Harish K Datta

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Lack of association of bone morphogenetic protein 2 gene haplotypes with bone mineral density, bone loss, or risk of fractures in men
    Satya S Varanasi
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Osteoporos 2011:243465. 2011
  2. pmc Osteoporosis in the aging male: treatment options
    Stephen P Tuck
    Department of Rheumatology, James Cook University Hospital, Marton Road, Middlesbrough, Cleveland, UK
    Clin Interv Aging 2:521-36. 2007
  3. ncbi request reprint Mechanisms of calcium disposal from osteoclastic resorption hemivacuole
    H K Datta
    School of Clinical and Laboratory Science, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Endocrinol 176:1-5. 2003
  4. ncbi request reprint Hepatic surgery-related hypophosphatemia
    Harish K Datta
    Department of Clinical Biochemistry and Metabolism, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Chim Acta 380:13-23. 2007
  5. doi request reprint The cell biology of bone metabolism
    H K Datta
    Institute of Cellular Medicine, Musculoskeletal Research Group, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Pathol 61:577-87. 2008
  6. doi request reprint Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes
    Michail Kalogeropoulos
    Musculoskeletal Research Group, ICM, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    FASEB J 24:2893-903. 2010
  7. pmc Skeletal site-related variation in human trabecular bone transcriptome and signaling
    Satya S Varanasi
    Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 5:e10692. 2010
  8. doi request reprint Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis
    Suhair Jabbar
    Rheumatology Department, The James Cook University Hospital, Middlesbrough, UK
    J Clin Pathol 64:354-7. 2011
  9. ncbi request reprint Real-time activity bioassay of single osteoclasts using a silicon nanocrystal-impregnated artificial matrix
    Naif H Alsharif
    Musculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    Small 9:3685-92. 2013
  10. ncbi request reprint Assessment of vitamin D status in male osteoporosis
    Ziad H Al-oanzi
    School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Clin Chem 52:248-54. 2006

Collaborators

  • Mark A Birch
  • Benjamin R Horrocks
  • Ole K Olstad
  • Sjur Reppe
  • S P Tuck
  • Roger M Francis
  • Satya S Varanasi
  • Naif H Alsharif
  • S S Varanasi
  • Suhair Jabbar
  • Kaare M Gautvik
  • Paul Sanderson
  • Vigdis T Gautvik
  • Michail Kalogeropoulos
  • Ziad H Al-oanzi
  • Said A Farha Al-Said
  • Josephine Vila
  • John Drury
  • Sarabjit S Mastana
  • Cyrus Cooper
  • John N Fordham
  • Elaine Dennison
  • Daniel C Swan
  • Christine E M Berger
  • Yimin Chao
  • David B Cook
  • John S Harrop
  • Gregory D Summers
  • Nicholas Raj

Detail Information

Publications14

  1. pmc Lack of association of bone morphogenetic protein 2 gene haplotypes with bone mineral density, bone loss, or risk of fractures in men
    Satya S Varanasi
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Osteoporos 2011:243465. 2011
    ..Conclusion. There were no genotypic or haplotypic effects of the BMP2 candidate gene on BMD, change in BMD, or fracture risk identified in this cohort...
  2. pmc Osteoporosis in the aging male: treatment options
    Stephen P Tuck
    Department of Rheumatology, James Cook University Hospital, Marton Road, Middlesbrough, Cleveland, UK
    Clin Interv Aging 2:521-36. 2007
    ..In cases where bisphosphonates are contra-indicated or ineffective, teriparatide or alternatives such as strontium should be considered...
  3. ncbi request reprint Mechanisms of calcium disposal from osteoclastic resorption hemivacuole
    H K Datta
    School of Clinical and Laboratory Science, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Endocrinol 176:1-5. 2003
    ..The understanding of the mechanisms involved in Ca2+ handling by osteoclasts indicates the lack of a simple link between osteoclast function and changes in overall cytosolic [Ca2+]...
  4. ncbi request reprint Hepatic surgery-related hypophosphatemia
    Harish K Datta
    Department of Clinical Biochemistry and Metabolism, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Clin Chim Acta 380:13-23. 2007
    ....
  5. doi request reprint The cell biology of bone metabolism
    H K Datta
    Institute of Cellular Medicine, Musculoskeletal Research Group, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Pathol 61:577-87. 2008
    ..The intracellular signalling regulating key cellular pathways involved in cell differentiation and activity are outlined. The emerging evidence of osteocytes as mechanosensors as well as regulators of mineralisation is discussed...
  6. doi request reprint Zic1 transcription factor in bone: neural developmental protein regulates mechanotransduction in osteocytes
    Michail Kalogeropoulos
    Musculoskeletal Research Group, ICM, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    FASEB J 24:2893-903. 2010
    ..We conclude that Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes...
  7. pmc Skeletal site-related variation in human trabecular bone transcriptome and signaling
    Satya S Varanasi
    Musculoskeletal Research Group, Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 5:e10692. 2010
    ..The skeletal site-specific influence of multiple genes on bone morphology is recognised, but the question as to how these influences may be exerted at the molecular and cellular level has not been explored...
  8. doi request reprint Osteoprotegerin, RANKL and bone turnover in postmenopausal osteoporosis
    Suhair Jabbar
    Rheumatology Department, The James Cook University Hospital, Middlesbrough, UK
    J Clin Pathol 64:354-7. 2011
    ....
  9. ncbi request reprint Real-time activity bioassay of single osteoclasts using a silicon nanocrystal-impregnated artificial matrix
    Naif H Alsharif
    Musculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, UK
    Small 9:3685-92. 2013
    ....
  10. ncbi request reprint Assessment of vitamin D status in male osteoporosis
    Ziad H Al-oanzi
    School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Clin Chem 52:248-54. 2006
    ....
  11. ncbi request reprint Prostate cancer and osteoporosis
    Stephen P Tuck
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Curr Osteoporos Rep 11:11-20. 2013
    ..Both zoledronic acid and denosumab have been demonstrated to reduce skeletal related events. Comparative studies would suggest that densosumab may have an advantage over zoledronic acid...
  12. pmc Alkyl-capped silicon nanocrystals lack cytotoxicity and have enhanced intracellular accumulation in malignant cells via cholesterol-dependent endocytosis
    Naif H Alsharif
    Musculoskeletal Research Group, Institute of Cellular Medicine Newcastle University, Framlington Place Newcastle upon Tyne, UK
    Small 5:221-8. 2009
    ..The observed dramatic difference in the rate and extent of internalization of the nanocrystals between malignant and non-malignant cells therefore offers potential application in the management of human neoplastic conditions...
  13. ncbi request reprint Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells
    S S Varanasi
    School of Clinical and Laboratory Sciences, The Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Bone 36:243-53. 2005
    ....
  14. ncbi request reprint Southern analysis of mitochondrial DNA in cortical bone of elderly patients undergoing knee and hip arthroplasty
    S S Varanasi
    School of Clinical and Laboratory Sciences, Department of Clinical Biochemistry, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    J Pathol 193:557-62. 2001
    ....