A K Daly

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc CYP2C9 polymorphism and warfarin dose requirements
    Ann K Daly
    Br J Clin Pharmacol 53:408-9. 2002
  2. ncbi request reprint Genetic regulation of warfarin metabolism and response
    Ann K Daly
    Department of Pharmacological Sciences, University of Newcastle, Medical School, Newcastle upon Tyne, United Kingdom
    Semin Vasc Med 3:231-8. 2003
  3. ncbi request reprint The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen
    Elizabeth A Sconce
    School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Blood 106:2329-33. 2005
  4. ncbi request reprint Human leukocyte antigen (HLA) pharmacogenomic tests: potential and pitfalls
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Curr Drug Metab 15:196-201. 2014
  5. ncbi request reprint Relevance of CYP2E1 to non-alcoholic fatty liver disease
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK
    Subcell Biochem 67:165-75. 2013
  6. ncbi request reprint Optimal dosing of warfarin and other coumarin anticoagulants: the role of genetic polymorphisms
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 87:407-20. 2013
  7. ncbi request reprint Institutional Profile: Pharmacogenomics research at Newcastle University
    Ann K Daly
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Pharmacogenomics 13:1333-8. 2012
  8. doi request reprint Genetic association studies in drug-induced liver injury
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Rev 44:116-26. 2012
  9. pmc Pharmacogenomics of anticoagulants: steps toward personal dosage
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Genome Med 1:10. 2009
  10. ncbi request reprint Pharmacogenetics of the major polymorphic metabolizing enzymes
    A K Daly
    Department of Pharmacological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Fundam Clin Pharmacol 17:27-41. 2003

Detail Information

Publications78

  1. pmc CYP2C9 polymorphism and warfarin dose requirements
    Ann K Daly
    Br J Clin Pharmacol 53:408-9. 2002
  2. ncbi request reprint Genetic regulation of warfarin metabolism and response
    Ann K Daly
    Department of Pharmacological Sciences, University of Newcastle, Medical School, Newcastle upon Tyne, United Kingdom
    Semin Vasc Med 3:231-8. 2003
    ..There is less information available on genetic factors affecting other anticoagulants, but the CYP2C9 genotype is also relevant to acenocoumarol dose...
  3. ncbi request reprint The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen
    Elizabeth A Sconce
    School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Blood 106:2329-33. 2005
    ..Based upon the data, a new warfarin dosing regimen has been developed. The validity of the dosing regimen was confirmed in a second cohort of patients on warfarin therapy...
  4. ncbi request reprint Human leukocyte antigen (HLA) pharmacogenomic tests: potential and pitfalls
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Curr Drug Metab 15:196-201. 2014
    ..Genotyping single nucleotide polymorphisms tagging HLA alleles is a simpler alternative to HLA typing but appears insufficiently accurate for clinical use. ..
  5. ncbi request reprint Relevance of CYP2E1 to non-alcoholic fatty liver disease
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK
    Subcell Biochem 67:165-75. 2013
    ....
  6. ncbi request reprint Optimal dosing of warfarin and other coumarin anticoagulants: the role of genetic polymorphisms
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 87:407-20. 2013
    ....
  7. ncbi request reprint Institutional Profile: Pharmacogenomics research at Newcastle University
    Ann K Daly
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Pharmacogenomics 13:1333-8. 2012
    ..This article describes the various ongoing research projects and the teams involved together with our teaching activities in the subject...
  8. doi request reprint Genetic association studies in drug-induced liver injury
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Rev 44:116-26. 2012
    ..Other associations with genes relevant to drug disposition, innate immunity, oxidative stress, and mitochondrial function have also been reported, though these still need to be confirmed by replication in independent cohorts...
  9. pmc Pharmacogenomics of anticoagulants: steps toward personal dosage
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Genome Med 1:10. 2009
    ..Here we review recent advances in the area of coumarin anticoagulant genetics and its potential clinical application...
  10. ncbi request reprint Pharmacogenetics of the major polymorphic metabolizing enzymes
    A K Daly
    Department of Pharmacological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Fundam Clin Pharmacol 17:27-41. 2003
    ..The availability of comprehensive information on the occurrence and functional significance of polymorphisms affecting drug metabolism should facilitate their application to pharmacogenomic profiling...
  11. ncbi request reprint Candidate gene case-control studies
    Ann K Daly
    Pharmacogenetics Group, School of Clinical and Laboratory Sciences, University of Newcastle Medical School, Newcastle upon Tyne, NE2 4HH, UK
    Pharmacogenomics 4:127-39. 2003
    ....
  12. ncbi request reprint HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
    Ann K Daly
    Institute of Cellular Medicine and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK
    Nat Genet 41:816-9. 2009
    ..1, P = 1.4 x 10(-8)). These findings provide new insights into the mechanism of flucloxacillin DILI and have the potential to substantially improve diagnosis of this serious disease...
  13. ncbi request reprint Pharmacogenetics of oral anticoagulants
    Ann K Daly
    Pharmacogenetics Group, School of Clinical and Laboratory Sciences, University of Newcastle, Medical School, Newcastle uopn Tyne, UK
    Pharmacogenetics 13:247-52. 2003
    ....
  14. ncbi request reprint Pharmacogenetics of the cytochromes P450
    Ann K Daly
    Pharmacogenetics Group, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Curr Top Med Chem 4:1733-44. 2004
    ..The relevance of the various polymorphisms to drug response and toxicity is considered as well as the possibility that genotype for these polymorphisms may be a determinant for "personalized prescribing" in the future...
  15. ncbi request reprint Pharmacogenetics and pharmacogenomics
    Ann K Daly
    Pharmacogenetics Group, School of Clinical and Laboratory Sciences, University of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Pharmacogenomics 8:1493-6. 2007
  16. ncbi request reprint Development of analytical technology in pharmacogenetic research
    Ann K Daly
    Pharmacogenetics Group, School of Clinical and Laboratory Sciences, Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Naunyn Schmiedebergs Arch Pharmacol 369:133-40. 2004
    ..In addition, a range of methods that can be used to detect novel polymorphisms, thereby further increasing understanding of interindividual variability in drug disposition and response, is described...
  17. ncbi request reprint Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes
    Ann K Daly
    School of Clinical and Laboratory Sciences, University of Newcastle Medical School, Framlington Place, Newcastle upon Tyne, UK
    Gastroenterology 132:272-81. 2007
    ....
  18. ncbi request reprint Individualized drug therapy
    Ann K Daly
    School of Clinical and Laboratory Sciences, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Curr Opin Drug Discov Devel 10:29-36. 2007
    ..The introduction of pharmacogenetic tests into routine healthcare requires both a demonstration of cost-effectiveness and the availability of appropriate accessible testing systems...
  19. ncbi request reprint Contribution of CYP2C9 to variability in vitamin K antagonist metabolism
    Ann K Daly
    University of Newcastle Medical School, School of Clinical and Laboratory Sciences, Framlington Place, Newcastle upon Tyne, UK
    Expert Opin Drug Metab Toxicol 2:3-15. 2006
    ..There is a need for prospective studies to assess the value of predicting dose requirement on the basis of all these factors, including the CYP2C9 genotype...
  20. ncbi request reprint Significance of the minor cytochrome P450 3A isoforms
    Ann K Daly
    Pharmacogenetics Group, School of Clinical and Laboratory Sciences, University of Newcastle Medical School, Newcastle upon Tyne, UK
    Clin Pharmacokinet 45:13-31. 2006
    ..In addition to a low level of expression in liver, it is expressed in prostate and testis. Its substrate specificity is currently unclear. Polymorphisms predicting absence of active enzyme have been identified...
  21. doi request reprint Genome-wide association studies in pharmacogenomics
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Nat Rev Genet 11:241-6. 2010
    ..Since 2007, a range of pharmacogenomics GWA studies have been published that have identified several interesting and novel associations between drug responses or reactions and clinically relevant loci, showing the value of this approach...
  22. doi request reprint Drug-induced liver injury: past, present and future
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, UK
    Pharmacogenomics 11:607-11. 2010
    ..Other not-yet-replicated associations have been described for genes relevant to drug metabolism and oxidative stress and cytokine genes...
  23. doi request reprint Pharmacogenetics and human genetic polymorphisms
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, UK
    Biochem J 429:435-49. 2010
    ..Genome-wide association studies are increasingly being used to study drug response and susceptibility to adverse drug reactions, resulting in identification of some novel pharmacogenetic associations...
  24. ncbi request reprint Polymorphisms in immunoregulatory genes: towards individualized immunosuppressive therapy?
    Ann K Daly
    Centre for Liver Research, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Am J Pharmacogenomics 2:13-23. 2002
    ..In conclusion, additional large series studies of these and other cytokine genes, as well as other immunoregulatory gene polymorphisms of proven functional significance are needed to achieve major progress in this area...
  25. doi request reprint Genetic determinants of susceptibility and severity in nonalcoholic fatty liver disease
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Expert Rev Gastroenterol Hepatol 5:253-63. 2011
    ..A new genome-wide association study has identified several additional novel associations with NAFLD severity. Other disease genes may be identified by similar approaches in the future...
  26. doi request reprint Using genome-wide association studies to identify genes important in serious adverse drug reactions
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom
    Annu Rev Pharmacol Toxicol 52:21-35. 2012
    ..Larger GWA studies and whole-genome sequencing may provide additional insights into all these toxicities...
  27. ncbi request reprint Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer
    M Welfare
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, England
    Cancer Epidemiol Biomarkers Prev 8:289-92. 1999
    ..We also observed possible effects of the GSTT1 null genotype on the age and stage at presentation, and these, together with the findings of an apparent interaction with NAT2 genotypes, need to be confirmed in further studies...
  28. pmc CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system
    G A Ford
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, UK
    Br J Clin Pharmacol 50:77-80. 2000
    ..We sought to determine whether CYP2D6 (debrisoquine hydroxylase) or CYP2C19 (S-mephenytoin hydroxylase) status is a risk factor for terodiline cardiotoxicity...
  29. ncbi request reprint Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease
    G P Aithal
    Department of Medicine, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Dig Dis Sci 46:1520-5. 2001
    ..We conclude that polymorphisms at -627 and -1117 sites in the IL-10 gene do not contribute to the susceptibility to IBD or determining the extent of the disease in our population...
  30. ncbi request reprint Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype
    A K Daly
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, UK
    Pharmacogenetics 6:319-28. 1996
    ..5 kb fragment in samples positive for the 13 kb CYP2D6*5 allele. Therefore, it is now possible to screen for the large CYP2D gene deletions by a single long PCR method...
  31. ncbi request reprint Detailed modelling of caffeine metabolism and examination of the CYP1A2 gene: lack of a polymorphism in CYP1A2 in Caucasians
    M R Welfare
    Department of Pharmacological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Pharmacogenetics 9:367-75. 1999
    ..We therefore conclude that CYP1A2 does not show functionally significant polymorphism but that the wide interindividual variation in activity may be due to environmental factors...
  32. ncbi request reprint Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
    J Smart
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, UK
    Pharmacogenetics 10:11-24. 2000
    ....
  33. ncbi request reprint Role of glutathione S-transferase P1, P-glycoprotein and multidrug resistance-associated protein 1 in acquired doxorubicin resistance
    A Harbottle
    Department of Surgical Sciences, The Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Int J Cancer 92:777-83. 2001
    ..Stable transfection of HEp2 cells with human GSTP1 increases doxorubicin resistance 3-fold over control cells. Our study indicates involvement of GSTP enzymes as well as efflux mechanisms in the acquired doxorubicin-resistance phenotype...
  34. ncbi request reprint Genetic association studies in drug-induced liver injury
    Ann K Daly
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Semin Liver Dis 29:400-11. 2009
    ..The possibility of interethnic variation in susceptibility to DILI also requires further study...
  35. ncbi request reprint Pharmacogenetics of cytotoxic drugs
    A K Daly
    Department of Pharmacological Sciences, University of Newcastle Medical School, Framlington Place, Newcastle-upon-Tyne, NE2 4HH, UK
    Expert Rev Anticancer Ther 1:301-8. 2001
    ..Likely future approaches to pharmacogenetics and emerging technologies, such as tumor classification using microarray analysis, are also considered...
  36. ncbi request reprint Factors affecting drug concentrations and QT interval during thioridazine therapy
    R H K Thanacoody
    School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Clin Pharmacol Ther 82:555-65. 2007
    ..Plasma concentrations of thioridazine are influenced by age, smoking, and CYP2D6 genotype, but CYP2D6 genotype does not appear to influence on-treatment QTc interval...
  37. ncbi request reprint Identification of human cytochrome P450 isoforms that contribute to all-trans-retinoic acid 4-hydroxylation
    L C McSorley
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK
    Biochem Pharmacol 60:517-26. 2000
    ....
  38. pmc Candidate gene case-control association studies: advantages and potential pitfalls
    A K Daly
    Centre for Liver Research, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Br J Clin Pharmacol 52:489-99. 2001
    ....
  39. ncbi request reprint Upstream and coding region CYP2C9 polymorphisms: correlation with warfarin dose and metabolism
    Barry P King
    School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, UK
    Pharmacogenetics 14:813-22. 2004
    ..To assess whether CYP2C9 alleles other than CYP2C9*2 and *3 are associated with a low-warfarin dose requirement and the relevance of upstream CYP2C9 polymorphisms to dose requirement and metabolism...
  40. ncbi request reprint Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity
    Guruprasad P Aithal
    School of Clinical Medical Sciences Hepatology, Medical School, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Hepatology 39:1430-40. 2004
    ..In conclusion, the observed polymorphisms, resulting in low IL-10 and high IL-4 gene transcription, could favor a T helper (Th)-2 mediated antibody response to neoantigenic stimulation associated with disease susceptibility...
  41. ncbi request reprint Recent advances in understanding the molecular basis of polymorphisms in genes encoding cytochrome P450 enzymes
    A K Daly
    Department of Pharmacological Sciences, Medical School, University of Newcastle upon Tyne, UK
    Toxicol Lett 102:143-7. 1998
    ..05, appears to be of functional significance, with an apparent 1.8-fold increase in levels of transcriptional activity compared with the wild-type...
  42. pmc The effect of NAT2 genotype and gender on the metabolism of caffeine in nonsmoking subjects
    M R Welfare
    Department of Pharmacological Sciences and Department of Medicine, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Br J Clin Pharmacol 49:240-3. 2000
    ..To establish whether gender or N-acetyltransferase 2 (NAT2) genotype influence the urinary 17 U+17X/137X ratio after dosing with caffeine...
  43. pmc Characterization of the metabolism of fenretinide by human liver microsomes, cytochrome P450 enzymes and UDP-glucuronosyltransferases
    N A Illingworth
    Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK
    Br J Pharmacol 162:989-99. 2011
    ..Here, we assessed the enzymes involved in various 4-HPR metabolic pathways...
  44. pmc Influence of IL-6, COL1A1, and VDR gene polymorphisms on bone mineral density in Crohn's disease
    C E Todhunter
    Department of Medicine, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK
    Gut 54:1579-84. 2005
    ..The pathogenesis of reduced bone mineral density (BMD) is multifactorial. A range of genetic factors have been implicated in other populations of patients with osteoporosis...
  45. ncbi request reprint An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution
    A K Daly
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, UK
    Hum Genet 95:337-41. 1995
    ..In a group of 50 white Americans, the allele frequency for the new mutant allele was 0.01. The new allele explains some cases of anomalous genotype/phenotype relationships for CYP2D6...
  46. doi request reprint Inter-individual variation in nucleotide excision repair in young adults: effects of age, adiposity, micronutrient supplementation and genotype
    John Tyson
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Br J Nutr 101:1316-23. 2009
    ..While there was no detectable effect of micronutrient supplementation on NER capacity, there was evidence that the effect of fruit intake on the NER capacity may be modulated by the ERCC2 Lys751Gnl single nucleotide polymorphism...
  47. ncbi request reprint Altered tropomyosin expression in essential hypertension
    Stuart A Dunn
    Department of Medicine, Medical School, University of Newcastle upon Tyne, Newcastle, England
    Hypertension 41:347-54. 2003
    ....
  48. ncbi request reprint Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarin
    Farhad Kamali
    School of Clinical and Laboratory Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Clin Pharmacol Ther 75:204-12. 2004
    ..Our objective was to assess the contribution of CYP2C9 genotype, age, body size, and vitamin K and lipid status to warfarin dose requirements...
  49. ncbi request reprint Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype
    Fiona Caple
    Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Br J Nutr 103:1585-93. 2010
    ..037) between the three genotypes for the Val16Ala single nucleotide polymorphism in manganese superoxide dismutase (rs4880) with individuals homozygous/wild type showing less damage than those carrying the alanine variant...
  50. ncbi request reprint The Relationship between PON1 phenotype and PON1-192 genotype in detoxification of three oxons by human liver
    Elaine Mutch
    Toxicology Unit, School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Drug Metab Dispos 35:315-20. 2007
    ....
  51. doi request reprint Flucloxacillin-induced liver injury
    Elise Andrews
    Institute of Cellular Medicine, Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Toxicology 254:158-63. 2008
    ....
  52. ncbi request reprint Is there a need to teach pharmacogenetics?
    A K Daly
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Pharmacol Ther 95:245-7. 2014
    ....
  53. pmc Family history of cancer and tobacco exposure in index cases of pancreatic ductal adenocarcinoma
    R Lochan
    Hepato Pancreato Biliary Unit, Department of Surgery, Freeman Hospital, Newcastle University, Newcastle upon Tyne NE7 7DN, UK
    J Oncol 2011:215985. 2011
    ..Furthermore, individuals with a family history of malignancy and who smoke appear to require a lesser degree of tobacco exposure for the development of pancreatic cancer...
  54. ncbi request reprint Association of single nucleotide polymorphisms in the interleukin-4 gene and interleukin-4 receptor gene with Crohn's disease in a British population
    G P Aithal
    Centre for Liver Research, Medical School, University of Newcastle upon Tyne, UK
    Genes Immun 2:44-7. 2001
    ..005). Association with alleles resulting in high IL-4 transcription and enhanced signalling activity suggests that IL-4 may have a role in the pathogenesis of Crohn's disease...
  55. pmc CYP3A5 phenotype-genotype correlations in a British population
    Barry P King
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Br J Clin Pharmacol 55:625-9. 2003
    ..To develop a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP)-based assay to genotype for hepatic CYP3A5 expression and to use this assay to study a British population...
  56. ncbi request reprint APOE genotype makes a small contribution to warfarin dose requirements
    Elizabeth A Sconce
    School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Pharmacogenet Genomics 16:609-11. 2006
    ..This study suggests that APOE genotype is unlikely to have a clinically significant effect on warfarin dose requirements...
  57. ncbi request reprint Genotyping for cytochrome P450 polymorphisms
    Ann K Daly
    School of Clinical and Laboratory Sciences, University of Newcastle upon Tyne Medical School, UK
    Methods Mol Biol 320:193-207. 2006
    ....
  58. ncbi request reprint Carriage of the PNPLA3 rs738409 C >G polymorphism confers an increased risk of non-alcoholic fatty liver disease associated hepatocellular carcinoma
    Y L Liu
    Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 61:75-81. 2014
    ..We examined whether rs738409 C >G was associated with HCC-risk in patients with NAFLD...
  59. ncbi request reprint Genetic susceptibility in pancreatic ductal adenocarcinoma
    R Lochan
    Hepato Pancreato Biliary Unit, Department of Surgery, Freeman Hospital, Newcastle upon Tyne, UK
    Br J Surg 95:22-32. 2008
    ..The strongest risk factors for pancreatic adenocarcinoma are tobacco smoking and increasing age. However, only a few smokers or elderly individuals develop the disease and genetic factors are also likely to be important...
  60. ncbi request reprint Detection and characterization of novel polymorphisms in the CYP2E1 gene
    K S Fairbrother
    Department of Pharmacological Sciences, University of Newcastle upon Tyne, Medical School, UK
    Pharmacogenetics 8:543-52. 1998
    ..In summary, this study demonstrated six novel CYP2E1 polymorphisms, including three upstream of the promoter, but with the possible exception of G(-35)T, none appeared to be of functional significance...
  61. ncbi request reprint Do multiple cytochrome P450 isoforms contribute to parathion metabolism in man?
    Elaine Mutch
    Department of Environmental Medicine, School of Clinical and Laboratory Sciences, The Medical School, University of Newcastle, NE2 4HH, Newcastle, UK
    Arch Toxicol 77:313-20. 2003
    ..However, several other isoforms could play an important role when CYP3A and CYP2C8 are poorly expressed due to environmental factors or the presence of a genetic polymorphism...
  62. doi request reprint Relevance of nonsynonymous CYP2C8 polymorphisms to 13-cis retinoic acid and paclitaxel hydroxylation
    Sophie E Rowbotham
    Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Dispos 38:1261-6. 2010
    ..No differences were observed with respect to 13cisRA 4-hydroxylase activity. We conclude that common CYP2C8 polymorphisms are unlikely to explain reported interindividual variation in 13cisRA or paclitaxel pharmacokinetics...
  63. ncbi request reprint CTLA-4 gene polymorphism confers susceptibility to primary biliary cirrhosis
    K Agarwal
    Centre for Liver Research, University of Newcastle, Newcastle upon Tyne, UK
    J Hepatol 32:538-41. 2000
    ..This gene on chromosome 2q33 (designated IDDM12) is associated with susceptibility to both type 1 diabetes and autoimmune thyroid disease...
  64. doi request reprint A role for the pregnane X receptor in flucloxacillin-induced liver injury
    Elise Andrews
    Institute of Cellular Medicine, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Hepatology 51:1656-64. 2010
    ..37, 95% confidence interval = 1.55-7.30, P = 0.0023). Reporter gene experiments showed lower promoter activity for the C allele than the T allele...
  65. ncbi request reprint Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans
    Sophie E Rowbotham
    Northern Institute for Cancer Research, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
    Drug Metab Dispos 38:1211-7. 2010
    ..Therefore, UGT1A9 is likely to be the most important enzyme in the glucuronidation of both substrates as this enzyme had the lowest K(m) and is expressed in both the intestine and at high levels in the liver...
  66. ncbi request reprint CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes
    Namrata Bahadur
    Department of Pharmacological Sciences, University of Newcastle Medical School, Framlington Place, NE2 4HH, Newcastle upon Tyne, UK
    Biochem Pharmacol 64:1579-89. 2002
    ..Median activity associated with CYP2C8*4 also appeared lower than the wild-type but the difference was not significant. There was no evidence that either upstream polymorphism gave rise to altered CYP2C8 expression...
  67. doi request reprint Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways
    Catherine Potter
    Musculoskeletal Research Group, Institute of Cellular Medicine, University of Newcastle, 4th Floor Catherine Cookson Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Ann Rheum Dis 69:1315-20. 2010
    ....
  68. ncbi request reprint Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or liver fibrosis
    Stephen F Stewart
    Centre for Liver Research, and Department of Pharmacological Sciences, Medical School, Framlington Place, Newcastle upon Tyne, United Kingdom
    Hepatology 36:1355-60. 2002
    ..In conclusion, in our population Val-Ala polymorphism in Mn-SOD influences neither susceptibility to alcohol-induced liver fibrosis nor alcohol-induced oxidative stress...
  69. ncbi request reprint N-acetyltransferase (NAT2) polymorphism and breast cancer susceptibility: a lack of association in a case-control study of Turkish population
    Neslihan Aygun Kocabas
    Department of Toxicology, University of Gazi, Pharmacy Faculty, Ankara, Turkey
    Int J Toxicol 23:25-31. 2004
    ....
  70. ncbi request reprint Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics
    Mikko Niemi
    Department of Clinical Pharmacology, University of Helsinki University Central Hospital, Helsinki
    Clin Pharmacol Ther 77:468-78. 2005
    ....
  71. ncbi request reprint Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
    Kim M Smits
    University Maastricht, Maastricht, The Netherlands
    Int J Cancer 110:266-70. 2004
    ..No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected...
  72. ncbi request reprint Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide
    Mikko Niemi
    Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Clin Pharmacol Ther 74:380-7. 2003
    ..Our objective was to investigate the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C8 on the pharmacokinetics and pharmacodynamics of the meglitinide analog antidiabetic drug repaglinide...
  73. ncbi request reprint Impact of cytochrome p450 3A5 genetic polymorphism on tacrolimus doses and concentration-to-dose ratio in renal transplant recipients
    Eric Thervet
    INSERM UMR S490, Centre Universitaire des Saints Peres, Paris, France
    Transplantation 76:1233-5. 2003
    ..Subjects with the CYP3A5*1/*1 genotype express large amounts of CYP3A5. Heterozygotes (genotype CYP3A5*1/*3) also express the enzyme. We postulated that CYP3A5 polymorphism is associated with tacrolimus pharmacokinetic variations...
  74. ncbi request reprint Genetic polymorphism of manganese superoxide dismutase (MnSOD) and breast cancer susceptibility
    Neslihan Aygun Kocabas
    Department of Toxicology, University of Gazi, Pharmacy Faculty, Ankara, Turkey
    Cell Biochem Funct 23:73-6. 2005
    ..42 (95%ci=1.04-1.93))...
  75. ncbi request reprint Pharmacogenetics of tardive dyskinesia: combined analysis of 780 patients supports association with dopamine D3 receptor gene Ser9Gly polymorphism
    Bernard Lerer
    Biological Psychiatry Laboratory, Department of Psychiatry, Hadassah Hebrew University Medical Center, Ein Karem, Jerusalem 91120, Israel
    Neuropsychopharmacology 27:105-19. 2002
    ..68, p <.0001). These findings support a small but significant contribution of the DRD3 ser9gly polymorphism to TD susceptibility that is demonstrable over and above population effects and the effect of age and gender on the phenotype...
  76. ncbi request reprint Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population
    Neslihan Aygun Kocabas
    Department of Toxicology, Pharmacy Faculty, Gazi University, 06330 Hipodrom, Ankara, Turkey
    Arch Toxicol 76:643-9. 2002
    ..We conclude that the CYP1B1* 3 allele appears to be a factor for susceptibility to breast cancer in Turkish women especially those with a BMI greater than 24 kg/m(2)...
  77. ncbi request reprint Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    ..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...