Publications17

  1. pmc IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells
    Donald J Davidson
    Child and Family Research Institute and Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    J Immunol 177:8202-11. 2006
    ....
  2. pmc Activation of conventional protein kinase C (PKC) is critical in the generation of human neutrophil extracellular traps
    Robert D Gray
    MRC Centre for Inflammation Research, The Queen s Medical Research Institute, University of Edinburgh Medical School, 47 Little France Crescent, Edinburgh, Scotland, UK
    J Inflamm (Lond) 10:12. 2013
    ..Activation of NADPH oxidase is required for neutrophil extracellular trap (NET) formation. Protein kinase C (PKC) is an upstream mediator of NADPH oxidase activation and thus likely to have a role in NET formation...
  3. pmc Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
    Kelly L Brown
    Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada
    J Transl Med 8:6. 2010
    ..Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and the transcription factor NFkappaB for the rapid expression of immunity genes...
  4. pmc Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37
    Y Elaine Lau
    Centre for Microbial Diseases and Immunity Research, Room 232, 2259 Lower Mall Research Station, University of British Columbia, Vancouver, BC V6T 1Z4 Canada
    Am J Respir Cell Mol Biol 34:399-409. 2006
    ..We propose that LL-37-induced apoptosis of epithelial cells at low serum tissue sites may have a protective role against bacterial infection...
  5. pmc Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells
    Y Elaine Lau
    The Department of Microbiology and Immunology, University of British Columbia, 6174 University Blvd, Vancouver, British Columbia, Canada
    Infect Immun 73:583-91. 2005
    ..These results indicate the mode of interaction of LL-37 with epithelial cells and further our understanding of its role in modulating the innate immune response...
  6. pmc Immunomodulatory activities of small host defense peptides
    Dawn M E Bowdish
    Centre for Microbial Diseases and Immunity Research, University of British Columbia, 2259 Lower Mall Road, Vancouver, British Columbia, Canada V6T 1Z4
    Antimicrob Agents Chemother 49:1727-32. 2005
    ..This indicates that in addition to the potential for direct microbicidal activity, cationic host defense peptides may have diverse and complementary abilities to modulate the innate immune response...
  7. ncbi request reprint Impact of LL-37 on anti-infective immunity
    Dawn M E Bowdish
    Centre for Microbial Diseases and Immunity Research, Vancouver, British Columbia, Canada
    J Leukoc Biol 77:451-9. 2005
    ..A peptide with no antimicrobial activity was found to be protective in animal models of Staphylococcus aureus and Salmonella infection, implying that a host defense peptide can protect by exerting immunomodulatory properties...
  8. pmc The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium
    Peter G Barlow
    Medical Research Council University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, W2 05, 47 Little France Crescent, Edinburgh, Scotland, UK
    Am J Respir Cell Mol Biol 43:692-702. 2010
    ..We propose that the LL-37-mediated apoptosis of infected, compromised airway epithelial cells may represent a novel inflammomodulatory role for this peptide in innate host defense, promoting the clearance of respiratory pathogens...
  9. ncbi request reprint A re-evaluation of the role of host defence peptides in mammalian immunity
    Dawn M E Bowdish
    Department of Microbiology, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Protein Pept Sci 6:35-51. 2005
    ....
  10. ncbi request reprint Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
    Aaron F Hirschfeld
    Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Clin Immunol 122:271-8. 2007
    ....
  11. ncbi request reprint Murine epithelial cells: isolation and culture
    Donald J Davidson
    B C Research Institute, Room 381, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
    J Cyst Fibros 3:59-62. 2004
    ....
  12. pmc Persistence of Burkholderia multivorans within the pulmonary macrophage in the murine lung
    Karen K Chu
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Infect Immun 72:6142-7. 2004
    ..multivorans-infected lungs localized bacteria to macrophages. Clearance of B. cenocepacia was associated with greater interleukin-1beta and neutrophil responses than the responses induced by B. multivorans...
  13. ncbi request reprint The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes
    Dawn M E Bowdish
    Department of Microbiology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 172:3758-65. 2004
    ..The ability of LL-37 to signal through these pathways has broad implications in immunity, monocyte activation, proliferation, and differentiation...
  14. ncbi request reprint The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses
    Monisha G Scott
    Department of Microbiology and Immunology and British Columbia Research Institute for Child and Family Health, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 169:3883-91. 2002
    ..These findings indicate that LL-37 may contribute to the immune response by limiting the damage caused by bacterial products and by recruiting immune cells to the site of infection so that they can clear the infection...
  15. pmc The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system
    Peter G Barlow
    MRC University of Edinburgh Centre for Inflammation Research, Queen s Medical Research Institute, W2 03, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland
    J Leukoc Biol 80:509-20. 2006
    ....
  16. ncbi request reprint Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling
    Andrew J Currie
    Division of Infectious and Immunological Diseases, British Columbia s Research Institute for Child and Family Health, 950 West 28th Avenue, Vancouver, British Columbia, Canada V5Z 4H4
    J Pediatr 144:512-8. 2004
    ..We investigated the role of TLR signaling in defense against infection in a 3-year-old boy with a severe defect resulting in recurrent Streptococcus pneumoniae bacteremia...
  17. ncbi request reprint The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization
    Donald J Davidson
    British Columbia Research Institute for Child and Family Health, Room 381, 950 West 28th Avenue, Vancouver, British Columbia, Canada V5Z 4H4
    J Immunol 172:1146-56. 2004
    ..LL-37 may be an attractive therapeutic candidate for manipulating T cell polarization by DC...