C J Daly

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. doi request reprint Previously unsuspected widespread cellular and tissue distribution of β-adrenoceptors and its relevance to drug action
    C J Daly
    School of Life Sciences, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Trends Pharmacol Sci 32:219-26. 2011
  2. pmc Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries
    C J Daly
    Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, UK
    Br J Pharmacol 159:787-96. 2010
  3. ncbi request reprint A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse
    Craig J Daly
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland
    Physiol Genomics 9:85-91. 2002
  4. ncbi request reprint Fluorescent ligands, antibodies, and proteins for the study of receptors
    Craig J Daly
    Faculty of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, Wolfson Building Office 448, West Medical Building Lab 440, University Avenue, G12 8QQ, Glasgow, UK
    Pharmacol Ther 100:101-18. 2003
  5. ncbi request reprint Importance of agonists in alpha-adrenoceptor classification and localisation of alpha1-adrenoceptors in human prostate
    J C McGrath
    Autonomic Physiology Unit, Division of Neurosciences, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, UK
    Eur Urol 36:80-8. 1999
  6. ncbi request reprint Quantitative imaging in live human cells reveals intracellular alpha(1)-adrenoceptor ligand-binding sites
    J F Mackenzie
    Autonomic Physiology Unit, Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom
    J Pharmacol Exp Ther 294:434-43. 2000
  7. ncbi request reprint Endothelium dependent relaxation in rabbit genital resistance arteries is predominantly mediated by endothelial-derived hyperpolarizing factor in females and nitric oxide in males
    J S Morton
    University of Glasgow, Glasgow, UK
    J Urol 177:786-91. 2007
  8. ncbi request reprint Confocal microscopic characterization of a lesion in a cerebral vessel of the stroke-prone spontaneously hypertensive rat
    S M Arribas
    Clinical Research Initiative in Heart Failure, University of Glasgow, UK
    Stroke 27:1118-22; discussion 1122-3. 1996
  9. ncbi request reprint Two "knockout" mouse models demonstrate that aortic vasodilatation is mediated via alpha2a-adrenoceptors located on the endothelium
    Majid Malekzadeh Shafaroudi
    Autonomic Physiology Unit, Institute of Biomedical and Life Sciences, West Medical Bldg, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Pharmacol Exp Ther 314:804-10. 2005
  10. ncbi request reprint Single-cell recombinant pharmacology: bovine alpha(1a)-adrenoceptors in rat-1 fibroblasts release intracellular ca(2+), display subtype-characteristic agonism and antagonism, and exhibit an antagonist-reversible inverse concentration-response phase
    J D Pediani
    Autonomic Physiology Unit, Division of Neuroscience and Biomedical Systems, University of Glasgow, UK
    J Pharmacol Exp Ther 293:887-95. 2000

Collaborators

Detail Information

Publications24

  1. doi request reprint Previously unsuspected widespread cellular and tissue distribution of β-adrenoceptors and its relevance to drug action
    C J Daly
    School of Life Sciences, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Trends Pharmacol Sci 32:219-26. 2011
    ....
  2. pmc Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries
    C J Daly
    Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, UK
    Br J Pharmacol 159:787-96. 2010
    ..We have now investigated the distribution of alpha-adrenoceptors, beta-adrenoceptors and cannabinoid-like (GPR55) receptors in the mouse arteries...
  3. ncbi request reprint A knockout approach indicates a minor vasoconstrictor role for vascular alpha1B-adrenoceptors in mouse
    Craig J Daly
    Institute of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, University Avenue, Glasgow G12 8QQ, Scotland
    Physiol Genomics 9:85-91. 2002
    ....
  4. ncbi request reprint Fluorescent ligands, antibodies, and proteins for the study of receptors
    Craig J Daly
    Faculty of Biomedical and Life Sciences, Division of Neuroscience and Biomedical Systems, University of Glasgow, Wolfson Building Office 448, West Medical Building Lab 440, University Avenue, G12 8QQ, Glasgow, UK
    Pharmacol Ther 100:101-18. 2003
    ....
  5. ncbi request reprint Importance of agonists in alpha-adrenoceptor classification and localisation of alpha1-adrenoceptors in human prostate
    J C McGrath
    Autonomic Physiology Unit, Division of Neurosciences, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, UK
    Eur Urol 36:80-8. 1999
    ..Possible errors in antagonist classification arising from complexity in the actions of agonists and the recently developed method of fluorescent ligand binding on isolated living human prostatic smooth muscle cells will be discussed...
  6. ncbi request reprint Quantitative imaging in live human cells reveals intracellular alpha(1)-adrenoceptor ligand-binding sites
    J F Mackenzie
    Autonomic Physiology Unit, Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, United Kingdom
    J Pharmacol Exp Ther 294:434-43. 2000
    ..This provides a potential new site for physiological agonism and makes intracellular access a potential differentiator of drug action...
  7. ncbi request reprint Endothelium dependent relaxation in rabbit genital resistance arteries is predominantly mediated by endothelial-derived hyperpolarizing factor in females and nitric oxide in males
    J S Morton
    University of Glasgow, Glasgow, UK
    J Urol 177:786-91. 2007
    ..We compared nitric oxide and endothelial-derived hyperpolarizing factor contributions to acetylcholine induced relaxation in the genital arteries of the 2 sexes...
  8. ncbi request reprint Confocal microscopic characterization of a lesion in a cerebral vessel of the stroke-prone spontaneously hypertensive rat
    S M Arribas
    Clinical Research Initiative in Heart Failure, University of Glasgow, UK
    Stroke 27:1118-22; discussion 1122-3. 1996
    ..The effect of perindopril treatment on SHRSP structure and function was also assessed...
  9. ncbi request reprint Two "knockout" mouse models demonstrate that aortic vasodilatation is mediated via alpha2a-adrenoceptors located on the endothelium
    Majid Malekzadeh Shafaroudi
    Autonomic Physiology Unit, Institute of Biomedical and Life Sciences, West Medical Bldg, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    J Pharmacol Exp Ther 314:804-10. 2005
    ..Knockout or genetic malfunction of this receptor should increase arterial stiffness, exacerbated by raised catecholamines, and contribute to heart failure...
  10. ncbi request reprint Single-cell recombinant pharmacology: bovine alpha(1a)-adrenoceptors in rat-1 fibroblasts release intracellular ca(2+), display subtype-characteristic agonism and antagonism, and exhibit an antagonist-reversible inverse concentration-response phase
    J D Pediani
    Autonomic Physiology Unit, Division of Neuroscience and Biomedical Systems, University of Glasgow, UK
    J Pharmacol Exp Ther 293:887-95. 2000
    ..The study also showed a form of fade that could be readily explained...
  11. ncbi request reprint Beta-arrestin-dependent spontaneous alpha1a-adrenoceptor endocytosis causes intracellular transportation of alpha-blockers via recycling compartments
    John D Pediani
    Autonomic Physiology Unit, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Mol Pharmacol 67:992-1004. 2005
    ..We conclude that alpha(1a)-ARs recycle rapidly by an agonist-independent, constitutive, beta-arrestin-dependent process and that this can transport "alpha-blockers" into cells carrying these receptors...
  12. ncbi request reprint New aspects of vascular remodelling: the involvement of all vascular cell types
    John C McGrath
    Autonomic Physiology Unit, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Physiol 90:469-75. 2005
    ..The objective of this paper is to show how the functions of blood vessels depend on their architecture and a continuous interaction of different cell types and extracellular proteins...
  13. pmc Do fluorescent drugs show you more than you wanted to know?
    J C McGrath
    Autonomic Physiology Unit, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland
    Br J Pharmacol 139:187-9. 2003
  14. pmc Alpha(1A)-adrenoceptors mediate contractions to phenylephrine in rabbit penile arteries
    J S Morton
    Autonomic Physiology Unit, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, UK
    Br J Pharmacol 150:112-20. 2007
    ..This study seeks the alpha(1)-AR subtypes involved in order to inform the pro-erectile consequences of subtype selective blockade...
  15. pmc Evidence for involvement of alpha1D-adrenoceptors in contraction of femoral resistance arteries using knockout mice
    Joseph Zacharia
    Vascular Biology Group, Department of Biological and Biomedical Sciences, School of Life Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow G4 0BA, Scotland, UK
    Br J Pharmacol 146:942-51. 2005
    ..The present study with alpha(1D)-KO mice shows that alpha(1D)-adrenoceptors contribute to vasoconstrictor responses to exogenous and neurally released noradrenaline in femoral resistance arteries...
  16. pmc Insights into the functional roles of alpha(1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice
    Clare Deighan
    Autonomic Physiology Unit, Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow
    Br J Pharmacol 144:558-65. 2005
    ....
  17. ncbi request reprint 3-d image analysis of fluorescent drug binding
    M Raquel Miquel
    Universidad de Valencia, Valencia, Spain
    Mol Imaging 4:40-52. 2005
    ..Although our application is specific to adrenergic receptors, the general method could be applied to any volumetric, fluorescence-image-based assay...
  18. pmc Role of elastin in spontaneously hypertensive rat small mesenteric artery remodelling
    Ana M Briones
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo 2, 28029 Madrid, Spain
    J Physiol 552:185-95. 2003
    ..Differences in elastin organisation are, therefore, a central element in small artery remodelling in hypertension...
  19. ncbi request reprint Confocal myography for the study of hypertensive vascular remodelling
    Silvia M Arribas
    Universidad Autonoma de Madrid, Spain
    Clin Hemorheol Microcirc 37:205-10. 2007
    ..Confocal myography offers a new approach to the study of vascular remodelling in intact small arteries from a 3D point of view...
  20. pmc Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries
    Ana M Briones
    Departament de Farmacologia, de Terapeutica i de Toxicologia, Institut de Neurociencies, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellatera, Spain
    Br J Pharmacol 146:679-91. 2005
    ..Furthermore, we have demonstrated, for the first time, the usefulness of BODIPY TMR-CGP 12177 for identifying beta-AR distribution in the 'living' vascular wall...
  21. ncbi request reprint Postnatal alterations in elastic fiber organization precede resistance artery narrowing in SHR
    Jose M Gonzalez
    Universidad Autonoma de Madrid, C Arzobispo Morcillo 2, 28029 Madrid, Spain
    Am J Physiol Heart Circ Physiol 291:H804-12. 2006
    ..These data suggest that abnormal elastic fiber deposition in SHR increases resistance artery stiffness at an early age, which might participate in vessel narrowing later in life...
  22. ncbi request reprint The role of the alpha1B-adrenergic receptor in vascular structure and function
    Craig J Daly
    Hypertension 45:e20; author reply e20-1. 2005
  23. pmc Imaging the vascular wall using confocal microscopy
    Silvia M Arribas
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    J Physiol 584:5-9. 2007
    ..In conclusion, confocal microscopy and image analysis software provide insight into vascular wall structure and function and the active process of vascular remodelling in physiological and pathological situations...
  24. ncbi request reprint Visualisation of morphological changes in living intact human microvessels using confocal microscopy
    Shabaz A Hamid
    Royal Veterinary College, London NW1 0TU, UK
    Microvasc Res 69:173-7. 2005
    ....