Philippa D Darbre

Summary

Affiliation: University of Reading
Country: UK

Publications

  1. ncbi request reprint Oestrogenic activity of parabens in MCF7 human breast cancer cells
    J R Byford
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    J Steroid Biochem Mol Biol 80:49-60. 2002
  2. ncbi request reprint Environmental oestrogens, cosmetics and breast cancer
    P D Darbre
    School of Biological Sciences, The University of Reading, P O Box 228, Whiteknights, Reading RG6 6AJ, UK
    Best Pract Res Clin Endocrinol Metab 20:121-43. 2006
  3. ncbi request reprint Aluminium in human breast tissue
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 101:1344-6. 2007
  4. doi request reprint Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks
    Philippa D Darbre
    School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
    J Appl Toxicol 28:561-78. 2008
  5. pmc Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells
    D Pugazhendhi
    School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
    J Endocrinol 197:503-15. 2008
  6. ncbi request reprint Hypersensitivity and growth adaptation of oestrogen-deprived MCF-7 human breast cancer cells
    Philippa D Darbre
    School of Biological Sciences, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, U K
    Anticancer Res 34:99-105. 2014
  7. ncbi request reprint Effect of aluminium on migratory and invasive properties of MCF-7 human breast cancer cells in culture
    Philippa D Darbre
    School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK Electronic address
    J Inorg Biochem 128:245-9. 2013
  8. ncbi request reprint Aluminium and breast cancer: Sources of exposure, tissue measurements and mechanisms of toxicological actions on breast biology
    Philippa D Darbre
    School of Biological Sciences, University of Reading, Reading RG6 6UB, UK Electronic address
    J Inorg Biochem 128:257-61. 2013
  9. doi request reprint Aluminium and human breast diseases
    P D Darbre
    Biomedical Sciences Section, School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK
    J Inorg Biochem 105:1484-8. 2011
  10. ncbi request reprint Environmental oestrogens and breast cancer: evidence for combined involvement of dietary, household and cosmetic xenoestrogens
    Philippa D Darbre
    Biomedical Sciences Section, School of Biological Sciences, The Hopkins Building, The University of Reading, Whiteknights, Reading RG6 6UB, UK
    Anticancer Res 30:815-27. 2010

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Oestrogenic activity of parabens in MCF7 human breast cancer cells
    J R Byford
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    J Steroid Biochem Mol Biol 80:49-60. 2002
    ..Future work will need to address the extent to which parabens can accumulate in hormonally sensitive tissues and also the extent to which their weak oestrogenic activity can add to the more general environmental oestrogen problem...
  2. ncbi request reprint Environmental oestrogens, cosmetics and breast cancer
    P D Darbre
    School of Biological Sciences, The University of Reading, P O Box 228, Whiteknights, Reading RG6 6AJ, UK
    Best Pract Res Clin Endocrinol Metab 20:121-43. 2006
    ....
  3. ncbi request reprint Aluminium in human breast tissue
    Christopher Exley
    Birchall Centre for Inorganic Chemistry and Materials Science, Lennard Jones Laboratories, Keele University, Staffordshire ST5 5BG, UK
    J Inorg Biochem 101:1344-6. 2007
    ..Whether differences in the regional distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained...
  4. doi request reprint Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks
    Philippa D Darbre
    School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
    J Appl Toxicol 28:561-78. 2008
    ....
  5. pmc Effect of sulphation on the oestrogen agonist activity of the phytoestrogens genistein and daidzein in MCF-7 human breast cancer cells
    D Pugazhendhi
    School of Biological Sciences, The University of Reading, Reading RG6 6AJ, UK
    J Endocrinol 197:503-15. 2008
    ..This is the first report of sulphation enhancing activity of an isoflavone and inverse effects of sulphation between individual phytoestrogens...
  6. ncbi request reprint Hypersensitivity and growth adaptation of oestrogen-deprived MCF-7 human breast cancer cells
    Philippa D Darbre
    School of Biological Sciences, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, U K
    Anticancer Res 34:99-105. 2014
    ..The model of long-term oestrogen-deprived MCF-7 human breast cancer cells has suggested the mechanism results from hypersensitivity to low levels of residual oestrogen...
  7. ncbi request reprint Effect of aluminium on migratory and invasive properties of MCF-7 human breast cancer cells in culture
    Philippa D Darbre
    School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK Electronic address
    J Inorg Biochem 128:245-9. 2013
    ..This is important because mortality from breast cancer arises mainly from tumour spread rather than from the presence of a primary tumour in the breast...
  8. ncbi request reprint Aluminium and breast cancer: Sources of exposure, tissue measurements and mechanisms of toxicological actions on breast biology
    Philippa D Darbre
    School of Biological Sciences, University of Reading, Reading RG6 6UB, UK Electronic address
    J Inorg Biochem 128:257-61. 2013
    ....
  9. doi request reprint Aluminium and human breast diseases
    P D Darbre
    Biomedical Sciences Section, School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK
    J Inorg Biochem 105:1484-8. 2011
    ....
  10. ncbi request reprint Environmental oestrogens and breast cancer: evidence for combined involvement of dietary, household and cosmetic xenoestrogens
    Philippa D Darbre
    Biomedical Sciences Section, School of Biological Sciences, The Hopkins Building, The University of Reading, Whiteknights, Reading RG6 6UB, UK
    Anticancer Res 30:815-27. 2010
    ..Updated incidence figures show a continued disproportionate incidence of breast cancer in Britain in the upper outer quadrant of the breast which is also the region to which multiple cosmetic chemicals are applied...
  11. ncbi request reprint Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast
    P D Darbre
    School of Biological Sciences, The University of Reading, UK
    J Appl Toxicol 26:191-7. 2006
    ..The potential for these metal ions to add to the burden of aberrant oestrogen signalling within the human breast is discussed...
  12. ncbi request reprint Recorded quadrant incidence of female breast cancer in Great Britain suggests a disproportionate increase in the upper outer quadrant of the breast
    Philippa D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, P O Box 228, Whiteknights, Reading, RG6 6AJ, UK
    Anticancer Res 25:2543-50. 2005
    ..The upper outer quadrant (UOQ) of the breast is the most frequent site for incidence of breast cancer, but the reported disproportionate incidence in this quadrant appears to rise with year of publication...
  13. ncbi request reprint Aluminium, antiperspirants and breast cancer
    P D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, P O Box 228, Whiteknights, Reading, RG6 6AJ, UK
    J Inorg Biochem 99:1912-9. 2005
    ....
  14. ncbi request reprint Underarm cosmetics and breast cancer
    P D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, PO Box 228, Whiteknights, Reading RG6 6AJ, UK
    J Appl Toxicol 23:89-95. 2003
    ....
  15. ncbi request reprint Oestrogenic activity of isobutylparaben in vitro and in vivo
    P D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, UK
    J Appl Toxicol 22:219-26. 2002
    ..The results here show that branching of the alkyl chain to isobutylparaben increases oestrogenic activity beyond that of the equivalent length linear alkyl chain in n-butylparaben...
  16. doi request reprint Oestrogenic activity of benzyl salicylate, benzyl benzoate and butylphenylmethylpropional (Lilial) in MCF7 human breast cancer cells in vitro
    A K Charles
    University of Reading, UK
    J Appl Toxicol 29:422-34. 2009
    ..Further research is now needed to investigate whether oestrogenic responses are detectable using in vivo models and the extent to which these compounds might be absorbed through human skin and might enter human breast tissues...
  17. ncbi request reprint Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells
    A Matsumura
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, P O Box 228, Whiteknights, Reading RG6 6AJ, UK
    J Steroid Biochem Mol Biol 94:431-43. 2005
    ..We found no evidence for any oestrogen antagonist action of any of these phytoestrogens at concentrations of up to 10(-6)M on either reporter gene induction or on stimulation of cell growth...
  18. ncbi request reprint Oestrogenic activity of p-hydroxybenzoic acid (common metabolite of paraben esters) and methylparaben in human breast cancer cell lines
    D Pugazhendhi
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    J Appl Toxicol 25:301-9. 2005
    ..It can be concluded that removal of the ester group from parabens does not abrogate its oestrogenic activity and that p-hydroxybenzoic acid can give oestrogenic responses in human breast cancer cells...
  19. ncbi request reprint Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells
    D Pugazhendhi
    School of Biological Sciences, The University of Reading, Reading, RG6 6AJ, UK
    J Appl Toxicol 27:67-77. 2007
    ....
  20. doi request reprint Combinations of parabens at concentrations measured in human breast tissue can increase proliferation of MCF-7 human breast cancer cells
    Amelia K Charles
    School of Biological Sciences, University of Reading, Reading, RG66UB, UK
    J Appl Toxicol 33:390-8. 2013
    ....
  21. ncbi request reprint Oestrogenic and androgenic activity of triclosan in breast cancer cells
    R H Gee
    School of Biological Sciences, The University of Reading, Reading, RG6 6AJ, UK
    J Appl Toxicol 28:78-91. 2008
    ..The finding that triclosan has oestrogenic and androgenic activity warrants further investigation in relation to both endocrine disruption of aquatic wildlife and any possible impact on human health...
  22. pmc Loss of growth inhibitory effects of retinoic acid in human breast cancer cells following long-term exposure to retinoic acid
    R Stephen
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, Whiteknights, P O Box 228, Reading, RG6 6AJ, England
    Br J Cancer 83:1183-91. 2000
    ....
  23. doi request reprint Parabens enable suspension growth of MCF-10A immortalized, non-transformed human breast epithelial cells
    Sugandha Khanna
    Biomedical Sciences Section, School of Biological Sciences, University of Reading, Reading, RG6 6UB, UK
    J Appl Toxicol 33:378-82. 2013
    ....
  24. ncbi request reprint Insulin-like growth factor receptor levels are regulated by cell density and by long term estrogen deprivation in MCF7 human breast cancer cells
    R L Stephen
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, The University of Reading, Whiteknights, P. O. Box 228, Reading RG6 6AJ, United Kingdom
    J Biol Chem 276:40080-6. 2001
    ....
  25. ncbi request reprint Oestrogenic activity of benzylparaben
    P D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, Reading, RG6 6AJ, UK
    J Appl Toxicol 23:43-51. 2003
    ..These results demonstrate that the oestrogenicity of methylparaben can be increased by the addition of an aryl group as well as by lengthening or branching the alkyl grouping...
  26. ncbi request reprint Concentrations of parabens in human breast tumours
    P D Darbre
    Division of Cell and Molecular Biology, School of Animal and Microbial Sciences, University of Reading, Reading RG6 6AJ, UK
    J Appl Toxicol 24:5-13. 2004
    ....
  27. doi request reprint Use of global gene expression patterns in mechanistic studies of oestrogen action in MCF7 human breast cancer cells
    A J Sadler
    School of Biological Sciences, University of Reading, Whiteknights, Reading RG6 6UB, UK
    J Steroid Biochem Mol Biol 114:21-32. 2009
    ....
  28. ncbi request reprint Changes in oestrogen receptor-alpha and -beta during progression to acquired resistance to tamoxifen and fulvestrant (Faslodex, ICI 182,780) in MCF7 human breast cancer cells
    L E Shaw
    School of Biological Sciences, The University of Reading, Reading, RG6 6AJ, UK
    J Steroid Biochem Mol Biol 99:19-32. 2006
    ....
  29. doi request reprint Enhanced sensitivity to rapamycin following long-term oestrogen deprivation in MCF-7, T-47-D and ZR-75-1 human breast cancer cells
    Swagat Ray
    Biomedical Sciences Section, School of Biological Sciences, University of Reading, Hopkins Building, Whiteknights, Reading RG6 6UB, UK
    J Endocrinol 208:21-9. 2011
    ....