John Danesh

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 294:1799-809. 2005
  2. pmc Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e78. 2008
  3. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
  4. pmc The association between psychiatric diagnosis and violent re-offending in adult offenders in the community
    Martin Grann
    1Department of Psychology, University of Stockholm, Stockholm, Sweden
    BMC Psychiatry 8:92. 2008
  5. ncbi request reprint Antibiotics in the prevention of heart attacks
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Lancet 365:365-7. 2005
  6. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
  7. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
  8. ncbi request reprint Glycated hemoglobin measurement and prediction of cardiovascular disease
    Emanuele Di Angelantonio
    University of Cambridge, Cambridge, United Kingdom
    JAMA 311:1225-33. 2014
  9. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010
  10. pmc Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 7:e1000278. 2010

Detail Information

Publications42

  1. ncbi request reprint Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 294:1799-809. 2005
    ..Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke...
  2. pmc Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e78. 2008
    ..We updated a systematic review to put the new findings in context...
  3. pmc BRCA2 variants and cardiovascular disease in a multi-ethnic study
    Kevin Zbuk
    Population Health Research Institute, Hamilton Health Sciences, Hamilton, ON, Canada
    BMC Med Genet 13:56. 2012
    ..We therefore tested the association of BRCA2 variants with clinical cardiovascular disease (CVD)...
  4. pmc The association between psychiatric diagnosis and violent re-offending in adult offenders in the community
    Martin Grann
    1Department of Psychology, University of Stockholm, Stockholm, Sweden
    BMC Psychiatry 8:92. 2008
    ..Although psychiatric disorders are believed to be risk factors for violent reoffending, the available evidence is sparse and liable to bias...
  5. ncbi request reprint Antibiotics in the prevention of heart attacks
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Lancet 365:365-7. 2005
  6. pmc C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
    Stephen Kaptoge
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:132-40. 2010
    ..We assessed the associations of CRP concentration with risk of vascular and non-vascular outcomes under different circumstances...
  7. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
    ..We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease...
  8. ncbi request reprint Glycated hemoglobin measurement and prediction of cardiovascular disease
    Emanuele Di Angelantonio
    University of Cambridge, Cambridge, United Kingdom
    JAMA 311:1225-33. 2014
    ..The value of measuring levels of glycated hemoglobin (HbA1c) for the prediction of first cardiovascular events is uncertain...
  9. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010
    ..Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges...
  10. pmc Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 7:e1000278. 2010
    ..We report new data from a prospective study and a systematic review to help quantify these associations...
  11. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  12. ncbi request reprint Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis
    Gurdeep S Sagoo
    United Kingdom HuGENet Coordinating Centre, Strangeways Research Laboratory, Cambridge, United Kingdom
    Am J Epidemiol 168:1233-46. 2008
    ..88, 8.87). The study of LPL genotypes confirms the existence of close interrelations between high density lipoprotein cholesterol and triglyceride pathways. The influence of these genotypes on CHD risk warrants further investigation...
  13. pmc Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis
    Stephen Kaptoge
    Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Worts Causeway, CB1 8RN Cambridge, UK
    Eur Heart J 35:578-89. 2014
    ....
  14. ncbi request reprint Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls
    Zheng Ye
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 367:651-8. 2006
    ..We did meta-analyses on seven such haemostatic genetic variants for which the available evidence on each comprises at least 5000 coronary disease cases and at least 5000 controls...
  15. ncbi request reprint Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk
    Alexander Thompson
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, England CB1 8RN
    JAMA 299:2777-88. 2008
    ..The importance of the cholesteryl ester transfer protein (CETP) pathway in coronary disease is uncertain. Study of CETP genotypes can help better understand the relevance of this pathway to lipid metabolism and disease risk...
  16. ncbi request reprint Apolipoprotein(a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants
    Sebhat Erqou
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    J Am Coll Cardiol 55:2160-7. 2010
    ..The purpose of this study was to assess the association of apolipoprotein(a) (apo[a]) isoforms with cardiovascular disease risk...
  17. ncbi request reprint Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data
    Anna Bennet
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    Arch Intern Med 168:598-608. 2008
    ....
  18. ncbi request reprint B-type natriuretic peptides and cardiovascular risk: systematic review and meta-analysis of 40 prospective studies
    Emanuele Di Angelantonio
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge, England CB1 8RN
    Circulation 120:2177-87. 2009
    ....
  19. ncbi request reprint Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England, UK
    Circulation 115:450-8. 2007
    ..In the present study, we report 2 separate nested case-control comparisons in 2 different prospective, population-based cohorts, plus an updated meta-analysis of 27 additional prospective studies in general Western populations...
  20. ncbi request reprint C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  21. pmc Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
    Alexander Thompson
    Lp PLA2 Studies Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 375:1536-44. 2010
    ..We investigated associations of circulating Lp-PLA(2) mass and activity with risk of coronary heart disease, stroke, and mortality under different circumstances...
  22. pmc Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis
    Jeremy G Wheeler
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, United Kingdom
    PLoS Med 2:e76. 2005
    ..It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain...
  23. pmc Chronic kidney disease and risk of major cardiovascular disease and non-vascular mortality: prospective population based cohort study
    Emanuele Di Angelantonio
    Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    BMJ 341:c4986. 2010
    ..To quantify associations of chronic kidney disease stages with major cardiovascular disease and non-vascular mortality in the general adult population...
  24. ncbi request reprint Association of apolipoprotein E genotypes with lipid levels and coronary risk
    Anna M Bennet
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 298:1300-11. 2007
    ..Previous reviews of associations of apolipoprotein E (apoE) genotype and coronary disease have been dominated by smaller studies that are liable to biases...
  25. pmc Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies
    Zheng Ye
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Cambridge, United Kingdom
    PLoS Med 3:e91. 2006
    ..It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflicting results...
  26. pmc Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
    Ricardo C Ferreira
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 9:e1003444. 2013
    ....
  27. ncbi request reprint Circulating concentrations of insulin markers and coronary heart disease: a quantitative review of 19 Western prospective studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
    Eur Heart J 28:2491-7. 2007
    ..We report an updated meta-analysis of studies of circulating levels of three insulin markers (fasting insulin, non-fasting insulin, and pro-insulin) and CHD risk...
  28. pmc The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia
    Danish Saleheen
    Center for Non Communicable Diseases, Karachi, Pakistan
    Eur J Epidemiol 24:329-38. 2009
    ..Findings from this study should advance scientific understanding and inform regionally appropriate disease prevention and control strategies...
  29. ncbi request reprint Associations between differential leucocyte count and incident coronary heart disease: 1764 incident cases from seven prospective studies of 30,374 individuals
    Jeremy G Wheeler
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Eur Heart J 25:1287-92. 2004
    ..We aimed to assess potential associations between different leucocyte components and coronary heart disease (CHD) in a prospective cohort study, and to put these findings in context of other relevant prospective studies in a meta-analysis...
  30. pmc Renal function and risk of coronary heart disease in general populations: new prospective study and systematic review
    Emanuele Di Angelantonio
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 4:e270. 2007
    ..This study aims to quantify the association of markers of renal function with CHD risk in essentially general populations...
  31. ncbi request reprint EPIC-Heart: the cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
    John Danesh
    EPIC Heart Secretariat, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Worts Causeway, Cambridge, CB1 8RN, UK
    Eur J Epidemiol 22:129-41. 2007
    ..Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors...
  32. ncbi request reprint Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies
    Jeremy G Wheeler
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 363:689-95. 2004
    ....
  33. ncbi request reprint Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'
    Bernard Keavney
    Institute of Human Genetics, University of Newcastle upon Tyne, UK
    Int J Epidemiol 35:935-43. 2006
    ....
  34. ncbi request reprint Chlamydia pneumoniae IgA titres and coronary heart disease: prospective study and meta-analysis
    John Danesh
    Eur Heart J 24:881. 2003
  35. ncbi request reprint Large-scale evidence that the cardiotoxicity of smoking is not significantly modified by the apolipoprotein E epsilon2/epsilon3/epsilon4 genotype
    Bernard Keavney
    Institute of Human Genetics, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Lancet 361:396-8. 2003
    ..7). When differences in risk between different genotypes are not extreme (as with this APOE polymorphism), reliable assessment of hypothesised gene-environment interactions will often require the study of many thousands of disease cases...
  36. ncbi request reprint Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk
    Bernard Keavney
    Institute of Human Genetics, University of Newcastle upon Tyne, UK
    Int J Epidemiol 33:1002-13. 2004
    ..Various associations between CHD risk and genes that moderately affect plasma lipid levels have been described, but previous studies have typically involved too few 'cases' to assess these associations reliably...
  37. pmc Angiotensin converting enzyme insertion or deletion polymorphism and coronary restenosis: meta-analysis of 16 studies
    Francois Bonnici
    Clinial Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 325:517-20. 2002
    ..To assess the association between genotype at the insertion or deletion polymorphism of the angiotensin converting enzyme gene and risk of coronary restenosis after percutaneous coronary intervention...
  38. ncbi request reprint Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27,247 adults in 15 prospective studies
    Angela M Wood
    Int J Epidemiol 35:1570-8. 2006
    ..The extent of this regression dilution bias for plasma fibrinogen was investigated using repeat measurement data collected at varying time intervals on 27 247 adults in 15 prospective studies...
  39. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  40. ncbi request reprint Adiponectin and coronary heart disease: a prospective study and meta-analysis
    Naveed Sattar
    University Department of Vascular Biochemistry, Glasgow, Scotland
    Circulation 114:623-9. 2006
    ..We report new data from a prospective study in the context of a meta-analysis of previously published prospective studies...
  41. ncbi request reprint A road map for efficient and reliable human genome epidemiology
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, and Biomedical Research Institute, Foundation for Research and Technology Hellas, Ioannina 45110, Greece
    Nat Genet 38:3-5. 2006
    ..Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews...
  42. ncbi request reprint Hemostatic and rheological variables and risk of cardiovascular disease
    Gordon D O Lowe
    University Department of Medicine, Royal Infirmary, Glasgow, United Kingdom
    Semin Vasc Med 2:429-39. 2002
    ....