Genomes and Genes
Affiliation: University of Aberdeen
- Seasonal variations of clock gene expression in the suprachiasmatic nuclei and pars tuberalis of the European hamster (Cricetus cricetus)Benjamin B Tournier
Institut des Neurosciences Cellulaires et Integratives, Département Neurobiologie des Rythmes, UMR 7168 LC2 CNRS Université L Pasteur, 5 rue Blaise Pascal, 67084 Strasbourg, France
Eur J Neurosci 25:1529-36. 2007..The putative role of such seasonal-dependent changes in clock gene expression on the control of seasonal functions is discussed...
- [Synchronization and genetic redundancy in circadian clocks]Hugues Dardente
School of Biological Sciences, Zoology Building, Tillydrone Avenue, Aberdeen AB24 2TZ, Ecosse, Royaume Uni
Med Sci (Paris) 24:270-6. 2008..The present review aims at summarizing current knowledge of the molecular basis of circadian clocks and possible differences between central and peripheral clocks in light of recent findings in Clock knock-out mice...
- Does a melatonin-dependent circadian oscillator in the pars tuberalis drive prolactin seasonal rhythmicity?H Dardente
School of Biological Sciences, University of Aberdeen, Zoology Building, Tillydrone Avenue, Aberdeen, UK
J Neuroendocrinol 19:657-66. 2007..The strengths and weaknesses of current hypotheses that link melatonin action in the PT to its seasonal effect on lactotrophs of the PD are discussed and alternative working hypotheses are suggested...
- A molecular switch for photoperiod responsiveness in mammalsHugues Dardente
Institute of Biological and Environmental Sciences, Zoology Building, Tillydrone Avenue, University of Aberdeen, Aberdeen AB24 2TZ, UK
Curr Biol 20:2193-8. 2010..Our findings define a molecular pathway linking the circadian clock to the evolution of seasonal timing in mammals...
- RFamide-related peptide and its cognate receptor in the sheep: cDNA cloning, mRNA distribution in the hypothalamus and the effect of photoperiodH Dardente
School of Biological Sciences, Aberdeen University, Scotland, UK
J Neuroendocrinol 20:1252-9. 2008..Taken together, these data strengthen the emerging view that interplay between ependymal cells and the pars tuberalis might be important for the seasonal timing system...
- Transcriptional feedback loops in the ovine circadian clockHugues Dardente
School of Biological Sciences, Tillydrone Avenue, Aberdeen University, Scotland, UK
Comp Biochem Physiol A Mol Integr Physiol 153:391-8. 2009..Taken together, these data are consistent with a broad conservation of transcriptional and post-translational mechanisms in the circadian clock of diurnal and nocturnal mammals...
- Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammalsHugues Dardente
School of Biological Sciences, Aberdeen University, Aberdeen, Scotland, United Kingdom
PLoS ONE 3:e3530. 2008..Altogether, these data establish Fbxl21 as a novel circadian clock-controlled gene that plays a specific role within the mammalian circadian pacemaker...
- Egr1 involvement in evening gene regulation by melatoninJ M Fustin
Aberdeen University, School of Biological Sciences, Department of Zoology, Tillydrone Avenue, Aberdeen, AB242TZ, Scotland, UK
FASEB J 23:764-73. 2009..We propose that melatonin-dependent effects on EGR1-RE's contribute to evening gene expression profiles in this pituitary melatonin target tissue...
- Circannual variation in thyroid hormone deiodinases in a short-day breederC Sáenz de Miera
School of Biological Sciences, University of Aberdeen, Aberdeen, UK
J Neuroendocrinol 25:412-21. 2013....
- Photoperiodic variation in CD45-positive cells and cell proliferation in the mediobasal hypothalamus of the Soay sheepD G Hazlerigg
Institute of Biological and Environmental Science, University of Aberdeen, Aberdeen, United Kingdom
Chronobiol Int 30:548-58. 2013..These data suggest that neuroimmune mechanisms may be involved in photoperiod-dependent seasonal remodeling of the adult brain...
- Cry1 circadian phase in vitro: wrapped up with an E-boxJ M Fustin
Aberdeen University, School of Biological Sciences, Aberdeen, UK
J Biol Rhythms 24:16-24. 2009....
- Effect of photoperiod on the thyroid-stimulating hormone neuroendocrine system in the European hamster (Cricetus cricetus)E A Hanon
School of Biological Sciences, University of Aberdeen, Aberdeen, UK
J Neuroendocrinol 22:51-5. 2010..These data are consistent with recent observations in sheep, and suggest that the PT TSH third ventricle-ependymal cell relay plays a conserved role in initiating the photoperiodic response in both long- and short-day breeding mammals...
- Ancestral TSH mechanism signals summer in a photoperiodic mammalElodie A Hanon
School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland
Curr Biol 18:1147-52. 2008..In mammals this provides the missing link between the pineal melatonin signal and thyroid-dependent seasonal biology...
- The circadian clock stops ticking during deep hibernation in the European hamsterFlorent G Revel
Département de Neurobiologie des Rythmes, Institut des Neurosciences Cellulaires et Integratives, Unité Mixte de Recherche 7168 LC2, Centre National de la Recherche Scientifique, Universite Louis Pasteur, Strasbourg Cedex, France
Proc Natl Acad Sci U S A 104:13816-20. 2007..Overall, these data provide strong evidence that in the European hamster the molecular circadian clock is arrested during hibernation and stops delivering rhythmic output signals...
- Molecular circadian rhythms in central and peripheral clocks in mammalsHugues Dardente
Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, QC, Canada
Chronobiol Int 24:195-213. 2007....
- Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by lightHugues Dardente
Neurobiologie des Rythmes, UMR 7518 CNRS ULP, IFR 37, 12 rue de l Université, 67000 Strasbourg, France
Brain Res 958:261-71. 2002..Altogether, our results suggest that Per1 and Per2 are mainly expressed in AVP cells during the daytime and suggest that GRP cells play an important role in resetting of the clock by light...
- Expression and regulation of Icer mRNA in the Syrian hamster pineal glandElena Diaz
Departamento de Biologi a Funcional, Area Fisiologi a, Facultad de Medicina, Universidad de Oviedo, 33006, Oviedo, Spain
Brain Res Mol Brain Res 112:163-9. 2003..These data indicate that ICER may be involved in both daily and seasonal regulation of melatonin synthesis in the Syrian hamster...
- Melatonin induces Cry1 expression in the pars tuberalis of the ratHugues Dardente
Neurobiologie des Rythmes, UMR 7518 CNRS ULP, IFR 37, 12, rue de l université, 67000 Strasbourg, France
Brain Res Mol Brain Res 114:101-6. 2003..These data support the existence of a time-measurement model in the PT based on direct opposite actions of melatonin on Per1 and Cry1 expression...
- Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodentsHugues Dardente
Laboratoire de Neurobiologie des Rythmes, CNRS ULP UMR 7518, IFR 37, 12, rue de l université, Strasbourg 67000, France
Brain Res Mol Brain Res 124:143-51. 2004..The different circadian organization of SCN neuropeptides mRNA profiles in both light/dark and constant darkness conditions between mice and A. ansorgei could be related with diurnality...
- Phenotype of Per1- and Per2-expressing neurons in the suprachiasmatic nucleus of a diurnal rodent (Arvicanthis ansorgei): comparison with a nocturnal species, the ratHugues Dardente
Laboratory of Neurobiology of Rhythms, UMR 7518 CNRS ULP, University of Strasbourg, 12, rue de l université, 67000 Strasbourg, France
Cell Tissue Res 310:85-92. 2002....
- Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycleJorge Mendoza
Laboratory of Neurobiology of Rhythms, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7518, Department of Neuroscience, Institut Fédératif de Recherche 37, University Louis Pasteur, F 67084 Strasbourg, France
J Neurosci 25:1514-22. 2005....
- Timed hypocaloric feeding and melatonin synchronize the suprachiasmatic clockwork in rats, but with opposite timing of behavioral outputIvette Caldelas
Laboratory of Neurobiology of Rhythms, Centre National de la Recherche UMR7518, Departement of Neuroscience IFR37, University Louis Pasteur, 5 Rue Blaise Pascal 67084 Strasbourg Cedex, France
Eur J Neurosci 22:921-9. 2005....
- Differential control of Bmal1 circadian transcription by REV-ERB and ROR nuclear receptorsFabienne Guillaumond
Douglas Hospital Research Centre, McGill University, 6875 LaSalle Blvd, Montreal, QC, Canada
J Biol Rhythms 20:391-403. 2005..Furthermore, their strikingly different patterns of expression in nervous and peripheral tissues provide important insights into functional differences between circadian clocks within the organism...
- Cryptochromes impair phosphorylation of transcriptional activators in the clock: a general mechanism for circadian repressionHugues Dardente
Laboratory of Molecular Chronobiology, Douglas Hospital Research Centre, McGill University, Montreal, QC, Canada H4H 1R3
Biochem J 402:525-36. 2007..In contrast, PER proteins, which are weak repressors, are without effect. From these results, we propose a general mechanism for the inhibition of CLOCK(NPAS2)-BMAL1(BMAL2) circadian transcriptional activation by CRY1-2...
- Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profilesZeina S Malek
Laboratoire de Neurobiologie des Rythmes, UMR 7518, CNRS ULP, Centre de Neurochimie, Strasbourg France
Eur J Neurosci 22:895-901. 2005..Taking our result with previous data into consideration, we further suggest that 5-HT synthesis and release within the circadian system could be directly or indirectly under the control of the SCN...
- The mt1 melatonin receptor and RORbeta receptor are co-localized in specific TSH-immunoreactive cells in the pars tuberalis of the rat pituitaryPaul Klosen
Neurobiologie des Rythmes, CNRS UMR 7518, IFR 37, Universite Louis Pasteur, Strasbourg, France
J Histochem Cytochem 50:1647-57. 2002..Gonadotrophs, as well as other pars distalis cell types, were never labeled for mt1 melatonin receptor. Therefore, this study identifies the "specific" cells of the PT as the mt1 melatonin receptor-expressing cells...
- [How many pieces to build a circadian clock?]Hugues Dardente
Centre de recherche de l Hôpital Douglas, Laboratoire de Chronobiologie moléculaire, Universite McGill, 6875, boulevard LaSalle, Montreal, Quebec, H4H 1R3 Canada
Med Sci (Paris) 21:66-72. 2005..Finally, we discuss the role of the SCN within the circadian system, which also includes oscillators located in various tissues and cell types...