Michael R Dashwood

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Does external stenting reduce porcine vein-graft occlusion via an action on vascular nerves?
    M R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
    J Card Surg 17:556-60. 2002
  2. ncbi Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide production
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London, United Kingdom
    Ann Thorac Surg 80:939-44. 2005
  3. ncbi Hypothesis: a potential role for the vasa vasorum in the maintenance of vein graft patency
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
    Angiology 55:385-95. 2004
  4. ncbi Surgical trauma and vein graft failure: further evidence for a role of ET-1 in graft occlusion
    Michael Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
    J Cardiovasc Pharmacol 44:S16-9. 2004
  5. ncbi Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts
    Xu Shi-Wen
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Matrix Biol 26:625-32. 2007
  6. doi Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgery
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
    Interact Cardiovasc Thorac Surg 12:170-3. 2011
  7. ncbi Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
    J Vasc Res 44:175-81. 2007
  8. doi Retaining perivascular tissue of human saphenous vein grafts protects against surgical and distension-induced damage and preserves endothelial nitric oxide synthase and nitric oxide synthase activity
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London, United Kingdom
    J Thorac Cardiovasc Surg 138:334-40. 2009
  9. doi Endothelin-1 stimulates colon cancer adjacent fibroblasts
    Jonathan P Knowles
    Department of Surgery, UCL Division of Surgery and Interventional Science, London, United Kingdom
    Int J Cancer 130:1264-72. 2012
  10. ncbi Localization of nitric oxide synthase in saphenous vein grafts harvested with a novel "no-touch" technique: potential role of nitric oxide contribution to improved early graft patency rates
    Janice C S Tsui
    Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Vasc Surg 35:356-62. 2002

Collaborators

Detail Information

Publications46

  1. ncbi Does external stenting reduce porcine vein-graft occlusion via an action on vascular nerves?
    M R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
    J Card Surg 17:556-60. 2002
    ..Neural reorganization occurs in porcine vein grafts and placement of an external stent reduces graft occlusion...
  2. ncbi Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide production
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London, United Kingdom
    Ann Thorac Surg 80:939-44. 2005
    ..Nitric oxide, a potent vasodilator, also inhibits platelet aggregation, thrombus formation and vascular smooth muscle cell proliferation, is implicated in various vascular pathologies, including graft failure...
  3. ncbi Hypothesis: a potential role for the vasa vasorum in the maintenance of vein graft patency
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
    Angiology 55:385-95. 2004
    ..Preservation of the vasa vasorum of saphenous veins used as bypass conduits may play an important role in the maintenance of graft patency...
  4. ncbi Surgical trauma and vein graft failure: further evidence for a role of ET-1 in graft occlusion
    Michael Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
    J Cardiovasc Pharmacol 44:S16-9. 2004
    ..These results suggest that endothelin-1 plays a role in vein graft failure, predominantly via the endothelin-A receptor...
  5. ncbi Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts
    Xu Shi-Wen
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    Matrix Biol 26:625-32. 2007
    ..Thus endogenous endothelin signaling contributes to the fibrotic phenotype of fibrotic fibroblasts, suggesting that antagonizing endothelin receptors may be of benefit in combating fibrotic disease...
  6. doi Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgery
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
    Interact Cardiovasc Thorac Surg 12:170-3. 2011
    ..Our findings suggest that, as a potent vasodilator, PVF-derived leptin may also play an important role both at harvesting and in the improved long-term performance of no-touch SVs in patients undergoing CABG...
  7. ncbi Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
    J Vasc Res 44:175-81. 2007
    ..Apart from these grafts exhibiting an intact luminal endothelium they are harvested complete with a surrounding cushion of tissue, much of which is fat...
  8. doi Retaining perivascular tissue of human saphenous vein grafts protects against surgical and distension-induced damage and preserves endothelial nitric oxide synthase and nitric oxide synthase activity
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London, United Kingdom
    J Thorac Cardiovasc Surg 138:334-40. 2009
    ....
  9. doi Endothelin-1 stimulates colon cancer adjacent fibroblasts
    Jonathan P Knowles
    Department of Surgery, UCL Division of Surgery and Interventional Science, London, United Kingdom
    Int J Cancer 130:1264-72. 2012
    ..Upregulated genes were consistent with these processes. By acting as a strong stimulus for tumour stroma creation, ET-1 is proposed as a target for adjuvant cancer therapy...
  10. ncbi Localization of nitric oxide synthase in saphenous vein grafts harvested with a novel "no-touch" technique: potential role of nitric oxide contribution to improved early graft patency rates
    Janice C S Tsui
    Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Vasc Surg 35:356-62. 2002
    ..The separate contribution of perivascular tissue removal and distension to alterations in nitric oxide synthase was also studied...
  11. ncbi Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusion
    Janice C S Tsui
    Department of Surgery, Royal Free Hospital, London, UK
    Angiology 58:586-92. 2007
    ..In the development of therapeutic agents based on manipulation of the NO pathway, targeting the appropriate NOS isoenzymes may be important...
  12. ncbi The saphenous vein as a bypass conduit: the potential role of vascular nerves in graft performance
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, London NW3 2QG, UK
    Curr Vasc Pharmacol 7:47-57. 2009
    ..Also, we consider the value of various common experimental techniques for studying vasoactive and mitogenic factors and their potential role in vein graft performance...
  13. ncbi On the sympathetic innervation of the human greater saphenous vein: relevance to clinical practice
    Andrzej Loesch
    Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, UK
    Curr Vasc Pharmacol 7:58-67. 2009
    ..An account of a possible contribution of sympathetic nerves to the physiology of the saphenous vein, as well as their relevance to the outcome of coronary artery bypass surgery that uses the vein as a graft, is discussed...
  14. pmc Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors
    Xu Shi-Wen
    Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    Mol Cell Biol 26:5518-27. 2006
    ....
  15. ncbi Endothelin-1 and endothelin receptors in the basilar artery of the capybara
    Andrzej Loesch
    Department of Anatomy and Developmental Biology Royal Free Campus, Royal Free and University College Medical School, University College London, Rowland Hill Street, London, UK, NW3 2PF
    J Mol Histol 36:25-34. 2005
    ..These results suggest that the endothelin system is present throughout the wall of the basilar artery of capybara...
  16. ncbi Expression and cellular localisation of renal endothelin-1 and endothelin receptor subtypes in autosomal-dominant polycystic kidney disease
    Albert C M Ong
    Sheffield Kidney Institute, Section of Human Metabolism, Division of Clinical Sciences NGH, University of Sheffield, London, UK
    Nephron Exp Nephrol 93:e80. 2003
    ..This is the first study to demonstrate a specific upregulation of ETA receptors in human renal disease. Future studies should address whether ETA selective antagonists may be effective in slowing renal disease progression in ADPKD...
  17. ncbi Altered endothelin receptor subtypes in colorectal cancer
    Moinuddin M Hoosein
    Department of Surgery, Royal Free and University College Medical School, London, UK
    Eur J Gastroenterol Hepatol 19:775-82. 2007
    ..To identify other potential stimulatory loops, we investigated the distribution and cell-specific localization of both ETAR and ETBR in tissue sections from patients with colorectal cancer...
  18. doi 'No-touch' saphenous vein harvesting improves graft performance in patients undergoing coronary artery bypass surgery: a journey from bedside to bench
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London NW3 2QG, United Kingdom
    Vascul Pharmacol 58:240-50. 2013
    ..Here we describe a 'bedside to bench' situation where the mechanisms underlying the improved performance of 'no touch' saphenous vein grafts in patients have been studied in the laboratory...
  19. ncbi The effect of acute ischemia on ET-1 and its receptors in patients with underlying chronic ischemia of the lower limb
    Michael R Dashwood
    Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
    Exp Biol Med (Maywood) 231:802-5. 2006
    ..ET-1 antagonists may therefore be useful adjuncts in CLI and other surgical procedures in which ischemia-reperfusion damage occurs...
  20. ncbi Detection of glucagon receptor mRNA in the rat proximal tubule: potential role for glucagon in the control of renal glucose transport
    J Marks
    Department of Physiology and Centre for Nephrology, Institute of Urology and Nephrology, Royal Free and University College Medical School, Middlesex Hospital, London, UK
    Clin Sci (Lond) 104:253-8. 2003
    ....
  21. doi Endothelin-1 and vein graft occlusion in patients undergoing bypass surgery
    M R Dashwood
    Royal Free and University College Medical School, London, UK
    Eur J Clin Invest 39:78-87. 2009
    ..In this review, data supporting a role of endothelin-1 in vein graft occlusion are presented, and the therapeutic potential of endothelin receptor antagonists in improving graft performance is discussed...
  22. doi Determination of cell-specific receptor binding using a combination of immunohistochemistry and in vitro autoradiography: relevance to therapeutic receptor targeting in cancer
    Michael R Dashwood
    Department of Clinical Biochemistry, Royal Free and UCL Medical School, London, UK
    Methods Mol Biol 878:137-47. 2012
    ..The system described has been used to compare receptor binding to cells in normal human colorectal tissue with that in colorectal cancer specimens...
  23. ncbi Identification of neuronal nitric oxide synthase (nNOS) in human penis: a potential role of reduced neuronally-derived nitric oxide in erectile dysfunction
    Michael R Dashwood
    Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, United Kingdom
    Curr Pharm Biotechnol 12:1316-21. 2011
    ..We have shown that nerve degeneration observed in penile tissue from ED patients is accompanied by a decrease in nNOS suggesting that reduced neuronal- as well as endothelium-derived NO plays a role in this condition...
  24. ncbi Recent strategies to reduce vein graft occlusion: a need to limit the effect of vascular damage
    J C S Tsui
    Department of Surgery, Royal Free and University College London Medical School, London, NW3 2QG, UK
    Eur J Vasc Endovasc Surg 23:202-8. 2002
    ....
  25. doi Efficacy of the Specific Endothelin A Receptor Antagonist Zibotentan (ZD4054) in Colorectal Cancer: A Preclinical Study
    Samer Ul Haque
    Corresponding Author Marilena Loizidou, Division of Surgery and Interventional Science, UCL Medical School, 9th Floor, Royal Free Hospital, Pond Street, London, NW3 2QG, United Kingdom
    Mol Cancer Ther 12:1556-67. 2013
    ..With its known safety profile, we provide evidence for zibotentan's potential role as adjuvant therapy in colorectal cancer. Mol Cancer Ther; 12(8); 1556-67. ©2013 AACR. ..
  26. ncbi Human saphenous vein and coronary bypass surgery: ultrastructural aspects of conventional and "no-touch" vein graft preparations
    S R Ahmed
    Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, London, UK
    Histol Histopathol 19:421-33. 2004
    ..These features are suggested to contribute to the improved early patency rate described using the no-touch technique of SV harvesting...
  27. doi Immunoreactive endothelin-1 and endothelin a receptor in basilar artery perivascular nerves of young and adult capybaras
    Andrzej Loesch
    Division of Medicine, University College London Medical School, London NW3 2PF, UK
    Cells Tissues Organs 198:47-56. 2013
    ..The role of ET-1 in cerebrovascular nerves is still unclear but its involvement in neural (sensory) control of cerebral blood flow and nerve function is possible. ..
  28. ncbi Endothelin-1 and atherosclerosis: potential complications associated with endothelin-receptor blockade
    Michael R Dashwood
    Department of Molecular Pathology and Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
    Atherosclerosis 160:297-304. 2002
    ..In such situations ET antagonism may be undesirable...
  29. ncbi Effect of ischemic preconditioning on hepatic microcirculation and function in a rat model of ischemia reperfusion injury
    Rahul S Koti
    Hepatic Haemodynamic Unit, University Department of Surgery, Royal Free and University College Medical School, University College London Royal Free Hospital, London, United Kingdom
    Liver Transpl 8:1182-91. 2002
    ..IPC induced NOS and attenuated HM impairment and hepatocellular injury. These data strongly suggest a role for nitric oxide in IPC...
  30. ncbi Nitric oxide synthase in critically ischaemic muscle and alterations in isoform expression during revascularization surgery
    J C S Tsui
    Department of Surgery, Royal Free and University College Medical School, London, UK
    Br J Surg 95:72-9. 2008
    ..Nitric oxide synthase (NOS) isoforms and NOS activity were studied in muscle from patients with critical leg ischaemia (CLI). Alterations in NOS during revascularization surgery were also assessed...
  31. ncbi Preserved endothelial integrity and nitric oxide synthase in saphenous vein grafts harvested by a 'no-touch' technique
    J C Tsui
    Department of Surgery, Royal Free and University College Medical School, London, UK
    Br J Surg 88:1209-15. 2001
    ..These sites were preserved after no-touch harvesting, suggesting the potential to improve coronary artery bypass graft patency...
  32. ncbi Potential role of endothelin 1 in ischaemia-induced angiogenesis in critical leg ischaemia
    J C S Tsui
    Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
    Br J Surg 89:741-7. 2002
    ..The aim of this study was to quantify microvessels and study ET receptor expression and distribution in critically ischaemic leg muscle...
  33. ncbi Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1
    X Shi-Wen
    Center for Rheumatology and Department of Molecular Pathology, Royal Free and University College Medical School, London, UK
    J Invest Dermatol 116:417-25. 2001
    ..These data further implicate dysregulated endothelin-receptor pathways in fibroblasts in the pathogenesis of connective tissue fibrosis...
  34. ncbi Evidence for the involvement of endothelin-1 but not urotensin-II in chronic lower limb ischaemia in man
    J C S Tsui
    Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
    Eur J Vasc Endovasc Surg 25:443-50. 2003
    ..This study investigated endothelin-1 (ET-1) and urotensin-II (U-II) mRNA expression, peptide distribution and ET receptor subtype binding in chronically ischaemic muscle...
  35. ncbi Altered endothelin-1 levels in acute lower limb ischemia and reperfusion
    J C S Tsui
    Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, London, UK
    Angiology 55:533-9. 2004
    ..It is concluded that the ET-1 pathway is involved in acute ischemia and reperfusion and it may contribute to the muscle injury that occurs during surgical procedures...
  36. ncbi Endothelin receptors in the aetiology and pathophysiology of varicose veins
    O Agu
    Department of Surgery, Royal Free and University College Medical School, Pond Street, London, NW3 2QG, UK
    Eur J Vasc Endovasc Surg 23:165-71. 2002
    ..We hypothesise that endothelial cells and endothelin receptor density and distribution may play a role in the development of varicosis...
  37. ncbi Endothelin receptors in cultured and native human radial artery smooth muscle
    Alan R Conant
    Cardiothoracic Center, Liverpool NHS Trust, Liverpool, UK
    J Cardiovasc Pharmacol 39:130-41. 2002
    ....
  38. ncbi Improved patency in vein grafts harvested with surrounding tissue: results of a randomized study using three harvesting techniques
    Domingos S R Souza
    Department of Thoracic and Cardiovascular Surgery, Orebro University Hospital, Sweden
    Ann Thorac Surg 73:1189-95. 2002
    ..The patency rate of a novel "no-touch" technique in which the vein is harvested with a pedicle of surrounding tissue and not distended was compared with two other techniques...
  39. ncbi Harvesting the saphenous vein with surrounding tissue for CABG provides long-term graft patency comparable to the left internal thoracic artery: results of a randomized longitudinal trial
    Domingos S R Souza
    Department of Cardiothoracic Surgery and Anesthesiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
    J Thorac Cardiovasc Surg 132:373-8. 2006
    ..Conventional harvesting of the saphenous vein in coronary artery bypass surgery produces vessel damage that contributes to graft failure. A novel "no touch" technique provides high short- and long-term patency rates...
  40. ncbi The pathobiology of endothelin-1 in vein graft disease: are ETA receptor antagonists the solution to prevent vein graft failure?
    Jamie Y Jeremy
    Bristol Heart Institute, University of Bristol, UK
    Curr Vasc Pharmacol 3:315-23. 2005
    ....
  41. ncbi Improved saphenous vein graft patency for coronary artery bypass grafting: "no-touch" harvesting or "dissection without touching"?
    Andrzej Loesch
    J Thorac Cardiovasc Surg 134:819-20; author reply 820-1. 2007
  42. ncbi The endothelin 1A receptor antagonist BSF 302146 is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein-carotid artery interposition grafts
    Song Wan
    Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
    J Thorac Cardiovasc Surg 127:1317-22. 2004
    ....
  43. ncbi Surgical damage of the saphenous vein and graft patency
    Michael R Dashwood
    J Thorac Cardiovasc Surg 133:274-5. 2007
  44. ncbi Endothelins and the 'French paradox': are detrimental effects of red wine also associated with an action on endothelin synthesis?
    Michael R Dashwood
    Angiology 53:749-51. 2002
  45. ncbi A role for endothelin-1 in peripheral vascular disease
    Janice C S Tsui
    Southend Hospital, Prittlewell Chase, Southend on Sea, Essex SS0 0RY, UK
    Curr Vasc Pharmacol 3:325-32. 2005
    ..Here, the possible role of endothelin-1 in peripheral vascular disease is discussed and potential therapeutic tools are considered...
  46. ncbi Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK
    Shi wen Xu
    Centre for Rheumatology, Department of Medicine, Royal Free and University College London, United Kingdom
    J Biol Chem 279:23098-103. 2004
    ..Our results suggest that ET-1 induces a program of matrix synthesis in lung fibroblasts and that ET-1 may play a key role in connective tissue deposition during wound repair and in pulmonary fibrosis...