Research Topics
Genomes and Genes | Michael R DashwoodSummaryAffiliation: University College London Country: UK Publications
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Publications
Hypothesis: a potential role for the vasa vasorum in the maintenance of vein graft patencyMichael R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
Angiology 55:385-95. 2004..Preservation of the vasa vasorum of saphenous veins used as bypass conduits may play an important role in the maintenance of graft patency...- Effect of vein graft harvesting on endothelial nitric oxide synthase and nitric oxide productionMichael R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London, United Kingdom
Ann Thorac Surg 80:939-44. 2005..Nitric oxide, a potent vasodilator, also inhibits platelet aggregation, thrombus formation and vascular smooth muscle cell proliferation, is implicated in various vascular pathologies, including graft failure... - Surgical trauma and vein graft failure: further evidence for a role of ET-1 in graft occlusionMichael Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
J Cardiovasc Pharmacol 44:S16-9. 2004..These results suggest that endothelin-1 plays a role in vein graft failure, predominantly via the endothelin-A receptor... - Does external stenting reduce porcine vein-graft occlusion via an action on vascular nerves?M R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, London, United Kingdom
J Card Surg 17:556-60. 2002..Neural reorganization occurs in porcine vein grafts and placement of an external stent reduces graft occlusion... - Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblastsXu Shi-Wen
Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
Matrix Biol 26:625-32. 2007..Thus endogenous endothelin signaling contributes to the fibrotic phenotype of fibrotic fibroblasts, suggesting that antagonizing endothelin receptors may be of benefit in combating fibrotic disease... 
Perivascular fat-derived leptin: a potential role in improved vein graft performance in coronary artery bypass surgeryMichael R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
Interact Cardiovasc Thorac Surg 12:170-3. 2011..Our findings suggest that, as a potent vasodilator, PVF-derived leptin may also play an important role both at harvesting and in the improved long-term performance of no-touch SVs in patients undergoing CABG...- Retaining perivascular tissue of human saphenous vein grafts protects against surgical and distension-induced damage and preserves endothelial nitric oxide synthase and nitric oxide synthase activityMichael R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London, United Kingdom
J Thorac Cardiovasc Surg 138:334-40. 2009.... - Does periadventitial fat-derived nitric oxide play a role in improved saphenous vein graft patency in patients undergoing coronary artery bypass surgery?Michael R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, London, UK
J Vasc Res 44:175-81. 2007..Apart from these grafts exhibiting an intact luminal endothelium they are harvested complete with a surrounding cushion of tissue, much of which is fat... - Endothelin-1 stimulates colon cancer adjacent fibroblastsJonathan P Knowles
Department of Surgery, UCL Division of Surgery and Interventional Science, London, United Kingdom
Int J Cancer 130:1264-72. 2012..Upregulated genes were consistent with these processes. By acting as a strong stimulus for tumour stroma creation, ET-1 is proposed as a target for adjuvant cancer therapy... - Localization of nitric oxide synthase in saphenous vein grafts harvested with a novel "no-touch" technique: potential role of nitric oxide contribution to improved early graft patency ratesJanice C S Tsui
Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
J Vasc Surg 35:356-62. 2002..CONCLUSION: The new no-touch technique of saphenous vein harvesting preserves nitric oxide synthase, which suggests that improved nitric oxide availability may be an important mechanism in the success of this technique... - Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusionJanice C S Tsui
Department of Surgery, Royal Free Hospital, London, UK
Angiology 58:586-92. 2007..In the development of therapeutic agents based on manipulation of the NO pathway, targeting the appropriate NOS isoenzymes may be important... - The saphenous vein as a bypass conduit: the potential role of vascular nerves in graft performanceMichael R Dashwood
Department of Clinical Biochemistry, Royal Free and University College Medical School, London NW3 2QG, UK
Curr Vasc Pharmacol 7:47-57. 2009..Also, we consider the value of various common experimental techniques for studying vasoactive and mitogenic factors and their potential role in vein graft performance... - Altered endothelin receptor subtypes in colorectal cancerMoinuddin M Hoosein
Department of Surgery, Royal Free and University College Medical School, London, UK
Eur J Gastroenterol Hepatol 19:775-82. 2007..To identify other potential stimulatory loops, we investigated the distribution and cell-specific localization of both ETAR and ETBR in tissue sections from patients with colorectal cancer... - On the sympathetic innervation of the human greater saphenous vein: relevance to clinical practiceAndrzej Loesch
Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, UK
Curr Vasc Pharmacol 7:58-67. 2009..An account of a possible contribution of sympathetic nerves to the physiology of the saphenous vein, as well as their relevance to the outcome of coronary artery bypass surgery that uses the vein as a graft, is discussed... 
Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptorsXu Shi-Wen
Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
Mol Cell Biol 26:5518-27. 2006....- Endothelin-1 and endothelin receptors in the basilar artery of the capybaraAndrzej Loesch
Department of Anatomy and Developmental Biology Royal Free Campus, Royal Free and University College Medical School, University College London, Rowland Hill Street, London, UK, NW3 2PF
J Mol Histol 36:25-34. 2005..These results suggest that the endothelin system is present throughout the wall of the basilar artery of capybara... - Expression and cellular localisation of renal endothelin-1 and endothelin receptor subtypes in autosomal-dominant polycystic kidney diseaseAlbert C M Ong
Sheffield Kidney Institute, Section of Human Metabolism, Division of Clinical Sciences NGH, University of Sheffield, London, UK
Nephron Exp Nephrol 93:e80. 2003..This is the first study to demonstrate a specific upregulation of ETA receptors in human renal disease. Future studies should address whether ETA selective antagonists may be effective in slowing renal disease progression in ADPKD... - The effect of acute ischemia on ET-1 and its receptors in patients with underlying chronic ischemia of the lower limbMichael R Dashwood
Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
Exp Biol Med (Maywood) 231:802-5. 2006..ET-1 antagonists may therefore be useful adjuncts in CLI and other surgical procedures in which ischemia-reperfusion damage occurs... - Detection of glucagon receptor mRNA in the rat proximal tubule: potential role for glucagon in the control of renal glucose transportJ Marks
Department of Physiology and Centre for Nephrology, Institute of Urology and Nephrology, Royal Free and University College Medical School, Middlesex Hospital, London, UK
Clin Sci (Lond) 104:253-8. 2003.... - Endothelin-1 and vein graft occlusion in patients undergoing bypass surgeryM R Dashwood
Royal Free and University College Medical School, London, UK
Eur J Clin Invest 39:78-87. 2009..In this review, data supporting a role of endothelin-1 in vein graft occlusion are presented, and the therapeutic potential of endothelin receptor antagonists in improving graft performance is discussed... - Determination of cell-specific receptor binding using a combination of immunohistochemistry and in vitro autoradiography: relevance to therapeutic receptor targeting in cancerMichael R Dashwood
Department of Clinical Biochemistry, Royal Free and UCL Medical School, London, UK
Methods Mol Biol 878:137-47. 2012..The system described has been used to compare receptor binding to cells in normal human colorectal tissue with that in colorectal cancer specimens... - Identification of neuronal nitric oxide synthase (nNOS) in human penis: a potential role of reduced neuronally-derived nitric oxide in erectile dysfunctionMichael R Dashwood
Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, United Kingdom
Curr Pharm Biotechnol 12:1316-21. 2011..We have shown that nerve degeneration observed in penile tissue from ED patients is accompanied by a decrease in nNOS suggesting that reduced neuronal- as well as endothelium-derived NO plays a role in this condition... - Recent strategies to reduce vein graft occlusion: a need to limit the effect of vascular damageJ C S Tsui
Department of Surgery, Royal Free and University College London Medical School, London, NW3 2QG, UK
Eur J Vasc Endovasc Surg 23:202-8. 2002.... - Human saphenous vein and coronary bypass surgery: ultrastructural aspects of conventional and "no-touch" vein graft preparationsS R Ahmed
Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, London, UK
Histol Histopathol 19:421-33. 2004..These features are suggested to contribute to the improved early patency rate described using the no-touch technique of SV harvesting... - Effect of ischemic preconditioning on hepatic microcirculation and function in a rat model of ischemia reperfusion injuryRahul S Koti
Hepatic Haemodynamic Unit, University Department of Surgery, Royal Free and University College Medical School, University College London Royal Free Hospital, London, United Kingdom
Liver Transpl 8:1182-91. 2002..IPC induced NOS and attenuated HM impairment and hepatocellular injury. These data strongly suggest a role for nitric oxide in IPC... - Endothelin-1 and atherosclerosis: potential complications associated with endothelin-receptor blockadeMichael R Dashwood
Department of Molecular Pathology and Clinical Biochemistry, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
Atherosclerosis 160:297-304. 2002..In such situations ET antagonism may be undesirable... - Altered endothelin-1 levels in acute lower limb ischemia and reperfusionJ C S Tsui
Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, London, UK
Angiology 55:533-9. 2004..It is concluded that the ET-1 pathway is involved in acute ischemia and reperfusion and it may contribute to the muscle injury that occurs during surgical procedures... - Nitric oxide synthase in critically ischaemic muscle and alterations in isoform expression during revascularization surgeryJ C S Tsui
Department of Surgery, Royal Free and University College Medical School, London, UK
Br J Surg 95:72-9. 2008..Nitric oxide synthase (NOS) isoforms and NOS activity were studied in muscle from patients with critical leg ischaemia (CLI). Alterations in NOS during revascularization surgery were also assessed... - Endothelin receptors in the aetiology and pathophysiology of varicose veinsO Agu
Department of Surgery, Royal Free and University College Medical School, Pond Street, London, NW3 2QG, UK
Eur J Vasc Endovasc Surg 23:165-71. 2002..We speculate that the increase in endothelin-B receptor binding CD31-positive endothelial cells in varicose veins may potentially stimulate mitogenesis and migration, leading to new vessel formation... - Preserved endothelial integrity and nitric oxide synthase in saphenous vein grafts harvested by a 'no-touch' techniqueJ C Tsui
Department of Surgery, Royal Free and University College Medical School, London, UK
Br J Surg 88:1209-15. 2001..These sites were preserved after no-touch harvesting, suggesting the potential to improve coronary artery bypass graft patency... - Potential role of endothelin 1 in ischaemia-induced angiogenesis in critical leg ischaemiaJ C S Tsui
Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
Br J Surg 89:741-7. 2002..The aim of this study was to quantify microvessels and study ET receptor expression and distribution in critically ischaemic leg muscle... - Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1X Shi-Wen
Center for Rheumatology and Department of Molecular Pathology, Royal Free and University College Medical School, London, UK
J Invest Dermatol 116:417-25. 2001..These data further implicate dysregulated endothelin-receptor pathways in fibroblasts in the pathogenesis of connective tissue fibrosis... - Evidence for the involvement of endothelin-1 but not urotensin-II in chronic lower limb ischaemia in manJ C S Tsui
Department of Surgery, Royal Free and University College Medical School, Royal Free Campus, Pond Street, London NW3 2QG, UK
Eur J Vasc Endovasc Surg 25:443-50. 2003..ET-1 binding to ET(B) receptors in particular may play an important role in the pathophysiology of CLI underscoring the therapeutic potential of ET(B) receptor antagonists in the management of CLI... - Improved saphenous vein graft patency for coronary artery bypass grafting: "no-touch" harvesting or "dissection without touching"?Andrzej Loesch
J Thorac Cardiovasc Surg 134:819-20; author reply 820-1. 2007 - Improved patency in vein grafts harvested with surrounding tissue: results of a randomized study using three harvesting techniquesDomingos S R Souza
Department of Thoracic and Cardiovascular Surgery, Orebro University Hospital, Sweden
Ann Thorac Surg 73:1189-95. 2002..The patency rate of a novel "no-touch" technique in which the vein is harvested with a pedicle of surrounding tissue and not distended was compared with two other techniques... - Surgical damage of the saphenous vein and graft patencyMichael R Dashwood
J Thorac Cardiovasc Surg 133:274-5. 2007 - Harvesting the saphenous vein with surrounding tissue for CABG provides long-term graft patency comparable to the left internal thoracic artery: results of a randomized longitudinal trialDomingos S R Souza
Department of Cardiothoracic Surgery and Anesthesiology, Orebro University Hospital, SE 701 85 Orebro, Sweden
J Thorac Cardiovasc Surg 132:373-8. 2006..Conventional harvesting of the saphenous vein in coronary artery bypass surgery produces vessel damage that contributes to graft failure. A novel "no touch" technique provides high short- and long-term patency rates... - The endothelin 1A receptor antagonist BSF 302146 is a potent inhibitor of neointimal and medial thickening in porcine saphenous vein-carotid artery interposition graftsSong Wan
Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
J Thorac Cardiovasc Surg 127:1317-22. 2004..The administration of this endothelin 1(A) receptor antagonist might therefore be therapeutically effective in preventing late vein graft failure in patients undergoing coronary artery bypass grafting... - Endothelin receptors in cultured and native human radial artery smooth muscleAlan R Conant
Cardiothoracic Center, Liverpool NHS Trust, Liverpool, UK
J Cardiovasc Pharmacol 39:130-41. 2002.... - The pathobiology of endothelin-1 in vein graft disease: are ETA receptor antagonists the solution to prevent vein graft failure?Jamie Y Jeremy
Bristol Heart Institute, University of Bristol, UK
Curr Vasc Pharmacol 3:315-23. 2005.... - A role for endothelin-1 in peripheral vascular diseaseJanice C S Tsui
Southend Hospital, Prittlewell Chase, Southend on Sea, Essex SS0 0RY, UK
Curr Vasc Pharmacol 3:325-32. 2005..Here, the possible role of endothelin-1 in peripheral vascular disease is discussed and potential therapeutic tools are considered... - Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERKShi wen Xu
Centre for Rheumatology, Department of Medicine, Royal Free and University College London, United Kingdom
J Biol Chem 279:23098-103. 2004..Our results suggest that ET-1 induces a program of matrix synthesis in lung fibroblasts and that ET-1 may play a key role in connective tissue deposition during wound repair and in pulmonary fibrosis... - Endothelins and the 'French paradox': are detrimental effects of red wine also associated with an action on endothelin synthesis?Michael R Dashwood
Angiology 53:749-51. 2002