Tamas Dalmay

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. doi request reprint Mechanism of miRNA-mediated repression of mRNA translation
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Essays Biochem 54:29-38. 2013
  2. pmc Reducing ligation bias of small RNAs in libraries for next generation sequencing
    Karim Sorefan
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Silence 3:4. 2012
  3. pmc Characterisation and expression of microRNAs in developing wings of the neotropical butterfly Heliconius melpomene
    Alison K Surridge
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB23EJ, UK
    BMC Genomics 12:62. 2011
  4. ncbi request reprint MicroRNAs and the hallmarks of cancer
    T Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Oncogene 25:6170-5. 2006
  5. doi request reprint Short RNAs in tomato
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    J Integr Plant Biol 52:388-92. 2010
  6. doi request reprint MicroRNAs and cancer
    T Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Intern Med 263:366-75. 2008
  7. doi request reprint Identification of genes targeted by microRNAs
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Biochem Soc Trans 36:1194-6. 2008
  8. pmc Short RNAs in environmental adaptation
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Proc Biol Sci 273:1579-85. 2006
  9. doi request reprint mRNA expression profiling reveals conserved and non-conserved miR-140 targets
    Francisco Esteban Nicolas
    School of Biological Sciences, University of East Anglia, Norwich, UK
    RNA Biol 8:607-15. 2011
  10. ncbi request reprint Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation
    Katarzyna Goljanek-Whysall
    Cell and Developmental Biology, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    J Cell Sci 125:3590-600. 2012

Collaborators

Detail Information

Publications51

  1. doi request reprint Mechanism of miRNA-mediated repression of mRNA translation
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Essays Biochem 54:29-38. 2013
    ..It is now clear that both animal and plant microRNAs mediate both translational repression of intact mRNAs and also cause mRNA degradation. ..
  2. pmc Reducing ligation bias of small RNAs in libraries for next generation sequencing
    Karim Sorefan
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Silence 3:4. 2012
    ..abstract:..
  3. pmc Characterisation and expression of microRNAs in developing wings of the neotropical butterfly Heliconius melpomene
    Alison K Surridge
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB23EJ, UK
    BMC Genomics 12:62. 2011
    ..For this reason we characterised miRNAs in developing butterfly wings and examined differences in their expression between colour pattern races...
  4. ncbi request reprint MicroRNAs and the hallmarks of cancer
    T Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Oncogene 25:6170-5. 2006
    ....
  5. doi request reprint Short RNAs in tomato
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    J Integr Plant Biol 52:388-92. 2010
    ..The present study reviews the current state of tomato short RNAs research and suggests future directions...
  6. doi request reprint MicroRNAs and cancer
    T Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, UK
    J Intern Med 263:366-75. 2008
    ..This paper reviews our current knowledge about microRNAs focusing on their involvement in cancer and their potential as diagnostics and therapeutics...
  7. doi request reprint Identification of genes targeted by microRNAs
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Biochem Soc Trans 36:1194-6. 2008
    ..The present paper reviews the different approaches to predict and experimentally identify genes targeted by miRNAs...
  8. pmc Short RNAs in environmental adaptation
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Proc Biol Sci 273:1579-85. 2006
    ..Initially, short RNAs were believed to primarily regulate the normal development of plants and animals, but recent advances implicate short RNAs in environmental adaptation...
  9. doi request reprint mRNA expression profiling reveals conserved and non-conserved miR-140 targets
    Francisco Esteban Nicolas
    School of Biological Sciences, University of East Anglia, Norwich, UK
    RNA Biol 8:607-15. 2011
    ..In addition, we found that a commercially available scrambled siRNA, which is regularly used as a negative control, regulate the accumulation of many genes...
  10. ncbi request reprint Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation
    Katarzyna Goljanek-Whysall
    Cell and Developmental Biology, School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
    J Cell Sci 125:3590-600. 2012
    ..This indicates that the concerted downregulation of multiple microRNA targets is not only crucial to the skeletal muscle differentiation program but also serves to prevent alternative cell fate choices...
  11. doi request reprint Diverse correlation patterns between microRNAs and their targets during tomato fruit development indicates different modes of microRNA actions
    Sara López-Gomollón
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 236:1875-87. 2012
    ..Our results also highlight potential problems for expression profiling-based microRNA target identification/validation...
  12. pmc MicroRNA regulation of the paired-box transcription factor Pax3 confers robustness to developmental timing of myogenesis
    Katarzyna Goljanek-Whysall
    Department of Cell and Developmental Biology, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Proc Natl Acad Sci U S A 108:11936-41. 2011
    ....
  13. pmc Deep sequencing of tomato short RNAs identifies microRNAs targeting genes involved in fruit ripening
    Simon Moxon
    School of Computing, University of East Anglia, Norwich NR4 7TJ, United Kingdom
    Genome Res 18:1602-9. 2008
    ..This study opens a new avenue in the field of fleshy fruit biology by raising the possibility that fruit development and ripening may be under miRNA regulation...
  14. pmc PAREsnip: a tool for rapid genome-wide discovery of small RNA/target interactions evidenced through degradome sequencing
    Leighton Folkes
    School of Computing Sciences and School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Nucleic Acids Res 40:e103. 2012
    ..By searching for targets of a complete 'sRNAome' we can facilitate large-scale identification of sRNA targets, allowing us to discover regulatory interaction networks...
  15. doi request reprint Profiling of short RNAs during fleshy fruit development reveals stage-specific sRNAome expression patterns
    Irina Mohorianu
    School of Computing Sciences, University of East Anglia, Norwich, UK
    Plant J 67:232-46. 2011
    ..Expression pattern and putative function of these targets indicate a possible role in glutamate accumulation, which contributes to establishing the taste of the fruit...
  16. doi request reprint High throughput sequencing of microRNAs in chicken somites
    Tina Rathjen
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    FEBS Lett 583:1422-6. 2009
    ..One of the six new miRNAs is highly enriched in somite tissue suggesting that deep sequencing of other specific tissues has the potential to identify novel tissue specific miRNAs...
  17. doi request reprint Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133
    Dylan Sweetman
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK
    Dev Biol 321:491-9. 2008
    ..Taken together our results demonstrate differential requirements of distinct MRFs for the induction of microRNA gene expression during skeletal myogenesis...
  18. doi request reprint miR395 is a general component of the sulfate assimilation regulatory network in Arabidopsis
    Colette A Matthewman
    John Innes Centre, Norwich Research Park, Norwich, UK
    FEBS Lett 586:3242-8. 2012
    ..Thus, miR395 is an integral part of the regulatory network of sulfate assimilation...
  19. pmc The UEA sRNA workbench: a suite of tools for analysing and visualizing next generation sequencing microRNA and small RNA datasets
    Matthew B Stocks
    School of Computing Sciences, University of East Anglia, Norwich Research Park, NR4 7TJ, Norwich, UK
    Bioinformatics 28:2059-61. 2012
    ..Herein, we present the UEA sRNA workbench, a suite of tools that is a successor to the web-based UEA sRNA Toolkit, but in downloadable format and with several enhanced and additional features...
  20. pmc High-throughput sequencing of Medicago truncatula short RNAs identifies eight new miRNA families
    Gyorgy Szittya
    School of Biological Sciences, University of East Anglia, Norwich, UK
    BMC Genomics 9:593. 2008
    ..High-throughput sequencing technology is capable to identify novel short RNAs in plant species. We used Solexa sequencing to find new microRNAs in one of the model legume species, barrel medic (Medicago truncatula)...
  21. ncbi request reprint Deciphering the diversity of small RNAs in plants: the long and short of it
    Frank Schwach
    School of Computing Sciences, University of East Anglia, Norwich, UK
    Brief Funct Genomic Proteomic 8:472-81. 2009
    ..In this review we present an overview of RNA silencing pathways in plants and the current challenges in analysing sRNA data, with a special focus on computational approaches...
  22. doi request reprint Sulphur starvation induces the expression of microRNA-395 and one of its target genes but in different cell types
    Cintia Goulart Kawashima
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Plant J 57:313-21. 2009
    ..These results illustrate that negative temporal correlation between the expression level of a miRNA and its target gene in a complex tissue cannot be a requirement for target gene validation...
  23. doi request reprint Interplay of SLIM1 and miR395 in the regulation of sulfate assimilation in Arabidopsis
    Cintia G Kawashima
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Plant J 66:863-76. 2011
    ..Thus, miR395 is an integral part of the regulatory circuit controlling plant sulfate assimilation with a complex mechanism of action...
  24. doi request reprint Detection of small non-coding RNAs
    Tamas Dalmay
    School of Biological Sciences, University of East Anglia, Norwich, Norfolk, England
    Methods Mol Biol 655:265-74. 2010
    ..This chapter describes optimised RNA extraction methods, which give good yields of short RNAs, and separation, transfer and hybridisation protocols to study the accumulation of short RNAs...
  25. ncbi request reprint Silencing human cancer: identification and uses of microRNAs
    Francisco E Nicolas
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Recent Pat Anticancer Drug Discov 6:94-105. 2011
    ....
  26. doi request reprint Small RNA discovery and characterisation in eukaryotes using high-throughput approaches
    Helio Pais
    School of Computing Sciences, University of East Anglia, Norwich, UK
    Adv Exp Med Biol 722:239-54. 2011
    ..In this chapter we will review RNA silencing, the different types of sRNAs that mediate it and the computational methods that have been developed to use high-throughput technologies in the study of sRNAs and their targets...
  27. doi request reprint MirPlex: a tool for identifying miRNAs in high-throughput sRNA datasets without a genome
    Daniel Mapleson
    University of East Anglia, Norwich, United Kingdom
    J Exp Zool B Mol Dev Evol 320:47-56. 2013
    ..Tests on sRNA datasets from model animals demonstrate that the tool is effective at predicting genuine miRNA duplexes, and, for some sets, achieves a high degree of precision when considering only the mature sequence...
  28. doi request reprint The expression and function of microRNAs in chondrogenesis and osteoarthritis
    Tracey E Swingler
    University of East Anglia, Norwich, UK
    Arthritis Rheum 64:1909-19. 2012
    ..To use an in vitro model of chondrogenesis to identify microRNAs (miRNAs) with a functional role in cartilage homeostasis...
  29. pmc Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level
    Helio Pais
    School of Computing Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    RNA 16:489-94. 2010
    ..Our findings establish a valid strategy for the discovery of microRNA targets regulated only at protein level, and we propose that additional targets could be identified by re-analysis of existing microarray datasets...
  30. pmc Endogenous short RNAs generated by Dicer 2 and RNA-dependent RNA polymerase 1 regulate mRNAs in the basal fungus Mucor circinelloides
    Francisco Esteban Nicolas
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Nucleic Acids Res 38:5535-41. 2010
    ..Our results expand the range of esRNAs in eukaryotes and reveal a new role for esRNAs in fungi...
  31. doi request reprint A toolkit for analysing large-scale plant small RNA datasets
    Simon Moxon
    School of Computing Sciences, School of Biological Sciences, University of East Anglia, Norwich NR47TJ, UK
    Bioinformatics 24:2252-3. 2008
    ..Here, we describe a suite of web-based tools for processing plant small RNA datasets. Our tools can be used to identify micro RNAs and their targets, compare expression levels in sRNA loci, and find putative trans-acting siRNA loci...
  32. ncbi request reprint Analysis of short RNAs in the malaria parasite and its red blood cell host
    Tina Rathjen
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    FEBS Lett 580:5185-8. 2006
    ..Interestingly, mir-451 was not detectable in a series of immortalised cell lines representing progenitor stages of all major blood lineages, suggesting that mir-451 may play a role in the differentiation of erythroid cells...
  33. ncbi request reprint Identification of novel small RNAs in tomato (Solanum lycopersicum)
    Rachel L Rusholme Pilcher
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Planta 226:709-17. 2007
    ....
  34. doi request reprint microRNA-449 is a putative regulator of choroid plexus development and function
    Nicholas Redshaw
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Brain Res 1250:20-6. 2009
    ..Taken together, these findings suggest that miR449 has a specific role in the development and functioning of choroid plexuses...
  35. pmc Structural and functional analysis of viral siRNAs
    Gyorgy Szittya
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    PLoS Pathog 6:e1000838. 2010
    ..The sequence profiles and Terminator digests suggest that CymRSV siRNAs are produced from the structured positive strand rather than from perfect double stranded RNA or by RNA dependent RNA polymerase...
  36. ncbi request reprint In situ detection of animal and plant microRNAs
    Guy Wheeler
    School of Biological Sciences, University of East Anglia, Norwich, United Kingdom
    DNA Cell Biol 26:251-5. 2007
    ..This enabled several research groups to analyze the expression patterns of miRNAs in both plant and animal tissues. This review focuses on the results of recent publications on the detection of miRNAs by ISH...
  37. ncbi request reprint SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA
    Inmaculada Hernandez-Pinzon
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Plant J 50:140-8. 2007
    ..As the sequence of SDE5 has sequence features shared by TAP, a human mRNA export factor, we propose that its role could be in the transport of RNA molecules that are converted into a double-stranded form by RDR6...
  38. ncbi request reprint FGF-4 signaling is involved in mir-206 expression in developing somites of chicken embryos
    Dylan Sweetman
    School of Biological Science, University of East Anglia, Norwich, United Kingdom
    Dev Dyn 235:2185-91. 2006
    ..Thus far, miRNAs have not been studied extensively in chicken embryos, and our results show that this system can complement other model organisms to investigate the regulation of many other miRNAs...
  39. pmc Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140
    Francisco Esteban Nicolas
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    RNA 14:2513-20. 2008
    ..Interestingly, none of these were predicted by the published target prediction methods we used. One of the potential target mRNAs, Cxcl12, was experimentally validated by Northern blot analysis and a luciferase reporter assay...
  40. doi request reprint Biogenesis of Y RNA-derived small RNAs is independent of the microRNA pathway
    Francisco Esteban Nicolas
    School of Biological Sciences, University of East Anglia, Norwich, UK
    FEBS Lett 586:1226-30. 2012
    ..Therefore we conclude that Y RNA fragments do not enter the microRNA pathway...
  41. ncbi request reprint RNA silencing: Recent developments on miRNAs
    Francisco E Nicolas
    University of East Anglia, Norwich, UK
    Recent Pat DNA Gene Seq 3:77-87. 2009
    ....
  42. ncbi request reprint Recent patents in RNA silencing in plants: constructs, methods and applications in plant biotechnology
    Sara López-Gomollón
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Recent Pat DNA Gene Seq 4:155-66. 2010
    ....
  43. ncbi request reprint The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells
    Lee Tuddenham
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    FEBS Lett 580:4214-7. 2006
    ..5 embryos. A potential target of miR-140, histone deacetylase 4, was validated experimentally and the possible role of miR-140 in long bone development is discussed...
  44. doi request reprint Discovery of novel small RNAs in the quest to unravel genome complexity
    Adam E Hall
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Biochem Soc Trans 41:866-70. 2013
    ..The recent discovery of novel small RNAs derived from tRNAs, snoRNAs and Y RNAs, as well as the development of techniques that can reduce sequencing bias of these molecules, is slowly helping us to unveil the secrets of the genome. ..
  45. pmc Small RNA analysis in Sindbis virus infected human HEK293 cells
    Andras Donaszi-Ivanov
    Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
    PLoS ONE 8:e84070. 2013
    ..Since RNAi has a well-established role in controlling infection of the alphavirus Sindbis virus (SINV) in insects, we have used this virus to investigate the role of RNAi in SINV infection of human cells...
  46. ncbi request reprint Identification of new central nervous system specific mouse microRNAs
    Guy Wheeler
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    FEBS Lett 580:2195-200. 2006
    ..In addition, the expression of miR-500 in limb buds showed very strong asymmetry in favour of the left hand side...
  47. ncbi request reprint Evidence for targeting common siRNA hotspots and GC preference by plant Dicer-like proteins
    Thien Ho
    NERC Centre for Ecology and Hydrology Oxford, Oxford, UK
    FEBS Lett 581:3267-72. 2007
    ..Furthermore, dicot micro-(mi)RNAs displayed higher GC% than their DCL1 substrate RNAs, implicating that the GC bias may be ancient, therefore may be important for the RNAi technology...
  48. doi request reprint Cloning of short interfering RNAs from virus-infected plants
    Thien X Ho
    NERC Centre for Ecology and Hydrology Oxford, Mansfield Road, Oxford OX1 3SR, UK
    Methods Mol Biol 451:229-41. 2008
    ..Concatamers containing as many as 15 small RNA inserts can be produced. This protocol has successfully been applied to leaf materials of monocots and dicots infected with poty-, carmo-, and sobemo-viruses...
  49. doi request reprint Evidence for GC preference by monocot Dicer-like proteins
    Thien Ho
    NERC Centre for Ecology and Hydrology CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
    Biochem Biophys Res Commun 368:433-7. 2008
    ..This supports the notion that GC preference is an ancient feature for plant DCLs, and suggests that monocot miRNA genes might have evolved to a high GC% resulting in GC bias being not detectable during mature miRNA production...
  50. ncbi request reprint A simplified method for cloning of short interfering RNAs from Brassica juncea infected with Turnip mosaic potyvirus and Turnip crinkle carmovirus
    Thien Ho
    NERC Centre for Ecology and Hydrology CEH Oxford, Mansfield Road, Oxford OX1 3SR, UK
    J Virol Methods 136:217-23. 2006
    ..6%) from the +ss RNA. However, for TuMV infections, siRNAs were derived from both strands (+/-, 58.1-41.9%), indicating the presence of alternative siRNA production mechanisms...
  51. ncbi request reprint The role of small RNAs in abiotic stress
    Jonathan R Phillips
    Institute of Molecular Plant Physiology and Biotechnology of Plants IMBIO, University of Bonn, Kirschallee 1, D 53115 Bonn, Germany
    FEBS Lett 581:3592-7. 2007
    ..Using the CDT-1 gene from the desiccation tolerant plant Craterostigma plantagineum as an example, it is discussed that generation of novel small RNAs could be an evolutionary pathway in plants to adapt to extreme environments...